Muscle spasms

Definition: a sudden, violent, involuntary contraction of a muscle or a group of muscles, attended by pain and interference with function, producing involuntary movement and distortion.

Synonyms (terms occurring on more labels are shown first): spasm, muscle spasm, spasms, muscle spasms, muscular spasm, muscular spasms

More information: PubMed search and possibly Wikipedia or Medpedia

Proteins predicted to cause Muscle spasms: HTR2A, DRD5 (inhibition), DRD5 (36 predictions in total) Show drugs for which this side effect directly occurs

Drugs with this side effect as MedDRA Preferred Term Ambenonium cation Cramp muscle Carbenicillin Cramp muscle Mivacurium Muscle spasms Sincalide Cramp muscle Tolcapone Cramp muscle acamprosate calcium Cramps of lower extremities: infrequent Cramp muscle: infrequent acetaminophen Muscle spasms acitretin Cramps of lower extremities Cramp muscle albuterol Cramps of lower extremities: 0% - 2.7% Cramp muscle: postmarketing, 0% - 3% Muscle spasms: 1% almotriptan Cramp muscle: infrequent alprazolam Cramp muscle: frequent, 2.4% alprostadil Cramps of lower extremities Cramp muscle Muscle spasms ambrisentan Cramp muscle amiloride Cramp muscle Muscle spasms amlodipine Cramp muscle amphotericin b Cramp muscle anagrelide hydrochloride Cramps of lower extremities Cramp muscle argipressin Cramp muscle aripiprazole Cramp muscle: rare, frequent Muscle spasms: postmarketing, infrequent, 2% Night cramps: rare asenapine Muscle spasms atorvastatin calcium Cramps of lower extremities Cramp muscle Muscle spasms azacitidine Cramp muscle azilect Cramps of lower extremities Cramp muscle aztreonam Cramp muscle balsalazide Cramp muscle: 1.16% baycol Cramp muscle betaxolol Cramps of lower extremities Cramp muscle bethanechol Cramp muscle bexarotene Muscle spasms bezafibrate Cramp muscle bicalutamide Cramps of lower extremities Cramp muscle bisacodyl Cramp muscle bisoprolol fumarate Cramp muscle: postmarketing bortezomib Cramp muscle: 0% - 12.4% Muscle spasms: postmarketing bromazepam Muscle spasms bromocriptine Cramp muscle: postmarketing brompheniramine Cramp muscle Muscle spasms budesonide Cramp muscle bumetanide Cramp muscle bupivacaine Muscle spasms buprenorphine Muscle spasms bupropion Cramps of lower extremities: postmarketing Cramp muscle: postmarketing Muscle spasms: postmarketing buspirone Cramp muscle: infrequent Muscle spasms: infrequent butoconazole nitrate Cramp muscle butorphanol tartrate Muscle spasms: infrequent calcitriol Cramp muscle carbachol Cramp muscle carbamazepine Cramps of lower extremities Cramp muscle: rare carbenicillin indanyl sodium Cramp muscle carboprost (carboprost tromethamine) Cramps of lower extremities Cramp muscle carvedilol Cramps of lower extremities Cramp muscle cefadroxil Cramp muscle cefazolin Cramp muscle: postmarketing cefpodoxime Cramp muscle ceftobiprole (ceftobiprole medocaril) Muscle spasms cefuroxime Cramp muscle Muscle spasms celecoxib Cramps of lower extremities Cramp muscle cetirizine Cramps of lower extremities Cramp muscle cevimeline hydrochloride Cramps of lower extremities Cramp muscle chloroquine Cramp muscle chlorothiazide Cramp muscle Muscle spasms chlorpromazine Muscle spasms chlorthalidone Cramp muscle Muscle spasms cidofovir anhydrous Cramps of lower extremities Cramp muscle cilazapril (cilazapril monohydrate) Cramps of lower extremities Cramp muscle cinoxacin Cramp muscle ciprofloxacin Cramp muscle Muscle spasms Night cramps cisplatin Cramp muscle Muscle spasms citalopram Cramps of lower extremities: infrequent Cramp muscle: postmarketing, infrequent, frequent clindamycin Cramp muscle: postmarketing clobazam Muscle spasms: postmarketing clodronate disodium (clodronate disodium tetrahydrate) Cramp muscle Muscle spasms clomiphene Muscle spasms: postmarketing clomipramine Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: rare Spasm generalised: rare clonazepam Cramps of lower extremities Cramp muscle clonidine Cramps of lower extremities Cramp muscle: postmarketing clotrimazole Cramp muscle clozapine Muscle spasms: postmarketing, 1% codeine Cramp muscle colchicine Cramp muscle colestipol Cramp muscle cubicin Cramp muscle cyclophosphamide Muscle spasms cyclosporine Cramps of lower extremities: 1% - 12% Cramp muscle: rare, 0% - 12% danazol Cramp muscle Muscle spasms dantrolene Cramp muscle decitabine Muscle spasms: 7.07% deferoxamine mesylate Cramps of lower extremities Cramp muscle Muscle spasms delavirdine mesylate Cramps of lower extremities Cramp muscle desipramine Cramp muscle desmopressin acetate Cramps of lower extremities Cramp muscle dextroamphetamine sulfate Cramp muscle: postmarketing diclofenac Cramps of lower extremities: postmarketing Cramp muscle: postmarketing diflunisal Cramp muscle: postmarketing dihydroergotamine Cramp muscle: infrequent diltiazem Cramp muscle dimercaprol Muscle spasms dinoprostone Cramps of lower extremities Cramp muscle dipyridamole Cramp muscle docetaxel Cramp muscle domperidone (domperidone maleate) Cramps of lower extremities Cramp muscle donepezil Cramps of lower extremities: infrequent Cramp muscle: infrequent, 2% - 8% Muscle spasms: infrequent doxazosin Cramps of lower extremities Cramp muscle: postmarketing, 0% - 1% doxepin Cramp muscle doxorubicin hydrochloride Muscle spasms: postmarketing doxycycline anhydrous Cramp muscle: 2% - 4% duloxetine Cramp muscle: 4% - 5% Muscle spasms: postmarketing, 3% - 4% enalapril sodium Cramp muscle epoprostenol sodium Cramps of lower extremities Cramp muscle eprosartan (eprosartan mesylate) Cramps of lower extremities Cramp muscle erythromycin Cramp muscle estazolam Cramp muscle: infrequent Muscle spasms: infrequent estradiol Cramps of lower extremities: postmarketing Cramp muscle: postmarketing Muscle spasms estramustine phosphate sodium Cramps of lower extremities Cramp muscle estrogens, conjugated Cramps of lower extremities: postmarketing Cramp muscle: postmarketing eszopiclone Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms ethosuximide Cramp muscle etidronate disodium Cramps of lower extremities: postmarketing Cramp muscle: postmarketing etonogestrel Cramp muscle etoposide Cramp muscle exemestane Cramp muscle famotidine Cramp muscle febuxostat Muscle spasms felodipine Cramp muscle: postmarketing fenofibrate Cramps of lower extremities: postmarketing Cramp muscle: postmarketing Muscle spasms: postmarketing fenoldopam Cramp of limb Cramp muscle fentanyl Cramps of lower extremities Cramp muscle Muscle spasms fluoxetine Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: rare fluphenazine Muscle spasms fluticasone propionate Cramp muscle Muscle spasms fluvastatin sodium Cramp muscle: postmarketing fluvoxamine maleate Cramps of lower extremities: rare Cramp muscle: rare Muscle spasms formoterol fumarate Cramps of lower extremities Cramp muscle: postmarketing forteo Cramps of lower extremities Cramp muscle Muscle spasms: postmarketing foscarnet sodium Cramps of lower extremities Cramp muscle Muscle spasms Spasm generalised fosinopril sodium Cramp muscle fosphenytoin sodium Cramps of lower extremities Cramp muscle frovatriptan Cramps of lower extremities: infrequent Cramp muscle: infrequent furosemide Cramps of lower extremities Cramp muscle Muscle spasms gabapentin Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: rare gadobenic acid Cramps of lower extremities Cramp muscle Muscle spasms gadofosveset Cramp muscle Muscle spasms gadoteridol Cramp muscle gadoversetamide Cramps of lower extremities Cramp muscle Muscle spasms galantamine Cramps of lower extremities: infrequent Cramp muscle: infrequent ganciclovir Cramps of lower extremities Cramp muscle gatifloxacin Cramps of lower extremities Cramp muscle gemifloxacin mesylate Cramps of lower extremities Cramp muscle geodon Muscle spasms glatiramer acetate Muscle spasms: postmarketing Spasm generalised: postmarketing glipizide Cramps of lower extremities Cramp muscle goserelin Cramps of lower extremities: 2% Cramp muscle: 2% guanfacine Cramps of lower extremities: postmarketing Cramp muscle: postmarketing haloperidol Muscle spasms histamine Cramp muscle hydralazine Cramp muscle hydrochlorothiazide Cramp muscle Muscle spasms hydroflumethiazide Cramp muscle Muscle spasms hydromorphone Cramps of lower extremities Cramp muscle Muscle spasms hydroxychloroquine Cramp muscle ibandronate sodium Cramp muscle: 1.8% - 2% ibuprofen Muscle spasms ibutilide Cramps of lower extremities Cramp muscle idarubicin Cramp muscle: 68% - 73% iloprost Cramp muscle imatinib mesylate Cramp muscle: postmarketing, 0.4% - 62% imipramine Cramp muscle indapamide Cramp muscle Muscle spasms invanz Cramp muscle Muscle spasms invirase Cramps of lower extremities Cramp muscle Muscle spasms iodine Cramp muscle: postmarketing iodixanol Cramps of lower extremities Cramp muscle iopamidol Cramps of lower extremities Cramp muscle Muscle spasms iopromide Muscle spasms: postmarketing iothalamic acid Muscle spasms ioversol Muscle spasms ioxaglic acid Muscle spasms irbesartan Cramp muscle irinotecan Cramp muscle: postmarketing, 16% - 57% labetalol Cramp muscle lacosamide Muscle spasms lactulose Cramp muscle lamivudine Cramp muscle: 3% lamotrigine Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: rare lansoprazole Cramps of lower extremities: postmarketing Cramp muscle: postmarketing leflunomide Cramps of lower extremities: 0% - 6% Cramp muscle: postmarketing, 0% - 6% lenalidomide Cramp muscle Muscle spasms leuprolide acetate Cramp muscle Muscle spasms levitra Cramp muscle levocarnitine Cramps of lower extremities Cramp muscle levofloxacin Cramps of lower extremities Cramp muscle levonorgestrel Cramps of lower extremities Cramp muscle levothyroxine Cramp muscle lincocin Cramp muscle linezolid Cramp muscle lisinopril Cramp muscle Muscle spasms loperamide hydrochloride Cramp muscle: 0.5% - 3% losartan Cramp muscle: 1% Muscle spasms lotronex Cramp muscle: infrequent Muscle spasms: infrequent lovastatin Cramp muscle: postmarketing, 0.6% - 1.1% loxapine Muscle spasms lubiprostone Cramp muscle: postmarketing Muscle spasms: postmarketing maxaquin Cramps of lower extremities Cramp muscle medroxyprogesterone acetate Cramps of lower extremities Cramp muscle Muscle spasms: postmarketing mefloquine hydrochloride Cramp muscle: postmarketing meloxicam Muscle spasms meperidine Muscle spasms meridia Cramps of lower extremities Cramp muscle mesalamine Cramps of lower extremities: postmarketing Cramp muscle: postmarketing, 7.81% - 8.1% Muscle spasms metformin Cramp muscle methadone Cramp muscle Muscle spasms methoxsalen Cramps of lower extremities Cramp muscle methylergonovine Cramps of lower extremities Cramp muscle Muscle spasms methylnaltrexone bromide Muscle spasms methylphenidate hydrochloride Cramps of lower extremities Cramp muscle: rare Muscle spasms metolazone Cramp muscle Muscle spasms metoprolol Cramp muscle metronidazole Cramp muscle mexiletine Cramp muscle miconazole nitrate Cramp muscle: postmarketing midodrine Cramps of lower extremities Cramp muscle mifepristone Cramp muscle miglustat Cramps of lower extremities Cramp muscle minoxidil Muscle spasms misoprostol Cramp muscle: postmarketing modafinil Cramps of lower extremities Cramp muscle molindone hydrochloride Muscle spasms morphine Cramp muscle Muscle spasms moxifloxacin hydrochloride Cramps of lower extremities Cramp muscle mycophenolic acid Cramps of lower extremities Cramp muscle Muscle spasms nalbuphine Cramp muscle naloxone Cramp muscle naltrexone Cramp muscle: postmarketing Muscle spasms: postmarketing naproxen Muscle spasms naratriptan Cramp muscle Muscle spasms natrecor Cramps of lower extremities Cramp muscle nefazodone Cramp muscle nelfinavir mesylate Cramp muscle neostigmine Cramp muscle Muscle spasms niacin Cramps of lower extremities Cramp muscle nifedipine Cramps of lower extremities Cramp muscle nilotinib (nilotinib hydrochloride monohydrate) Muscle spasms nimodipine Cramp muscle nisoldipine Cramps of lower extremities Cramp muscle nitazoxanide Cramps of lower extremities Cramp muscle norfloxacin Cramp muscle nortriptyline Cramp muscle octreotide (octreotide acetate) Cramps of lower extremities Cramp muscle olanzapine Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: 1% - 3% Spasm generalised: 2% - 3% olmesartan medoxomil Cramp muscle Muscle spasms olopatadine Muscle spasms olsalazine Cramp muscle: 10.1% omeprazole Cramp muscle: postmarketing orlistat Cramp muscle oxaliplatin Cramp muscle Muscle spasms oxtriphylline Cramp muscle oxycodone Cramp muscle Muscle spasms oxymetholone Cramp muscle oxytocin Muscle spasms paliperidone Muscle spasms pamidronate disodium Cramp muscle: rare pantoprazole Cramps of lower extremities Cramp muscle paromomycin Cramp muscle paroxetine Muscle spasms: rare, postmarketing Spasm generalised: rare, postmarketing pentazocine Cramp muscle pentoxifylline Cramps of lower extremities Cramp muscle Muscle spasms perindopril erbumine Cramp muscle: postmarketing perphenazine Muscle spasms phenytoin Cramps of lower extremities Cramp muscle pilocarpine Cramps of lower extremities Cramp muscle Muscle spasms pindolol Cramp muscle: 1% - 3% pirbuterol Cramp muscle plavix Cramps of lower extremities Cramp muscle polyethylene glycol 3350 Cramp muscle polythiazide Cramp muscle Muscle spasms posaconazole Cramp muscle pramipexole dihydrochloride monohydrate Cramps of lower extremities Cramp muscle Muscle spasms: 3% - 5% pravastatin sodium Cramp muscle: 2% - 5.1% prazosin Cramps of lower extremities Cramp muscle pregabalin Cramps of lower extremities: frequent Cramp muscle: frequent Muscle spasms: rare, 2% - 4% Spasm generalised: rare prialt Cramps of lower extremities Cramp muscle Muscle spasms primaquine Cramp muscle prochlorperazine Muscle spasms progesterone Cramps of lower extremities Cramp muscle: postmarketing, 15% - 20% Muscle spasms: 2.72% - 3.71% promethazine Muscle spasms propafenone hydrochloride Cramp muscle: postmarketing, 1% - 8% Muscle spasms propofol Cramp muscle: postmarketing propranolol Cramp muscle: postmarketing protriptyline Cramp muscle pyridostigmine Cramp muscle quetiapine (quetiapine fumarate) Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: 1% - 3% rabeprazole sodium Cramps of lower extremities Cramp muscle raloxifene Cramps of lower extremities: 5.9% - 7% Cramp muscle: 5.9% - 7% Muscle spasms ramipril Cramp muscle: postmarketing relpax Cramp muscle: 1% - 2% rifampin Cramp muscle rifapentine Muscle spasms rifaximin Muscle spasms riluzole Cramps of lower extremities: rare, infrequent Cramp muscle: rare, infrequent risedronate sodium Cramps of lower extremities Cramp muscle Muscle spasms: 1% - 2.3% risperidone Cramps of lower extremities: rare, infrequent Cramp muscle: rare, infrequent Muscle spasms: 6% - 25% ritonavir Cramps of lower extremities Cramp muscle rivaroxaban Muscle spasms rivastigmine Cramps of lower extremities: frequent Cramp muscle: infrequent, frequent Muscle spasms: infrequent rizatriptan (rizatriptan benzoate) Cramp muscle Muscle spasms rofecoxib Cramp muscle Muscle spasms roflumilast Muscle spasms ropinirole Cramps of lower extremities Cramp muscle: 3% Muscle spasms: frequent ropivacaine hydrochloride Cramp muscle salmeterol xinafoate Cramps of lower extremities Cramp muscle: 1% - 3% Muscle spasms: postmarketing, 1% - 3% secreflo Cramp muscle selegiline Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: infrequent Spasm generalised: infrequent sensipar Cramp muscle sertraline Cramps of lower extremities: infrequent Cramp muscle: infrequent simvastatin Cramp muscle: postmarketing singulair Cramp muscle: postmarketing sirolimus Cramps of lower extremities Cramp muscle sitagliptin (sitagliptin phosphate monohydrate) Muscle spasms sitaxsentan sodium Cramp muscle Muscle spasms sodium oxybate Cramps of lower extremities: frequent Cramp muscle: frequent spironolactone Cramp muscle sulindac Cramp muscle Muscle spasms sumatriptan (sumatriptan succinate) Cramp muscle tacrolimus Cramps of lower extremities Cramp muscle Muscle spasms Spasm generalised tadalafil Muscle spasms tamoxifen citrate Cramps of lower extremities Cramp muscle: 1% - 2% tekturna Muscle spasms telbivudine Cramp muscle telithromycin Cramp muscle: postmarketing telmisartan Cramps of lower extremities: postmarketing Cramp muscle: postmarketing terazosin Muscle spasms terbinafine Cramp muscle terbutaline Cramp muscle testosterone Cramp muscle thalidomide Cramps of lower extremities Cramp muscle thiothixene Muscle spasms tiagabine hydrochloride Cramps of lower extremities: infrequent Cramp muscle: infrequent Muscle spasms: infrequent Spasm generalised: infrequent timolol Muscle spasms: 0.6% tinidazole Cramp muscle tipranavir Cramp muscle tizanidine Muscle spasms topiramate Cramps of lower extremities Cramp muscle topotecan Cramp muscle tracleer Cramp muscle tramadol Cramps of lower extremities Cramp muscle Muscle spasms trandolapril Cramp muscle Muscle spasms tranexamic acid Cramp muscle trelstar Cramps of lower extremities: postmarketing Cramp muscle: postmarketing treprostinil (treprostinil sodium) Cramps of lower extremities Cramp muscle triazolam Cramp muscle trifluoperazine Muscle spasms trospium Cramp muscle trovafloxacin Cramp muscle urofollitropin Cramps of lower extremities Cramp muscle Muscle spasms ursodiol Cramps of lower extremities Cramp muscle valcyte Cramp muscle valproic acid Cramps of lower extremities: postmarketing Cramp muscle: postmarketing valrubicin Muscle spasms: 3% - 31% valsartan Cramp muscle vancomycin Muscle spasms varenicline Cramp muscle: frequent Muscle spasms: infrequent venlafaxine Cramps of lower extremities: infrequent Cramp muscle: rare, infrequent Muscle spasms: rare, infrequent, frequent venofer Cramps of lower extremities: postmarketing Cramp muscle: postmarketing verapamil Cramp muscle: postmarketing Muscle spasms vincristine Cramp muscle voriconazole Cramps of lower extremities: postmarketing Cramp muscle: postmarketing warfarin Cramp muscle zalcitabine Cramps of lower extremities Cramp muscle zelnorm Cramp muscle Muscle spasms: postmarketing zidovudine Cramp muscle Muscle spasms: postmarketing zoledronic acid Muscle spasms: 1.5% - 5.6% zolmitriptan Cramps of lower extremities Cramp muscle zolpidem Cramps of lower extremities: infrequent Cramp muscle: infrequent zonisamide Cramps of lower extremities Cramp muscle

Drugs with this indication epinephrine diatrizoic acid baclofen cyclobenzaprine dantrolene diazepam diltiazem dipivefrin hydrochloride hyoscine butylbromide hyoscyamine nifedipine papaverine ephedrine vigabatrin Corticotropin