ICI 182,780
  
Side effects 
	
		
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| Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 
| Asthenia | postmarketing, 5.82% - 27% |  | x | x | x | 
| Nausea | postmarketing, 9.7% - 26% |  | x | x | x | 
| Pain | postmarketing, 18.9% - 20.3% |  |  | x | x | 
| Malnutrition | 17.7% - 18.2% |  | x | x | x | 
| Vasodilation | postmarketing, 17.3% - 17.7% |  |  | x |  | 
| Headache | postmarketing, 6.68% - 16.8% |  | x | x | x | 
| Pharyngitis | 11.6% - 16.1% |  |  | x | x | 
| Bone pain | 7.49% - 15.8% |  |  | x | x | 
| Back pain | 7.48% - 14.4% |  | x | x | x | 
| Diarrhoea | postmarketing, 12.3% - 12.8% |  | x | x | x | 
| Dyspnoea | 4.43% - 14.9% |  |  | x | x | 
| Vomiting | postmarketing, 5.61% - 13% |  | x | x | x | 
| Abdominal pain | 11.6% - 11.8% |  |  | x | x | 
| Constipation | 3.48% - 12.5% |  |  | x | x | 
| Cough increased | 10.4% |  |  | x | x | 
| Injection site pain | 6.6% - 11.6% |  |  | x | x | 
| Oedema peripheral | 9% - 10.2% |  |  | x | x | 
| Pelvic pain | 9% - 9.9% |  |  | x | x | 
| Anorexia | postmarketing, 3.74% - 10.9% |  | x | x | x | 
| Arthralgia | 7.75% - 8.03% |  |  |  | x | 
| Insomnia | 6.9% - 8.5% |  |  | x | x | 
| Rash | postmarketing, 7.3% - 8% |  | x | x | x | 
| Paraesthesia | 6.4% - 7.6% |  |  | x | x | 
| Fatigue | 6.42% - 7.48% |  |  |  | x | 
| Pain in extremity | 6.93% - 6.95% |  |  |  | x | 
| Dizziness | 6.6% - 6.9% |  |  | x | x | 
| Influenza | 6.4% - 7.1% |  |  | x | x | 
| Body temperature increased | 6.4% |  |  | x | x | 
| Depression | 5.7% - 6.9% |  |  | x | x | 
| Chest pain | 5% - 7.1% |  |  | x | x | 
| Cough | 5.26% - 5.35% |  |  |  | x | 
| Sweating | 5% - 5.2% |  |  | x | x | 
| Accidental injury | 4.5% - 5.7% |  |  | x | x | 
| Anaemia | 4.5% - 5% |  |  | x | x | 
| Arthritis | 2.8% - 6.1% |  |  | x | x | 
| Anxiety | 3.8% - 5% |  |  | x | x | 
| Musculoskeletal pain | 3.21% - 5.54% |  |  |  | x | 
| Urinary tract infection | postmarketing, 3.5% - 6.1% |  | x | x | x | 
| Hot flush | postmarketing, 5.88% - 6.65% |  | x | x | x | 
| Angioedema | postmarketing |  |  | x | x | 
| Haemorrhage | postmarketing |  |  |  | x | 
| Hepatitis | postmarketing |  |  |  | x | 
| Hypersensitivity | postmarketing |  | x | x | x | 
| Inflammation | postmarketing |  |  | x | x | 
| Leukopenia | postmarketing |  |  |  | x | 
| Pruritus | postmarketing |  |  | x |  | 
| Urticaria | postmarketing |  |  | x | x | 
| Vertigo | postmarketing |  |  |  | x | 
| Hepatic failure | postmarketing |  | x |  | x | 
| Injection site reaction | postmarketing |  | x | x | x | 
| Myalgia | postmarketing |  |  |  | x | 
| Digestion impaired | postmarketing |  |  | x |  | 
| Hepatic enzyme increased | postmarketing |  |  | x |  | 
| Breast cancer stage IV | postmarketing |  |  | x |  | 
| Vaginal haemorrhage | postmarketing |  | x |  | x | 
| Breast disorder |  |  | x |  |  | 
| Vaginal moniliasis |  |  | x |  |  | 
| Infection |  |  | x |  |  | 
| Connective tissue disorder |  |  | x |  |  | 
| Gastrointestinal disorder |  |  | x |  |  | 
| Hepatitis C |  |  | x |  |  | 
| Immune system disorder |  |  | x |  |  | 
| Leukorrhea |  |  | x |  |  | 
| Nervous system disorder |  |  | x |  |  | 
| Angiopathy |  |  | x |  |  | 
| Gamma-glutamyltransferase increased |  |  | x |  |  | 
| Injection site haemorrhage |  |  | x |  |  | 
| Unspecified disorder of skin and subcutaneous tissue |  |  | x |  |  | 
| Hepatobiliary disease |  |  | x |  |  | 
| Blood bilirubin increased |  |  | x |  |  | 
| Gastrointestinal symptom NOS |  |  |  |  | x | 
| Injection site haematoma |  |  | x |  |  | 
| Infestation NOS |  |  | x |  |  | 
| Venous thromboembolism |  |  | x |  |  | 
	 
 
  Indications
	Information about indications was extracted from the indications and usage sections of the labels.
	
 
	  
	  
		| Side effects: | 33 | 
|---|
		| Source: | EMA | 
|---|
		 
	  
	  
		| Side effects: | 43 | 
|---|
		| Source: | Health Canada | 
|---|
		 
	  
	  
		| Side effects: | 51 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
  
 
  
	Color scheme:
	  
	  standard – alternative
	  
	
	
|  |  | 100% | 
|  |  | 75% | 
|  |  | 50% | 
|  |  | 10% | 
|  |  | frequent (1% to 100%) | 
|  |  | infrequent (0.1% to 1%) | 
|  |  | rare (<0.1%) | 
|  |  | postmarketing | 
|  |  | 0% | 
|  |  | no frequency information | 
|  |  | not found on label |