Amantadine
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
Oedema peripheral
|
Oedema peripheral
|
very common
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Livedo reticularis
|
Livedo reticularis
|
common, very common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
Asthenia
|
common
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
common
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspepsia
|
Dyspepsia
|
common
|
|
|
x
|
|
|
|
|
|
|
Fatigue
|
Fatigue
|
common
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
Lightheadedness
|
common
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Agitation
|
Excitement
|
common
|
|
|
x
|
|
|
|
|
|
|
Agitation
|
postmarketing — common
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Hyperkinesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Disturbance in attention
|
Cerebration impaired
|
common
|
|
|
x
|
|
|
|
|
|
|
Mental disability
|
Cerebration impaired
|
common
|
|
|
x
|
|
|
|
|
|
|
Decreased appetite
|
Anorexia
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ataxia
|
Ataxia
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Constipation
|
Constipation
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Headache
|
Headache
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Orthostatic hypotension
|
Orthostatic hypotension
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lethargy
|
Lethargy
|
uncommon, common
|
|
x
|
x
|
|
|
|
|
|
|
Nausea
|
Nausea
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nervousness
|
Nervousness
|
uncommon, common
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Tension
|
Nervousness
|
uncommon, common
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Palpitations
|
Palpitations
|
uncommon, common
|
|
x
|
x
|
|
|
|
|
|
|
Vomiting
|
Vomiting
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dry mouth
|
Dry mouth
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vision blurred
|
Vision blurred
|
uncommon, common
|
|
x
|
x
|
|
|
|
|
|
|
Insomnia
|
Insomnia
|
uncommon, common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysarthria
|
Dysarthria
|
uncommon
|
|
x
|
x
|
|
|
|
|
|
|
Slurred speech
|
postmarketing, common
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Osteoarthritis
|
Dysarthria
|
uncommon
|
|
x
|
x
|
|
|
|
|
|
|
Elevated mood
|
Elevated mood
|
uncommon
|
|
x
|
|
|
|
|
|
|
|
Mental disorder
|
Mental disorder
|
postmarketing, uncommon
|
|
x
|
x
|
|
|
|
|
|
|
Nightmare
|
Nightmare
|
postmarketing, uncommon
|
|
x
|
x
|
|
|
|
|
|
|
Aggression
|
Aggression
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Agranulocytosis
|
Agranulocytosis
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Anaphylactic shock
|
Anaphylactic shock
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Anxiety
|
Anxiety
|
postmarketing — common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arrhythmia
|
Arrhythmia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Coma
|
Coma
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Confusional state
|
Confusional state
|
postmarketing — uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Feeling abnormal
|
Confusional state
|
postmarketing — uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysphagia
|
Dysphagia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Delirium
|
Delirium
|
postmarketing, rare
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
Delusion
|
Delusion
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Diarrhoea
|
Diarrhoea
|
rare
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Dyskinesia
|
Dyskinesia
|
rare
|
|
x
|
x
|
|
|
|
|
|
|
Dyspnoea
|
Dyspnoea
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eczema
|
Eczema
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema
|
Oedema
|
postmarketing
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
Dermatitis
|
Rash
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Body temperature increased
|
Body temperature increased
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hallucination
|
Hallucination
|
postmarketing, uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cardiac arrest
|
Cardiac arrest
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hypersensitivity
|
Hypersensitivity
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hypotension
|
Hypotension
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Libido increased
|
Libido increased
|
postmarketing
|
|
x
|
x
|
|
|
|
|
x
|
x
|
Disturbance in sexual arousal
|
Libido increased
|
postmarketing
|
|
x
|
x
|
|
|
|
|
x
|
x
|
Libido decreased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Keratitis
|
Keratitis
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Leukocytosis
|
Leukocytosis
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Mediastinal disorder
|
Mediastinal disorder
|
rare
|
|
|
x
|
|
|
|
|
|
|
Hypertonia
|
Hypertonia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Mydriasis
|
Mydriasis
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Neuroleptic malignant syndrome
|
Neuroleptic malignant syndrome
|
very rare, postmarketing
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Paraesthesia
|
Paraesthesia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Pathological gambling
|
Pathological gambling
|
postmarketing
|
|
x
|
x
|
|
|
|
|
x
|
x
|
Pruritus
|
Pruritus
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Psychotic disorder
|
Psychotic disorder
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary oedema
|
Pulmonary oedema
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Convulsion
|
Convulsion
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tachycardia
|
Tachycardia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Tremor
|
Tremor
|
postmarketing, rare
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
Urinary incontinence
|
Urinary incontinence
|
rare
|
|
x
|
x
|
|
|
|
|
|
|
Urinary retention
|
Urinary retention
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Stupor
|
Stupor
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Depressed level of consciousness
|
Stupor
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hypokinesia
|
Hypokinesia
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Mania
|
Manic psychosis
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Mania
|
rare
|
|
x
|
|
|
|
|
|
|
|
Paranoia
|
Paranoid reaction
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Tachypnoea
|
Tachypnoea
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Disorientation
|
Disorientation
|
rare
|
|
x
|
x
|
|
|
|
|
|
|
Muscle contractions involuntary
|
Muscle contractions involuntary
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Renal failure acute
|
Acute respiratory failure
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Acute respiratory failure
|
Acute respiratory failure
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hypersexuality
|
Hypersexuality
|
postmarketing
|
|
x
|
x
|
|
|
|
|
x
|
x
|
Gait disturbance
|
Gait disturbance
|
postmarketing
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hyperhidrosis
|
Sweating increased
|
postmarketing — common
|
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
Alopecia
|
Alopecia
|
very rare
|
|
|
x
|
|
|
|
|
|
|
Eye disorder
|
Eye disorder
|
very rare
|
|
x
|
x
|
|
|
|
|
|
|
Cardiac failure
|
Cardiac failure
|
very rare
|
|
x
|
x
|
|
|
|
|
|
|
Cardiac failure congestive
|
Cardiac failure congestive
|
very rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Leukopenia
|
Leukopenia
|
very rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neutropenia
|
Neutropenia
|
very rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Liver function test abnormal
|
Liver function test abnormal
|
very rare
|
|
|
x
|
|
|
|
|
|
|
Photosensitivity reaction
|
Photosensitivity
|
very rare
|
|
x
|
|
|
|
|
|
|
|
Amnesia
|
Amnesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Corneal oedema
|
Corneal oedema
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Corneal opacity
|
Corneal opacity
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Subepithelial opacities
|
|
|
x
|
x
|
|
|
|
|
|
|
Libido decreased
|
Libido decreased
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
Cardiac disorder
|
Cardiac disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
Hypertension
|
Hypertension
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Body temperature decreased
|
Body temperature decreased
|
|
|
x
|
|
|
|
|
|
|
|
Hypothermia
|
Body temperature decreased
|
|
|
x
|
|
|
|
|
|
|
|
Irritability
|
Irritability
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Nervous system disorder
|
Nervous system disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
Completed suicide
|
Suicide
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Urethral disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
|
|
|
|
|
|
Angiopathy
|
Angiopathy
|
|
|
x
|
x
|
|
|
|
|
|
|
Oculogyric crisis
|
Oculogyric crisis
|
|
|
|
x
|
|
|
|
|
|
|
Sudden visual loss
|
Sudden visual loss
|
|
|
|
x
|
|
|
|
|
|
|
Malnutrition
|
Malnutrition
|
|
|
x
|
x
|
|
|
|
|
|
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
x
|
x
|
|
|
|
|
|
|
Nasal dryness
|
Nasal dryness
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Visual acuity reduced
|
Visual acuity reduced
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
Euphoric mood
|
Euphoric mood
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Punctate keratitis
|
Punctate keratitis
|
|
|
x
|
x
|
|
|
|
|
|
|
Paralysis
|
Nerve paralysis
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Suicidal ideation
|
Suicidal ideation
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Hyperkinesia
|
Hyperkinesia
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Visual impairment
|
Visual disturbance
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
Somnolence
|
Somnolence
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 55 |
Source: | Medsafe |
---|
Side effects: | 68 |
Source: | medicines.org.au |
---|
Side effects: | 30 |
Source: | Health Canada |
---|
Side effects: | 47 |
Source: | FDA Structured Product Label |
---|
Side effects: | 78 |
Source: | FDA Structured Product Label |
---|
Side effects: | 78 |
Source: | FDA Structured Product Label |
---|
Side effects: | 81 |
Source: | FDA Structured Product Label |
---|
Side effects: | 81 |
Source: | FDA Structured Product Label |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|