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Bupivacaine

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Codes: N01BB01, N01BB10

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13
Gastrointestinal disorder 7.37% - 42.3% 13.8% - 39.6% x
Hypotension 19.6% - 31% x x x x x x x x x x x x x
Nausea 2.11% - 40.2% 1.06% - 37.5% x x x x x x x x x x x x x
Nervous system disorder 0% - 20.6% 0% - 31.2% x
Anaemia 8.17% - 12% x x
Foetal distress syndrome 5% - 9.63% x
Vomiting 2.11% - 27.8% 4.26% - 17.7% x x x x x x x x x x x x x
Postoperative pain 7.27% - 18% x
Delayed delivery 6.29% - 6.84% x
Dizziness 0% - 11.3% 0% - 26% x x x x x x x x x x x x x
Back pain 4.19% - 5.7% x x x x x x x x x x x
Headache 0% - 7% 0% - 8.33% x x x x x x x x x x x
Unspecified disorder of skin and subcutaneous tissue 0% - 8.25% 0% - 7.29% x
Pain 3.54% - 8% x
Pruritus 0% - 9% 0% - 1.04% x x x x x x x x x
Electrocardiogram abnormal 3.14% - 3.75% x
Body temperature increased 0% - 17% 0% - 3.19% x x x x x x x x x x
Diplopia 2.55% - 3.09% x x x
Enlargement abdomen 2.65% - 2.95% x
Rigors 2.65% - 2.95% x
Constipation 2.06% - 7% 1.04% - 2.13% x x
Pruritus generalised 0% - 5.15% 0% - 6.25% x
Hypoaesthesia 1.5% - 3.31% x x
Flatulence 2.36% - 2.43% x
Haemorrhage in pregnancy 1.77% - 2.65% x
Dyspepsia 1.96% - 2.43% x
Bradycardia 1.6% - 2.21% x x x x x x x x x x x x
Wound discharge increased 1.38% - 2.87% x
Alanine aminotransferase increased 1.05% - 3.09% 0% - 3.12% x
Tachycardia 1.55% - 3.9% x x x x x x x x x
Abdominal pain 1.32% - 2.16% x
Body temperature decreased 1.32% - 2.16% x
Anal haemorrhage 0% - 3.16% 0% - 4.26% x
Aspartate aminotransferase increased 0% - 3.09% 0% - 2.08% x
Urine abnormality 1.32% - 1.77% x
Haematuria 1.1% - 1.96% x
Hypertension 0.982% - 1.77% x x x x x x x
Lethargy 1.3% x
Somnolence 0% - 5.15% 0% - 1.04% x x
Anxiety 0.982% - 1.32% x x x x x x x x x x
Diarrhoea 0.982% - 1.32% x
Purpura 0.883% - 1.38% x
Dyschezia 0% - 2.11% 0% - 5.32% x
Infection 0% - 2.06% 0% - 1.04% x
Fungal infection 0% - 2.06% 0% - 1.04% x
Syncope 0% - 2.06% 0% x x x x x x x x x
Malnutrition 0% - 2.06% 0% - 2.08% x
Decreased appetite 0% - 2.06% 0% - 2.08% x
Blood creatinine increased 0% - 2.06% 0% x
Infestation NOS 0% - 2.06% 0% - 1.04% x
Post procedural swelling 0% - 2.06% 0% x
Feeling hot 0% - 2.06% 0% x
Breast pain 0.883% - 0.982% x
Cough 0.662% - 1.18% x
Leukocytosis 0.662% - 1.18% x
Urinary tract infection 0.662% - 0.982% x
Urine flow decreased 0.662% - 0.982% x
Urinary incontinence 0.221% - 1.18% x x x x x x x x x
Rectal discharge 0% - 1.05% 0% - 3.19% x
Paraesthesia postmarketing, 0.442% - 1.77% x x x x x x x x x x x x
Anaphylactic shock postmarketing x x
Asthenia postmarketing x x x x x x
Drug toxicity postmarketing x
Flushing postmarketing x
Horner's syndrome postmarketing x
Miosis postmarketing x
Priapism postmarketing x
Convulsion postmarketing x x x x x x x x x x x
Sweating postmarketing x
Trauma postmarketing x x
Sensory disturbance postmarketing x
Cauda equina syndrome postmarketing x x x x
Paralysis postmarketing x x x x x x x x x
Acidosis x x x x x x x x x
Angioedema x x x x x x x x
Apnoea x x x x x x x x
Arachnoiditis x x x x x x x
Arrhythmia x
Arthralgia x
Mental disorder x
Bone disorder x
Bronchospasm x
Cardiac output decreased x x x x x x x x
Cardiovascular disorder x
Neck pain x
Confusional state x x x x
Dysphagia x x
Drowsiness x x x x x x x x x x x x
Drug hypersensitivity x
Dysarthria x
Dyspnoea x
Oedema x x x x x x
Extravasation x x
Cardiac arrest x x x x x x x x x x x
Block heart x x x x x x x x x
Cardiac disorder x
Hypercapnia x
Hyperhidrosis x
Hyperkalaemia x x
Hypersensitivity x x x x x x
Hypocalcaemia x x
Orthostatic hypotension x
Laryngeal oedema x x x x x x x x
Laryngospasm x
Meningism x x x x x x
Meningitis x x x x x x x
Meningitis aseptic x x
Nervousness x x x x x
Numbness x x
Pallor x
Palpitations x
Paraplegia x x x x
Paresis x x x
Neuropathy peripheral x
Supraventricular extrasystoles x
Prurigo x
Pulmonary oedema x
Hyperacusis x
Respiratory insufficiency x
Respiratory paralysis x x x x x x x x
Shivering x x
Shock x x x x x x x
Sneezing x x x x x x x x
Muscle spasms x x
Tinnitus x x x x x x x x x x x x
Tremor x x x x x x x x x x x
Loss of consciousness x x x x x x x x x x x x
Erythema x x x x x x x x x
Urticaria x x x x x x x x x x x x x
Ventricular fibrillation x x x x x x
Ventricular tachycardia x x x x x x x
Urinary retention x x x x x x x x x x x
Chills x x x x x x x x
Sinus bradycardia x
Ventricular arrhythmia x x x x x x x x
Agitation x x x x x x x x x
Oedema peripheral x
Hypokinesia x
Cranial nerve paralysis x x x x x x
Neck stiffness x x
CNS depression NOS x x
Swelling face x
Ventricular extrasystoles x
Muscular weakness x x
Circumoral paresthesia x
Skin discolouration x
Respiratory arrest x x x x x x x x x x
Lightheadedness x x x x
Anterior spinal artery syndrome x
Muscle twitching x x
Cardiac fibrillation x x
Cold sweat x
Apprehension x x
Excitement x x x x x x x x x
Sensation of heat x x
Slurred speech x x
Dizziness postural x
Neurologic reaction x
Neurotoxicity x x
Respiratory depression x x x x x x
Muscle contractions involuntary x
Euphoric mood x x
Vasoconstriction peripheral x x
Peripheral nerve injury x
Extradural abscess x
Blood bilirubin increased x
Extrasystoles x
Anaphylactoid reaction x x
Chondrolysis x
Vision blurred x x x x x x x x x x x x x
Depressed mood x
Dysaesthesia x
Stiffness x
Neuropathy x x x
Total spinal block x x x x x x
Blood pressure increased x
Numbness of tongue x x x
Sweating increased x x x x x x x x
Oxygen saturation decreased x
Needle injury x
Hypotensive x x x x x
Anaemia postoperative x
Insomnia x
Haemorrhagic anaemia x
Respiratory failure x
Ileus x
Procedural hypotension x
Procedural hypertension x
Procedural pain x
Incision site oedema x
Procedural nausea x
Hypoesthesia tongue x x x
CNS toxicity x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

BUPIVACAINE

Side effects:79
Source:FDA Structured Product Label

BUPIVACAINE HYDROCHLORIDE / MARCAINE SPINAL 7.5 MG/ML

Side effects:47
Source:Health Canada

BUPIVACAINE

Side effects:47
Source:FDA Structured Product Label

BUPIVACAINE

Side effects:48
Source:FDA Structured Product Label

Bupivacaine

Side effects:46
Source:FDA Structured Product Label

Bupivacaine

Side effects:46
Source:FDA Structured Product Label

Bupivacaine

Side effects:48
Source:FDA Structured Product Label

BUPIVACAINE HYDROCHLORIDE / SENSORCAINE 0.25%

Side effects:54
Source:Health Canada

Levobupivacaine Injection / CHIROCAINE

Side effects:94
Source:medicines.org.au

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label