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Lapatinib

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XE07

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3
Arthralgia Arthralgia very common x
Musculoskeletal discomfort Arthralgia very common x
Myalgia very common, 0% - 10% x
Dehydration Dehydration very common x x
Dermatitis Dermatitis very common x
Rash very common, 0% - 24% x x x
Asthenia Fatigue very common, 0% - 21% x x x
Asthenia very common, 0% - 11% x x x
Fatigue Fatigue very common, 0% - 21% x x x
Neuropathy peripheral Neuropathy peripheral very common x
Dermatitis acneiform Dermatitis acneiform very common x x
Menopausal symptoms Hot flush very common x
Hot flush Hot flush very common x
Abdominal pain Abdominal pain very common, 12% x x
Gastrointestinal pain Abdominal pain very common, 12% x x
Mucosal inflammation Mucosal inflammation very common, 0% - 12% x x x
Neutropenia Neutropenia 5% - 47% x
Constipation Constipation common, very common x x
Diarrhoea Diarrhoea very common, 0% - 40% x x x
Hyperbilirubinaemia Hyperbilirubinaemia common, very common x x
Decreased appetite Anorexia very common, 0% - 18% x x x
Decreased appetite 0% - 19% x
Stomatitis Stomatitis very common, 0% - 11% x x x
Nausea Nausea very common, 0% - 43% x x x
Leukopenia Leukopenia 1% - 33% x
Alopecia Alopecia very common, 0% - 7% x x x
Rash Rash very common, 0% - 24% x x x
Pain in extremity Pain in extremity very common, 0% - 7% x x x
Back pain Back pain very common, 0% - 6% x x x
Insomnia Insomnia very common, 0% - 6% x x x
Dyspnoea Dyspnoea very common, 0% - 8% x x x
Headache Headache common — 0% - 13% x x x
Paronychia Paronychia postmarketing, common x x x
Peripheral sensory neuropathy Peripheral sensory neuropathy 5% x
Dry skin Dry skin very common, 0% - 6% x x x
Myalgia Myalgia very common, 0% - 10% x
Hepatotoxicity Hepatotoxicity common x x x
Ejection fraction decreased Left ventricular ejection fraction decreased common x x
Cough Cough very common, 0% - 9% x x
Pruritus Pruritus very common, 0% - 9% x x x
Anaemia Anaemia 0% - 10% x
Dyspepsia Dyspepsia very common, 0% - 3% x x x
Vomiting Vomiting very common, 0% - 21% x x x
Pneumonia Pneumonia uncommon x x x
Interstitial lung disease Interstitial lung disease uncommon x x x
Epistaxis Epistaxis very common, 0% - 2% x x x
Alanine aminotransferase increased Alanine aminotransferase increased 0% - 8% x
Haemoglobin decreased Haemoglobin decreased 0% - 2% x
Nail disorder Nail disorder postmarketing — 0% - 2% x x x
Anaphylactic shock Anaphylactic shock postmarketing, rare x x x
Hypersensitivity Hypersensitivity postmarketing, rare x x x
Immune system disorder Immune system disorder postmarketing x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing x x x
Mental disorder Mental disorder x x x
Neoplasm malignant Neoplasm malignant x x x
Infection Infection x
Connective tissue disorder Connective tissue disorder x x x
Gastrointestinal disorder Gastrointestinal disorder x x x
Cardiac disorder Cardiac disorder x x
Cardiac failure Cardiac failure x x
Blood disorder Blood disorder x
Renal failure acute Renal failure acute x
Mediastinal disorder Mediastinal disorder x x x
Nervous system disorder Nervous system disorder x x x
Palpitations Palpitations x x
Angiopathy Angiopathy x
Malnutrition Malnutrition x x
Hepatobiliary disease Hepatobiliary disease x x
Blood bilirubin increased Blood bilirubin increased x
Infestation Infestation NOS x
Cardiotoxicity Cardiotoxicity x x
Metastatic neoplasm Metastatic disease x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

LAPATINIB

Side effects:39
Source:FDA Structured Product Label

lapatinib / lapatinib

Side effects:51
Source:EMA

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label