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Topiramate

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: N03AX11

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 68 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Neuropathy peripheral Neuropathy peripheral 2% - 32% 15% x x x x x x x x x x x x x x x x x x
Neuropathy infrequent x x x x x x x x x x x x x x x
Headache Headache postmarketing — 1% - 29% x
Upper respiratory tract infection Upper respiratory tract infection 12% - 36.7% 12% x x x x x x x x x x x x x x x x x x
Nervousness Nervousness 0% - 19.3% 2% - 7.4% x x x x x x x x x x x x x x x x x x
Feeling jittery
Tension Nervousness 0% - 19.3% 2% - 7.4% x x x x x x x x x x x x x x x x x x
Vaginal inflammation Vaginal inflammation 13% x x x
Vaginal infection Vaginal inflammation 13% x x x
Asthenia Fatigue postmarketing — 1% - 30.7% 4% - 13.4% x x x x x x x x x x x x x x x x x x x
Asthenia very rare — 0% - 8% 1% - 1.8% x x x x x x x x x x x x x x x x x x
Fatigue Fatigue postmarketing — 1% - 30.7% 4% - 13.4% x x x x x x x x x x x x x x x x x x x
Nystagmus Nystagmus 6.1% - 15% 6.8% - 9.3% x x x x x x x x x x x x x x x x x x
Abnormal behaviour Abnormal behaviour 0% - 11.2% 3.9% - 9% x x x x x x x x x x x x x x x x x x x
Irritability Irritability 2% - 14.6% 1% - 8.8% x x
Decreased appetite Anorexia postmarketing — 2% - 24.5% 1% - 15% x x x x x x x x x x x x x x x x x x x
Decreased appetite 1.3% - 19.2% 2% - 12.7% x
Malnutrition Malnutrition postmarketing, 6% - 21% 3% - 4% x x x x x x x x x x x x x x x x x x x
Somnolence Somnolence postmarketing — 0% - 30.1% 2% - 16% x x x x x x x x x x x x x x x x x x x
Purpura Purpura 4% - 8.2% 4% x x x x x x x x x x x x x x x x x
Vascular purpura Purpura 4% - 8.2% 4% x x x x x x x x x x x x x x x x x
Weight decreased Weight decreased postmarketing — 2.5% - 31% 0% - 4.2% x x x x x x x x x x x x x x x x x x x
Disturbance in attention Disturbance in attention 2.6% - 11.9% 1.8% - 2.3% x
Cerebration impaired postmarketing, 0% - 15% 0% - 2% x x x x x x x x x x x x x x x
Attention concentration difficulty postmarketing x x x x x x x x x x x x x x x x x x x
Insomnia Insomnia very rare — 0% - 14% 3% - 7% x x x x x x x x x x x x x x x x x x x
Depression Depression rare, 0% - 13% 3.4% - 6% x x x x x x x x x x x x x x x x x x
Depression aggravated 1% - 3% 1% x x x x x
Anxiety depression x
Dizziness Dizziness postmarketing, 0% - 34.1% 2% - 15.3% x x x x x x x x x x x x x x x x x x x
Syncope infrequent — 1% x x x x x x x x x x x x x x x x x x x
Paraesthesia Paraesthesia postmarketing — 0% - 51% 0% - 6% x x x x x x x x x x x x x x x x x x x
Mental disability Cerebration impaired postmarketing, 0% - 15% 0% - 2% x x x x x x x x x x x x x x x
Mental disability 0.4% - 5% 0.9% - 1.3% x
Thinking abnormal x x x
Lethargy Lethargy 1.2% - 13.5% 2.1% - 8.8% x
Abdominal pain Abdominal pain very rare — 1.1% - 15% 0.8% - 5% x x x x x x x x x x x x x x x x x x
Gastrointestinal pain Abdominal pain very rare — 1.1% - 15% 0.8% - 5% x x x x x x x x x x x x x x x x x x
Nausea Nausea postmarketing — 0% - 15.1% 5% - 8.4% x x x x x x x x x x x x x x x x x x x
Salivary hypersecretion Salivary hypersecretion 4% - 6.1% 4% x x x x x x x x x x x x x x x x x x
Viral infection Viral infection 1% - 15% 1% - 3% x x x x x x x x x x x x x x x x x
Anaemia Anaemia frequent, 0.8% - 3% x x x x x x x x x x x x x x x x x x x x
Arthralgia Arthralgia postmarketing — 1% - 7% 2% x x x x x x x x x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia postmarketing — 1% - 7% 2% x x x x x x x x x x x x x x x x x x x
Myalgia postmarketing, 2% - 2.5% 1% - 1.3% x x x x x x x x x x x x x x x x x x
Conjunctivitis Conjunctivitis frequent, 0% - 7% 1% x x x x x x x x x x x x x x x x x x
Diarrhoea Diarrhoea very rare — 2% - 14% 1% - 5.2% x x x x x x x x x x x x x x x x x x x
Hallucination Hallucination very rare — frequent x x x x x x x x x x x x x x x x x x
Pain Pain 2.9% - 6.2% 4.2% x x x x x x x x x x x x x x x x x x
Pharyngitis Pharyngitis 2% - 21% 2% - 4% x x x x x x x x x x x x x x x x x
Pneumonia Pneumonia 1% - 5.1% 1% x x x x x x x x x x x x x x x x x
Psychotic disorder Psychotic disorder very rare — frequent x x x x x x x x x x x x x x x x x x x
Paranoia infrequent x x x x x x x x x x x x x x x x
Sinusitis Sinusitis 1% - 15% 4% - 6% x x x x x x x x x x x x x x x x x
Suicide attempt Suicide attempt postmarketing — frequent x x x x x x x x x x x x x x x x x x
Shock Syncope infrequent — 1% x x x x x x x x x x x x x x x x x x x
Syncope Syncope infrequent — 1% x x x x x x x x x x x x x x x x x x x
Loss of consciousness Syncope infrequent — 1% x x x x x x x x x x x x x x x x x x x
Erectile dysfunction Erectile dysfunction frequent, 1% - 2% x x x x x x x x x x x x x x x x x x x
Agitation Hyperkinesia postmarketing, 0% - 21% 4% x x x x x x x x x x x x x x x x x
Agitation postmarketing — 1% - 4.4% 1% - 2% x x x x x x x x x x x x x x x x x x
Hyperkinesia Hyperkinesia postmarketing, 0% - 21% 4% x x x x x x x x x x x x x x x x x
Vomiting Vomiting very rare — 1% - 14% 2% x x x x x x x x x x x x x x x x x x x
Bradyphrenia Bradyphrenia 0% - 19.5% 1.4% - 3.1% x
Expressive language disorder Expressive language disorder postmarketing, 3.5% - 9.4% 1.4% - 1.6% x
Anxiety Anxiety 0% - 10.4% 1.8% - 6% x x x x x x x x x x x x x x x x x x x
Ataxia Ataxia postmarketing, 1% - 21.2% 1% - 7% x x x x x x x x x x x x x x x x x x x
Confusional state Confusional state very rare — 0% - 14% 0.8% - 5% x x x x x x x x x x x x x x x x x x x
Feeling abnormal Confusional state very rare — 0% - 14% 0.8% - 5% x x x x x x x x x x x x x x x x x x x
Feeling abnormal very rare, postmarketing x
Malaise x
Constipation Constipation 0% - 7% 0% - 4.9% x x x x x x x x x x x x x x x x x x
Dysarthria Dysarthria 1.6% - 6.2% 1% x
Osteoarthritis Dysarthria 1.6% - 6.2% 1% x
Arthropathy infrequent x x x x x x x x x x x x x x x
Dyspepsia Dyspepsia 0% - 8% 0% - 6.5% x x x x x x x x x x x x x x x x x x
Breast pain Breast pain 0% - 8.3% 1.7% - 2% x x x x x x x x x x x x x x x
Breast pain female x x
Rhinitis Rhinitis 0% - 21% 0% - 6.9% x x x x x x x x x x x x x x x x x
Speech disorder Speech disorder very rare — 1% - 16.8% 0.5% - 2.3% x x x x x x x x x x x x x x x x x x x
Coordination abnormal Coordination abnormal 3.6% - 11.4% 1.9% - 4.2% x x x x x x x x x x x x x x x x x x
Action tremor Action tremor 3.1% - 4.8% 2.9% x
Abdominal pain upper Abdominal pain upper 3.7% - 3.9% 2.1% x
Balance disorder Balance disorder 0.4% - 5.8% 0% - 2.4% x
Amnesia Amnesia very rare — 2.9% - 5.3% 0.5% - 1% x x x
Dysmenorrhoea Dysmenorrhoea 0% - 8.3% 6.8% x x x x x x x x x x x x x x x x x
Abdominal discomfort Upset stomach 1% - 3.2% 0.2% - 1.3% x
Abdominal discomfort x
Convulsion Convulsions aggravated 3% - 3.1% x x x x x x x x x x x x x x x x x x
Convulsion postmarketing — 1% - 2.3% 0% x x x x x x x x x x x x x x x x x x x
Bronchitis Bronchitis 0% - 7% 2% x x x x x x x x x x x x x x x x
Dysgeusia Dysgeusia very rare — 0% - 15.4% 0% - 1% x x x x x x x x x x x x x x x x x
Gastroenteritis Gastroenteritis 0% - 7% 1% - 2% x x x x x x x x x x x x x x x x x
Skin disorder Skin disorder 1% - 3.1% 1% - 2% x x x x x x x x x x x x x x x x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x
Tremor Tremor 0% - 10.6% 1.4% - 6% x x x x x x x x x x x x x x x x x x
Mood swings Mood swings postmarketing, 0% - 5.1% 0.2% - 2% x x x x x x x x x x x x x x
Mood alteration NOS x
Affect lability Mood swings postmarketing, 0% - 5.1% 0.2% - 2% x x x x x x x x x x x x x x
Affect lability 0.2% - 1.1% 0.2% x
Influenza like illness Influenza-like symptoms 0% - 7% 1% - 3.2% x x x x x x x x x x x x x x x x x
Influenza like illness postmarketing x
Gait disturbance Gait disturbance 0% - 8% 1% - 5% x x x x x x x x x x x x x x x x x x x
Aggression Aggressive reaction 0% - 9.2% 0% - 4% x x x x x x x x x x x x x x x x x x x
Aggression very rare — 2.8% - 8.7% 1.8% - 6.9% x
Hypoaesthesia Hypoaesthesia 1% - 8% 0% - 2% x x x x x x x x x x x x x x x x x x
Hypoaesthesia facial 0.4% - 2% x
Disorientation Disorientation 1.7% - 3.2% 1% x
Muscle spasms Muscle spasms 1.7% - 3.3% 0.8% x
Cramps of lower extremities 0% - 2% 0% x x x x x x x x x x x x x x x x
Alopecia Alopecia postmarketing — 0% - 6.3% 1% x x x x x x x x x x x x x x x x x x
Amenorrhoea Amenorrhoea 2% 1% x x x x x x x x x x x x x x
Aphasia Aphasia 2% 0% x
Dysphasia 1% 0% x
Word finding difficulty x
Back pain Back pain 0% - 6.2% 0% - 4.2% x x x x x x x x x x x x x x x x x
Chest pain Chest pain 1% - 4.4% 1% - 3% x x x x x x x x x x x x x x x x x
Infection Infection postmarketing, 0% - 14% 1% - 13% x x x x x x x x x x x x x x x x x x
Cough Cough 0% - 7% 2% x x x x x x x x x x x x x x x x x x
Cystitis Cystitis 0% - 3% 0% x x x x x x x x x x x x x x x
Bladder pain Cystitis 0% - 3% 0% x x x x x x x x x x x x x x x
Cystitis noninfective Cystitis 0% - 3% 0% x x x x x x x x x x x x x x x
Dermatitis Dermatitis 0% - 7% 0% x x x x x x x x x x x x x x x x x
Rash very rare — 0.4% - 6.7% 1% - 5.9% x x x x x x x x x x x x x x x x x x x
Diplopia Diplopia 0% - 12.1% 0% - 5% x x x x x x x x x x x x x x x x x x x
Oedema Oedema postmarketing, 1% - 2% 1% x x x x x x x x x x x x x x
Epistaxis Epistaxis 0% - 8% 0.5% - 1% x x x x x x x x x x x x x x x x x x
Congenital eye disorder Congenital eye disorder 1% - 2% 1% x x x x x x x x x x x x x x x x x
Eye disorder Congenital eye disorder 1% - 2% 1% x x x x x x x x x x x x x x x x x
Eye disorder postmarketing x
Body temperature increased Body temperature increased very rare — 0% - 12% 1% x x x x x x x x x x x x x x x x x x x
Haematuria Haematuria 0% - 2% 1% x x x x x x x x x x x x x x x
Hypersensitivity Hypersensitivity 0% - 7% 1% x x x x x x x x x x x
Hypertrichosis Hypertrichosis 1% - 2% 1% x x x x x x x x x x x x x x x x x
Pain in extremity Leg pain 1% - 8% 2% - 2.3% x x x x x x x x x x x x x x x x x x
Leukopenia Leukopenia postmarketing, 0% - 2.7% 0% - 1% x x x x x x x x x x x x x x x x x
Vaginal discharge Leukorrhea 2% 0% x x x x x x x x x x x x x x x x
Menorrhagia Menorrhagia 1% - 2% 0% x x x x x x x x x x x x x x x x x
Menstrual disorder Menstrual disorder 0.8% - 4.2% 0% - 2% x x x x x x x x x x x x x x x x
Otitis media Otitis media 0% - 8% 1% x x x x x
Prostatic disorder Prostatic disorder 0% - 2.2% 1% - 0.6% x x x x x x x x x x x x x x x x
Tachycardia Tachycardia 2% x x x
Thirst Thirst 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Tinnitus Tinnitus 0.4% - 2% 0% - 1% x x x x x x x x x x x x x x x x x
Urinary incontinence Urinary incontinence 1% - 4.1% 1% - 2% x x x x x x x x x x x x x x x x x
Urinary tract infection Urinary tract infection 0% - 5% 1% - 2% x x x x x x x x x x x x x x x x x
Urethral disorder Urinary tract disorder postmarketing, 0% - 4.1% 0% x x x x x x x x x x x x x x x x x x x
Urinary tract disorder Urinary tract disorder postmarketing, 0% - 4.1% 0% x x x x x x x x x x x x x x x x x x x
Visual impairment Disorder sight 0% - 13% x x x x x x x x x x x x x x x x x x
Abnormal vision 0% - 14.2% 0% - 2% x x x x x x x x x x x x x x x x x x x
Visual disturbance postmarketing — 1.4% - 2% 0.3% x x x
Visual impairment x x
Dry mouth Dry mouth 0.4% - 5% 0% - 2.5% x x x x x x x x x x x x x x x x x x
Stupor Stupor 1% - 2% 0% x x x x x x x x x x x x x x x
Depressed level of consciousness Stupor 1% - 2% 0% x x x x x x x x x x x x x x x
Depressed level of consciousness
Oedema peripheral Oedema peripheral 2% x x x
Hyporeflexia Hyporeflexia 0% - 2% 0% x x x x x x x x x x x x x x x x x
Myalgia Myalgia postmarketing, 2% - 2.5% 1% - 1.3% x x x x x x x x x x x x x x x x x x
Rash erythematous Rash erythematous 0% - 8% 0% - 1% x x x x x x x x x x x x x x x x x
Muscle contractions involuntary Muscle contractions involuntary 0% - 8% 1% x x x x x x x x x x x x x x x x x
Vision blurred Vision blurred postmarketing — 2% - 8.9% 2% - 2.5% x x x x x x
Depressed mood Depressed mood 0.4% - 2.9% 0.9% x
Psychomotor retardation Psychomotor retardation 2% 0%
Menopausal symptoms Hot flush postmarketing, 0.7% - 2.7% 1% - 1.9% x x x x x x x x x x x x x x x x x x
Hot flush Hot flush postmarketing, 0.7% - 2.7% 1% - 1.9% x x x x x x x x x x x x x x x x x x
Acne Acne 0% - 3% x x x x x x x x x x x x x x
Deafness Hearing impaired 1% - 2% 1% x x x x x x x x x x x x x x
Deafness x
Hearing impaired Hearing impaired 1% - 2% 1% x x x x x x x x x x x x x x
Auditory disorder NOS 1% - 2% 1% x x
Deafness unilateral x
Anger Anger 1.7% - 2.1% 0.5% x
Depersonalisation Depersonalisation 1% - 2.2% 0.9% - 1% x x x x x x x x x x x x x x x
Apathy Apathy 1% - 3.1% 0% - 1% x x x x x x x x x x x x x x x x x x
Flat affect Apathy 1% - 3.1% 0% - 1% x x x x x x x x x x x x x x x x x x
Flat affect x
Paraesthesia oral Paraesthesia oral 1.2% - 3.3% 0.5% x
Learning disability Learning disability 0% - 3.2% x
Coagulopathy Coagulopathy 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Clotting x
Cardiovascular disorder Cardiovascular disorder 1% - 2% 0% x x x x x x x x x x x x x x x
Haemorrhage Haemorrhage 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Haemoglobin Haemorrhage 1% - 2% 1% x x x x x x x x x x x x x x x x x x
Musculoskeletal chest pain Musculoskeletal chest pain 1.1% - 1.8% 0.3% x
Mental retardation Mental disability 0.4% - 5% 0.9% - 1.3% x
Personality disorder Personality disorder 0% - 11.2% 9% x x x x x x x x x x x x x x x x x x x
Muscle twitching Muscle twitching 0.4% - 1.8% 0.7% x
Cognitive disorder Cognitive disorder 0.4% - 2% x
Cognitive impairment x x
Memory impairment Memory impairment postmarketing, 1.2% - 10.8% 1% - 1.8% x x x
Candida infection Candida infection 0% - 1% 0% - 1% x x x x x x x x x x x x x
Libido decreased Libido decreased 0% - 3% 1% x x x x x x x x x x x x x x x x x x
Disturbance in sexual arousal Libido decreased 0% - 3% 1% x x x x x x x x x x x x x x x x x x
Libido increased rare, infrequent x x x x x x x x x x x x x x x
Disturbance in sexual arousal x
Dysphagia Dysphagia 1% 0% x x x x x x x x x x x x x x
Dyspnoea Dyspnoea 1% - 6% 0.9% - 2% x x x x x x x x x x x x x x x x x
Eczema Eczema 0% - 1% 0% x x x x x x x x x x x x x x
Grand mal convulsion Grand mal convulsion 0% - 7% 0% x x x x x x x x x x x
Rash Rash very rare — 0.4% - 6.7% 1% - 5.9% x x x x x x x x x x x x x x x x x x x
Faecal incontinence Faecal incontinence 0% - 1% 0% x x x x x x x x x x x x x x
Flatulence Flatulence 1% 0% x x x x x x x x x x x x x x x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease 0.4% - 2% 0% - 0.5% x x x x x x x x x x x x x x x x x
Gingival hyperplasia Gingival hyperplasia 1% 0% x x x x x x x x x x x x x
Gingivitis Gingivitis 1% 1% x x x x x x x x x x x x x x
Glossitis Glossitis 1% 0% x x x x x x x x x x x x x x
Haematoma Haematoma 0% - 2% 0% x x x x x x x x x x x x x x x x
Hypertension Hypertension 1% - 3% 0% - 1% x x x x x x x x x x x x x
Hypoglycaemia Hypoglycaemia 0% - 1% 0% x x x x x x x x x x x x x x
Myopia Myopia very rare — 0% - 1% 0% x x x x x x x x x x x x x x x x x
Neurosis Neurosis infrequent, 1% 0% x x x x x x x x x x x x x
Nocturia Nocturia 0% - 1% 0% x x x x x x x x x x x x x
Pallor Pallor 1% 0% x x x x x x x x x x x x x
Pruritus Pruritus 0% - 4% 2% x x x x x x x x x x x x x x x x
Seborrhoeic dermatitis Seborrhoeic dermatitis 0% - 1% 0% x x x x x x x x x x x x x x
Thrombocytopenia Thrombocytopenia postmarketing, 1% 0% x x x x x x x x x x x x x x x
Toothache Toothache 1% - 7% x x x
Pollakiuria Pollakiuria 0% - 4% 1% x x x x x x x x x x x x x x x x x x
Micturition urgency x
Vertigo Vertigo 0% - 3.2% 1% x x x x x x x x x x x x x x x x x
Weight increased Weight increased postmarketing, 0% - 1% 0% x x x x x x x x x x x x x x x x
Skin odour abnormal Body odor 0% - 1% 0% x x x x x x x x x x x x x x
Skin odour abnormal x
Migraine Migraine postmarketing, 0% - 2% x
Migraine aggravated x x x x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased infrequent, 1% - 3% x x x x x x x x x x x x x
Muscular weakness Muscular weakness frequent, 1% x x x x x x x x x x x x x x x x x x x
Bone pain Bone pain 0% - 1% 0% x x x x x x x x x x x x x
Prothrombin level increased Prothrombin level increased 1% 0% x x x x x x x x x x x x x x
Skin discolouration Skin discolouration 0% - 1% 0% x x x x x x x x x x x x x x
Increased appetite Increased appetite 1% 0% x x x x x x x x x x x x x x x
Urine abnormality Urine abnormality 0% - 1% 0% x x x x x x x x x x x x x
Urine analysis abnormal Urine abnormality 0% - 1% 0% x x x x x x x x x x x x x
Lacrimal disorder Lacrimation abnormal NOS 0% - 1% 0% x x x x x x x x x x x x x x
Rash maculo-papular Rash maculo-papular 0% - 2% x x x
Chills Rigors 1% 0% x x x x x x x x x x x x x
Bradycardia Bradycardia 1% 0% x x x x x x x x x x x x x
Hyperhidrosis Sweating increased 1% - 2% 1% x x x x x x x x x x x x x x x x x
Psychomotor skills impaired Psychomotor skills impaired 0% - 2% x
Ear pain Ear pain 0% - 1.3% x x x x
Dry eye Dry eye 0% - 1.3% x
Pruritus generalised Pruritus generalised 0% - 1.3% x
Nasopharyngitis Rhinorrhoea 0% - 1.3% x
Nasopharyngitis postmarketing x
Rhinorrhoea Rhinorrhoea 0% - 1.3% x
Agranulocytosis Agranulocytosis infrequent x x x x x x x x x x x x x x x
Albuminuria Albuminuria infrequent x x x x x x x x x x x x x x x
Angina pectoris Angina pectoris infrequent x x x x x x x x x x x x x x x
Apraxia Apraxia infrequent x x x x x x x x x x x x x x x x
Atrioventricular block Atrioventricular block infrequent x x x x x x x x x x x x x x x
Dehydration Dehydration postmarketing — frequent x x x x x x x x x x x x x x x x x
Delirium Delirium infrequent x x x x x x x x x x x x x x x
Delusion Delusion postmarketing, infrequent x x x x x x x x x x x x x x x x x
Diabetes mellitus Diabetes mellitus rare, infrequent x x x x x x x x x x x x x x x
Diabetic
Dyskinesia Dyskinesia infrequent x x x x x x x x x x x x x x x x x x x
Eosinophilia Eosinophilia infrequent x x x x x x x x x x x x x x x x
Oesophagitis Oesophagitis infrequent x x x x x