Alprazolam
Side effects
Options: Show MedDRA Preferred Terms, display all 44 labels
| Side effect | Data for drug | Placebo | Labels | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |||
| Coordination abnormal | 1.9% - 40.1% | 0.3% - 18% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Irritability | frequent, 33% - 33.1% | 30% - 30.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Memory impairment | 1.5% - 33.1% | 0.3% - 22.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Salivation | 32.8% | 34.2% | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Increased appetite | 7% - 33% | 6% - 23% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Cognitive disorder | 28.8% - 29% | 20.5% - 21% | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Decreased appetite | 7.3% - 28% | 3.8% - 24.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Dysarthria | 2.1% - 23.3% | 0% - 6.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Lightheadedness | 1.2% - 29.8% | 19% - 36.9% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Abdominal distress | 18.3% - 21.5% | 21.5% | x | x | x | x | x | x | x | |||||||||||||
| Anxiety | 1.1% - 16.6% | 0.6% - 24.9% | x | x | x | x | x | x | x | x | ||||||||||||
| Drowsiness | 1.8% - 76.8% | 21.6% - 42.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Sweating | 15.1% - 23.5% | 23.5% | x | x | x | x | x | x | x | |||||||||||||
| Abnormal involuntary movements | 14.8% | 21% | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Libido decreased | 6% - 14.4% | 2.3% - 8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Somnolence | 3.2% - 23% | 0.3% - 6% | x | x | x | x | ||||||||||||||||
| Headache | frequent, 1.1% - 29.2% | 12.6% - 35.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Strangury | frequent, 8.6% - 12.2% | 8.6% - 9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Depression | 2.4% - 13.9% | 1.2% - 18.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Rash | infrequent, 8.1% - 11% | 8% - 8.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Chest pain | frequent, 10.6% - 18.1% | 18.1% | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Constipation | 0.9% - 26.2% | 4.3% - 15.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Menstrual disorder | 8.7% - 10.4% | 8.7% - 9% | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Dry mouth | 0.7% - 15% | 9.7% - 13.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Diarrhoea | frequent, 1.2% - 22.8% | 3.1% - 22.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Confusional state | 0.9% - 10.4% | 0.9% - 10% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Hyperventilation | frequent, 8.5% - 14.5% | 2.7% - 14.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Nausea | 1.7% - 31.8% | 3.2% - 31.8% | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Vomiting | frequent, 1.7% - 31.8% | 12.8% - 31.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Malnutrition | 9.5% | 3.8% | x | x | x | x | ||||||||||||||||
| Insomnia | frequent, 1.3% - 29.4% | 9.6% - 41.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Muscle twitching | frequent, 7.4% - 7.9% | 2.7% - 11.8% | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Libido increased | frequent, 7.7% - 8% | 4% - 4.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Tachycardia | 0.4% - 26.8% | 15.6% - 26.8% | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Sexual dysfunction | 2.4% - 7.4% | 1.1% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Nasal congestion | frequent, 7.3% - 17.4% | 9.3% - 16.5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Ataxia | 7.2% | 3.2% | x | x | x | x | x | x | ||||||||||||||
| Mental disability | 7.2% | 5.7% | x | x | x | x | ||||||||||||||||
| Tinnitus | infrequent, 6.6% - 21% | 10.4% - 21.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Vision blurred | frequent, 0.4% - 21.4% | 6.2% - 21.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Asthenia | infrequent — 7.1% - 8.4% | 8.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Weight increased | 2.7% - 27.2% | 2.7% - 18% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Abdominal pain | frequent | x | x | x | x | |||||||||||||||||
| Back pain | frequent | x | x | x | x | |||||||||||||||||
| Depersonalisation | frequent, 5.7% | 1.9% | x | x | x | x | x | x | ||||||||||||||
| Dyspepsia | frequent | x | x | x | x | |||||||||||||||||
| Nervous system disorder | frequent | x | x | x | x | |||||||||||||||||
| Nightmare | frequent | x | x | x | x | |||||||||||||||||
| Palpitations | frequent, 0.4% - 7.7% | 15.6% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Vertigo | frequent | x | x | x | x | |||||||||||||||||
| Malaise | frequent | x | x | x | x | |||||||||||||||||
| Sweating increased | frequent | x | x | x | x | |||||||||||||||||
| Oedema | infrequent, 4.9% - 5.6% | 5.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Hypotension | infrequent, 4.7% - 5% | 2% - 2.2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Upper respiratory tract infection | 1.9% - 4.3% | 1.7% - 3.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Weight decreased | 2.3% - 23% | 3% - 17% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Muscle rigidity | 0.4% - 4.2% | 5.3% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Salivary hypersecretion | infrequent, 4% - 6% | 2% - 4.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Nervousness | frequent, 1.1% - 21.8% | 8.8% - 10.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Tremor | frequent, 0.4% - 28.2% | 8.8% - 10.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Dermatitis | 0.6% - 4% | 3% - 3.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hypersensitivity | 0.6% - 4% | 3% - 3.1% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Dysmenorrhoea | 3.6% | 2.9% | x | x | x | x | ||||||||||||||||
| Disturbance in attention | 3.2% | 0.6% | x | x | x | x | ||||||||||||||||
| Pharyngolaryngeal pain | 3.2% | 2.6% | x | x | x | x | ||||||||||||||||
| Syncope | infrequent, 3.1% - 4.8% | 4% - 4.8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Agitation | frequent, 2.6% - 2.9% | 2.6% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Disinhibition | 1.5% - 3% | 1.5% - 2% | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Dizziness | frequent, 1.8% - 29.8% | 0.8% - 36.9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Arthralgia | 2.4% | 0.6% | x | x | x | x | ||||||||||||||||
| Influenza | 2.4% | 2.3% | x | x | x | x | ||||||||||||||||
| Cramp muscle | frequent, 2.4% | 2.4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Paraesthesia | 2.4% - 7.1% | 1.7% - 3.2% | x | x | x | x | x | x | x | x | x | |||||||||||
| Muscle stiffness | 2.2% - 3.3% | 3.3% | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Talkativeness | 1% - 2.2% | 1% | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Derealisation | frequent, 1.2% - 8% | 1% - 3.8% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Fatigue | 1.7% - 49% | 0.6% - 42.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Dyskinesia | 1.7% | 1.4% | x | x | x | x | ||||||||||||||||
| Lethargy | 1.7% | 0.6% | x | x | x | x | x | |||||||||||||||
| Premenstrual syndrome | 1.7% | 0.6% | x | x | x | x | ||||||||||||||||
| Akathisia | 1.6% - 4.3% | 1% - 4.3% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Mental disorder | postmarketing — 2.5% | 1.2% | x | x | x | x | x | |||||||||||||||
| Anorexia | 1.5% | 0% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Dyspnoea | 1.5% | 0.3% | x | x | ||||||||||||||||||
| Incontinence | 0.6% - 2% | 0.6% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Road traffic accident | 1.5% | 0% | x | x | x | x | ||||||||||||||||
| Myalgia | 1.5% | 1.1% | x | x | x | x | ||||||||||||||||
| Disorientation | 1.5% | 0% | x | x | x | x | ||||||||||||||||
| Hot flush | 1.5% - 5.9% | 1.4% - 2.7% | x | x | x | |||||||||||||||||
| Fear | 1% - 1.4% | 1% | x | x | x | x | x | x | x | x | x | x | ||||||||||
| Infection | 1.3% - 1.9% | 1.7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Hyperaesthesia | 1.3% | 0% | ||||||||||||||||||||
| Hypoaesthesia | 1.3% - 7.8% | 0.3% - 2.3% | x | x | x | x | ||||||||||||||||
| Depressed mood | 1.3% | 0.3% | x | x | x | x | ||||||||||||||||
| Hypersomnia | 1.3% | 0% | x | x | x | x | ||||||||||||||||
| Pain in extremity | 1.1% | 0.3% | x | x | x | x | ||||||||||||||||
| Pruritus | 1.1% | 0.9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Rhinitis allergic | 1.1% | 0.6% | x | x | x | x | ||||||||||||||||
| Aggression | infrequent | x | x | x | x | |||||||||||||||||
| Amnesia | infrequent | x | x | x | x | x | x | |||||||||||||||
| Anger | infrequent | x | x | x | x | |||||||||||||||||
| Connective tissue disorder | infrequent, 7.4% | 2.7% | x | x | x | x | ||||||||||||||||
| Dysphagia | infrequent | x | x | x | x | |||||||||||||||||
| Ear pain | infrequent | x | x | x | x | |||||||||||||||||
| Epistaxis | infrequent | x | x | x | x | |||||||||||||||||
| Eye disorder | infrequent | x | x | x | x | |||||||||||||||||
| Body temperature increased | infrequent | x | x | x | x | |||||||||||||||||
| Hallucination | infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Mediastinal disorder | infrequent, 8.5% | 2.7% | x | x | x | x | ||||||||||||||||
| Hypotonia | infrequent | x | x | x | x | |||||||||||||||||
| Mydriasis | infrequent | x | x | x | ||||||||||||||||||
| Panic disorder | infrequent | x | x | |||||||||||||||||||
| Convulsion | infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Sleep apnoea syndrome | infrequent | x | x | x | x | |||||||||||||||||
| Sinus tachycardia | infrequent | x | x | x | x | |||||||||||||||||
| Thirst | infrequent | x | x | x | x | |||||||||||||||||
| Pollakiuria | infrequent | x | x | x | x | |||||||||||||||||
| Urinary incontinence | infrequent | x | x | x | x | |||||||||||||||||
| Urinary tract disorder | infrequent | x | x | x | x | |||||||||||||||||
| Urticaria | infrequent | x | x | x | x | |||||||||||||||||
| Angiopathy | infrequent, 1.5% - 5.9% | 1.4% - 2.7% | x | x | x | x | ||||||||||||||||
| Stupor | infrequent | x | x | x | x | |||||||||||||||||
| Apathy | infrequent | x | x | x | x | |||||||||||||||||
| Mood swings | infrequent | x | x | x | x | x | ||||||||||||||||
| Photophobia | infrequent | x | x | x | x | |||||||||||||||||
| Unspecified disorder of skin and subcutaneous tissue | postmarketing — 1.1% | 0.9% | x | x | x | x | x | |||||||||||||||
| Hangover | infrequent | x | x | x | x | |||||||||||||||||
| Chest tightness | infrequent | x | x | x | x | |||||||||||||||||
| Clumsiness | infrequent | x | x | x | x | |||||||||||||||||
| Abnormal dreams | infrequent | x | x | x | x | |||||||||||||||||
| Euphoric mood | infrequent | x | x | x | x | |||||||||||||||||
| Sticky skin | infrequent | x | x | x | x | |||||||||||||||||
| Suicidal ideation | infrequent | x | x | x | x | x | x | x | x | |||||||||||||
| Psychomotor retardation | infrequent | x | x | x | x | |||||||||||||||||
| Rigors | infrequent | x | x | x | x | |||||||||||||||||
| Homicidal ideation | infrequent | x | x | x | x | |||||||||||||||||
| Energy increased | infrequent | x | x | x | x | |||||||||||||||||
| Loss of control of legs | infrequent | x | x | x | x | |||||||||||||||||
| Feeling of relaxation | infrequent | x | x | x | x | |||||||||||||||||
| Feeling drunk | infrequent | x | x | x | x | |||||||||||||||||
| Sleep talking | infrequent | x | x | x | x | |||||||||||||||||
| Choking sensation | infrequent | x | x | x | x | |||||||||||||||||
| Feeling jittery | infrequent | x | x | x | x | |||||||||||||||||
| Depressed level of consciousness | infrequent | x | x | x | x | |||||||||||||||||
| Bradyphrenia | infrequent | x | x | x | x | |||||||||||||||||
| Ear and labyrinth disorders | infrequent | x | x | x | x | |||||||||||||||||
| Sluggishness | infrequent | x | x | x | x | |||||||||||||||||
| Rhinorrhoea | infrequent | x | x | x | x | |||||||||||||||||
| Dysphonia | infrequent | x | x | x | x | |||||||||||||||||
| Feeling hot | infrequent | x | x | x | x | |||||||||||||||||
| Logorrhoea | infrequent | x | x | x | x | |||||||||||||||||
| Hepatobiliary disease | postmarketing, uncommon | x | ||||||||||||||||||||
| Angioedema | postmarketing | x | x | x | x | x | ||||||||||||||||
| Gastrointestinal disorder | postmarketing — 12.1% | 3.1% | x | x | x | x | x | x | x | x | ||||||||||||
| Gynaecomastia | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hepatitis | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hyperprolactinaemia | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Jaundice | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Stevens-Johnson syndrome | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hepatic failure | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Oedema peripheral | postmarketing | x | x | x | x | x | ||||||||||||||||
| Menstruation irregular | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Photosensitivity reaction | postmarketing | x | ||||||||||||||||||||
| Galactorrhoea | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hypomania | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Mania | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Breast disorder | x | x | x | x | ||||||||||||||||||
| Diplopia | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Cardiac disorder | x | x | x | x | ||||||||||||||||||
| Hostility | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Muscle spasticity | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Panic reaction | x | |||||||||||||||||||||
| Sleep disturbance | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Withdrawal syndrome | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Suicide | x | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Urinary retention | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Hepatic function abnormal | x | x | x | |||||||||||||||||||
| Liver function test abnormal | x | x | ||||||||||||||||||||
| Muscular weakness | x | |||||||||||||||||||||
| Amnesia transient | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Slurred speech | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Intraocular pressure increased | x | x | x | |||||||||||||||||||
| Withdrawal seizures | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Cerebration impaired | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Blood bilirubin increased | x | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Gastrointestinal symptom NOS | x | x | ||||||||||||||||||||
| Balance disorder | x | |||||||||||||||||||||
| Substance abuse | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Infestation NOS | x | x | x | x | ||||||||||||||||||
| Major depression | x | x | x | x | x | x | x | x | x | x | ||||||||||||
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Color scheme:
standard – alternative
| 100% | ||
| 75% | ||
| 50% | ||
| 10% | ||
| frequent (1% to 100%) | ||
| infrequent (0.1% to 1%) | ||
| rare (<0.1%) | ||
| postmarketing | ||
| 0% | ||
| no frequency information | ||
| not found on label |
