|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
|
12
|
|
Wound infection
|
6.5% - 12.4%
|
|
|
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Anaemia
|
5.7% - 6.9%
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Alanine aminotransferase increased
|
postmarketing, 1.1% - 8.8%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diarrhoea
|
4.2% - 17%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infusion site pain
|
1% - 7%
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aspartate aminotransferase increased
|
postmarketing, 1.1% - 8.4%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Body temperature increased
|
2.3% - 8.3%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary tract infection
|
3.8% - 5.5%
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Haemoglobin decreased
|
postmarketing, 3.5% - 4.9%
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombocytosis
|
postmarketing, 2.8% - 6.5%
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis diaper
|
0% - 4.7%
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal pain
|
3% - 4.7%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Phosphatase alkaline increased
|
postmarketing, 2.8% - 6.6%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema
|
2.9% - 3.4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Swelling
|
2.9% - 3.4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal inflammation
|
1.4% - 3.7%
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Insomnia
|
3% - 4.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Postoperative infection
|
2.3% - 4%
|
|
|
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Nausea
|
0% - 8.5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pneumonia
|
2.1% - 4%
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Cough
|
0% - 4.4%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematocrit decreased
|
postmarketing, 2.4% - 3.4%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neutrophil count decreased
|
postmarketing, 3% - 5.8%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mental state abnormal
|
postmarketing, 2.5% - 5.1%
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atelectasis
|
1.9% - 3.4%
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Upper respiratory tract infection
|
2.3% - 3%
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
|
x
|
|
Wound complication
|
2.3% - 2.9%
|
|
|
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Infusion site erythema
|
2% - 2.6%
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspnoea
|
1% - 2.6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infusion site phlebitis
|
1.8% - 3%
|
|
x
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Constipation
|
0% - 4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Headache
|
0% - 6.9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash
|
1% - 8.3%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vomiting
|
1.1% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Small intestinal obstruction
|
1.9% - 2.1%
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Serum potassium decreased
|
1.7% - 2.4%
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
|
Glucose increased
|
1.2% - 2%
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nasopharyngitis
|
0% - 6%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Serum albumin decreased
|
0.9% - 1.7%
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dizziness
|
0% - 2.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
White blood cell count decreased
|
postmarketing, 0.8% - 1.5%
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus
|
0% - 2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombophlebitis
|
1.3%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotension
|
1% - 2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eosinophilia
|
postmarketing, 1.1% - 2.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Platelet count decreased
|
1% - 1.1%
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Serum bilirubin increased
|
0.6% - 1.7%
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
|
Dermatitis
|
0% - 1%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes simplex
|
1% - 4.2%
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neutropenia
|
0.8% - 1.5%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
x
|
x
|
|
x
|
|
Abdominal pain upper
|
0% - 2%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal abscess
|
0% - 4.2%
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Serum creatinine increased
|
postmarketing, 0.9% - 1.2%
|
|
|
|
|
|
x
|
x
|
|
|
x
|
x
|
|
x
|
|
Prothrombin level increased
|
0.3% - 1.2%
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
|
Serum potassium increased
|
0.5% - 1.3%
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
|
Infusion site swelling
|
0% - 1%
|
|
x
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aggression
|
postmarketing
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaphylactic shock
|
postmarketing
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mental disorder
|
postmarketing
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infection
|
postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Connective tissue disorder
|
postmarketing
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Delirium
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
Drug eruption
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
Dyskinesia
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
Gastrointestinal disorder
|
postmarketing
|
|
x
|
x
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Hallucination
|
postmarketing
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Immune system disorder
|
postmarketing
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
|
Myoclonus
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
Nervous system disorder
|
postmarketing
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Proteinuria
|
postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Tooth discolouration
|
postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Tremor
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscular weakness
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
Unspecified disorder of skin and subcutaneous tissue
|
postmarketing
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetic
|
postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Anaphylactoid reaction
|
postmarketing
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coordination abnormal
|
postmarketing
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Depressed level of consciousness
|
postmarketing
|
|
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
Gait disturbance
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
|
|
|
|
|
|
|
Protein urine present
|
postmarketing
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eosinophil count increased
|
postmarketing
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal distension
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anorexia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anuria
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anxiety
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arrhythmia
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthralgia
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthma
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast disorder
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Candida infection
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oral candidiasis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal moniliasis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cellulitis
|
|
|
|
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Chest pain
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pleuritic pain
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholecystitis
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Cholelithiasis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Clostridial infection
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Colitis
|
|
|
|
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Confusional state
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Contusion
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Dysphagia
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dehydration
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis atopic
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fungal skin infection
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Duodenitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysgeusia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspepsia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysuria
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Enteritis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Pseudomembranous enterocolitis
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Epistaxis
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophagitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Extravasation
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye disorder
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Fatigue
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Faecal incontinence
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Flank pain
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flatulence
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flushing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastritis
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal haemorrhage
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gout
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac arrest
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac disorder
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Cardiac failure
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac murmur
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematochezia
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Haematoma
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Subdural haematoma
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematuria
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemoptysis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhage
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Haemorrhoids
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hiccups
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypersensitivity
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
|
|
|
|
|
Hypertension
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoaesthesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoglycaemia
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Body temperature decreased
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Jaundice
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leg pain
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver disorder
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Mediastinal disorder
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Melaena
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Cramp muscle
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Fungal infection
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Nasal congestion
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Necrosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervousness
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oliguria
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pain
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancreatitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paraesthesia
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pelvic abscess
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Petechiae
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Pharyngitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Phlebitis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pleural effusion
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pregnancy
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Pulmonary embolism
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Pyloric stenosis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rales
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Restless legs syndrome
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Rhinitis
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rhonchi
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Scleral disorder
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Convulsion
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Septicemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Septic shock
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Shoulder pain
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Skin lesion
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle spasms
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastric ulcer
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Stomatitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebrovascular accident
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Postoperative wound infection
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Sweating
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tachycardia
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thirst
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Thrombocytopenia
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Toothache
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Erythema
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Urinary tract disorder
|
|
|
|
x
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Urticaria
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal itching
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angiopathy
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vasculitis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Ventricular tachycardia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Viral infection
|
|
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
Vulvovaginitis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Weight decreased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Wheezing
|
0% - 1%
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry mouth
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Bronchoconstriction
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary retention
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chills
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinus bradycardia
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Stupor
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mouth ulceration
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue oedema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Injection site pain
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abortion
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Malnutrition
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash macular
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Blood urine
|
|
|
x
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Malaise
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac fibrillation
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Decreased appetite
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bladder dysfunction
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disorientation
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Discomfort
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash erythematous
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Faeces discoloured
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Lung infiltration
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Skin exfoliation
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pain in elbow
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Genital rash
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal dryness
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Pulmonary congestion
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Wound dehiscence
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Seroma
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Hepatobiliary disease
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Viral pharyngitis
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
|
Peripheral coldness
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Pelvic peritonitis
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Induration
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Warmth
|
|
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Wound secretion
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Bradycardia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Respiratory distress
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tonic-clonic seizures
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Blood pressure increased
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Injection site induration
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Face oedema
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hot flush
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Ear infection
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoxemia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
White blood cell count increased
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Fungal rash
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Infestation NOS
|
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood and lymphatic system disorders
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Injection site erythema
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Genital haemorrhage
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Mental status changes
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Infusion site burning
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Anastomotic leak
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Incision site haemorrhage
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Infusion site oedema
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Infusion site induration
|
|
|
x
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infusion site warmth
|
|
|
x
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infusion site pruritus
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infusion site reaction
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Injection site stinging
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Incision site complication
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Intestinal stoma complication
|
|
|
|
|
|
|
|
x
|
|
|
|
|
x
|
x
|
|
Clostridium colitis
|
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
Ileus
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rhinorrhoea
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epithelial cells urine
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Voice disturbance
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acute renal insufficiency
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
Regurgitation
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Loose stools
|
0% - 2.1%
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Somnolence
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
