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Methylphenidate

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: N06BA04, N06BA11

Side effects

Options: Hide MedDRA Preferred Terms ,   display only 20 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33
Nervous system disorder Nervous system disorder postmarketing, 1.9% - 50% 0% - 28% x x x x x x x x x x x x x x x x
Mental disorder Mental disorder postmarketing, 1.2% - 46% 0% - 30% x x x x x x x x x x x x
Gastrointestinal disorder Gastrointestinal disorder 1.7% - 44% 0.5% - 24% x x x x x x x x x x x x x x x
Decreased appetite Decreased appetite common — 0.7% - 30% 0% - 9% x x x x x x x x x x x x x x x x x x x x
Anorexia postmarketing, 0% - 7% 0% - 4.23% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Appetite absent postmarketing x x x x x x x x x x x x x x x x x x x x x x x x
Headache Headache postmarketing — 0.6% - 39% 11% - 19% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Malnutrition Malnutrition 16% - 34% 5% - 11% x x x x x x x x x x x x x x x
Dry mouth Dry mouth very common, 4% - 20% 3.6% - 4% x x x x x x x x x x x x x x x x x x
Mediastinal disorder Mediastinal disorder 1.2% - 16% 0.3% - 8% x x x x x x x x x x x x x
Dyspepsia Dyspepsia common, 2% - 9% 0.9% - 4% x x x x x x x x x x x x x x x x
Nausea Nausea postmarketing — 9.66% - 14.3% 2.35% - 4.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Abdominal pain upper Abdominal pain upper 3.11% - 7.45% 3.8% x x x x x x x x x x
Stomach ache x x x x
Anxiety Anxiety postmarketing — 0.7% - 11% 0% - 2.9% x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperhidrosis Hyperhidrosis common, 5.1% - 5.7% 0.9% - 1.3% x x x x x x x x x
Sweating x x
Toothache Toothache common x
Sleep disorder Sleep disorder common x x x x x x x x
Insomnia Insomnia postmarketing — 0% - 17% 0% - 7.8% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Blood pressure fluctuation Change in blood pressure common x x x
Lethargy Lethargy 4.97% x x x x x x x x x
Asthenia Fatigue 4.7% 4.2% x x x x x x x x x x
Asthenia 1.2% 0% x x x x x x x
Fatigue Fatigue 4.7% 4.2% x x x x x x x x x x
Initial insomnia Initial insomnia 2% - 5.7% 0% - 2.8% x x x x x x x x
Infestation Infestation NOS 2.2% - 5.8% 0.9% - 1.4% x x x x x x x x
Laryngeal pain Pharyngolaryngeal pain 1.2% - 7% 0.9% - 2% x x x x x x x x x x
Nervousness Feeling jittery common, 1.4% x x x x x x x x x x x x x
Nervousness postmarketing — 0.7% - 3.1% 0.5% - 0.6% x x x x x x x x x x x x x x x x x x x x
Feeling jittery Feeling jittery common, 1.4% x x x x x x x x x x x x x
Palpitations Palpitations postmarketing — 3.1% - 4.5% 0.6% - 0.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Agitation Agitation common, 2.2% - 4% 0% - 0.6% x x x x x x x x x x x
Hyperkinesia very rare, postmarketing x x x x x x x
Nasopharyngitis Nasopharyngitis 2.48% - 6.83% 2.2% x x x x x x x x
Vomiting Vomiting common, 1.7% - 10.2% 0% - 4.71% x x x x x x x x x x x x x x x x
Tremor Tremor common, 2.7% - 3.4% 0.5% - 0.6% x x x x x x x x x x
Diarrhoea Diarrhoea 2.4% x x x x x x x x x
Infection Infection postmarketing, 2.2% - 5.8% 0.9% - 1.4% x x x x x x x x x x
Body temperature increased Body temperature increased postmarketing — 2.2% 0.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypertension Hypertension 2.2% 1.6% x x x x x x x x
Upper respiratory tract infection Upper respiratory tract infection 1.7% - 2.2% 0.9% - 1% x x x x x x x x
Excoriation Excoriation postmarketing, 4% 0% x x
Motion sickness Motion sickness 2% 0% x
Application site reaction Application site reaction 2% x
Eye pain Eye pain 2% 0% x
Cough Cough common, 1.2% - 1.9% 0.3% - 1% x x x x x x x x
Cough increased x x
Dizziness Dizziness postmarketing — 0% - 7.4% 0% - 5.5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Syncope x
Muscle tightness Muscle tightness 1.3% - 1.9% 0% x x x x x x
Thirst Thirst 1.8% 0.6% x x x x x
Bruxism Bruxism postmarketing, 1.5% - 1.7% 0.5% - 0.6% x x x x x x x x
Connective tissue disorder Connective tissue disorder 1.7% 0% x x x x x x x
Libido decreased Libido decreased 1.3% - 1.7% 0.5% - 0.6% x x x x x x
Disturbance in sexual arousal Libido decreased 1.3% - 1.7% 0.5% - 0.6% x x x x x x
Vertigo Vertigo 1.7% - 2% 0% - 0.3% x x x x x x x x x
Vision blurred Vision blurred postmarketing — 1.3% - 1.7% 0.5% - 1% x x x x x x x x x x x x
Constipation Constipation 1.4% - 1.5% 0.6% - 0.9% x x x x x x x x x
Irritability Irritability postmarketing — 0% - 11% 0% - 6.94% x x x x x x x x x x x x x x x x x x x
Affect lability Affect lability 0% - 9% 0% - 2% x x x x x x x x x
Mood swings 0% - 3% 2% x x x x x x x x x x x
Oropharyngeal pain Oropharyngeal pain 1.2% - 1.7% 0.9% - 1.4% x x x
Throat sore x x
Sinusitis Sinusitis 1.3% 1% x x x x x x
Panic attack Panic attack 1.3% 0.3% x x x x
Abdominal discomfort Abdominal discomfort 1.3% x x x x
Upset stomach x x x
Menopausal symptoms Hot flush 1.3% 0.6% x x x x
Hot flush Hot flush 1.3% 0.6% x x x x
Confusional state Confusional state 1% - 1.2% 0.3% - 0.5% x x x x x x x x x x
Feeling abnormal Confusional state 1% - 1.2% 0.3% - 0.5% x x x x x x x x x x
Malaise x x
Dyspnoea Dyspnoea 1.2% 0.6% x x x x x x x x x
Pain Pain postmarketing, 1.2% - 1.7% 0.9% - 1.4% x x x x
Paraesthesia Paraesthesia postmarketing, 1.2% 0% x x x x x x x x x
Tension headache Tension headache 1% - 1.2% 0.3% - 0.5% x x x x x x
Tension Tension 1.2% - 1.3% 0.3% - 0.5% x x x x x x x x
Nervousness postmarketing — 0.7% - 3.1% 0.5% - 0.6% x x x x x x x x x x x x x x x x x x x x
Muscle spasms Muscle spasms 1% 0.3% x x x x
Cramp muscle very rare x x x
Cramps of lower extremities x
Alanine aminotransferase increased Alanine aminotransferase increased 1% 0% x x x x
Erectile dysfunction Erectile dysfunction 1% 0.3% x x x x x x
Somnolence Somnolence 1% x x x x x x x x
Drowsiness postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x
Depression Depression 0% - 3% 0% - 0.9% x x x x x x x x x x x
Abdominal pain Abdominal pain postmarketing — 0.7% - 7.14% 0% - 5.88% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Stomach ache x x x x
Gastrointestinal pain Abdominal pain postmarketing — 0.7% - 7.14% 0% - 5.88% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Aggression Aggression postmarketing, 1.2% - 1.7% 0.5% - 0.6% x x x x x x x x x x x x x x x x x x x x x x x x x
Alopecia Alopecia postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Anaphylactic shock Anaphylactic shock very rare, postmarketing x x x x x x x x x x x x
Anaemia Anaemia very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x
Aplastic anaemia Aplastic anaemia postmarketing x x
Angina pectoris Angina pectoris postmarketing, rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Angioedema Angioedema very rare, postmarketing x x x x x x x x x x x x
Arrhythmia Arrhythmia postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x
Arthralgia Arthralgia postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Myalgia postmarketing x x x x x x x x x x
Bone disorder Bone disorder postmarketing x x x x x x x
Breast disorder Breast disorder postmarketing x x x x x x
Cerebral arteritis Cerebral arteritis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x
Chest pain Chest pain postmarketing x x x x x x x x x x x
Chest discomfort postmarketing x x x x x x x
Chest pain exertional x
Contusion Contusion postmarketing x x
Sudden death Sudden death postmarketing x x x x x
Dermatitis Dermatitis postmarketing x x x
Rash postmarketing — 1.3% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dermatitis exfoliative Dermatitis exfoliative very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x
Diplopia Diplopia postmarketing x x x x x x x x x
Dyskinesia Dyskinesia postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Eczema Eczema postmarketing x x x
Oedema Oedema postmarketing x
Grand mal convulsion Grand mal convulsion postmarketing x x x x x x x
Erythema multiforme Erythema multiforme very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x
Stevens-Johnson syndrome postmarketing x x
Rash Rash postmarketing — 1.3% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Eruption postmarketing x x x x x x x
Eye disorder Eye disorder postmarketing, 1.7% 0% x x x x x x x x x
Hallucination Hallucination postmarketing x x x x x x x x x x x
Cardiac arrest Cardiac arrest postmarketing x x x x x x x
Cardiac disorder Cardiac disorder postmarketing, 4.8% 0% x x x x x x x x x x x
Haemorrhage Haemorrhage postmarketing x
Haemoglobin Haemorrhage postmarketing x
Coma hepatic Coma hepatic very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypersensitivity Hypersensitivity very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypoglycaemia Hypoglycaemia postmarketing x x
Immune system disorder Immune system disorder postmarketing x x x x x x x x x x x x
Inflammation Inflammation postmarketing x
Leukopenia Leukopenia very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Mydriasis Mydriasis postmarketing x x x x x x x x x x
Neuroleptic malignant syndrome Neuroleptic malignant syndrome very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x
Obsessive-compulsive disorder Obsessive-compulsive disorder postmarketing x x x x
Pancreatitis Pancreatitis postmarketing x x
Pancytopenia Pancytopenia postmarketing x x x x x x x x x x
Priapism Priapism postmarketing x x x x x x
Psychotic disorder Psychotic disorder very rare, postmarketing x x x x x x x x x x
Convulsion Convulsion very rare, postmarketing x x x x x x x x x x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x
Completed suicide Suicide postmarketing x x x
Completed suicide postmarketing x x x x x x x
Suicide attempt Suicide attempt postmarketing x x x
Swelling Swelling postmarketing x
Tachycardia Tachycardia postmarketing — 0.69% - 6% 0% - 1.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Supraventricular tachycardia Supraventricular tachycardia postmarketing x x x x x x x
Thrombocytopenia Thrombocytopenia very rare, postmarketing x x x x x x x x x x x x x x x x x
Tourette's disorder Tourette's disorder very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x
Ulcer Ulcer postmarketing x
Erythema Erythema postmarketing x x x x x x x x x
Urticaria Urticaria postmarketing, common x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Angiopathy Angiopathy postmarketing x x x x x x x x x
Weight increased Weight increased rare x x x
Weight decreased Weight decreased postmarketing — 5.52% - 9.18% 0% - 3.6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Sudden cardiac death Sudden cardiac death postmarketing x x x x
Hepatic function abnormal Hepatic function abnormal very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x
Migraine Migraine postmarketing x x x x x x x x
Ventricular extrasystoles Ventricular extrasystoles postmarketing x x x x x x x
Growth retardation Growth retardation rare x x x
Blood alkaline phosphatase increased Phosphatase alkaline increased postmarketing x
Blood alkaline phosphatase increased postmarketing x x x x x x
Accommodation disorder Accommodation disorder postmarketing, rare x x x x x x x x
Dermatitis contact Allergic contact dermatitis postmarketing x
Skin hyperpigmentation Skin hyperpigmentation postmarketing x
Leukoderma Leukoderma postmarketing x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing, 1.7% 1.4% x x x x x x x x x x
Scab Scab postmarketing x
Drug eruption Fixed drug eruption postmarketing x x x x x x x
Myalgia Myalgia postmarketing x x x x x x x x x x
Muscle twitching Muscle twitching postmarketing x x x x x x x x x x x x x x x x x x x
Disorientation Disorientation postmarketing x x x x x x x x
Abnormal behaviour Abnormal behaviour postmarketing x x x x x x
Hallucination, auditory Hallucination, auditory postmarketing x x x x x x x
Hallucination, visual Hallucination, visual postmarketing x x x x x x x
Discomfort Discomfort postmarketing x
Malaise x x
Chest discomfort Chest discomfort postmarketing x x x x x x x
Therapeutic response decreased Therapeutic response decreased postmarketing x x x x x x
Hepatic enzyme increased Hepatic enzyme increased postmarketing x x x x x x x
Skin exfoliation Skin exfoliation postmarketing x
Peripheral coldness Peripheral coldness postmarketing x x x x x
Blood bilirubin increased Blood bilirubin increased postmarketing x x x x x x x
Induration Induration postmarketing x
Papule Papule postmarketing x
Mania Mania postmarketing x x x x x x x x
Extrasystoles Extrasystoles postmarketing x x x x x x x
Depressed mood Depressed mood very rare — 3.9% - 4.4% 1.4% - 2.6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Feeling sad x
Feeling hot Warmth postmarketing x
Platelet count decreased Platelet count decreased postmarketing x x x x x x x
Hyperpyrexia Hyperpyrexia postmarketing x x x x x x x x
Suicidal ideation Suicidal ideation postmarketing x x
Hyperkinesia Hyperkinesia very rare, postmarketing x x x x x x x
Bradycardia Bradycardia postmarketing x x x x x x x
Blood pressure increased Blood pressure increased postmarketing, 1% - 2.5% 1.9% x x x x x x x x x x x x x x x x x x
Drug effect decreased Drug effect decreased postmarketing x x x x x x
Visual impairment Visual disturbance postmarketing, rare x x x x x x x x x
Visual impairment postmarketing x x x x x
Abnormal vision x
Auricular swelling Auricular swelling postmarketing x x x x x x x x
Reversible ischaemic neurological deficit Reversible ischaemic neurological deficit postmarketing x x x x x
White blood cell count abnormal White blood cell count abnormal postmarketing x x x x x x x
Drug interaction Drug interaction postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Thrombocytopenic purpura Thrombocytopenic purpura very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vasculitis necrotising Vasculitis necrotising postmarketing x x x x x x x x x x x x x x x x x x x x x x x x
Suicidal behaviour Suicidal behaviour postmarketing x x x x x x
Logorrhoea Logorrhoea postmarketing x x x
Cerebrovascular disorder Cerebrovascular disorder very rare x x
Cerebrovascular accident Cerebrovascular accident very rare x x x
Vasculitis Vasculitis very rare x x x
Hallucination, tactile Hallucination, tactile very rare x x x
Choreoathetosis Choreoathetoid movements very rare x x x
Cerebral haemorrhage Cerebral haemorrhage very rare x x x
Abscess Abscess x
Albuminuria Albuminuria x
Anger Anger x x x x x x x x x
Asthma Asthma x x
Back pain Back pain x
Bronchitis Bronchitis x x
Neck pain Neck pain x
Coma Coma x
Conjunctivitis Conjunctivitis x x
Dehydration Dehydration x
Delirium Delirium x
Dental caries Dental caries x
Depersonalisation Depersonalisation x
Diabetes mellitus Diabetes mellitus x
Dysmenorrhoea Dysmenorrhoea x x
Ear disorder Ear disorder x x
Ear pain Ear pain