The SIDER Side Effect Resource represents an effort to aggregate dispersed public information on side effects. To our knowledge, no such resource exist in machine-readable form despite the importance of research on drugs and their effects. The creation of this resource was motivated by the many requests for data that we received related to our paper (Campillos, Kuhn et al., Science, 2008, 321(5886):263-6.) on the utilization of side effects for drug target prediction. Inclusion of side effects as readouts for drug treatment should have many applications and we hope to be able to enhance the respective research with this resource.
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A side effect resource to capture phenotypic effects of drugs.
Mol Syst Biol. 2010;6:343. Epub 2010 Jan 19.
Drug target identification using side-effect similarity.
Science. 2008 Jul 11;321(5886):263-6.
Large-scale prediction of drug-target relationships.
FEBS Lett. 2008 Apr 9;582(8):1283-90. Epub 2008 Feb 20.
STITCH: interaction networks of chemicals and proteins.
Nucleic Acids Res. 2008 Jan;36(Database issue):D684-8. Epub 2007 Dec 15.
STITCH 2: an interaction network database for small molecules and proteins.
Nucleic Acids Res. 2010 Jan;38(Database issue):D552-6. Epub 2009 Nov 6.