Side effect information for Tramadol

Side effects

Options: Hide MedDRA Preferred Terms , display only 20 labels

MedDRA Preferred Term	Side effect	Data for drug	Placebo	Labels
				1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44
Vertigo	Vertigo	0.926% - 33%	0.449% - 6.9%	x	x										x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dizziness	Dizziness	postmarketing — 7.41% - 33%	2.69% - 12.4%	x	x	x	x	x	x	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Syncope	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Dizziness aggravated																															x	x	x	x	x	x	x	x	x	x	x	x	x
Nausea	Nausea	postmarketing — 13% - 40%	5.54% - 21.4%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Constipation	Constipation	common, 9.32% - 46%	3.89% - 13.6%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Constipation	Constipation aggravated	postmarketing, uncommon																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Headache	Headache	common, 2.83% - 32%	3.14% - 22.1%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x
Headache	Headache aggravated	postmarketing, uncommon																											x	x	x														x	x	x
Somnolence	Somnolence	4.34% - 30.2%	1.72% - 13.8%	x	x											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vomiting	Vomiting	postmarketing — 3.24% - 17%	0.599% - 10.4%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dyspepsia	Dyspepsia	uncommon, 1.4% - 13%		x	x	x	x	x	x	x	x	x				x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dyspepsia	Dyspepsia aggravated	postmarketing, uncommon																											x	x	x														x	x	x
Dry mouth	Dry mouth	common, 1.13% - 13.1%	1.2% - 8.29%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x
Flushing	Flushing	uncommon, 7.69% - 15.8%	4.43%			x	x	x	x	x	x	x																x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pruritus	Pruritus	uncommon, 3.03% - 11.9%	0.985% - 5.76%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperhidrosis	Sweating	common, 4.2% - 9%	0.619% - 5.3%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x					x
Hyperhidrosis	Sweating increased	postmarketing, 0.463% - 7.44%	0.246% - 0.749%										x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Asthenia	Asthenia	rare — 0.744% - 12%	1.23% - 5.99%	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Asthenia	Fatigue	common, 1.7% - 4.2%	0.898%			x	x	x	x	x	x	x																x	x	x	x														x	x	x
Diarrhoea	Diarrhoea	uncommon, 2.33% - 10%	4.19%			x	x	x	x	x	x	x					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x
Diarrhoea	Loose stools	postmarketing, uncommon																																											x	x	x
Arthralgia	Arthralgia	0.9% - 5.36%	4.61% - 5.11%	x	x																								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Arthralgia	Polyarthralgia	postmarketing, uncommon																																											x	x	x
Musculoskeletal discomfort	Arthralgia	0.9% - 5.36%	4.61% - 5.11%	x	x																								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Myalgia	postmarketing, uncommon		x	x					x		x																x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Musculoskeletal discomfort	postmarketing, uncommon																																											x	x	x
Insomnia	Insomnia	postmarketing, 0.926% - 10.9%	1.2% - 3.2%	x	x				x	x		x																x	x	x	x	x		x	x	x	x	x	x	x	x	x	x		x	x	x
Insomnia	Insomnia NEC																																											x
Pain	Pain worsened	2.8%																																											x
Pain	Pain	postmarketing, uncommon																																												x	x
Fatigue	Fatigue	common, 1.7% - 4.2%	0.898%			x	x	x	x	x	x	x																x	x	x	x														x	x	x
Decreased appetite	Anorexia	0.744% - 7.44%	0.155% - 5.3%	x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Decreased appetite	Decreased appetite	postmarketing, uncommon																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Orthostatic hypotension	Orthostatic hypotension	postmarketing — 1.74% - 5.45%	2.22%										x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nasopharyngitis	Nasopharyngitis	1.9%																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nasopharyngitis	Rhinorrhoea	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Chills	Rigors	0.5% - 3.47%	0.246%																													x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Shivering	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Chills			x	x					x		x																x
Upper respiratory tract infection	Upper respiratory tract infection	1.4%																														x	x	x	x	x	x	x	x	x	x	x	x		x
Abdominal pain upper	Abdominal pain upper	1.4% - 4.19%																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Angina pectoris	Angina pectoris	postmarketing — 1.86% - 1.9%																										x																	x	x	x
Angina pectoris	Angina unstable	postmarketing, uncommon																																											x	x	x
Hypertension	Hypertension worsened	postmarketing — 1.86% - 1.9%																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypertension	Hypertension	postmarketing — 2.3% - 2.33%		x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Influenza like illness	Influenza like illness	postmarketing — 0.248% - 1.98%	0.493%																													x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Abdominal pain	Abdominal pain	uncommon, 0.9% - 1.4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal pain	Abdominal pain	uncommon, 0.9% - 1.4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Influenza	Influenza	0.9%		x	x																							x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary tract infection	Urinary tract infection	0.9%		x	x																							x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Alanine aminotransferase increased	Alanine aminotransferase increased	postmarketing — 0.8%		x	x																							x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Red blood cell sedimentation rate increased	Red blood cell sedimentation rate increased	postmarketing — 0.7%																																											x	x	x
Aspartate aminotransferase increased	Aspartate aminotransferase increased	postmarketing — 0.7%																										x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysgeusia	Dysgeusia	postmarketing — 3.72%											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																	x	x	x
Dermatitis	Rash	uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																	x	x	x
Dermatitis	Dermatitis	postmarketing, uncommon																										x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rash	Rash	uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																	x	x	x
Flatulence	Flatulence	uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Flatulence	Abdominal bloating																											x
Tremor	Trembling	postmarketing, uncommon				x	x	x	x	x	x	x																																		x	x
Tremor	Tremor	postmarketing — 0.5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Weight decreased	Weight decreased	0.5%		x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Menopausal symptoms	Hot flush	0.5%																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Menopausal symptoms	Menopausal symptoms												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hot flush	Hot flush	0.5%																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hot flush	Exacerbation of hot flushes	postmarketing, uncommon																																											x	x	x
Anxiety	Anxiety NEC	0.5%																																										x	x
Anxiety	Anxiety	postmarketing, rare		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x
Gamma-glutamyltransferase increased	Gamma-glutamyltransferase increased	0.4%		x	x																								x	x	x														x	x	x
Liver function test abnormal	Liver function test abnormal	0.4%																										x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Anaemia	Anaemia	postmarketing, uncommon		x	x																								x	x	x													x	x	x	x
Angina unstable	Angina unstable	postmarketing, uncommon																																											x	x	x
Aortic aneurysm	Aortic aneurysm	postmarketing, uncommon																																											x	x	x
Arthritis	Rheumatoid arthritis	postmarketing, uncommon																																											x	x	x
Arthritis	Arthritis			x	x																							x
Rheumatoid arthritis	Rheumatoid arthritis	postmarketing, uncommon																																											x	x	x
Ataxia	Ataxia	postmarketing, uncommon								x																		x	x	x	x														x	x	x
Atrial fibrillation	Atrial fibrillation	postmarketing, uncommon																																											x	x	x
Back injury	Back injury	postmarketing, uncommon																																											x	x	x
Bipolar disorder	Bipolar disorder	postmarketing, uncommon																																											x	x	x
Bipolar I disorder	Bipolar disorder	postmarketing, uncommon																																											x	x	x
Blister	Blister	postmarketing, uncommon																																											x	x	x
Dermatitis bullous	Blister	postmarketing, uncommon																																											x	x	x
Concussion	Concussion	postmarketing, uncommon																																											x	x	x
Breast cancer	Breast cancer	postmarketing, uncommon																																											x	x	x
Breast cancer	Breast cancer invasive NOS	postmarketing, uncommon																																											x	x	x
Bronchitis	Bronchitis	postmarketing, uncommon		x	x																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bronchitis	Acute bronchitis																																													x	x
Bursitis	Bursitis	postmarketing, uncommon																										x																	x	x	x
Cardiovascular disorder	Cardiovascular disorder	postmarketing, uncommon																																											x	x	x
Neck pain	Neck pain	postmarketing, uncommon		x	x																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Musculoskeletal chest pain	Chest wall pain	postmarketing, uncommon																																											x	x	x
Cholelithiasis	Cholelithiasis	postmarketing, uncommon																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Infection	Infection	postmarketing, uncommon																										x					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Contusion	Contusion	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cough	Cough	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x		x	x	x
Cough	Cough increased																											x
Dysphagia	Dysphagia	postmarketing, uncommon																											x	x	x														x	x	x
Dehydration	Dehydration	postmarketing, uncommon																											x	x	x														x	x	x
Dermatitis atopic	Dermatitis atopic	postmarketing, uncommon																											x	x	x														x	x	x
Dermatitis contact	Dermatitis contact	postmarketing, uncommon																																											x	x	x
Diabetes mellitus	Diabetes mellitus	postmarketing, uncommon																																											x	x	x
Diverticulitis	Diverticulitis	postmarketing, uncommon																										x	x	x	x														x	x	x
Dysarthria	Dysarthria	postmarketing, uncommon																											x	x	x														x	x	x
Osteoarthritis	Dysarthria	postmarketing, uncommon																											x	x	x														x	x	x
	Arthropathy	postmarketing, uncommon		x	x																							x																	x	x	x
	Osteoarthritis aggravated	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysmenorrhoea	Dysmenorrhoea	postmarketing, uncommon																																											x	x	x
Ear pain	Ear pain	postmarketing, uncommon																																											x	x	x
Eczema	Eczema	postmarketing, uncommon																										x																	x	x	x
Eczema	Eczema exacerbated	postmarketing, uncommon																																											x	x	x
Emotional disorder	Emotional disturbance NOS	postmarketing, uncommon																											x	x	x														x	x	x
Epistaxis	Epistaxis	postmarketing, uncommon																										x																	x	x	x
Erysipelas	Erysipelas	postmarketing, uncommon																																											x	x	x
Eye injury	Eye injury	postmarketing, uncommon																																											x	x	x
Eyelid disorder	Eyelid disorder	postmarketing, uncommon																																											x	x	x
Face injury	Face injury	postmarketing, uncommon																																											x	x	x
Faecalith	Faecalith	postmarketing, uncommon																											x	x	x														x	x	x
Faecaloma	Faecalith	postmarketing, uncommon																											x	x	x														x	x	x
Food poisoning	Food poisoning	postmarketing, uncommon																																											x	x	x
Gastroenteritis	Gastroenteritis	postmarketing, uncommon		x	x																							x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrooesophageal reflux disease	Gastrooesophageal reflux disease	postmarketing, uncommon																											x	x	x														x	x	x
Gout	Gout	postmarketing, uncommon		x	x																							x																x	x	x	x
Seasonal allergy	Seasonal allergy	postmarketing, uncommon																																											x	x	x
Rhinitis seasonal	Seasonal allergy	postmarketing, uncommon																																											x	x	x
Head injury	Head injury	postmarketing, uncommon																																											x	x	x
Cardiac murmur	Cardiac murmur	postmarketing, uncommon																																											x	x	x
Haematoma	Haematoma	postmarketing, uncommon																																											x	x	x
Haematuria	Haematuria	postmarketing, uncommon																										x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Herpes simplex	Herpes simplex	postmarketing, uncommon																										x																	x	x	x
Herpes zoster	Herpes zoster	postmarketing, uncommon																										x																	x	x	x
Hiccups	Hiccups	postmarketing, uncommon																										x																	x	x	x
Hordeolum	Hordeolum	postmarketing, uncommon																																											x	x	x
Hypercalcaemia	Hypercalcaemia	postmarketing, uncommon																																										x	x	x	x
Hypercalcaemia	Ca++ increased																																												x
Hyperglycaemia	Hyperglycaemia	postmarketing, uncommon		x	x																							x																	x	x	x
Hyperlipidaemia	Hyperlipidaemia	postmarketing, uncommon																										x																	x	x	x
Hypertriglyceridaemia	Hypertriglyceridaemia	postmarketing, uncommon																																											x	x	x
Blood triglycerides increased	Hypertriglyceridaemia	postmarketing, uncommon																																											x	x	x
Hypoaesthesia	Hypoaesthesia	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypocalcaemia	Hypocalcaemia	postmarketing, uncommon																																											x	x	x
Hypokalaemia	Hypokalaemia	postmarketing — 0.3%																																										x	x	x	x
Hypothyroidism	Hypothyroidism	postmarketing, uncommon																																											x	x	x
Cerumen impaction	Cerumen impaction	postmarketing, uncommon																																											x	x	x
Inflammation	Inflammation	postmarketing, uncommon																																											x	x	x
Inflammation	Inflammation localised	postmarketing, uncommon																																											x	x	x
Irritability	Irritability	postmarketing, uncommon																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Arthropathy	Arthropathy	postmarketing, uncommon		x	x																							x																	x	x	x
Nephrolithiasis	Calculus of kidney	postmarketing, uncommon																																											x	x	x
Labyrinthitis	Labyrinthitis	postmarketing, uncommon																																											x	x	x
Laryngitis	Laryngitis	postmarketing, uncommon																										x																	x	x	x
Fungal infection	Fungal infection	postmarketing, uncommon																																											x	x	x
Ingrowing nail	Ingrowing nail	postmarketing, uncommon																																											x	x	x
Nasal congestion	Nasal congestion	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nasal congestion	Nasal oedema	postmarketing, uncommon																																											x	x	x
Neck injury	Neck injury	postmarketing, uncommon																																											x	x	x
Neuralgia	Neuralgia	postmarketing, uncommon																																											x	x	x
Night sweats	Night sweats	postmarketing, uncommon																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nocturia	Nocturia	postmarketing, uncommon																										x																	x	x	x
Osteopenia	Osteopenia	postmarketing, uncommon																																											x	x	x
Osteoporosis	Osteoporosis	postmarketing, uncommon																																											x	x	x
Otitis externa	Otitis externa	postmarketing, uncommon																																											x	x	x
Otitis media	Otitis media	postmarketing, uncommon																										x																	x	x	x
Otitis media	Otitis media serous	postmarketing, uncommon																																											x	x	x
Pallor	Pallor	postmarketing, uncommon																											x	x	x														x	x	x
Piloerection	Piloerection	postmarketing, uncommon																										x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Piloerection	Cutis anserina																											x
Prostatitis	Prostatitis	postmarketing, uncommon																																											x	x	x
Prurigo	Prurigo	postmarketing, uncommon																																											x	x	x
Rales	Rales	postmarketing, uncommon																																											x	x	x
Rectal prolapse	Rectal prolapse	postmarketing, uncommon																											x	x	x														x	x	x
Rhonchi	Rhonchi	postmarketing, uncommon																																											x	x	x
Rosacea	Rosacea	postmarketing, uncommon																																											x	x	x
Sinus headache	Sinus headache	postmarketing, uncommon																																											x	x	x
Sinus headache	Sinus pain	postmarketing, uncommon																																											x	x	x
Sinusitis	Sinusitis	postmarketing, uncommon		x	x																							x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Skin disorder	Skin disorder	postmarketing, uncommon		x	x																																								x	x	x
Skin disorder	Unspecified disorder of skin and subcutaneous tissue	postmarketing		x	x						x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Skin ulcer	Skin ulcer	postmarketing, uncommon																																											x	x	x
Sleep apnoea syndrome	Sleep apnoea syndrome	postmarketing, uncommon																											x	x	x														x	x	x
Soft tissue injury	Soft tissue injury	postmarketing, uncommon																																											x	x	x
Tachycardia	Tachycardia	postmarketing — uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Sinus tachycardia	Sinus tachycardia	postmarketing, uncommon																																											x	x	x
Tendonitis	Tendonitis	postmarketing, uncommon																																											x	x	x
Tendon injury	Tendon injury	postmarketing, uncommon																																											x	x	x
Thrombocytopenia	Thrombocytopenia	postmarketing, uncommon																											x	x	x														x	x	x
Thyroid neoplasm	Thyroid neoplasm	postmarketing, uncommon																																											x	x	x
Tracheitis	Tracheitis	postmarketing, uncommon																																											x	x	x
Erythema	Erythema	postmarketing, uncommon																																											x	x	x
Pollakiuria	Pollakiuria	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pollakiuria	Micturition urgency	postmarketing, uncommon																																											x	x	x
Urinary incontinence	Urinary incontinence	postmarketing, uncommon																																											x	x	x
Uterine leiomyoma	Uterine leiomyoma	postmarketing, uncommon																																											x	x	x
Viral infection	Viral infection	postmarketing, uncommon		x	x																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Wound infection	Wound infection	postmarketing, uncommon																																											x	x	x
Laceration	Laceration	postmarketing, uncommon																																											x	x	x
Helicobacter infection	Helicobacter infection	postmarketing, uncommon																																											x	x	x
Muscle strain	Muscle strain	postmarketing, uncommon																																											x	x	x
Micturition urgency	Micturition urgency	postmarketing, uncommon																																											x	x	x
Burning sensation	Burning sensation	postmarketing, uncommon																																											x	x	x
Apathy	Apathy	postmarketing, uncommon		x	x																							x	x	x	x														x	x	x
Flat affect	Apathy	postmarketing, uncommon		x	x																							x	x	x	x														x	x	x
Photopsia	Photopsia	postmarketing, uncommon																																											x	x	x
Plantar fasciitis	Plantar fasciitis	postmarketing, uncommon																																											x	x	x
Deep vein thrombosis	Deep vein thrombosis	postmarketing, uncommon																																											x	x	x
Musculoskeletal stiffness	Neck stiffness	postmarketing, uncommon		x	x																																								x	x	x
Musculoskeletal stiffness	Musculoskeletal stiffness	postmarketing, uncommon																																											x	x	x
Nuchal rigidity	Neck stiffness	postmarketing, uncommon		x	x																																								x	x	x
Blood urea increased	Blood urea increased	postmarketing, uncommon		x	x																																								x	x	x
Blood urea increased	Urea increased																																												x
Bone pain	Bone pain	postmarketing, uncommon																																											x	x	x
Eye pain	Eye pain	postmarketing, uncommon																										x																	x	x	x
Dry skin	Dry skin	postmarketing, uncommon																										x																	x	x	x
Sinus congestion	Sinus congestion	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Joint swelling	Joint swelling	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary hesitation	Urinary hesitation	postmarketing, uncommon																											x	x	x														x	x	x
Lacrimation increased	Lacrimation increased	postmarketing, uncommon																																											x	x	x
Viral diarrhoea	Viral diarrhoea	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Acute myocardial infarction	Acute myocardial infarction	postmarketing, uncommon																																											x	x	x
Temporomandibular joint syndrome	Arthralgia of temporomandibular joint	postmarketing, uncommon																																											x	x	x
Haemoglobin decreased	Haemoglobin decreased	postmarketing, uncommon																																										x	x	x	x
Joint stiffness	Joint stiffness	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vaginal discharge	Vaginal discharge	postmarketing, uncommon																																											x	x	x
Malaise	Malaise	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Discomfort	Malaise	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Feeling abnormal	Malaise	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Feeling abnormal	postmarketing, uncommon																																											x	x	x
	Confusional state	postmarketing — uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x														x	x	x
Ill-defined disorder	Malaise	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Myalgia	Myalgia	postmarketing, uncommon		x	x					x		x																x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Joint crepitation	Joint crepitation	postmarketing, uncommon																																											x	x	x
Chest discomfort	Chest tightness	postmarketing, uncommon																																											x	x	x
Vascular insufficiency	Vascular insufficiency	postmarketing, uncommon																																											x	x	x
Cold sweat	Cold sweat	postmarketing, uncommon																											x	x	x														x	x	x
Cold sweat	Sticky skin																															x	x	x	x	x	x	x	x	x	x	x	x	x
Abdominal discomfort	Abdominal discomfort	postmarketing, uncommon																											x	x	x														x	x	x
	Gastrointestinal tract irritation	postmarketing, uncommon																											x	x	x														x	x	x
	Upset stomach																																													x	x
Abdominal pain lower	Abdominal pain lower	postmarketing, uncommon																											x	x	x														x	x	x
Abdominal tenderness	Abdominal tenderness	postmarketing, uncommon																											x	x	x														x	x	x
Retching	Retching	postmarketing, uncommon																											x	x	x														x	x	x
Menometrorrhagia	Menometrorrhagia	postmarketing, uncommon																																											x	x	x
Disturbance in attention	Disturbance in attention	postmarketing, uncommon																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Disturbance in attention	Cerebration impaired												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Abnormal behaviour	Abnormal behaviour	postmarketing, uncommon																											x	x	x														x	x	x
Euphoric mood	Euphoric mood	postmarketing, uncommon		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dry throat	Dry throat	postmarketing, uncommon																																											x	x	x
Faeces discoloured	Faeces discoloured	postmarketing, uncommon																																											x	x	x
Small intestinal obstruction	Small intestinal obstruction	postmarketing, uncommon																																											x	x	x
Blood creatinine increased	Blood creatinine increased	postmarketing, uncommon																											x	x	x													x	x	x	x
Blood creatinine increased	Creatinine increased																																												x
Productive cough	Productive cough	postmarketing, uncommon																																											x	x	x
Groin pain	Groin pain	postmarketing, uncommon																																											x	x	x
Haematocrit increased	Haematocrit increased	postmarketing, uncommon																																										x	x	x	x
Vaginal cyst	Vaginal cyst	postmarketing, uncommon																																											x	x	x
Wound haemorrhage	Wound haemorrhage	postmarketing, uncommon																																											x	x	x
Erectile dysfunction	Erectile dysfunction	postmarketing, uncommon																										x	x	x	x														x	x	x
Mammogram abnormal	Mammogram abnormal	postmarketing, uncommon																																											x	x	x
Back disorder	Back disorder	postmarketing, uncommon																																											x	x	x
Rectal haemorrhage	Rectal haemorrhage	postmarketing — 0.3%																										x	x	x	x													x	x	x	x
Hepatobiliary disease	Hepatobiliary disease	postmarketing, uncommon									x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Change of bowel habit	Change of bowel habit	postmarketing, uncommon																											x	x	x														x	x	x
Dry eye	Dry eye	postmarketing, uncommon																										x																	x	x	x
Benign breast neoplasm	Benign breast neoplasm	postmarketing, uncommon																																											x	x	x
Muscle injury	Muscle injury	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Red blood cell count decreased	Red blood cell count decreased	postmarketing, uncommon																																										x	x	x	x
Red blood cell count increased	Red blood cell count increased	postmarketing, uncommon																																										x	x	x	x
Ligament sprain	Joint sprain	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ligament injury	Ligament injury	postmarketing, uncommon																																											x	x	x
Wrist fracture	Wrist fracture	postmarketing, uncommon																																											x	x	x
Hand fracture	Hand fracture	postmarketing, uncommon																																											x	x	x
Nasal oedema	Nasal oedema	postmarketing, uncommon																																											x	x	x
Pruritus generalised	Pruritus generalised	postmarketing, uncommon																											x	x	x														x	x	x
Lymphadenopathy	Lymphadenopathy	postmarketing, uncommon																																											x	x	x
Tooth abscess	Tooth abscess	postmarketing, uncommon																																											x	x	x
Poor peripheral circulation	Poor peripheral circulation	postmarketing, uncommon																																											x	x	x
Pruritus genital	Genital itching female	postmarketing, uncommon																																											x	x	x
High density lipoprotein decreased	Low density lipoprotein increased	postmarketing, uncommon																																											x	x	x
Low density lipoprotein increased	Low density lipoprotein increased	postmarketing, uncommon																																											x	x	x
Haemoglobin increased	Haemoglobin increased	postmarketing, uncommon																																										x	x	x	x
Sexual dysfunction	Sexual dysfunction	postmarketing, uncommon																											x	x	x														x	x	x
Renal pain	Renal pain	postmarketing, uncommon																										x																	x	x	x
Gait disturbance	Gait disturbance	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x														x	x	x
Abscess limb	Abscess limb	postmarketing, uncommon																																											x	x	x
Blood glucose abnormal	Blood glucose abnormal	postmarketing, uncommon																																											x	x	x
Blood glucose increased	Blood glucose increased	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Blood cholesterol increased	Blood cholesterol increased	postmarketing, uncommon																																											x	x	x
Cystitis	Bladder infection	postmarketing, uncommon																																											x	x	x
Cystitis	Cystitis			x	x																							x
Ear infection	Ear infection	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Throat irritation	Throat irritation	postmarketing, uncommon																																											x	x	x
C-reactive protein increased	C-reactive protein increased	postmarketing, uncommon																																											x	x	x
Limb injury	Limb injury	postmarketing, uncommon																																											x	x	x
Tinea pedis	Foot infection fungal NOS	postmarketing, uncommon																																											x	x	x
Haematocrit decreased	Haematocrit decreased	postmarketing — 0.3%																																										x	x	x	x
Scleral haemorrhage	Scleral haemorrhage	postmarketing, uncommon																																											x	x	x
White blood cell count increased	White blood cell count increased	postmarketing — 0.3%																																										x	x	x	x
Ear congestion	Ear congestion	postmarketing, uncommon																																											x	x	x
Infestation	Infestation NOS	postmarketing, uncommon																															x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Blood alkaline phosphatase increased	Blood alkaline phosphatase increased	0.3%																																										x
Blood alkaline phosphatase increased	Phosphatase alkaline increased																											x
Amylase increased	Blood amylase increased	postmarketing, uncommon																											x	x	x														x	x	x
Amylase increased	Amylase increased																																												x
Blood lactate dehydrogenase increased	Blood lactate dehydrogenase increased	0.3%																																										x
Blood lactate dehydrogenase increased	Lactic dehydrogenase activity increased																																												x
Neutrophil count decreased	Neutrophil count decreased	postmarketing, uncommon																																											x	x	x
Lymphocyte count increased	Lymphocyte count increased	postmarketing, uncommon																																										x	x	x	x
Blood potassium abnormal	Blood potassium abnormal	postmarketing, uncommon																											x	x	x														x	x	x
Blood potassium abnormal	Potassium abnormal NOS																																												x
Alanine aminotransferase decreased	Alanine aminotransferase decreased	postmarketing, uncommon																											x	x	x														x	x	x
Aspartate aminotransferase decreased	Aspartate aminotransferase decreased	postmarketing, uncommon																											x	x	x														x	x	x
Pancreatitis	Pancreatitis aggravated	postmarketing, uncommon																											x	x	x														x	x	x
Pancreatitis	Pancreatitis																											x				x	x	x	x	x	x	x	x	x	x	x	x	x
Lip blister	Lip blister	postmarketing, uncommon																																											x	x	x
Protein total decreased	Protein total decreased	postmarketing, uncommon																																											x	x	x
Hyperkeratosis	Hyperkeratosis	postmarketing, uncommon																																											x	x	x
Tooth infection	Tooth infection	postmarketing, uncommon																																											x	x	x
Respiratory tract infection viral	Respiratory tract infection viral	postmarketing, uncommon																																											x	x	x
Postoperative wound complication	Postoperative wound complication	postmarketing, uncommon																																											x	x	x
Red cell distribution width increased	Red cell distribution width increased	postmarketing, uncommon																																											x	x	x
Ear discomfort	Ear discomfort	postmarketing, uncommon																																											x	x	x
Mean platelet volume decreased	Mean platelet volume decreased	postmarketing, uncommon																																											x	x	x
Rhinorrhoea	Rhinorrhoea	postmarketing, uncommon																														x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal infection	Gastrointestinal infection	postmarketing, uncommon																																											x	x	x
Excoriation	Abrasion NOS	postmarketing, uncommon																																											x	x	x
Mental retardation	Mental disability	postmarketing, uncommon																											x	x	x														x	x	x
Mental disability	Mental disability	postmarketing, uncommon																											x	x	x														x	x	x
	Thinking abnormal			x	x																							x
	Cerebration impaired												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Haematochezia	Blood in stool	postmarketing, uncommon																											x	x	x													x	x	x	x
Renal failure	Renal impairment	postmarketing, uncommon																																											x	x	x
Renal impairment	Renal impairment	postmarketing, uncommon																																											x	x	x
Exostosis	Bone spur	postmarketing, uncommon																																											x	x	x
Rhinitis allergic	Rhinitis allergic	postmarketing, uncommon																																											x	x	x
Gastrointestinal tract irritation	Gastrointestinal tract irritation	postmarketing, uncommon																											x	x	x														x	x	x
Anaphylactic shock	Anaphylactic shock	postmarketing, rare				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Angioedema	Angioedema	postmarketing																										x																x	x
Mental disorder	Mental disorder	postmarketing		x	x						x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Breast disorder	Breast disorder	postmarketing																											x	x	x														x	x	x
Coma	Coma	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Confusional state	Confusional state	postmarketing — uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x														x	x	x
Connective tissue disorder	Connective tissue disorder	postmarketing									x	x																	x	x	x														x	x	x
Cyst	Cyst	postmarketing																																											x	x	x
Deafness	Deafness	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Delirium	Delirium	postmarketing									x	x															x														x	x	x
Drug abuse	Drug abuse	postmarketing							x	x		x																																		x	x
Dyspnoea	Dyspnoea	postmarketing — uncommon				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysuria	Dysuria	rare		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysuria	Strangury	rare				x	x	x	x	x	x	x																	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Endocrine disorder	Endocrine disorder	postmarketing									x																																		x	x	x
Eye disorder	Eye disorder	postmarketing		x	x			x		x	x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Body temperature increased	Body temperature increased	postmarketing, uncommon		x	x					x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal haemorrhage	Gastrointestinal haemorrhage	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x														x	x	x
Hallucination	Hallucination	postmarketing, rare				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																		x	x
Hepatitis	Hepatitis	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Hypersensitivity	Hypersensitivity	postmarketing — 1.4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x													x	x	x	x
Hypoglycaemia	Hypoglycaemia	postmarketing																									x															x	x
Hypotension	Hypotension	postmarketing, uncommon		x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x														x	x	x
Immune system disorder	Immune system disorder	postmarketing									x	x																	x	x	x														x	x	x
Miosis	Miosis	postmarketing									x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x														x	x	x
Dyskinesia	Movement disorder	postmarketing																									x														x	x	x
Movement disorder	Movement disorder	postmarketing																									x														x	x	x
Mydriasis	Mydriasis	postmarketing					x	x		x	x	x															x														x	x	x
Neoplasm	Neoplasm	postmarketing																																											x	x	x
Nervous system disorder	Nervous system disorder	postmarketing		x	x						x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nervousness	Nervousness	postmarketing		x	x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nervousness	Feeling jittery																															x	x	x	x	x	x	x	x	x	x	x	x	x
Tension	Nervousness	postmarketing		x	x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Tension	Tension																																													x	x
Nightmare	Nightmare	postmarketing, rare				x	x	x	x	x	x	x																																		x	x
Palpitations	Palpitations	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Paraesthesia	Paraesthesia	postmarketing — uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x		x	x	x
Paraesthesia	Paraesthesia NEC																																											x
Polyp	Polyp	postmarketing																																											x	x	x
Proteinuria	Proteinuria	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Protein urine present	Proteinuria	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pulmonary oedema	Pulmonary oedema	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Pulmonary embolism	Pulmonary embolism	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Convulsion	Convulsion	postmarketing, rare		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x													x	x	x	x
Shock	Shock	postmarketing — uncommon				x	x	x	x	x	x	x																																		x	x
Shock	Syncope	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Sleep disorder	Sleep disturbance	postmarketing, rare				x	x	x	x	x	x	x																																		x	x
Sleep disorder	Sleep disorder												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Speech disorder	Speech disorder	postmarketing						x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x														x	x	x
Speech disorder	Speech impairment NOS						x
Erythema multiforme	Stevens-Johnson syndrome	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Stevens-Johnson syndrome	Stevens-Johnson syndrome	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Stomatitis	Stomatitis	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Syncope	Syncope	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Loss of consciousness	Syncope	postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Tinnitus	Tinnitus	postmarketing, uncommon							x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urethral disorder	Urinary tract disorder	postmarketing									x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary tract disorder	Urinary tract disorder	postmarketing									x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urticaria	Urticaria	postmarketing, uncommon		x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Angiopathy	Angiopathy	postmarketing, rare		x	x						x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary retention	Urinary retention	postmarketing — uncommon		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hepatic failure	Hepatic failure	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Agitation	Agitation	postmarketing, uncommon		x	x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Agitation	Hyperkinesia	postmarketing		x	x				x	x		x																x																x	x	x	x
Mood swings	Mood swings	postmarketing, rare		x	x	x	x	x	x	x	x	x		x	x									x	x	x																				x	x
Affect lability	Mood swings	postmarketing, rare		x	x	x	x	x	x	x	x	x		x	x									x	x	x																				x	x
Hypokinesia	Hypokinesia	postmarketing																										x																x	x
Cataract	Cataract	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																		x	x	x
Panic attack	Panic attack	postmarketing							x	x		x																																		x	x
Migraine	Migraine	postmarketing, uncommon											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Myocardial ischaemia	Myocardial ischaemia	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperreflexia	Hyperreflexia	postmarketing								x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Malnutrition	Malnutrition	postmarketing		x	x						x	x															x		x	x	x		x	x	x	x	x	x	x	x	x	x	x		x	x	x
Dysphoria	Dysphoria	postmarketing, rare				x	x	x	x	x	x	x																																		x	x
Respiratory depression	Respiratory depression	very rare — rare		x	x	x	x	x	x	x	x	x																x																x	x	x	x
Pulmonary function test decreased	Respiratory depression	very rare — rare		x	x	x	x	x	x	x	x	x																x																x	x	x	x
Muscle contractions involuntary	Muscle contractions involuntary	postmarketing, rare				x	x	x	x	x	x	x																																		x	x
Suicidal ideation	Suicidal tendency	postmarketing											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Hepatic enzyme increased	Hepatic enzyme increased	very rare, postmarketing				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																			x	x
Drug tolerance	Tolerance development	postmarketing							x	x		x																																		x	x
Strangury	Strangury	rare				x	x	x	x	x	x	x																	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vision blurred	Vision blurred	postmarketing — uncommon				x	x	x	x	x	x	x																	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperkinesia	Hyperkinesia	postmarketing		x	x				x	x		x																x																x	x	x	x
Gastrointestinal disorder	Gastrointestinal symptom NOS	postmarketing							x	x		x																x																	x	x	x
Gastrointestinal disorder	Gastrointestinal disorder			x	x						x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bradycardia	Bradycardia	postmarketing — uncommon				x	x	x	x	x	x	x																x	x	x	x													x	x	x	x
Blood pressure increased	Blood pressure increased	rare				x	x	x	x	x	x	x																	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Electrocardiogram abnormal	Electrocardiogram abnormal	postmarketing		x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Visual impairment	Visual disturbance	rare				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x														x	x	x
Visual impairment	Abnormal vision																											x
Serotonin syndrome	Serotonin syndrome	postmarketing		x	x					x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x	x	x	x
Coordination abnormal	Coordination disturbance	postmarketing, rare				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																			x	x
Coordination abnormal	Coordination abnormal																											x
Orthostatic intolerance	Orthostatic dysregulation	postmarketing — uncommon				x	x	x	x	x	x	x																																		x	x
Asthma	Asthma	very rare — uncommon				x	x	x	x	x	x	x																x																	x	x	x
Asthma	Asthma aggravated																																												x
Hyponatraemia	Hyponatraemia	very rare, postmarketing				x	x	x	x	x	x	x																																x		x	x
Inappropriate antidiuretic hormone secretion	Inappropriate antidiuretic hormone secretion	very rare, postmarketing				x	x	x	x	x	x	x																																		x	x
Abdominal distension	Abdominal distension																												x	x	x														x
Abdominal distension	Abdominal bloating																											x
Albuminuria	Albuminuria																											x
Amblyopia	Amblyopia																											x
Amnesia	Amnesia												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Haemolytic anaemia	Haemolytic anaemia																											x
Anosmia	Anosmia																											x
Appendicitis	Appendicitis																															x	x	x	x	x	x	x	x	x	x	x	x	x
Arrhythmia	Arrhythmia																											x
Atrial flutter	Atrial flutter																											x
Back pain	Back pain																											x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bacteriuria	Bacteriuria																																													x	x
Biliary tract disorder	Biliary tract disorder																												x	x	x														x	x	x
Blepharitis	Blepharitis																											x
Bone disorder	Bone disorder			x	x																												x	x	x	x	x	x	x	x	x	x	x	x
Bronchospasm	Bronchospasm																											x
Carpal tunnel syndrome	Carpal tunnel syndrome																											x
Cellulitis	Cellulitis																											x				x	x	x	x	x	x	x	x	x	x	x	x	x
Chest pain	Chest pain																											x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cholecystitis	Cholecystitis																															x	x	x	x	x	x	x	x	x	x	x	x	x		x	x
Conjunctivitis	Conjunctivitis																											x
Bladder pain	Cystitis			x	x																							x
Cystitis noninfective	Cystitis			x	x																							x
Libido decreased	Libido decreased																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Disturbance in sexual arousal	Libido decreased																											x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Delusion	Delusion									x		x
Depersonalisation	Depersonalisation			x	x																							x
Depression	Depression												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x																x
Diverticulum	Diverticulum																												x	x	x
Dysthymic disorder	Dysthymic disorder																																													x	x
Ecchymosis	Ecchymosis			x	x					x
Dermoid cyst	Cyst epidermal																											x
Dermal cyst	Cyst epidermal																											x
Toxic epidermal necrolysis	Toxic epidermal necrolysis												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Eructation	Eructation																											x																		x	x
Gastritis	Gastritis																											x	x	x	x														x	x	x
	Gastroduodenitis																																													x	x
	Gastritis aggravated																																													x	x
Gynaecomastia	Gynaecomastia																											x
Hair disorder	Hair disorder			x	x
Breath odour	Breath odour																											x
Cardiac disorder	Cardiac disorder			x	x						x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Haematemesis	Haematemesis																																											x
Haemoptysis	Haemoptysis																											x																x
Haemorrhage	Haemorrhage									x
Haemoglobin	Haemorrhage									x
Herpangina	Herpangina																																													x	x
Hypercholesterolaemia	Hypercholesterolaemia																											x																	x	x	x
Hyperaesthesia	Hyperaesthesia																											x
Hyperkalaemia	Hyperkalaemia																																											x
Hyperventilation	Hyperventilation																											x
Irritable bowel syndrome	Irritable bowel syndrome																											x
Functional gastrointestinal disorder	Irritable bowel syndrome																											x
Lacrimal disorder	Lacrimal disorder			x	x																							x
Lacrimal structural disorder	Lacrimal disorder			x	x																							x
Muscle spasms	Cramps of lower extremities			x	x
	Cramp muscle																											x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Muscle spasms																															x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Lethargy	Lethargy																															x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Lymphatic disorder	Lymphatic disorder			x	x
Breast pain	Breast pain																																													x	x
Mediastinal disorder	Mediastinal disorder			x	x						x	x																	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Melaena	Melaena																											x
Menstrual disorder	Menstrual disorder												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypertonia	Hypertonia			x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypotonia	Hypotonia																																													x	x
Muscle relaxant therapy	Hypotonia																																													x	x
Muscle spasticity	Muscle spasticity													x	x							x	x	x	x	x
Myopathy	Myopathy																											x
Musculoskeletal disorder	Musculoskeletal disorder			x	x
Myocardial infarction	Myocardial infarction																															x	x	x	x	x	x	x	x	x	x	x	x	x
Acute coronary syndrome	Myocardial infarction																															x	x	x	x	x	x	x	x	x	x	x	x	x
Myoclonus	Myoclonus									x																		x
Tubulointerstitial nephritis	Nephritis interstitial																																													x	x
Neurosis	Neurosis																																													x	x
Pain in extremity	Pain in extremity																															x	x	x	x	x	x	x	x	x	x	x	x		x	x	x
Pelvic pain	Pelvic pain			x	x
Pharyngitis	Pharyngitis			x	x																							x																	x	x	x
Phlebitis	Phlebitis																											x
Pneumonia	Pneumonia			x	x																							x				x	x	x	x	x	x	x	x	x	x	x	x	x
Polyuria	Polyuria																											x
Urine output increased	Polyuria																											x
Prostatic disorder	Prostatic disorder			x	x
Purpura	Purpura																											x
Vascular purpura	Purpura																											x
Anorectal disorder	Rectal disorder																											x
Rhinitis	Rhinitis			x	x																							x																	x	x	x
Sciatica	Sciatica																																													x	x
Sneezing	Sneezing																															x	x	x	x	x	x	x	x	x	x	x	x	x
Withdrawal syndrome	Withdrawal syndrome			x	x
Completed suicide	Suicide			x	x
Thirst	Thirst																											x																	x	x	x
Tongue disorder	Tongue disorder																											x
Tooth disorder	Tooth disorder																											x
Toothache	Toothache																															x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vasodilation procedure	Vasodilation												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Yawning	Yawning																															x	x	x	x	x	x	x	x	x	x	x	x	x
Urogenital disorder	Urogenital disorder			x	x
Peripheral vascular disorder	Peripheral vascular disorder																											x
Essential hypertension	Essential hypertension																																													x	x
Encephalopathy	Encephalopathy																																													x	x
Oedema peripheral	Oedema peripheral			x	x																							x																	x	x	x
Oedema peripheral	Edema of lower extremities																															x	x	x	x	x	x	x	x	x	x	x	x	x
Hypophosphataemia	Hypophosphataemia																																											x
Pyelonephritis chronic	Pyelonephritis chronic																																													x	x
Drug withdrawal syndrome	Withdrawal symptom			x	x
Drug withdrawal syndrome	Drug withdrawal syndrome																															x	x	x	x	x	x	x	x	x	x	x	x	x
Acute sinusitis	Acute sinusitis																																													x	x
Tracheobronchitis	Acute bronchitis																																													x	x
Hypercalciuria	Crystalluria calcium																											x
Neutrophil count increased	Neutrophil count increased																																											x
Injury	Accidental injury			x	x								x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Muscular weakness	Muscular weakness																											x
Tendon disorder	Tendon disorder																											x
Abnormal faeces	Abnormal faeces																											x
Muscle twitching	Muscle twitching			x	x																											x	x	x	x	x	x	x	x	x	x	x	x	x
Tachypnoea	Tachypnoea																																													x	x
Increased appetite	Increased appetite																																													x	x
Disorientation	Disorientation																															x	x	x	x	x	x	x	x	x	x	x	x	x
Thinking abnormal	Thinking abnormal			x	x																							x
Derealisation	Derealisation									x		x
Abnormal dreams	Abnormal dreams																											x				x	x	x	x	x	x	x	x	x	x	x	x	x
Visual acuity reduced	Visual acuity reduced																																													x	x
Peripheral ischaemia	Peripheral ischaemia																															x	x	x	x	x	x	x	x	x	x	x	x	x
Vascular pain	Vein pain																																													x	x
Urine abnormality	Urine abnormality			x	x																							x
Urine analysis abnormal	Urine abnormality			x	x																							x
Parkinsonism	Parkinsonism aggravated																																													x	x
Oropharyngeal discomfort	Throat sore																															x	x	x	x	x	x	x	x	x	x	x	x	x
Oropharyngeal pain	Throat sore																															x	x	x	x	x	x	x	x	x	x	x	x	x
Gastroduodenitis	Gastroduodenitis																																													x	x
Eustachian tube disorder	Eustachian tube disorder																											x
Blood bilirubin increased	Blood bilirubin increased																																											x	x
Cognitive disorder	Cognitive impairment												x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Extrasystoles	Extrasystoles																																													x	x
Joint effusion	Effusion of knee																											x
Photosensitivity reaction	Photosensitivity																											x
Sticky skin	Sticky skin																															x	x	x	x	x	x	x	x	x	x	x	x	x
Epigastric discomfort	Gastric irritation																												x	x	x														x	x	x
Platelet count decreased	Platelet count decreased																																												x
Prostatomegaly	Prostatomegaly																											x
Stress	Stress symptoms																																													x	x
Duodenal ulcer	Duodenal ulcer aggravated																																													x	x
Coronary artery insufficiency	Coronary artery insufficiency																																													x	x
Feeling jittery	Feeling jittery																															x	x	x	x	x	x	x	x	x	x	x	x	x
Monocyte count increased	Monocyte count increased																																											x
White blood cells urine positive	White blood cells urine positive																																													x	x
Blood sodium increased	Blood sodium increased																																											x
Drug interaction	Drug interaction									x
Dyssomnia	Dyssomnia																																													x	x
Blood uric acid increased	Hyperuricaemia																																												x	x	x
Blood uric acid increased	Uric acid increased																																												x
Hyperuricaemia	Hyperuricaemia																																												x	x	x
Thrombocytosis	Thrombocytosis																																											x
Blood creatine phosphokinase increased	Blood creatine phosphokinase increased																															x	x	x	x	x	x	x	x	x	x	x	x
Arthropod bite	Arthropod bite																																												x	x	x
Blood cholesterol abnormal	Blood cholesterol abnormal																																													x	x
Blood potassium increased	Blood potassium increased																																											x
Blood potassium decreased	Blood potassium decreased																																											x
Lymphocyte count decreased	Lymphocyte count decreased																																												x
Laryngeal pain	Pharyngolaryngeal pain																																												x	x	x
Food aversion	Food aversion																																													x	x
Local swelling	Peripheral swelling																															x	x	x	x	x	x	x	x	x	x	x	x	x
Hypersomnia	Hypersomnia																																													x	x
Band neutrophil count increased	Band neutrophil count increased																																											x
Photodermatosis	Photodermatosis																																													x	x
Ischaemic stroke	Ischaemic stroke																																													x	x
Analgesic therapy	Analgesic effect									x
Genitourinary tract infection	Genitourinary tract infection																																													x	x
Psychotic disorder	Paranoia									x		x
Paranoia	Paranoia									x		x
Thrombophlebitis superficial	Thrombophlebitis superficial																																													x	x
Oral pain	Sore mouth																											x
Eosinophil count increased	Eosinophil count increased																																											x
Ejaculation disorder	Abnormal ejaculation																											x
Feeling hot	Feeling hot																															x	x	x	x	x	x	x	x	x	x	x	x	x
Vaginal haemorrhage	Vaginal haemorrhage																											x
Blood calcium decreased	Blood calcium decreased																																											x

Indication	Labels
Acute pain																					x
Chronic pain	x	x																										x	x	x	x	x	x	x	x	x	x	x	x	x	x
Low back pain																													x	x	x	x	x	x	x	x	x	x	x	x	x
Osteoarthritis																																									x
Pain	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Postoperative pain							x

Side effects:	93
Source:	FDA Structured Product Label

Side effects:	93
Source:	FDA Structured Product Label

Side effects:	47
Source:	medicines.org.au

Side effects:	50
Source:	medicines.org.au

		100%
		75%
		50%
		10%
		frequent (1% to 100%)
		infrequent (0.1% to 1%)
		rare (<0.1%)
		postmarketing
		0%
		no frequency information
		not found on label

Side effects:	171
Source:	Health Canada

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Tramadol

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