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Tigecycline

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: J01AA12

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8
Diarrhoea Diarrhoea very common, 10.8% - 12.7% x x x x x x x x
Local reaction Local reaction 9% - 9.1% x x x x x x
Vomiting Vomiting very common, 1% - 19.7% x x x x x x x x
Body temperature increased Body temperature increased 7.1% - 9.8% x x x x x x
Nausea Nausea very common, 1% - 29.5% x x x x x x x x
Thrombocytosis Thrombocytosis 6.1% - 6.2% x x x x x x
Headache Headache common, 5.9% - 7% x x x x x x x x
Abdominal pain Abdominal pain common, 4% - 6.8% x x x x x x x x
Gastrointestinal pain Abdominal pain common, 4% - 6.8% x x x x x x x x
Infection Infection common, 5% - 8.3% x x x x
Hypertension Hypertension 4.9% - 5.6% x x x x x x
Decreased appetite Anorexia common x x x x x x x x
Angiopathy Angiopathy common x
Prothrombin level increased Prothrombin level increased common x x x x x x x x
Alanine aminotransferase increased Alanine aminotransferase increased common, 4.7% - 5.6% x x x x x x
Activated partial thromboplastin time prolonged Activated partial thromboplastin time prolonged common x x x x x x x
Pseudomembranous colitis Pseudomembranous colitis common x x
Anaemia Anaemia 4.2% - 6% x x x x x x x
Hypoproteinaemia Hypoproteinaemia common, 3% - 5% x x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased common, 4% - 5% x x x x x x
Pruritus Pruritus common, 2.6% - 4.1% x x x x x x x x
Dermatitis Rash common, 2.4% - 4.1% x x x x x x x
Rash Rash common, 2.4% - 4.1% x x x x x x x
Phlebitis Phlebitis common, 1.8% - 4% x x x x x x x x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased 3.5% - 4% x x x x x x
Cough Cough increased 3.7% - 3.8% x x x x x x
Constipation Constipation 2.8% - 4.1% x x x x x x
Pain Pain 2.9% - 3.7% x x x x x x
Oedema peripheral Oedema peripheral 3.3% x x x x x x
Dizziness Dizziness common, 2.7% - 3.5% x x x x x x x x
Syncope x
Abscess Abscess common, 2% - 3.2% x x x x x x x x
Leukocytosis Leukocytosis 2.5% - 3.7% x x x x x x
Amylase increased Amylase increased common, 1.4% - 3.1% x x x x x x x x
Blood alkaline phosphatase increased Phosphatase alkaline increased 2.6% - 3.5% x x x x x x x
Dyspnoea Dyspnoea 2.7% - 2.9% x x x x x x
Insomnia Insomnia 2.3% - 3.3% x x x x x x
Impaired healing Impaired healing postmarketing — 2% - 3.5% x x x x x x x x
Hypokalaemia Hypokalaemia 2.1% - 2.9% x x x x x x
Dyspepsia Dyspepsia common, 1.6% - 2.9% x x x x x x x x
Hyperglycaemia Hyperglycaemia 1.8% - 2.9% x x x x x x
Asthenia Asthenia 1.7% - 3% x x x x x x x
Hyperbilirubinaemia Hyperbilirubinaemia common, 0.9% - 2.3% x x x x x x x x
Blood urea increased Blood urea increased common, 0.2% - 3% x x x x x x
Serum urea increased common, 0.2% - 2.1% x x
Hypotension Hypotension 1.7% - 2.3% x x x x x x
Pneumonia Pneumonia postmarketing — 2% x x x x x
Nosocomial pneumonia x x x
Ventilator associated pneumonia x x
Hyperhidrosis Sweating 1.6% - 2.3% x x x x x x
Back pain Back pain 1.2% - 2.3% x x x x x
Hyponatraemia Hyponatraemia 1% - 2% x x x x x
Septic shock Septic shock uncommon, common x x x x x x x x
Thrombophlebitis Thrombophlebitis uncommon x x x x x x x x
Injection site swelling Injection site swelling uncommon x x x x x x x x
Injection site inflammation Injection site inflammation uncommon x x x x x x x x
Injection site reaction Injection site reaction postmarketing — common x x x x x x x x
Injection site pain Injection site pain uncommon x x x x x x x x
Liver injury Liver injury uncommon x
Hepatocellular injury x
Traumatic liver injury Liver injury uncommon x
Sepsis Sepsis uncommon, common x x x x x x x x
Injection site phlebitis Injection site phlebitis uncommon x x x x x x x x
Thrombocytopenia Thrombocytopenia postmarketing, uncommon x x x x x x x
Pancreatitis acute Pancreatitis acute postmarketing, uncommon x x x x x x x
Anaphylactic shock Anaphylactic shock postmarketing x x x x x
Anaphylactoid reaction postmarketing x x x x x
Cholestasis Cholestasis postmarketing x x x
Diabetes mellitus Diabetes mellitus postmarketing x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x x x
Hypoglycaemia Hypoglycaemia postmarketing, common x x x x x x x x
Immune system disorder Immune system disorder postmarketing x x x
Jaundice Jaundice postmarketing, uncommon x x x x x x x x
Mediastinal disorder Mediastinal disorder postmarketing x x
Erythema multiforme Stevens-Johnson syndrome postmarketing x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x x x
Malnutrition Malnutrition postmarketing x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing x x x
Hepatobiliary disease Hepatobiliary disease postmarketing x x x
Anaphylactoid reaction Anaphylactoid reaction postmarketing x x x x x
Abdominal distension Abdominal distension x
Acidosis Acidosis x
Atrial fibrillation Atrial fibrillation x
Coagulopathy Coagulopathy x
Candida infection Candida infection x
Oral candidiasis x
Oral candidiasis Oral candidiasis x
Vulvovaginal candidiasis Vaginal moniliasis x x x x x
Vulvovaginal mycotic infection Vaginal moniliasis x x x x x
Cardiovascular disorder Cardiovascular disorder x x
Chest pain Chest pain x
Confusional state Confusional state x
Feeling abnormal Confusional state x
Malaise x
Fungal skin infection Fungal skin infection x
Dysgeusia Dysgeusia x x x x x
Ecchymosis Ecchymosis x
Eosinophilia Eosinophilia x x x x x
Faecal incontinence Faecal incontinence x
Flatulence Flatulence x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease x
Glossitis Glossitis x
Cardiac failure congestive Cardiac failure congestive x
Herpes simplex Herpes simplex x
Hiccups Hiccups x
Hyperkalaemia Hyperkalaemia x
Hypersensitivity Hypersensitivity x x x x x
Hypocalcaemia Hypocalcaemia x x x x x
Leukopenia Leukopenia x
Vaginal discharge Leukorrhea x x x x x
Nervous system disorder Nervous system disorder x x x
Nervousness Nervousness x
Tension Nervousness x
Neutropenia Neutropenia x
Osteomyelitis Osteomyelitis x x
Palpitations Palpitations x
Pancreatitis Pancreatitis x x
Peritonitis Peritonitis x
Pharyngitis Pharyngitis x
Pleural effusion Pleural effusion x
Polyuria Polyuria x
Urine output increased Polyuria x
Prurigo Prurigo x
Benign intracranial hypertension Benign intracranial hypertension x
Shock Syncope x
Syncope Syncope x
Loss of consciousness Syncope x
Tachycardia Tachycardia x x x x
Sinus tachycardia Sinus tachycardia x
Tooth discolouration Tooth discolouration x
Tremor Tremor x
Urinary tract infection Urinary tract infection x
Urticaria Urticaria x
Vaginal inflammation Vaginal inflammation x x x x x
Vaginal infection Vaginal inflammation x x x x x
Vertigo Vertigo x
Vulvovaginitis Vulvovaginitis x
Wound infection Wound infection x x x x x x
Dry mouth Dry mouth x x x x
Chills Chills x x x x x
Hepatic failure Hepatic failure x x
Sinus bradycardia Sinus bradycardia x
Ventricular arrhythmia Ventricular arrhythmia x
Atrioventricular block first degree Atrioventricular block first degree x
Hyperphosphataemia Hyperphosphataemia x x
Hypophosphataemia Hypophosphataemia x
Blood creatine phosphokinase increased Creatine phosphokinase increased x
Creatinine renal clearance decreased Creatinine renal clearance decreased x
Blood creatinine increased Creatinine increased x x x x x
Scrotal oedema Scrotal oedema x
Ventricular extrasystoles Ventricular extrasystoles x
Hypomagnesaemia Hypomagnesaemia x
Renal impairment Kidney function abnormal x
Hepatocellular injury Hepatocellular injury x
Liver function test abnormal Liver function test abnormal x
Electrocardiogram QT prolonged Electrocardiogram QT prolonged x
Skin discolouration Skin discolouration x
Vulvovaginal disorder Vulvovaginal disorder x
Abnormal faeces Abnormal faeces x x x x x
Malaise Malaise x
Discomfort Malaise x
Ill-defined disorder Malaise x
Myalgia Myalgia x
Musculoskeletal discomfort Myalgia x
Muscle twitching Muscle twitching x
Sputum increased Sputum increased x
Increased bronchial secretion Sputum increased x
Azotaemia Azotaemia x
Mucosal inflammation Mucosal inflammation x
Photosensitivity reaction Photosensitivity x
Rash maculo-papular Rash maculo-papular x
Bradycardia Bradycardia x x x x
Electrocardiogram abnormal Electrocardiogram abnormal x
Prothrombin level decreased Prothrombin level decreased x
Prothrombin time shortened Prothrombin time shortened x
Diabetic foot infection Diabetic foot infection x x
Infestation Infestation NOS x x x
International normalised ratio increased International normalised ratio increased x
Device malfunction Device malfunction x
Somnolence Somnolence x x x x
Visual impairment Abnormal vision x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

tigecycline / tigecycline

Side effects:56
Source:EMA

TIGECYCLINE

Side effects:53
Source:FDA Structured Product Label

TIGECYCLINE / TYGACIL

Side effects:67
Source:FDA

TIGECYCLINE / TYGACIL

Side effects:68
Source:FDA

TIGECYCLINE / TYGACIL

Side effects:69
Source:FDA

TIGECYCLINE / TYGACIL

Side effects:133
Source:Health Canada

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label