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Refludan

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: B01AE02

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4
Anaemia 1.1% - 13.1% x x x x
Haemoglobin decreased 1.1% - 13.1% x x x
Haematoma 4.4% - 11.1% x x x x
Wound 4.4% - 14.1% x x x
Haemorrhage 0.7% - 21.5% x x x x
Rectal haemorrhage 5.1% - 6.6% x x x x
Pneumonia 5% x x x
Multi-organ failure 4% x x x
Aspartate aminotransferase increased 3% x
Sepsis 3% x x x
Body temperature increased 2.5% - 3% x x x
Haematuria 0% - 6.6% x x x x
Injection site haemorrhage 1.9% - 2.1% x
Prothrombin level increased 1.5% x
Vaginal haemorrhage 0% - 1.8% x x x x
Epistaxis 0.6% - 4.4% x x x x
Haemothorax 0% - 3% x x x x
Shock postmarketing, 2% x x x x
Eczema 1% x
Rash 1% x x x x
Gastrointestinal haemorrhage 0.7% - 1.3% x x
Hypersensitivity 1% x x x
Anaphylactic shock postmarketing x x x
Haemorrhage intracranial postmarketing, 0% - 2.2% x x x x
Abscess x
Angioedema x x x x
Bronchospasm x x x
Infection x x
Confusional state x
Coronary artery thrombosis x
Cough x x x x
Diarrhoea x
Dyspepsia x
Dyspnoea x x x x
Oedema x x x
Flushing x x x
Gastritis x
Gingival bleeding x
Headache x
Cardiac arrest x
Cardiac failure x x
Haematemesis x
Pericardial haemorrhage x
Peritoneal haemorrhage x x x
Haemoptysis x x x
Hypotension x
Immune system disorder x
Laryngeal oedema x x x x
Mediastinal disorder x
Nausea x
Mouth haemorrhage x x x
Pain x x
Pericardial effusion x x x
Pruritus x x x x
Pulmonary embolism x
Convulsion x
Stridor x x x x
Superinfection x
Thrombophlebitis x
Urticaria x x x x
Angiopathy x
Vasodilation x
Ventricular fibrillation x x x
Ventricular tachycardia x
Vomiting x
Chills x x x
Fever chills x
Agitation x
Hepatic function abnormal x x
Antinuclear antibody positive x
Tongue oedema x x x x
Pulmonary haemorrhage x x
Retroperitoneal haemorrhage x x x
Injection site reaction x x
Kidney function abnormal x x
Liver function test abnormal x
Skin necrosis x
Injection site pain x
Arterial thrombosis x
Acute myocardial infarction x x
Unspecified disorder of skin and subcutaneous tissue x
Bradycardia x
Subcutaneous haematoma x
Face oedema x x x x
Hypovolaemia x
Surgical intervention x
Hot flush x
Serum creatinine increased x
Sweating increased x
Skin haemorrhage x
Insomnia x
Gastritis haemorrhagic x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

lepirudin / lepirudin

Side effects:31
Source:EMA

LEPIRUDIN

Side effects:43
Source:FDA Structured Product Label

LEPIRUDIN RECOMBINANT / REFLUDAN

Side effects:43
Source:FDA

LEPIRUDIN / REFLUDAN

Side effects:80
Source:Health Canada

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label