Side effect information for Topiramate

Side effects

Options: Hide MedDRA Preferred Terms , display all 68 labels

MedDRA Preferred Term	Side effect	Data for drug	Placebo	Labels
				1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Neuropathy peripheral	Neuropathy peripheral	2% - 32%	15%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Neuropathy peripheral	Neuropathy	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Headache	Headache	postmarketing — 1% - 29%							x
Upper respiratory tract infection	Upper respiratory tract infection	12% - 36.7%	12%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nervousness	Nervousness	0% - 19.3%	2% - 7.4%		x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nervousness	Feeling jittery
Tension	Nervousness	0% - 19.3%	2% - 7.4%		x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vaginal inflammation	Vaginal inflammation	13%					x	x	x	x
Vaginal infection	Vaginal inflammation	13%					x	x	x	x
Asthenia	Fatigue	postmarketing — 1% - 30.7%	4% - 13.4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Asthenia	Asthenia	very rare — 0% - 8%	1% - 1.8%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Fatigue	Fatigue	postmarketing — 1% - 30.7%	4% - 13.4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nystagmus	Nystagmus	6.1% - 15%	6.8% - 9.3%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Abnormal behaviour	Abnormal behaviour	0% - 11.2%	3.9% - 9%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Irritability	Irritability	2% - 14.6%	1% - 8.8%					x
Decreased appetite	Anorexia	postmarketing — 2% - 24.5%	1% - 15%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Decreased appetite	Decreased appetite	1.3% - 19.2%	2% - 12.7%
Malnutrition	Malnutrition	postmarketing, 6% - 21%	3% - 4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Somnolence	Somnolence	postmarketing — 0% - 30.1%	2% - 16%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Purpura	Purpura	4% - 8.2%	4%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vascular purpura	Purpura	4% - 8.2%	4%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Weight decreased	Weight decreased	postmarketing — 2.5% - 31%	0% - 4.2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Disturbance in attention	Disturbance in attention	2.6% - 11.9%	1.8% - 2.3%
	Cerebration impaired	postmarketing, 0% - 15%	0% - 2%			x	x	x		x			x	x	x	x	x	x	x	x	x	x	x
	Attention concentration difficulty	postmarketing			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Insomnia	Insomnia	very rare — 0% - 14%	3% - 7%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Depression	Depression	rare, 0% - 13%	3.4% - 6%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Depression aggravated	1% - 3%	1%				x	x	x	x
	Anxiety depression									x
Dizziness	Dizziness	postmarketing, 0% - 34.1%	2% - 15.3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dizziness	Syncope	infrequent — 1%		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Paraesthesia	Paraesthesia	postmarketing — 0% - 51%	0% - 6%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Mental disability	Cerebration impaired	postmarketing, 0% - 15%	0% - 2%			x	x	x		x			x	x	x	x	x	x	x	x	x	x	x
	Mental disability	0.4% - 5%	0.9% - 1.3%
	Thinking abnormal						x			x
Lethargy	Lethargy	1.2% - 13.5%	2.1% - 8.8%
Abdominal pain	Abdominal pain	very rare — 1.1% - 15%	0.8% - 5%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal pain	Abdominal pain	very rare — 1.1% - 15%	0.8% - 5%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nausea	Nausea	postmarketing — 0% - 15.1%	5% - 8.4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Salivary hypersecretion	Salivary hypersecretion	4% - 6.1%	4%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Viral infection	Viral infection	1% - 15%	1% - 3%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Anaemia	Anaemia	frequent, 0.8% - 3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Arthralgia	Arthralgia	postmarketing — 1% - 7%	2%	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Musculoskeletal discomfort	Arthralgia	postmarketing — 1% - 7%	2%	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Musculoskeletal discomfort	Myalgia	postmarketing, 2% - 2.5%	1% - 1.3%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Conjunctivitis	Conjunctivitis	frequent, 0% - 7%	1%	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Diarrhoea	Diarrhoea	very rare — 2% - 14%	1% - 5.2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hallucination	Hallucination	very rare — frequent		x	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pain	Pain	2.9% - 6.2%	4.2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pharyngitis	Pharyngitis	2% - 21%	2% - 4%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pneumonia	Pneumonia	1% - 5.1%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Psychotic disorder	Psychotic disorder	very rare — frequent		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Psychotic disorder	Paranoia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Sinusitis	Sinusitis	1% - 15%	4% - 6%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Suicide attempt	Suicide attempt	postmarketing — frequent		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Shock	Syncope	infrequent — 1%		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Syncope	Syncope	infrequent — 1%		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Loss of consciousness	Syncope	infrequent — 1%		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Erectile dysfunction	Erectile dysfunction	frequent, 1% - 2%		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Agitation	Hyperkinesia	postmarketing, 0% - 21%	4%			x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x
Agitation	Agitation	postmarketing — 1% - 4.4%	1% - 2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperkinesia	Hyperkinesia	postmarketing, 0% - 21%	4%			x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x
Vomiting	Vomiting	very rare — 1% - 14%	2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bradyphrenia	Bradyphrenia	0% - 19.5%	1.4% - 3.1%
Expressive language disorder	Expressive language disorder	postmarketing, 3.5% - 9.4%	1.4% - 1.6%						x
Anxiety	Anxiety	0% - 10.4%	1.8% - 6%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ataxia	Ataxia	postmarketing, 1% - 21.2%	1% - 7%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Confusional state	Confusional state	very rare — 0% - 14%	0.8% - 5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Feeling abnormal	Confusional state	very rare — 0% - 14%	0.8% - 5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Feeling abnormal	very rare, postmarketing							x
	Malaise
Constipation	Constipation	0% - 7%	0% - 4.9%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysarthria	Dysarthria	1.6% - 6.2%	1%
Osteoarthritis	Dysarthria	1.6% - 6.2%	1%
Osteoarthritis	Arthropathy	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Dyspepsia	Dyspepsia	0% - 8%	0% - 6.5%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Breast pain	Breast pain	0% - 8.3%	1.7% - 2%			x	x		x	x		x	x	x	x	x	x	x	x	x	x	x	x
Breast pain	Breast pain female							x			x
Rhinitis	Rhinitis	0% - 21%	0% - 6.9%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Speech disorder	Speech disorder	very rare — 1% - 16.8%	0.5% - 2.3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Coordination abnormal	Coordination abnormal	3.6% - 11.4%	1.9% - 4.2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Action tremor	Action tremor	3.1% - 4.8%	2.9%
Abdominal pain upper	Abdominal pain upper	3.7% - 3.9%	2.1%
Balance disorder	Balance disorder	0.4% - 5.8%	0% - 2.4%
Amnesia	Amnesia	very rare — 2.9% - 5.3%	0.5% - 1%				x		x	x
Dysmenorrhoea	Dysmenorrhoea	0% - 8.3%	6.8%		x	x	x	x	x	x	x	x	x	x	x	x	x	x		x	x	x	x
Abdominal discomfort	Upset stomach	1% - 3.2%	0.2% - 1.3%
Abdominal discomfort	Abdominal discomfort
Convulsion	Convulsions aggravated	3% - 3.1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Convulsion	Convulsion	postmarketing — 1% - 2.3%	0%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bronchitis	Bronchitis	0% - 7%	2%			x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x
Dysgeusia	Dysgeusia	very rare — 0% - 15.4%	0% - 1%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Gastroenteritis	Gastroenteritis	0% - 7%	1% - 2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Skin disorder	Skin disorder	1% - 3.1%	1% - 2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Skin disorder	Unspecified disorder of skin and subcutaneous tissue	postmarketing							x
Tremor	Tremor	0% - 10.6%	1.4% - 6%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Mood swings	Mood swings	postmarketing, 0% - 5.1%	0.2% - 2%				x	x	x	x		x	x	x	x		x		x	x	x	x	x
Mood swings	Mood alteration NOS							x
Affect lability	Mood swings	postmarketing, 0% - 5.1%	0.2% - 2%				x	x	x	x		x	x	x	x		x		x	x	x	x	x
Affect lability	Affect lability	0.2% - 1.1%	0.2%
Influenza like illness	Influenza-like symptoms	0% - 7%	1% - 3.2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Influenza like illness	Influenza like illness	postmarketing
Gait disturbance	Gait disturbance	0% - 8%	1% - 5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Aggression	Aggressive reaction	0% - 9.2%	0% - 4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Aggression	Aggression	very rare — 2.8% - 8.7%	1.8% - 6.9%						x
Hypoaesthesia	Hypoaesthesia	1% - 8%	0% - 2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypoaesthesia	Hypoaesthesia facial	0.4% - 2%
Disorientation	Disorientation	1.7% - 3.2%	1%
Muscle spasms	Muscle spasms	1.7% - 3.3%	0.8%
Muscle spasms	Cramps of lower extremities	0% - 2%	0%			x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x
Alopecia	Alopecia	postmarketing — 0% - 6.3%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Amenorrhoea	Amenorrhoea	2%	1%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Aphasia	Aphasia	2%	0%
	Dysphasia	1%	0%
	Word finding difficulty							x
Back pain	Back pain	0% - 6.2%	0% - 4.2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Chest pain	Chest pain	1% - 4.4%	1% - 3%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Infection	Infection	postmarketing, 0% - 14%	1% - 13%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cough	Cough	0% - 7%	2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cystitis	Cystitis	0% - 3%	0%			x	x	x	x	x		x		x	x	x	x	x	x	x	x	x	x
Bladder pain	Cystitis	0% - 3%	0%			x	x	x	x	x		x		x	x	x	x	x	x	x	x	x	x
Cystitis noninfective	Cystitis	0% - 3%	0%			x	x	x	x	x		x		x	x	x	x	x	x	x	x	x	x
Dermatitis	Dermatitis	0% - 7%	0%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dermatitis	Rash	very rare — 0.4% - 6.7%	1% - 5.9%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Diplopia	Diplopia	0% - 12.1%	0% - 5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Oedema	Oedema	postmarketing, 1% - 2%	1%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Epistaxis	Epistaxis	0% - 8%	0.5% - 1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Congenital eye disorder	Congenital eye disorder	1% - 2%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Eye disorder	Congenital eye disorder	1% - 2%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Eye disorder	Eye disorder	postmarketing							x
Body temperature increased	Body temperature increased	very rare — 0% - 12%	1%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Haematuria	Haematuria	0% - 2%	1%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Hypersensitivity	Hypersensitivity	0% - 7%	1%			x			x	x				x	x	x	x	x	x	x	x	x	x
Hypertrichosis	Hypertrichosis	1% - 2%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pain in extremity	Leg pain	1% - 8%	2% - 2.3%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Leukopenia	Leukopenia	postmarketing, 0% - 2.7%	0% - 1%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Vaginal discharge	Leukorrhea	2%	0%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Menorrhagia	Menorrhagia	1% - 2%	0%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Menstrual disorder	Menstrual disorder	0.8% - 4.2%	0% - 2%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Otitis media	Otitis media	0% - 8%	1%				x	x	x	x
Prostatic disorder	Prostatic disorder	0% - 2.2%	1% - 0.6%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Tachycardia	Tachycardia	2%					x	x	x	x
Thirst	Thirst	1% - 2%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Tinnitus	Tinnitus	0.4% - 2%	0% - 1%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Urinary incontinence	Urinary incontinence	1% - 4.1%	1% - 2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary tract infection	Urinary tract infection	0% - 5%	1% - 2%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urethral disorder	Urinary tract disorder	postmarketing, 0% - 4.1%	0%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary tract disorder	Urinary tract disorder	postmarketing, 0% - 4.1%	0%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Visual impairment	Disorder sight	0% - 13%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Abnormal vision	0% - 14.2%	0% - 2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Visual disturbance	postmarketing — 1.4% - 2%	0.3%				x		x	x
	Visual impairment						x			x
Dry mouth	Dry mouth	0.4% - 5%	0% - 2.5%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Stupor	Stupor	1% - 2%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Depressed level of consciousness	Stupor	1% - 2%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Depressed level of consciousness	Depressed level of consciousness
Oedema peripheral	Oedema peripheral	2%					x	x	x	x
Hyporeflexia	Hyporeflexia	0% - 2%	0%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Myalgia	Myalgia	postmarketing, 2% - 2.5%	1% - 1.3%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rash erythematous	Rash erythematous	0% - 8%	0% - 1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Muscle contractions involuntary	Muscle contractions involuntary	0% - 8%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vision blurred	Vision blurred	postmarketing — 2% - 8.9%	2% - 2.5%				x	x	x	x
Depressed mood	Depressed mood	0.4% - 2.9%	0.9%
Psychomotor retardation	Psychomotor retardation	2%	0%
Menopausal symptoms	Hot flush	postmarketing, 0.7% - 2.7%	1% - 1.9%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hot flush	Hot flush	postmarketing, 0.7% - 2.7%	1% - 1.9%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Acne	Acne	0% - 3%				x	x	x	x	x		x		x	x	x	x	x	x	x	x	x	x
Deafness	Hearing impaired	1% - 2%	1%			x						x	x	x	x	x	x	x	x	x	x	x	x
Deafness	Deafness
Hearing impaired	Hearing impaired	1% - 2%	1%			x						x	x	x	x	x	x	x	x	x	x	x	x
	Auditory disorder NOS	1% - 2%	1%		x						x
	Deafness unilateral
Anger	Anger	1.7% - 2.1%	0.5%
Depersonalisation	Depersonalisation	1% - 2.2%	0.9% - 1%			x	x	x	x	x		x		x	x	x	x	x	x	x	x	x	x
Apathy	Apathy	1% - 3.1%	0% - 1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Flat affect	Apathy	1% - 3.1%	0% - 1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Flat affect	Flat affect
Paraesthesia oral	Paraesthesia oral	1.2% - 3.3%	0.5%
Learning disability	Learning disability	0% - 3.2%
Coagulopathy	Coagulopathy	1% - 2%	1%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Coagulopathy	Clotting				x
Cardiovascular disorder	Cardiovascular disorder	1% - 2%	0%		x	x					x	x	x	x	x	x	x	x	x	x	x	x	x
Haemorrhage	Haemorrhage	1% - 2%	1%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Haemoglobin	Haemorrhage	1% - 2%	1%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Musculoskeletal chest pain	Musculoskeletal chest pain	1.1% - 1.8%	0.3%
Mental retardation	Mental disability	0.4% - 5%	0.9% - 1.3%
Personality disorder	Personality disorder	0% - 11.2%	9%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Muscle twitching	Muscle twitching	0.4% - 1.8%	0.7%
Cognitive disorder	Cognitive disorder	0.4% - 2%
Cognitive disorder	Cognitive impairment
Memory impairment	Memory impairment	postmarketing, 1.2% - 10.8%	1% - 1.8%					x	x
Candida infection	Candida infection	0% - 1%	0% - 1%			x						x	x	x	x	x	x	x	x	x	x	x	x
Libido decreased	Libido decreased	0% - 3%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Disturbance in sexual arousal	Libido decreased	0% - 3%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Libido increased	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
	Disturbance in sexual arousal
Dysphagia	Dysphagia	1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Dyspnoea	Dyspnoea	1% - 6%	0.9% - 2%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Eczema	Eczema	0% - 1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Grand mal convulsion	Grand mal convulsion	0% - 7%	0%			x			x	x			x	x	x		x	x	x	x	x	x	x
Rash	Rash	very rare — 0.4% - 6.7%	1% - 5.9%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Faecal incontinence	Faecal incontinence	0% - 1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Flatulence	Flatulence	1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrooesophageal reflux disease	Gastrooesophageal reflux disease	0.4% - 2%	0% - 0.5%			x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gingival hyperplasia	Gingival hyperplasia	1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Gingivitis	Gingivitis	1%	1%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Glossitis	Glossitis	1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Haematoma	Haematoma	0% - 2%	0%			x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x
Hypertension	Hypertension	1% - 3%	0% - 1%			x						x	x	x	x	x	x	x	x	x	x	x	x
Hypoglycaemia	Hypoglycaemia	0% - 1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Myopia	Myopia	very rare — 0% - 1%	0%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Neurosis	Neurosis	infrequent, 1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Nocturia	Nocturia	0% - 1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Pallor	Pallor	1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Pruritus	Pruritus	0% - 4%	2%			x	x	x	x	x		x		x	x	x	x	x	x	x	x	x	x
Seborrhoeic dermatitis	Seborrhoeic dermatitis	0% - 1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Thrombocytopenia	Thrombocytopenia	postmarketing, 1%	0%			x	x		x	x		x	x	x	x		x	x	x	x	x	x	x
Toothache	Toothache	1% - 7%					x	x	x	x
Pollakiuria	Pollakiuria	0% - 4%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pollakiuria	Micturition urgency
Vertigo	Vertigo	0% - 3.2%	1%			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Weight increased	Weight increased	postmarketing, 0% - 1%	0%			x		x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Skin odour abnormal	Body odor	0% - 1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Skin odour abnormal	Skin odour abnormal
Migraine	Migraine	postmarketing, 0% - 2%						x	x	x
Migraine	Migraine aggravated						x		x	x
Gamma-glutamyltransferase increased	Gamma-glutamyltransferase increased	infrequent, 1% - 3%				x						x	x	x	x	x	x	x	x	x	x	x	x
Muscular weakness	Muscular weakness	frequent, 1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bone pain	Bone pain	0% - 1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Prothrombin level increased	Prothrombin level increased	1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Skin discolouration	Skin discolouration	0% - 1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Increased appetite	Increased appetite	1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Urine abnormality	Urine abnormality	0% - 1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Urine analysis abnormal	Urine abnormality	0% - 1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Lacrimal disorder	Lacrimation abnormal NOS	0% - 1%	0%			x					x	x	x	x	x	x	x	x	x	x	x	x	x
Rash maculo-papular	Rash maculo-papular	0% - 2%					x	x	x	x
Chills	Rigors	1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Bradycardia	Bradycardia	1%	0%			x						x	x	x	x	x	x	x	x	x	x	x	x
Hyperhidrosis	Sweating increased	1% - 2%	1%			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Psychomotor skills impaired	Psychomotor skills impaired	0% - 2%
Ear pain	Ear pain	0% - 1.3%					x	x	x	x
Dry eye	Dry eye	0% - 1.3%
Pruritus generalised	Pruritus generalised	0% - 1.3%
Nasopharyngitis	Rhinorrhoea	0% - 1.3%
Nasopharyngitis	Nasopharyngitis	postmarketing
Rhinorrhoea	Rhinorrhoea	0% - 1.3%
Agranulocytosis	Agranulocytosis	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Albuminuria	Albuminuria	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Angina pectoris	Angina pectoris	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Apraxia	Apraxia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Atrioventricular block	Atrioventricular block	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Dehydration	Dehydration	postmarketing — frequent		x	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Delirium	Delirium	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Delusion	Delusion	postmarketing, infrequent		x	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Diabetes mellitus	Diabetes mellitus	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Diabetes mellitus	Diabetic									x
Dyskinesia	Dyskinesia	infrequent		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Eosinophilia	Eosinophilia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Oesophagitis	Oesophagitis	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Flushing	Flushing	postmarketing — 0% - 5%		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastritis	Gastritis	infrequent, 0% - 3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gingival bleeding	Gingival bleeding	infrequent, 0% - 1.3%		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Haemorrhoids	Haemorrhoids	infrequent, frequent		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperaesthesia	Hyperaesthesia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperglycaemia	Hyperglycaemia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperlipidaemia	Hyperlipidaemia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hypocalcaemia	Hypocalcaemia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hypokalaemia	Hypokalaemia	postmarketing, infrequent			x		x	x	x	x	x		x			x	x			x
Hypotension	Hypotension	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Orthostatic hypotension	Orthostatic hypotension	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Arthropathy	Arthropathy	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Lymphopenia	Lymphopenia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Melaena	Melaena	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Oliguria	Oliguria	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Phlebitis	Phlebitis	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Polyuria	Polyuria	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Urine output increased	Polyuria	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Pulmonary embolism	Pulmonary embolism	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Scotoma	Scotoma	infrequent, 0.4% - 1.3%		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Stomatitis	Stomatitis	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Urticaria	Urticaria	infrequent, frequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Urticaria	Urticaria localised
Vasodilation procedure	Vasodilation	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Xerophthalmia	Xerophthalmia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary retention	Urinary retention	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Encephalopathy	Encephalopathy	postmarketing, infrequent		x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Photophobia	Photophobia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Breast discharge	Breast discharge	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Deep vein thrombosis	Deep vein thrombosis	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Electroencephalogram abnormal	Electroencephalogram abnormal	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Paranoia	Paranoid reaction	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Paranoia	Paranoia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Blood alkaline phosphatase increased	Phosphatase alkaline increased	infrequent			x						x		x			x	x			x
Blood alkaline phosphatase increased	Alkaline phosphatase serum increased					x
Aspartate aminotransferase increased	Aspartate aminotransferase increased	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Alanine aminotransferase increased	Alanine aminotransferase increased	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Accommodation disorder	Accommodation disorder	infrequent		x	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Photosensitivity reaction	Photosensitivity reaction	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Euphoric mood	Euphoric mood	infrequent, frequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hair texture abnormal	Hair texture abnormal	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Ejaculation disorder	Ejaculation disorder	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Abdominal distension	Enlargement abdomen	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Abdominal distension	Abdominal distension	0% - 1.3%	0.2%
Lymphadenopathy	Lymphadenopathy	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Face oedema	Face oedema	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Renal pain	Renal pain	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Thrombocytosis	Thrombocytosis	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Parosmia	Parosmia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Dysphonia	Dysphonia	infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Ageusia	Ageusia	infrequent, 1% - 2%	1%	x	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Neoplasm	Neoplasm	1% - 2%	1%		x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Renal tubular acidosis	Renal tubular acidosis	very rare, postmarketing			x								x			x	x			x
Road traffic accident	Renal tubular acidosis	very rare, postmarketing			x								x			x	x			x
Mental disorder	Mental disorder	postmarketing			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bipolar disorder	Bipolar disorder	postmarketing						x
Bipolar I disorder	Bipolar disorder	postmarketing						x
Cerebellar syndrome	Cerebellar syndrome	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Nervous system disorder	Cerebellar syndrome	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Nervous system disorder	Nervous system disorder	postmarketing					x	x	x	x
Connective tissue disorder	Connective tissue disorder	postmarketing							x
Toxic epidermal necrolysis	Toxic epidermal necrolysis	postmarketing			x	x				x	x	x		x	x	x	x	x	x	x	x	x	x
Epilepsy	Epilepsy	postmarketing						x
Erythema multiforme	Erythema multiforme	postmarketing			x	x				x	x	x		x	x	x	x	x	x	x	x	x	x
Erythema multiforme	Stevens-Johnson syndrome	postmarketing			x	x				x	x	x		x	x	x	x	x	x	x	x	x	x
Angle closure glaucoma	Angle closure glaucoma	very rare, postmarketing						x	x	x
Hepatitis	Hepatitis	postmarketing			x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypernatraemia	Hypernatraemia	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hypohidrosis	Hypohidrosis	postmarketing					x	x	x	x								x	x		x	x	x
Hypohidrosis	Sweating decreased	postmarketing, infrequent					x	x	x	x			x
Hyponatraemia	Hyponatraemia	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Immune system disorder	Immune system disorder	postmarketing
Libido increased	Libido increased	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Iritis	Iritis	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Lymphocytosis	Lymphocytosis	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Chloasma	Chloasma	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Musculoskeletal pain	Musculoskeletal pain	postmarketing							x
Mydriasis	Mydriasis	rare, infrequent		x	x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Neutropenia	Neutropenia	very rare, postmarketing							x
Eye movement disorder	Eye movement disorder	postmarketing
Pancreatitis	Pancreatitis	postmarketing			x	x					x	x	x	x	x	x	x	x	x	x	x	x	x
Pancytopenia	Pancytopenia	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Pancytopenia	Bone marrow depression	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Pemphigus	Pemphigus	postmarketing			x	x				x	x	x		x	x	x	x	x	x	x	x	x	x
Polycythaemia	Polycythaemia	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Stevens-Johnson syndrome	Stevens-Johnson syndrome	postmarketing			x	x				x	x	x		x	x	x	x	x	x	x	x	x	x
Completed suicide	Suicide	postmarketing					x		x	x
Completed suicide	Completed suicide	postmarketing					x	x	x	x
Hepatic failure	Hepatic failure	postmarketing			x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vasospasm	Vasospasm	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperchloraemia	Hyperchloraemia	rare, infrequent			x		x			x	x		x			x	x			x
Hypophosphataemia	Hypophosphataemia	rare			x						x		x			x	x			x
Periorbital oedema	Periorbital oedema	postmarketing
Alcohol intolerance	Alcohol intolerance	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Blood creatinine increased	Creatinine increased	rare		x	x	x					x	x	x	x	x	x	x	x	x	x	x	x	x
Generalised oedema	Generalised oedema	postmarketing
Fluid retention	Generalised oedema	postmarketing
Tongue disorder	Tongue oedema	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Tongue oedema	Tongue oedema	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hypocholesterolaemia	Hypocholesterolaemia	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Mania	Manic psychosis	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Mania	Mania
Eye pain	Eye pain	very rare, postmarketing			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Joint swelling	Joint swelling	postmarketing
Eyelid oedema	Eyelid oedema	postmarketing
Metabolic acidosis	Metabolic acidosis	very rare, postmarketing				x	x	x	x	x								x	x		x	x	x
Hyperammonaemia	Hyperammonaemia	postmarketing				x			x	x								x	x		x	x	x
Temperature intolerance	Heat intolerance	postmarketing								x
Feeling of despair	Feeling of despair	postmarketing
Tongue paralysis	Tongue paralysis	rare		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Ocular hyperaemia	Eye redness	postmarketing						x	x	x
Ocular hyperaemia	Ocular hyperaemia							x	x	x
Upper motor neurone lesion	Upper motor neurone lesion	rare, infrequent		x	x						x	x	x	x	x	x	x	x	x	x	x	x	x
Hepatic enzyme increased	Hepatic enzyme increased	postmarketing							x
Nephrolithiasis	Nephrolithiasis	postmarketing — 0% - 2.6%
Nephrolithiasis	Calculus of kidney	frequent, 0% - 7%	0%			x	x	x	x	x			x	x	x	x	x	x	x	x	x	x	x
Suicidal ideation	Suicidal ideation	very rare, postmarketing					x		x	x
Abnormal sensation in eye	Abnormal sensation in eye	postmarketing
Drug interaction	Drug interaction	postmarketing
Maculopathy	Maculopathy	postmarketing				x						x		x	x		x	x	x	x	x	x	x
Allergic oedema	Allergic oedema	postmarketing
Infestation	Infestation NOS	postmarketing
Limb discomfort	Limb discomfort	postmarketing
Pancreatitis acute	Pancreatitis acute	very rare
Blindness transient	Blindness transient	very rare
Acidosis	Acidosis	postmarketing — 0% - 7%					x	x	x	x	x		x
Respiratory alkalosis	Respiratory alkalosis							x
Amblyopia	Amblyopia						x			x
Anhidrosis	Anhidrosis
Anosmia	Anosmia
Asthma	Asthma	0% - 2%					x	x	x	x
Blepharospasm	Blepharospasm
Breast disorder	Breast disorder
Calcinosis	Calcinosis
Collagen disorder	Collagen disorder						x	x	x	x
Dermatitis atopic	Dermatitis atopic
Drooling	Drooling
Drug abuse	Drug abuse
Dysuria	Dysuria	frequent, 0% - 2%				x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Effusion	Effusion							x	x	x
Endocrine disorder	Endocrine disorder
Flank pain	Flank pain
Formication	Formication
Gastrointestinal disorder	Gastrointestinal disorder	postmarketing, 0% - 7%					x	x	x
Glaucoma	Glaucoma						x			x
Glossodynia	Glossodynia
Breath odour	Breath odour
Deafness neurosensory	Deafness neurosensory
Cardiac disorder	Cardiac disorder
Hyperplasia	Hyperplasia
Hyperthyroidism	Hyperthyroidism	0% - 8%
Body temperature decreased	Body temperature decreased					x												x	x		x	x	x
Hypothermia	Body temperature decreased					x												x	x		x	x	x
Incontinence	Incontinence
Nephropathy	Nephropathy							x
Laryngitis	Laryngitis	0% - 8%
Mastitis	Mastitis	0% - 2%					x	x	x	x
Mediastinal disorder	Mediastinal disorder
Metrorrhagia	Metrorrhagia	0% - 3%					x	x	x	x									x		x	x	x
Metrorrhagia	Bleeding breakthrough									x
Hypertonia	Hypertonia	frequent, 0% - 7%				x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Nail disorder	Nail disorder	0% - 2%					x	x	x	x
Nasal congestion	Nasal congestion
Night blindness	Night blindness
Obesity	Obesity						x		x	x
Osteomalacia	Osteomalacia							x
Palpitations	Palpitations						x	x	x	x
Panic reaction	Panic reaction
Panic disorder	Panic disorder
Pemphigoid	Pemphigoid
Premature ejaculation	Premature ejaculation	0% - 3%	0%				x	x	x	x
Presbyopia	Presbyopia
Renal failure	Renal failure							x	x	x
Respiratory tract infection	Respiratory tract infection																			x
Rickets	Rickets							x
Status epilepticus	Status epilepticus							x
Mouth ulceration	Ulcerative stomatitis						x	x	x	x
Testicular disorder	Testicular disorder						x	x	x	x
Tooth disorder	Tooth disorder						x		x	x
Unintended pregnancy	Unintended pregnancy						x	x	x
Erythema	Erythema
Erythema	Redness							x	x	x
Angiopathy	Angiopathy						x	x	x	x
Acidosis hyperchloraemic	Acidosis hyperchloraemic
Polydipsia	Polydipsia
Micturition urgency	Micturition urgency
Sinus bradycardia	Sinus bradycardia
Akinesia	Akinesia
Burning sensation	Burning sensation
Photopsia	Photopsia
Hypokinesia	Hypokinesia
Panic attack	Panic attack
Conjunctival oedema	Conjunctival oedema
Swelling face	Swelling face
Hypogeusia	Hypogeusia
Sensory disturbance	Sensory disturbance						x		x	x
Renal colic	Renal colic
Lacrimation increased	Lacrimation increased
Endophthalmitis	Ocular hyperaemia							x	x	x
Rash macular	Rash macular
Oral pain	Oral pain
Malaise	Malaise
Discomfort	Malaise
Ill-defined disorder	Malaise
Dyspnoea exertional	Dyspnoea exertional
Abdominal pain lower	Abdominal pain lower
Abdominal tenderness	Abdominal tenderness
Distractibility	Distractibility
Elevated mood	Elevated mood
Thinking abnormal	Thinking abnormal						x			x
Perseveration	Perseveration
Hallucination, auditory	Hallucination, auditory
Hallucination, visual	Hallucination, visual
Clumsiness	Clumsiness
Anorgasmia	Anorgasmia
Dysgraphia	Dysgraphia
Visual acuity reduced	Visual acuity reduced							x	x	x
Intraocular pressure increased	Intraocular pressure increased							x	x	x
Dizziness postural	Dizziness postural
Scintillating scotoma	Scintillating scotoma
Aura	Aura
Pharyngeal oedema	Pharyngeal oedema	0% - 8%
Hypomania	Hypomania
Food interaction	Drug - food interaction									x
Muscle fatigue	Muscle fatigue
Ketogenic diet	Ketogenic diet							x
Essential tremor	Essential tremor
Familial tremor	Essential tremor
Blindness unilateral	Blindness unilateral
Peripheral coldness	Peripheral coldness
Sensory loss	Sensory loss
Genital candidiasis	Genital candidiasis						x		x	x
Repetitive speech	Repetitive speech
Dysaesthesia	Dysaesthesia
Initial insomnia	Initial insomnia
Middle insomnia	Middle insomnia
Crying	Tearfulness
Tearfulness	Tearfulness
Blood bicarbonate	Bicarbonate level							x	x	x
Dependence	Dependence
Dyslexia	Dyslexia
Hypoaesthesia oral	Hypoaesthesia oral
Electrocardiogram abnormal	Electrocardiogram abnormal							x		x
Feeling drunk	Feeling drunk
Terminal insomnia	Terminal insomnia
Feeling jittery	Feeling jittery
Altered state of consciousness	Depressed level of consciousness
Sexual dysfunction	Sexual dysfunction
Blood potassium decreased	Serum potassium decreased					x
Blood potassium decreased	Potassium low					x
Presyncope	Presyncope
Diabetic neuropathy	Diabetic peripheral neuropathy						x		x	x
White blood cell count decreased	White blood cell count decreased
Partial seizures	Partial seizures
Administration site reaction	Administration site reaction
Sleep disorder	Sleep disorder	0% - 2%					x	x	x	x
Blood bicarbonate decreased	Blood bicarbonate decreased
Lack of spontaneous speech	Lack of spontaneous speech
Unresponsive to stimuli	Unresponsive to stimuli
Embolism	Thromboembolic event						x	x	x	x
Liver function test abnormal	Raised liver function tests									x
Circadian rhythm sleep disorder	Circadian rhythm sleep disorder
Hypersomnia	Hypersomnia
Sluggishness	Sluggishness
Crystal urine present	Crystal urine present
Ear discomfort	Ear discomfort
Musculoskeletal stiffness	Musculoskeletal stiffness
Orgasmic sensation decreased	Orgasmic sensation decreased
Dysphemia	Dysphemia
Altered visual depth perception	Altered visual depth perception
Paranasal sinus hypersecretion	Paranasal sinus hypersecretion
Tandem gait test abnormal	Tandem gait test abnormal
Autonomic neuropathy	Unspecified disorder of autonomic nervous system				x						x	x	x	x	x	x	x	x	x	x	x	x	x
Poor quality sleep	Poor quality sleep
Epigastric discomfort	Epigastric discomfort
Calculus ureteric	Calculus ureteric
Sudden unexplained death in epilepsy	Sudden unexplained death in epilepsy																	x	x		x	x	x
Suicidal behaviour	Suicidal behaviour					x												x	x		x	x	x
Hyposmia	Hyposmia
Deafness unilateral	Deafness unilateral
Vaginal haemorrhage	Vaginal haemorrhage	0% - 3%				x						x		x	x	x	x	x	x	x	x	x	x
Loss of libido	Loss of libido

Side effects:	85
Source:	FDA Structured Product Label

Side effects:	144
Source:	FDA Structured Product Label

Side effects:	160
Source:	FDA Structured Product Label

Side effects:	170
Source:	Health Canada

Side effects:	173
Source:	Health Canada

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Color scheme:

Indication
Bipolar disorder			x	x	x	x
Cerebration impaired							x
Chronic migraine			x	x	x	x
Cluster headache			x	x	x	x
Convulsion	x			x			x	x	x	x	x	x	x	x	x	x	x	x	x
Drug interaction				x	x	x
Epilepsy	x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x	x	x
Fatigue							x
Grand mal convulsion	x	x					x	x	x	x	x	x	x	x	x	x	x	x	x
Headache			x	x	x	x
Lennox-Gastaut syndrome	x			x			x	x	x	x	x	x	x	x	x	x	x	x	x
Liver disorder				x		x
Migraine			x	x	x	x
Nephrolithiasis				x	x	x
Nervousness							x
Pharmacokinetic interaction						x
Renal failure chronic				x	x	x
Renal impairment				x	x	x

		100%
		75%
		50%
		10%
		frequent (1% to 100%)
		infrequent (0.1% to 1%)
		rare (<0.1%)
		postmarketing
		0%
		no frequency information
		not found on label