Lubiprostone

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4
Nausea def 8% - 29% 3% - 4% x x x x
Diarrhoea def 3% - 12% 1% - 4% x x x x
Headache def 3% - 11% 5% x x x x
Abdominal pain def 3% - 8% 3% - 5% x x x x
Pain def 2% - 8% 3% - 5% x x x x
Abdominal distension def 3% - 6% 2% x x x x
Flatulence def 3% - 6% 2% x x x x
Dizziness def 3% 1% x x x x
Dyspnoea def 2% - 3% x x x x
Oedema def 3% 1% x x x x
Vomiting def 3% x x x x
Abdominal discomfort 2% - 3% 1% x x x x
Discomfort def 1% - 3% 1% x x x x
Chest discomfort 2% - 3% x x x x
Dyspepsia def 2% 1% x x x x
Fatigue def 2% 1% x x x x
Gastric disorder def 1% 1% x x x x
Dry mouth def 1% 1% x x x x
Upset stomach 1% 1% x x x x
Asthenia def postmarketing x x x x
Rash def postmarketing x x x x
Cramp muscle def postmarketing x x x x
Muscle spasms def postmarketing x x x
Swelling def postmarketing x x x
Syncope def postmarketing x x x x
Tachycardia def postmarketing x x x
Malaise def postmarketing x x x x
Throat tightness postmarketing x x x x
Adenoma benign def x
Anorexia def x x x x
Anxiety def x x x x
Arthralgia def x
Asthma def x
Back pain def x
Mental disorder def x
Breast feeding def x
Bronchitis def x
Chest pain def x
Connective tissue disorder def x
Cough def x x x x
Dysgeusia def x x x x
Eructation def x x x
Faecal incontinence def x x x x
Fertilization def x
Body temperature increased def x
Fibromyalgia def x x x
Flushing def x x
Intestinal functional disorder x x x
Gastritis def x x x
Gastroenteritis def x
Gastrooesophageal reflux disease def x x x x
Gastrointestinal disorder def x x x x
Haemorrhage def x x x
Hyperhidrosis def x x x x
Hypertension def x
Hypoaesthesia def x
Incontinence def x x x x
Infection def x x x x
Influenza def x x x x
Lethargy def x x x
Lymphoma def x
Mediastinal disorder def x x x x
Muscle rigidity def x x x
Nasopharyngitis def x
Neoplasm def x
Nervous system disorder def x x x x
Nervousness def x
Pain in extremity def x
Pallor def x x
Palpitations def x x x x
Paraesthesia def x
Pregnancy def x
Respiratory tract infection def x
Sinusitis def x
Sweating def x x x
Testicular disorder def x
Tremor def x x x x
Erythema def x x x
Upper respiratory tract infection def x
Pollakiuria def x x x
Urinary tract infection def x x x x
Urticaria def x
Angiopathy def x
Syncope vasovagal def x
Vertigo def x
Viral infection def x
Weight increased def x x x x
Oedema peripheral def x
Aspartate aminotransferase increased def x x x
Alanine aminotransferase increased def x x x
Skin irritation def x
Joint swelling x x x
Viral diarrhoea x
Abnormal bowel sounds x
Abdominal rigidity x x x
Hepatocellular adenoma def x
Myalgia def x x x
Cold sweat x x x
Decreased appetite x x x x
Abdominal pain upper x
Abdominal pain lower x
Abdominal tenderness x x x
Retching def x x
Borborygmi x
Teratogenicity def x
Tenderness def x x x
Frequent bowel movements x x x x
Rectal haemorrhage def x x x
Faeces hard x x x
Renal impairment def x
Electrolyte imbalance def x x x x
Painful respiration x
Rigors x
Defaecation urgency def x x x
Rebound effect x
Hot flush def x x
Drug interaction def x
Dissecting aortic aneurysm, thoracic x x x x
Infestation NOS x
Pharyngolaryngeal pain def x x x x
Carcinogenicity x
Insomnia def x
Hepatic impairment x
Gastrointestinal discomfort x x x
Abdominal bloating def x
Indication Labels
Constipation def x x
Irritability def x x
Irritable bowel syndrome def x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: A06AX03

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. LUBIPROSTONE / AMITIZA : 85 side effects (Drugs@FDA)
  2. LUBIPROSTONE : 72 side effects (FDA XML label)
  3. LUBIPROSTONE : 72 side effects (FDA XML label)
  4. LUBIPROSTONE / AMITIZA : 91 side effects (Drugs@FDA)