CGP 19835A
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
Chills
|
Chills
|
very common, 89%
|
|
x
|
Body temperature increased
|
Body temperature increased
|
very common, 85%
|
|
x
|
Nausea
|
Nausea
|
very common, 57%
|
|
x
|
Asthenia
|
Fatigue
|
very common, 53%
|
|
x
|
Asthenia
|
very common, 13%
|
|
x
|
Fatigue
|
Fatigue
|
very common, 53%
|
|
x
|
Headache
|
Headache
|
very common, 50%
|
|
x
|
Tachycardia
|
Tachycardia
|
very common, 50%
|
|
x
|
Vomiting
|
Vomiting
|
very common, 44%
|
|
x
|
Myalgia
|
Myalgia
|
very common, 31%
|
|
x
|
Musculoskeletal discomfort
|
Myalgia
|
very common, 31%
|
|
x
|
Arthralgia
|
very common, 10%
|
|
x
|
Hypotension
|
Hypotension
|
very common, 29%
|
|
x
|
Hypertension
|
Hypertension
|
very common, 26%
|
|
x
|
Body temperature decreased
|
Body temperature decreased
|
very common, 23%
|
|
x
|
Hypothermia
|
Body temperature decreased
|
very common, 23%
|
|
x
|
Decreased appetite
|
Anorexia
|
very common, 21%
|
|
x
|
Decreased appetite
|
common
|
|
x
|
Cough
|
Cough
|
very common, 18%
|
|
x
|
Constipation
|
Constipation
|
very common, 17%
|
|
x
|
Dizziness
|
Dizziness
|
very common, 17%
|
|
x
|
Abdominal pain
|
Abdominal pain
|
very common
|
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
very common
|
|
x
|
Anaemia
|
Anaemia
|
very common
|
|
x
|
Back pain
|
Back pain
|
very common, 15%
|
|
x
|
Dyspnoea
|
Dyspnoea
|
common — 21%
|
|
x
|
Pain
|
Pain
|
very common, 15%
|
|
x
|
Diarrhoea
|
Diarrhoea
|
very common, 13%
|
|
x
|
Malaise
|
Malaise
|
very common, 13%
|
|
x
|
Discomfort
|
Malaise
|
very common, 13%
|
|
x
|
Feeling abnormal
|
Malaise
|
very common, 13%
|
|
x
|
Confusional state
|
common
|
|
x
|
Ill-defined disorder
|
Malaise
|
very common, 13%
|
|
x
|
Tachypnoea
|
Tachypnoea
|
very common, 13%
|
|
x
|
Pain in extremity
|
Pain in extremity
|
very common, 12%
|
|
x
|
Chest pain
|
Chest pain
|
very common, 11%
|
|
x
|
Chest discomfort
|
common
|
|
x
|
Hyperhidrosis
|
Hyperhidrosis
|
very common, 11%
|
|
x
|
Arthralgia
|
Arthralgia
|
very common, 10%
|
|
x
|
Abdominal distension
|
Abdominal distension
|
common
|
|
x
|
Agranulocytosis
|
Agranulocytosis
|
common
|
|
x
|
Alopecia
|
Alopecia
|
common
|
|
x
|
Anxiety
|
Anxiety
|
common
|
|
x
|
Cellulitis
|
Cellulitis
|
common
|
|
x
|
Neck pain
|
Neck pain
|
common
|
|
x
|
Musculoskeletal chest pain
|
Chest wall pain
|
common
|
|
x
|
Confusional state
|
Confusional state
|
common
|
|
x
|
Cyanosis
|
Cyanosis
|
common
|
|
x
|
Dehydration
|
Dehydration
|
common
|
|
x
|
Depression
|
Depression
|
common
|
|
x
|
Dysmenorrhoea
|
Dysmenorrhoea
|
common
|
|
x
|
Dyspepsia
|
Dyspepsia
|
common
|
|
x
|
Dysuria
|
Dysuria
|
common
|
|
x
|
Oedema
|
Oedema
|
common
|
|
x
|
Epistaxis
|
Epistaxis
|
common
|
|
x
|
Dermatitis
|
Rash
|
common
|
|
x
|
Rash
|
Rash
|
common
|
|
x
|
Flushing
|
Flushing
|
common
|
|
x
|
Haematuria
|
Haematuria
|
common
|
|
x
|
Haemoptysis
|
Haemoptysis
|
common
|
|
x
|
Herpes simplex
|
Herpes simplex
|
common
|
|
x
|
Hypoaesthesia
|
Hypoaesthesia
|
common
|
|
x
|
Hypokalaemia
|
Hypokalaemia
|
common
|
|
x
|
Lethargy
|
Lethargy
|
common
|
|
x
|
Leukopenia
|
Leukopenia
|
common
|
|
x
|
Nasal congestion
|
Nasal congestion
|
common
|
|
x
|
Nasopharyngitis
|
Nasopharyngitis
|
common
|
|
x
|
Pallor
|
Pallor
|
common
|
|
x
|
Palpitations
|
Palpitations
|
common
|
|
x
|
Paraesthesia
|
Paraesthesia
|
common
|
|
x
|
Pharyngitis
|
Pharyngitis
|
common
|
|
x
|
Phlebitis
|
Phlebitis
|
common
|
|
x
|
Pleural effusion
|
Pleural effusion
|
common
|
|
x
|
Pruritus
|
Pruritus
|
common
|
|
x
|
Musculoskeletal pain
|
Shoulder pain
|
common
|
|
x
|
Muscle spasms
|
Muscle spasms
|
common
|
|
x
|
Thrombocytopenia
|
Thrombocytopenia
|
common
|
|
x
|
Tinnitus
|
Tinnitus
|
common
|
|
x
|
Tremor
|
Tremor
|
common
|
|
x
|
Erythema
|
Erythema
|
common
|
|
x
|
Upper respiratory tract infection
|
Upper respiratory tract infection
|
common
|
|
x
|
Pollakiuria
|
Pollakiuria
|
common
|
|
x
|
Urinary tract infection
|
Urinary tract infection
|
common
|
|
x
|
Vertigo
|
Vertigo
|
common
|
|
x
|
Weight decreased
|
Weight decreased
|
common
|
|
x
|
Wheezing
|
Wheezing
|
common
|
|
x
|
Oedema peripheral
|
Oedema peripheral
|
common
|
|
x
|
Bone pain
|
Bone pain
|
common
|
|
x
|
Dry skin
|
Dry skin
|
common
|
|
x
|
Sinus congestion
|
Sinus congestion
|
common
|
|
x
|
Dyspnoea exertional
|
Dyspnoea exertional
|
common
|
|
x
|
Abdominal pain upper
|
Abdominal pain upper
|
common
|
|
x
|
Abdominal pain lower
|
Abdominal pain lower
|
common
|
|
x
|
Chest discomfort
|
Chest discomfort
|
common
|
|
x
|
Productive cough
|
Productive cough
|
common
|
|
x
|
Groin pain
|
Groin pain
|
common
|
|
x
|
Sepsis
|
Sepsis
|
common
|
|
x
|
Mucosal inflammation
|
Mucosal inflammation
|
common
|
|
x
|
Vision blurred
|
Vision blurred
|
common
|
|
x
|
Hepatic pain
|
Hepatic pain
|
common
|
|
x
|
Cancer pain
|
Cancer pain
|
common
|
|
x
|
Febrile neutropenia
|
Febrile neutropenia
|
common
|
|
x
|
Laryngeal pain
|
Pharyngolaryngeal pain
|
common
|
|
x
|
Procedural pain
|
Post procedural pain
|
common
|
|
x
|
Infusion site erythema
|
Infusion site erythema
|
common
|
|
x
|
Insomnia
|
Insomnia
|
common
|
|
x
|
Musculoskeletal stiffness
|
Musculoskeletal stiffness
|
common
|
|
x
|
Catheter site pain
|
Catheter site pain
|
common
|
|
x
|
Infusion site reaction
|
Infusion site reaction
|
common
|
|
x
|
Catheter site infection
|
Catheter site infection
|
common
|
|
x
|
Deafness
|
Hearing impaired
|
common
|
|
x
|
Hearing impaired
|
Hearing impaired
|
common
|
|
x
|
Somnolence
|
Somnolence
|
common
|
|
x
|
Mental disorder
|
Mental disorder
|
|
|
x
|
Breast disorder
|
Breast disorder
|
|
|
x
|
Neoplasm malignant
|
Neoplasm malignant
|
|
|
x
|
Infection
|
Infection
|
|
|
x
|
Connective tissue disorder
|
Connective tissue disorder
|
|
|
x
|
Cyst
|
Cyst
|
|
|
x
|
Eye disorder
|
Eye disorder
|
|
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
|
|
x
|
Cardiac disorder
|
Cardiac disorder
|
|
|
x
|
Hypersensitivity
|
Hypersensitivity
|
|
|
x
|
Immune system disorder
|
Immune system disorder
|
|
|
x
|
Acute myeloid leukaemia
|
Acute myeloid leukaemia
|
|
|
x
|
Acute leukaemia
|
Acute myeloid leukaemia
|
|
|
x
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
x
|
Myelodysplastic syndrome
|
Myelodysplastic syndrome
|
|
|
x
|
Neoplasm
|
Neoplasm
|
|
|
x
|
Nervous system disorder
|
Nervous system disorder
|
|
|
x
|
Polyp
|
Polyp
|
|
|
x
|
Convulsion
|
Convulsion
|
|
|
x
|
Thrombosis
|
Thrombosis
|
|
|
x
|
Urethral disorder
|
Urinary tract disorder
|
|
|
x
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
x
|
Angiopathy
|
Angiopathy
|
|
|
x
|
Blood creatinine increased
|
Creatinine increased
|
|
|
x
|
Malnutrition
|
Malnutrition
|
|
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
x
|
Hepatobiliary disease
|
Hepatobiliary disease
|
|
|
x
|
Respiratory distress
|
Respiratory distress
|
|
|
x
|
Grand mal convulsion
|
Tonic-clonic seizures
|
|
|
x
|
Infestation
|
Infestation NOS
|
|
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 131 |
Source: | EMA |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|