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Topiramate

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: N03AX11

Side effects

Options: Show MedDRA Preferred Terms,   display only 20 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68
Neuropathy peripheral 2% - 32% 15% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Headache postmarketing — 1% - 29% x x x x
Upper respiratory tract infection 12% - 36.7% 12% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Nervousness 0% - 19.3% 2% - 7.4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vaginal inflammation 13% x x x x x x x x x
Fatigue postmarketing — 1% - 30.7% 4% - 13.4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Nystagmus 6.1% - 15% 6.8% - 9.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Abnormal behaviour 0% - 11.2% 3.9% - 9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Irritability 2% - 14.6% 1% - 8.8% x x x x x x
Anorexia postmarketing — 2% - 24.5% 1% - 15% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Malnutrition postmarketing, 6% - 21% 3% - 4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Somnolence postmarketing — 0% - 30.1% 2% - 16% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Purpura 4% - 8.2% 4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Taste disorders 2% - 15% 0% x x x x x x x x x x x
Weight decreased postmarketing — 2.5% - 31% 0% - 4.2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Disturbance in attention 2.6% - 11.9% 1.8% - 2.3% x x
Insomnia very rare — 0% - 14% 3% - 7% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Depression rare, 0% - 13% 3.4% - 6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dizziness postmarketing, 0% - 34.1% 2% - 15.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Paraesthesia postmarketing — 0% - 51% 0% - 6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Cerebration impaired postmarketing, 0% - 15% 0% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Lethargy 1.2% - 13.5% 2.1% - 8.8% x x
Abdominal pain very rare — 1.1% - 15% 0.8% - 5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Nausea postmarketing — 0% - 15.1% 5% - 8.4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Salivary hypersecretion 4% - 6.1% 4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Viral infection 1% - 15% 1% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Decreased appetite 1.3% - 19.2% 2% - 12.7% x x x
Anaemia frequent, 0.8% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Arthralgia postmarketing — 1% - 7% 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Conjunctivitis frequent, 0% - 7% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Diarrhoea very rare — 2% - 14% 1% - 5.2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hallucination very rare — frequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pain 2.9% - 6.2% 4.2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pharyngitis 2% - 21% 2% - 4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pneumonia 1% - 5.1% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Psychotic disorder very rare — frequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Sinusitis 1% - 15% 4% - 6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Suicide attempt postmarketing — frequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Syncope infrequent — 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Erectile dysfunction frequent, 1% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperkinesia postmarketing, 0% - 21% 4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vomiting very rare — 1% - 14% 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bradyphrenia 0% - 19.5% 1.4% - 3.1% x x
Expressive language disorder postmarketing, 3.5% - 9.4% 1.4% - 1.6% x x x x
Anxiety 0% - 10.4% 1.8% - 6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Asthenia very rare — 0% - 8% 1% - 1.8% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Ataxia postmarketing, 1% - 21.2% 1% - 7% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Confusional state very rare — 0% - 14% 0.8% - 5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Constipation 0% - 7% 0% - 4.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dysarthria 1.6% - 6.2% 1% x x x
Dyspepsia 0% - 8% 0% - 6.5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Breast pain 0% - 8.3% 1.7% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Rhinitis 0% - 21% 0% - 6.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Speech disorder very rare — 1% - 16.8% 0.5% - 2.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Coordination abnormal 3.6% - 11.4% 1.9% - 4.2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Action tremor 3.1% - 4.8% 2.9% x x
Abdominal pain upper 3.7% - 3.9% 2.1% x x
Balance disorder 0.4% - 5.8% 0% - 2.4% x x
Amnesia very rare — 2.9% - 5.3% 0.5% - 1% x x x x x x x x x x
Dysmenorrhoea 0% - 8.3% 6.8% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Upset stomach 1% - 3.2% 0.2% - 1.3% x x
Convulsions aggravated 3% - 3.1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bronchitis 0% - 7% 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dysgeusia very rare — 0% - 15.4% 0% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gastroenteritis 0% - 7% 1% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Skin disorder 1% - 3.1% 1% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Tremor 0% - 10.6% 1.4% - 6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Agitation postmarketing — 1% - 4.4% 1% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Mood swings postmarketing, 0% - 5.1% 0.2% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Influenza-like symptoms 0% - 7% 1% - 3.2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gait disturbance 0% - 8% 1% - 5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Aggressive reaction 0% - 9.2% 0% - 4% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypoaesthesia 1% - 8% 0% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Disorientation 1.7% - 3.2% 1% x x
Convulsion postmarketing — 1% - 2.3% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Muscle spasms 1.7% - 3.3% 0.8% x x
Alopecia postmarketing — 0% - 6.3% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Amenorrhoea 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Aphasia 2% 0% x x x
Back pain 0% - 6.2% 0% - 4.2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Chest pain 1% - 4.4% 1% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Infection postmarketing, 0% - 14% 1% - 13% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Cough 0% - 7% 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Cystitis 0% - 3% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dermatitis 0% - 7% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Diplopia 0% - 12.1% 0% - 5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Oedema postmarketing, 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Epistaxis 0% - 8% 0.5% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Congenital eye disorder 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Body temperature increased very rare — 0% - 12% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Haematuria 0% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypersensitivity 0% - 7% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypertrichosis 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Cramps of lower extremities 0% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Leg pain 1% - 8% 2% - 2.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Leukopenia postmarketing, 0% - 2.7% 0% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Leukorrhea 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Menorrhagia 1% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Menstrual disorder 0.8% - 4.2% 0% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Otitis media 0% - 8% 1% x x x x x x x x x x x x x x x
Prostatic disorder 0% - 2.2% 1% - 0.6% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Tachycardia 2% x x x x x x x x x
Thirst 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Tinnitus 0.4% - 2% 0% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Urinary incontinence 1% - 4.1% 1% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Urinary tract infection 0% - 5% 1% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Urinary tract disorder postmarketing, 0% - 4.1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Disorder sight 0% - 13% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dry mouth 0.4% - 5% 0% - 2.5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Stupor 1% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Oedema peripheral 2% x x x x x x x x
Hyporeflexia 0% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Myalgia postmarketing, 2% - 2.5% 1% - 1.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Rash erythematous 0% - 8% 0% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Muscle contractions involuntary 0% - 8% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vision blurred postmarketing — 2% - 8.9% 2% - 2.5% x x x x x x x x x x x x x x x x x
Depressed mood 0.4% - 2.9% 0.9% x x
Psychomotor retardation 2% 0% x
Hot flush postmarketing, 0.7% - 2.7% 1% - 1.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Acne 0% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hearing impaired 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Abnormal vision 0% - 14.2% 0% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Anger 1.7% - 2.1% 0.5% x x
Depersonalisation 1% - 2.2% 0.9% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Apathy 1% - 3.1% 0% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Paraesthesia oral 1.2% - 3.3% 0.5% x x
Learning disability 0% - 3.2% x x
Coagulopathy 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Cardiovascular disorder 1% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Haemorrhage 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Red blood cell disorders 1% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Auditory disorder NOS 1% - 2% 1% x x x x x x x
Musculoskeletal chest pain 1.1% - 1.8% 0.3% x x
Mental disability 0.4% - 5% 0.9% - 1.3% x x
Personality disorder 0% - 11.2% 9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Muscle twitching 0.4% - 1.8% 0.7% x x
Cognitive disorder 0.4% - 2% x x
Memory impairment postmarketing, 1.2% - 10.8% 1% - 1.8% x x x x x x x x x
Hypoaesthesia facial 0.4% - 2% x x
Candida infection 0% - 1% 0% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Libido decreased 0% - 3% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dysphagia 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dyspnoea 1% - 6% 0.9% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Eczema 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Grand mal convulsion 0% - 7% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Rash very rare — 0.4% - 6.7% 1% - 5.9% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Faecal incontinence 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Flatulence 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gastrooesophageal reflux disease 0.4% - 2% 0% - 0.5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gingival hyperplasia 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gingivitis 1% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Glossitis 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Haematoma 0% - 2% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypertension 1% - 3% 0% - 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypoglycaemia 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Myopia very rare — 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Neurosis infrequent, 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Nocturia 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pallor 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pruritus 0% - 4% 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Seborrhoeic dermatitis 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Thrombocytopenia postmarketing, 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Toothache 1% - 7% x x x x x x x x x
Pollakiuria 0% - 4% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vertigo 0% - 3.2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Weight increased postmarketing, 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Body odor 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Migraine postmarketing, 0% - 2% x x x x
Gamma-glutamyltransferase increased infrequent, 1% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Muscular weakness frequent, 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bone pain 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Prothrombin level increased 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Skin discolouration 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Increased appetite 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Urine abnormality 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Depression aggravated 1% - 3% 1% x x x x x x x x x x x x x x x
Lacrimation abnormal NOS 0% - 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Rash maculo-papular 0% - 2% x x x x x x x x x
Rigors 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bradycardia 1% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Sweating increased 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Psychomotor skills impaired 0% - 2% x x
Dysphasia 1% 0% x x x
Ear pain 0% - 1.3% x x x x x x x x x x x
Dry eye 0% - 1.3% x x
Pruritus generalised 0% - 1.3% x x
Rhinorrhoea 0% - 1.3% x x
Agranulocytosis infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Albuminuria infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Angina pectoris infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Apraxia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Atrioventricular block infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dehydration postmarketing — frequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Delirium infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Delusion postmarketing, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Diabetes mellitus rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dyskinesia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Eosinophilia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Oesophagitis infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Flushing postmarketing — 0% - 5% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gastritis infrequent, 0% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Gingival bleeding infrequent, 0% - 1.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Haemorrhoids infrequent, frequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperaesthesia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperglycaemia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperlipidaemia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypocalcaemia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypokalaemia postmarketing, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypotension infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Orthostatic hypotension infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Arthropathy infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Lymphopenia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Melaena infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Oliguria infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Phlebitis infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Polyuria infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pulmonary embolism rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Scotoma infrequent, 0.4% - 1.3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Stomatitis infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Urticaria infrequent, frequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vasodilation infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Xerophthalmia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Urinary retention infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Encephalopathy postmarketing, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Photophobia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Breast discharge infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Deep vein thrombosis infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Electroencephalogram abnormal infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Paranoid reaction infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Phosphatase alkaline increased infrequent x x x x x x x x x x x x x x x x x x x x x
Aspartate aminotransferase increased infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Alanine aminotransferase increased infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Accommodation disorder infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Photosensitivity reaction infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Euphoric mood infrequent, frequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hair texture abnormal infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Ejaculation disorder infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Enlargement abdomen infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Neuropathy infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Lymphadenopathy infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Face oedema infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Renal pain infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Thrombocytosis infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Paranoia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Parosmia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Dysphonia infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Ageusia infrequent, 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Neoplasm 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Affect lability 0.2% - 1.1% 0.2% x x
Abdominal distension 0% - 1.3% 0.2% x x
Renal tubular acidosis very rare, postmarketing x x x x x x x x x x x x x x x x x x x
Aggression very rare — 2.8% - 8.7% 1.8% - 6.9% x x x x
Mental disorder postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bipolar disorder postmarketing x x
Cerebellar syndrome rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Connective tissue disorder postmarketing x x x x
Toxic epidermal necrolysis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Epilepsy postmarketing x x
Erythema multiforme postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Eye disorder postmarketing x x x x
Angle closure glaucoma very rare, postmarketing x x x x x x x x x x
Hepatitis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypernatraemia rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypohidrosis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyponatraemia rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Immune system disorder postmarketing x x
Libido increased rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Iritis rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Lymphocytosis rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Chloasma rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Musculoskeletal pain postmarketing x x
Mydriasis rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Nasopharyngitis postmarketing x x
Nervous system disorder postmarketing x x x x x x x x x x x x
Neutropenia very rare, postmarketing x x x x
Eye movement disorder postmarketing x x
Pancreatitis postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pancytopenia rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Pemphigus postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Polycythaemia rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Stevens-Johnson syndrome postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Suicide postmarketing x x x x x x x x x
Hepatic failure postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Vasospasm rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperchloraemia rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypophosphataemia rare x x x x x x x x x x x x x x x x x x x x x
Periorbital oedema postmarketing x x
Alcohol intolerance rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Creatinine increased rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Generalised oedema postmarketing x x
Tongue oedema rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypocholesterolaemia rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Manic psychosis rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Bone marrow depression rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Eye pain very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Joint swelling postmarketing x x
Eyelid oedema postmarketing x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x x
Metabolic acidosis very rare, postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyperammonaemia postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Heat intolerance postmarketing x x x x
Feeling of despair postmarketing x x
Tongue paralysis rare x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Eye redness postmarketing x x x x x x x
Upper motor neurone lesion rare, infrequent x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hepatic enzyme increased postmarketing x x
Nephrolithiasis postmarketing — 0% - 2.6% x x x
Suicidal ideation very rare, postmarketing x x x x x x x x x x
Abnormal sensation in eye postmarketing x x
Influenza like illness postmarketing x x
Visual disturbance postmarketing — 1.4% - 2% 0.3% x x x x x x x x x x
Sweating decreased postmarketing, infrequent x x x x x x x x x x x
Drug interaction postmarketing x
Maculopathy postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Allergic oedema postmarketing x x
Infestation NOS postmarketing x x
Blood and lymphatic system disorders postmarketing x x x x
Completed suicide postmarketing x x x x x x x x x
Limb discomfort postmarketing x x
Attention concentration difficulty postmarketing x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Feeling abnormal very rare, postmarketing x x x x
Pancreatitis acute very rare x
Blindness transient very rare x x
Acidosis postmarketing — 0% - 7% x x x x x x x x x x x x x x x x x
Respiratory alkalosis x x x
Amblyopia x x x x x x x x
Anhidrosis x x
Anosmia x
Asthma 0% - 2% x x x x x x x x x x x x x x x
Blepharospasm x x
Clotting x x x x x
Breast disorder x x
Calcinosis x x
Collagen disorder x x x x x x x x x
Deafness x x
Dermatitis atopic x
Drooling x x
Drug abuse x
Dysuria frequent, 0% - 2% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Effusion x x x x x x x
Endocrine disorder x
Flank pain x x
Formication x x
Gastrointestinal disorder postmarketing, 0% - 7% x x x x x x x x x x x
Glaucoma x x x x x x x x
Glossodynia x x
Breath odour x x
Deafness neurosensory x
Cardiac disorder x
Hyperplasia x
Hyperthyroidism 0% - 8% x
Body temperature decreased x x x x x x x x x x x x x x x x x x x x x x x x x x
Incontinence x x
Calculus of kidney frequent, 0% - 7% 0% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Nephropathy x x x
Laryngitis 0% - 8% x
Mastitis 0% - 2% x x x x x x x x x
Mediastinal disorder x x
Metrorrhagia 0% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Hypertonia frequent, 0% - 7% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Nail disorder 0% - 2% x x x x x x x x x
Nasal congestion x x
Night blindness x x
Obesity x x x x x x x x
Osteomalacia x x x
Palpitations x x x x x x x x x x x
Panic reaction x
Panic disorder x x
Pemphigoid x
Premature ejaculation 0% - 3% 0% x x x x x x x x x x x x x x x
Presbyopia x x
Renal failure x x x x x x
Respiratory tract infection x
Rickets x x x
Status epilepticus x x x
Ulcerative stomatitis x x x x x x x x x
Testicular disorder x x x x x x x x x
Tooth disorder x x x x x x x x x x
Unintended pregnancy x x x x x x x x
Erythema x x
Angiopathy x x x x x x x x x x
Acidosis hyperchloraemic x
Polydipsia x x
Micturition urgency x x
Sinus bradycardia x x
Akinesia x
Burning sensation x x
Photopsia x
Hypokinesia x x
Panic attack x x
Conjunctival oedema x
Swelling face x x
Hypogeusia x x
Sensory disturbance x x x x x x x x x x x x x x x x
Renal colic x x
Lacrimation increased x x
Ocular hyperaemia x x x x x x x
Rash macular x
Oral pain x
Malaise x x
Dyspnoea exertional x x
Abdominal discomfort x x
Abdominal pain lower x
Abdominal tenderness x x
Distractibility x x
Flat affect x x
Elevated mood x
Thinking abnormal x x x x x x x x
Perseveration x x
Hallucination, auditory x
Hallucination, visual x
Clumsiness x x
Anorgasmia x
Dysgraphia x x
Visual acuity reduced x x x x x x x x x
Intraocular pressure increased x x x x x x x
Skin odour abnormal x x
Dizziness postural x x
Scintillating scotoma x
Migraine aggravated x x x x x x x x x x x x x x
Aura x x
Pharyngeal oedema 0% - 8% x
Diabetic x
Hypomania x
Drug - food interaction x
Muscle fatigue x
Ketogenic diet x x x
Essential tremor x
Blindness unilateral x
Peripheral coldness x x
Sensory loss x x
Redness x x x x x x x
Cognitive impairment x x x x x x
Mania x
Anxiety depression x x x x
Genital candidiasis x x x x x x x x x x x x x x
Repetitive speech x x
Dysaesthesia x x
Initial insomnia x x
Middle insomnia x x
Tearfulness x x
Fluid intake increased x x x x x x
Bicarbonate level x x x x x x
Dependence x
Word finding difficulty x x x
Dyslexia x x
Hypoaesthesia oral x x
Electrocardiogram abnormal x x x x
Feeling drunk x x
Terminal insomnia x
Feeling jittery x
Depressed level of consciousness x
Sexual dysfunction x x
Breast pain female x x x x x
Serum potassium decreased x x
Presyncope x x
Diabetic peripheral neuropathy x x x x x x x x
White blood cell count decreased x x
Alkaline phosphatase serum increased x x
Partial seizures x x
Ear and labyrinth disorders x x
Administration site reaction x
Sleep disorder 0% - 2% x x x x x x x x x x x
Blood bicarbonate decreased x
Lack of spontaneous speech x x
Disturbance in sexual arousal x x
Unresponsive to stimuli x x
Thromboembolic event x x x x x x x x x x
Potassium low x x
Raised liver function tests x x x x
Circadian rhythm sleep disorder x
Hypersomnia x
Sluggishness x
Crystal urine present x
Ear discomfort x x
Musculoskeletal stiffness x x
Orgasmic sensation decreased x
Dysphemia x x
Altered visual depth perception x
Paranasal sinus hypersecretion x x
Tandem gait test abnormal x x
Unspecified disorder of autonomic nervous system x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Urticaria localised x x
Poor quality sleep x x
Epigastric discomfort x x
Calculus ureteric x
Sudden unexplained death in epilepsy x x x x x x x x x x x x x x x x x x x x x x x x
Suicidal behaviour x x x x x x x x x x x x x x x x x x x x x x x x x x
Hyposmia x
Deafness unilateral x x
Mood alteration NOS x x x
Vaginal haemorrhage 0% - 3% x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
Loss of libido x x x
Bleeding breakthrough x
Visual impairment x x x x x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

TOPIRAMATE / RATIO-TOPIRAMATE

Side effects:173
Source:Health Canada

TOPIRAMATE / TOPAMAX SPRINKLE CAPSULES 15MG

Side effects:192
Source:Health Canada

TOPIRAMATE / PMS-TOPIRAMATE

Side effects:204
Source:Health Canada

TOPIRAMATE / APO-TOPIRAMATE

Side effects:177
Source:Health Canada

TOPIRAMATE / SANDOZ TOPIRAMATE

Side effects:170
Source:Health Canada

TOPIRAMATE / CO TOPIRAMATE

Side effects:183
Source:Health Canada

TOPIRAMATE / NOVO-TOPIRAMATE -(200MG)

Side effects:187
Source:Health Canada

TOPIRAMATE / GEN-TOPIRAMATE

Side effects:198
Source:Health Canada

TOPIRAMATE / PHL-TOPIRAMATE

Side effects:205
Source:Health Canada

TOPIRAMATE

Side effects:85
Source:FDA Structured Product Label

topiramate

Side effects:160
Source:FDA Structured Product Label

Topiramate

Side effects:169
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:133
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:133
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:137
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:144
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:144
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:144
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:145
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:207
Source:FDA Structured Product Label

topiramate / Topamax

Side effects:231
Source:FDA

topiramate / Topamax

Side effects:233
Source:FDA

TOPIRAMATE

Side effects:232
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:232
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:233
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:231
Source:FDA Structured Product Label

topiramate / Topamax

Side effects:238
Source:FDA

TOPIRAMATE

Side effects:237
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:237
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:237
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:237
Source:FDA Structured Product Label

Topiramate

Side effects:238
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:241
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:242
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:242
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:242
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:242
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

topiramate

Side effects:242
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:242
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:243
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:243
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:243
Source:FDA Structured Product Label

topiramate

Side effects:243
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:244
Source:FDA Structured Product Label

TOPIRAMATE / TOPAMAX SPRINKLE

Side effects:251
Source:FDA

TOPIRAMATE / TOPAMAX

Side effects:253
Source:FDA

topiramate

Side effects:247
Source:FDA Structured Product Label

topiramate

Side effects:253
Source:FDA Structured Product Label

TOPIRAMATE

Side effects:253
Source:FDA Structured Product Label

topiramate

Side effects:258
Source:FDA Structured Product Label

TOPAMAX / Topamax Sprinkle, Capsule

Side effects:268
Source:Medsafe

Color scheme:

standardalternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label