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Diclofenac

More information: STITCH, PubChem and possibly Wikipedia

ATC Codes: D11AX18, M01AB05, M02AA15, S01BC03

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 49 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Dry skin Dry skin postmarketing, 0% - 41.9% 0.301% - 6.86% x x
Gastrointestinal disorder Gastrointestinal disorder 6% - 9% 6% x x x x x x
Gastrointestinal symptom NOS x
Induration Induration 2% - 9% x
Upper respiratory tract infection Upper respiratory tract infection 8%
Skin exfoliation Skin exfoliation 4% - 24% x
Application site reaction Application site reaction 1.13% - 84% 0.904% - 2.17% x x x
Nasopharyngitis Nasopharyngitis 6%
Decreased appetite Anorexia common x x x x x x
Decreased appetite postmarketing, common x x
Appetite absent x
Flatulence Flatulence common, 2% - 3.84% 0% - 2% x x x x x x x x x x x x
Headache Headache postmarketing — 0% - 32.7% 2% - 26.9% x x x x x x x x x x x x x x x x x
Vertigo Vertigo common x x x x x x x x x x x
Vomiting Vomiting common, 3% - 9% 1% - 12% x x x x x x x x x x x x x x x x
Injection site reaction Injection site reaction common
Injection site pain Injection site pain common
Rash Eruption common x x
Rash postmarketing — 0% - 46% 1.51% - 2.86% x x x x x x x x x x x x x x
Transaminases increased Transaminases increased common x x x x
Injection site induration Injection site induration common
Dermatitis Rash postmarketing — 0% - 46% 1.51% - 2.86% x x x x x x x x x x x x x x
Dermatitis 1% - 2% x x x x
Malnutrition Malnutrition 2% - 8% x
Influenza Influenza 0% - 10% 4.57% x
Infection Infection 2.71% - 11.5% 2.41% - 4.57% x x x x x
Cough Cough 4% x
Cough increased x
Pharyngitis Pharyngitis postmarketing, 2% - 8% 3.92% - 6.86% x x
Pruritus Pruritus very rare — 1% - 59% 0.602% - 8% x x x x x x x x x x x x x x x x x
Osteoarthritis Osteoarthritis 2.6% - 5% x
Arthropathy 0% - 7.69% 12% - 15.4% x
Application site rash Application site rash 3.5% 0.685% x
Urinary tract infection Urinary tract infection 0.775% - 7%
Bronchitis Bronchitis 3% x
Diarrhoea Diarrhoea postmarketing — 0% - 6% 2.11% - 3% x x x x x x x x x x x x x x
Nausea Nausea postmarketing — 0% - 27% 0.904% - 37% x x x x x x x x x x x x x x x x x
Pain in extremity Pain in extremity 3% 1%
Abdominal pain upper Abdominal pain upper 3% 1% x
Stomach ache x
Epigastric pain x
Procedural pain Procedural pain 3%
Nervous system disorder Nervous system disorder 2% - 3% x x x x x
Ecchymosis Ecchymosis 2.09% 0.301% x x x x x
Abdominal pain Abdominal pain postmarketing — 0% - 5.93% 3.01% - 5.14% x x x x x x x x x x x x x x x
Abdominal cramps x x
Stomach ache x
Gastrointestinal pain Abdominal pain postmarketing — 0% - 5.93% 3.01% - 5.14% x x x x x x x x x x x x x x x
Arthralgia Arthralgia 0% - 40.4% 37.1% x
Musculoskeletal discomfort Arthralgia 0% - 40.4% 37.1% x
Myalgia postmarketing, 0% - 3% x x
Back pain Back pain postmarketing, 0% - 15.4% 7.43% x x
Dermatitis contact Dermatitis contact postmarketing, 0% - 33% 0% - 1.81% x x
Dyspepsia Dyspepsia postmarketing — 0% - 9.62% 1% - 4% x x x x x x x x x x x x x
Heartburn x x x
Pain Pain postmarketing, 0% - 30% 10.9% x x
Stinging x x
Rhinitis Rhinitis 2% x x x x
Abdominal discomfort Abdominal discomfort 2% x
Blood creatinine increased Blood creatinine increased 2% 0%
Creatinine increased postmarketing, 0% - 2% x x
Skin cancer Skin carcinoma 0% - 6%
Contusion Contusion 0.775% - 3%
Conjunctivitis Conjunctivitis 0% - 4% x x x x x x
Sinus congestion Sinus congestion 0.775% - 1.54%
Application site induration Application site induration 0.775% - 1.54%
Injury Accidental injury postmarketing, 0% - 4% 2.11% x x
Dizziness Dizziness postmarketing — 0% - 10% 0.5% - 16% x x x x x x x x x x x x x x x x x
Syncope x x x
Lightheadedness x
Paraesthesia Paraesthesia very rare — 0% - 20% 0.904% - 10.3% x x x x x x x x x x x x x
Tingling sensation x
Myalgia Myalgia postmarketing, 0% - 3% x x
Somnolence Somnolence rare, 1% 1% - 1.83% x x x x x x x x
Drowsiness postmarketing, rare x x x x x x x x x
Application site pruritus Application site pruritus 0.767% 0.114% x
Arthritis Rheumatoid arthritis 0.7% x
Arthritis x
Rheumatoid arthritis Rheumatoid arthritis 0.7% x
Application site erythema Application site erythema 0.657% 0.342% x
Breath odour Breath odour postmarketing, 1.21% 0.301% x x
Sinusitis Sinusitis 0% - 5% 0.602% - 1% x x
Application site paraesthesia Application site paraesthesia 0.548% 0.342% x
Dysgeusia Dysgeusia very rare — 0% - 3.81% 4.57% x x x x x
Bad taste x
Hypercholesterolaemia Hypercholesterolaemia 0% - 2% x
Hyperaesthesia Hyperaesthesia 0% - 3%
Hyperglycaemia Hyperglycaemia 0% - 2% x x x
Skin ulcer Skin ulcer 0% - 2%
Migraine Migraine 0% - 2%
Blood creatine phosphokinase increased Creatine phosphokinase increased 0% - 4%
Rash pustular Vesiculobullous rash 0% - 4% x
Rash pustular x
Dermatitis bullous Vesiculobullous rash 0% - 4% x
Dermatitis bullous very rare x x
Bullous eruption very rare x x x x x x
Scab Scab 1%
Acne Acne 0% - 4%
Application site dryness Application site dryness 0.438% 0.342% x x
Application site vesicles Application site vesicles 0.329% 0% x
Application site irritation Application site irritation common, 0.219% 0% x x
Flushing Flushing 0.2% x
Application site papules Application site papules 0.11% 0% x
Asthma Asthma postmarketing — 0% - 2% x x x x x x x x x x x x x
Exacerbation of asthma x
Cardiovascular disorder Cardiovascular disorder postmarketing x x
Dyspnoea Dyspnoea postmarketing — 0% - 2% x x x x x x x x x x x
Ear pain Ear pain postmarketing x x
Oedema Oedema postmarketing — 0% - 33% 0% - 32% x x x x x x x x x x x x x x
Eye disorder Eye disorder postmarketing x x x x x x
Gastritis Gastritis rare x x x x x x x x x
Gastroenteritis Gastroenteritis postmarketing x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage rare x x x x x x x x x x
Haematemesis Haematemesis rare x x x x x x x x x
Haemorrhage Haemorrhage rare x x x x x x x x x x x x
Haemoglobin Haemorrhage rare x x x x x x x x x x x x
Hepatitis Hepatitis rare x x x x x x x x x x x
Hypersensitivity Hypersensitivity postmarketing — 0% - 3% x x x x x x x x x x x x
Hypotension Hypotension rare x x x x x x x x x x x
Jaundice Jaundice rare x x x x x x x x x x x
Laryngospasm Laryngospasm postmarketing x x
Laryngitis Laryngitis postmarketing x x
Muscle spasms Cramps of lower extremities postmarketing x x
Cramp muscle x
Lethargy Lethargy postmarketing x
Liver disorder Liver disorder rare x x x x
Hepatocellular injury Liver disorder rare x x x x
Foetor hepaticus Liver disorder rare x x x x
Melaena Melaena rare x x x x x x x x x x x
Proctitis Proctitis rare x
Shock Shock rare x x x x
Syncope x x x
Mouth ulceration Ulcerative stomatitis postmarketing x x
Mouth ulceration postmarketing x x
Swelling Swelling postmarketing x
Urticaria Urticaria postmarketing — 0.2% x x x x x x x x x x x x x x
Dry mouth Dry mouth postmarketing x x x x x x x
Skin odour abnormal Body odor postmarketing x x
Cataract Cataract postmarketing x
Stomatitis Mouth ulceration postmarketing x x
Stomatitis very rare x x x x x x x x x
Musculoskeletal stiffness Neck stiffness postmarketing x x
Nuchal rigidity Neck stiffness postmarketing x x
Diarrhoea haemorrhagic Diarrhoea haemorrhagic rare x x x x x x x
Injection site necrosis Injection site necrosis rare
Drug ineffective Lack of drug effect postmarketing x x
Eye pain Eye pain postmarketing, 0% - 2% x x
Skin discolouration Skin discolouration postmarketing x x
Intestinal ulcer Intestinal ulcer rare x
Swollen tongue Swollen tongue postmarketing
Gastrointestinal ulcer Gastrointestinal ulcer rare x x x x
Lip swelling Lip swelling postmarketing x
Skin burning sensation Skin burning sensation postmarketing
Rectal haemorrhage Rectal haemorrhage postmarketing x x x x x
Anaphylactic shock Anaphylactoid reaction rare x x x x x x x
Anaphylactic shock x x x x x
Anaphylactoid reaction Anaphylactoid reaction rare x x x x x x x
Blood pressure increased Blood pressure increased postmarketing
Visual impairment Abnormal vision postmarketing x x x x x
Visual disturbance very rare x x x
Visual impairment very rare x x x x
Agranulocytosis Agranulocytosis very rare x x x x x x x x x x x
Alopecia Alopecia very rare, 0% - 2% x x x x x x x x x x x
Anaemia Anaemia very rare x x x x x x x x x
Secondary anemia x
Aplastic anaemia Aplastic anaemia very rare x x x x x x x x x x x
Haemolytic anaemia Haemolytic anaemia very rare x x x x x x x
Angioedema Angioedema very rare x x x x x x x x
Anxiety Anxiety very rare, 0% - 2% x x x x x x x x x x x
Chest pain Chest pain very rare — 0% - 2% x x x x x x x x
Colitis Colitis very rare x x x x x x x x x
Colitis ulcerative Colitis ulcerative very rare x x x x x x x
Proctocolitis Colitis ulcerative very rare x x x x x x x
Constipation Constipation very rare, 0% - 8% 0.301% - 4% x x x x x x x x x x x x x x
Crohn's disease Crohn's disease very rare x x x x x x x
Dermatitis exfoliative Dermatitis exfoliative very rare x x x x x x x x x x
Diplopia Diplopia very rare x x x x x x x
Eczema Eczema very rare, postmarketing x x x x x x x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis very rare x x x x x x x x x x x
Erythema multiforme Erythema multiforme very rare x x x x x x x x x x x x
Stevens-Johnson syndrome very rare x x x x x x x x x x x x
Oesophageal disorder Oesophageal disorder very rare x x x x
Glossitis Glossitis very rare x x x x x x x x x
Cardiac failure Cardiac failure very rare x x x x x x
Haematuria Haematuria very rare, 0% - 2% x x x x x x x x x x x
Haemorrhoids Haemorrhoids very rare x
Hemorrhoids aggravated very rare x
Hypertension Hypertension very rare — 0% - 3% 1% x x x x x x x x x x x
Irritability Irritability very rare x x x x x x x x
Renal failure acute Renal failure acute very rare x x x x x x x x
Renal papillary necrosis Renal papillary necrosis very rare x x x x x x x x
Leukopenia Leukopenia very rare x x x x x x x x x
Meningitis aseptic Meningitis aseptic very rare x x x x x x x
Myocardial infarction Myocardial infarction very rare x x x x x x x x x
Acute coronary syndrome Myocardial infarction very rare x x x x x x x x x
Tubulointerstitial nephritis Nephritis interstitial very rare x x x x x x x x x
Tubulointerstitial nephritis very rare x x
Nephrotic syndrome Nephrotic syndrome very rare x x x x x x x x
Nightmare Nightmare very rare x x x x x x x
Palpitations Palpitations very rare, postmarketing x x x x x x x x x x x x x
Pancreatitis Pancreatitis very rare x x x x x x x x x x
Pneumonia Pneumonia very rare, 0% - 2% x x x x x x x x x x
Proteinuria Proteinuria very rare x x x x x x x x x x x
Protein urine present Proteinuria very rare x x x x x x x x x x x
Psychotic disorder Psychotic disorder very rare x x x x x x x x
Purpura Purpura very rare x x x x x x x x x
Purpuric rash
Vascular purpura Purpura very rare x x x x x x x x x
Henoch-Schonlein purpura Henoch-Schonlein purpura very rare x x x x x x x
Convulsion Convulsion very rare x x x x x x x x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome very rare x x x x x x x x x x x x
Cerebrovascular accident Cerebrovascular accident very rare x x x x
Thrombocytopenia Thrombocytopenia very rare x x x x x x x x x x x
Tinnitus Tinnitus very rare x x x x x x x x x x x
Tremor Tremor very rare x x x x x x x x x x x
Erythema Erythema very rare — 4% x x x x x x x x x x
Redness
Vasculitis Vasculitis very rare x x x x x x x x x x
Encephalopathy Encephalopathy very rare x x
Hepatic failure Hepatic failure very rare x x x x x
Injection site abscess Injection site abscess very rare
Enterocolitis haemorrhagic Hemorrhagic colitis very rare x x x x x x x
Hepatic necrosis Hepatic necrosis very rare x x x x
Photosensitivity reaction Photosensitivity reaction very rare, 0% - 3% x x x x x x
Photosensitivity x x x x x
Disorientation Disorientation very rare x x x x x x x x
Memory impairment Memory impairment very rare x x x x x x
Erectile dysfunction Erectile dysfunction very rare x x
Hepatitis fulminant Hepatitis fulminant very rare, rare x x x x x x x x
Vision blurred Vision blurred very rare, postmarketing x x x x x x x x x x x x x x x
Face oedema Face oedema very rare, postmarketing x x x x x x x
Toxic shock syndrome Toxic shock syndrome very rare x
Insomnia Insomnia very rare x x x x x x x x x x x x x x x
Deafness Hearing impaired very rare x x x x x x x x
Hearing impaired Hearing impaired very rare x x x x x x x x
Partial hearing loss x x
Intestinal diaphragm disease Intestinal diaphragm disease very rare x x
Abdominal distension Abdominal distension x
Amblyopia Amblyopia x x
Angina pectoris Angina pectoris x x
Aphasia Aphasia x
Arrhythmia Arrhythmia x x x x x x
Arteriosclerosis Arteriosclerosis x
Asthenia Asthenia postmarketing, 0% - 2% x x x x x x x x
Fatigue x x x
Mental disorder Mental disorder x x x x
Bronchospasm Bronchospasm x x
Neoplasm malignant Carcinoma x
Neck pain Neck pain 0% - 2% x
Tongue coated Tongue coated x x
Coma Coma x x x
Confusional state Confusional state x x x x
Feeling abnormal Confusional state x x x x
Malaise x x x x x x x
Conjunctivitis allergic Conjunctivitis allergic x
Corneal disorder Corneal disorder x
Corneal oedema Corneal oedema x x x
Corneal opacity Corneal opacity x x x
Ulcerative keratitis Ulcerative keratitis x x
Cystitis Cystitis x x x
Bladder pain Cystitis x x x
Cystitis noninfective Cystitis x x x
Dental caries Dental caries x
Depression Depression x
Dysmenorrhoea Dysmenorrhoea x
Dysthymic disorder Dysthymic disorder x
Dysuria Dysuria x x x
Eosinophilia Eosinophilia x x x x
Epistaxis Epistaxis x x
Eructation Eructation x x x
Oesophagitis Oesophagitis x x x
Fatigue Fatigue x x x
Body temperature increased Body temperature increased x x x x x x x
Vitreous floaters Vitreous floaters x
Furuncle Furunculosis x
Gingivitis Gingivitis x
Gout Gout x
Hair disorder Hair disorder x
Hallucination Hallucination x x x
Cardiac disorder Cardiac disorder x x x x
Cardiac failure congestive Cardiac failure congestive x x x x x
Hepatorenal syndrome Hepatorenal syndrome x
Hernia Hernia x
Herpes simplex Herpes simplex 0% - 2%
Hyperventilation Hyperventilation x
Hypoaesthesia Hypoaesthesia x
Hypoglycaemia Hypoglycaemia x
Immune system disorder Immune system disorder x x x x
Intestinal perforation Intestinal perforation x
Iritis Iritis x x x
Eye pruritus Eye pruritus x
Arthropathy Arthropathy 0% - 7.69% 12% - 15.4% x
Keratitis Keratitis x x x
Lacrimal disorder Lacrimal disorder x x x
Lacrimal structural disorder Lacrimal disorder x x x
Laryngeal oedema Laryngeal oedema x
Mediastinal disorder Mediastinal disorder x x x x
Meningitis Meningitis x x x
Hypertonia Hypertonia x
Nail disorder Nail disorder x
Nervousness Nervousness x x x x
Tension Nervousness x x x x
Neuritis Neuritis x
Neuropathy peripheral Neuritis x
Night blindness Night blindness x
Nocturia Nocturia x
Oliguria Oliguria x x x x
Pancytopenia Pancytopenia x x x
Peptic ulcer Peptic ulcer x x x x x x
Tooth abscess Abscess periodontal x
Phlebitis Phlebitis 0% - 2%
Polyuria Polyuria x x x
Urine output increased Polyuria x x x
Anorectal disorder Rectal disorder x
Renal failure Renal failure x x x
Scotoma Scotoma x
Seborrhoeic dermatitis Seborrhoeic dermatitis
Skin mass Skin nodule 0% - 2% x
Speech disorder Speech disorder x
Aphthous stomatitis Aphthous stomatitis x x
Hyperhidrosis Sweating x
Sweating increased 0.612% x x x
Syncope Syncope x x x
Loss of consciousness Syncope x x x
Tachycardia Tachycardia x x x x
Testicular disorder Testicular disorder x
Thirst Thirst x
Toothache Toothache
Ulcer Ulcer x x x x x x
Pollakiuria Pollakiuria x
Urethral disorder Urinary tract disorder x x x x
Urinary tract disorder Urinary tract disorder x x x x
Angiopathy Angiopathy x x x x
Vasodilation procedure Vasodilation x x
Viral infection Viral infection x x x
Weight increased Weight increased x
Weight decreased Weight decreased x
Wheezing Wheezing x
Chills Chills 0% - 2% x x x x
Burning sensation Burning sensation x
Oedema peripheral Oedema peripheral x
Hypokinesia Hypokinesia 0% - 2%
Hepatic function abnormal Hepatic function abnormal x
Bleeding time prolonged Bleeding time prolonged x x x
Ventricular extrasystoles Ventricular extrasystoles x
Hyperchlorhydria Hyperchlorhydria x x
Gastric pH decreased Hyperchlorhydria x x
Skin hypertrophy Skin hypertrophy
Renal impairment Kidney function abnormal x x x
Bone pain Bone pain x
Aspartate aminotransferase increased Aspartate aminotransferase increased 0% - 3%
Alanine aminotransferase increased Alanine aminotransferase increased 0% - 4% 0%
Skin irritation Skin irritation
Endophthalmitis Ocular hyperaemia x
Ocular hyperaemia Ocular hyperaemia x
Corneal deposits Corneal deposits x x x
Eyelid oedema Eyelid oedema x
Swelling of eyelid x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x x x x
Prostatic specific antigen increased Prostatic specific antigen increased x
Malaise Malaise x x x x x x x
Discomfort Malaise x x x x x x x
Ill-defined disorder Malaise x x x x x x x
Thinking abnormal Thinking abnormal x
Mental disability Thinking abnormal x
Cerebration impaired x x
Respiratory depression Respiratory depression x x x
Pulmonary function test decreased Respiratory depression x x x
Disturbance in attention Cerebration impaired x x
Eye irritation Eye irritation x
Hepatic enzyme increased Hepatic enzyme increased x x x
Erythema of eyelid Erythema of eyelid x
Azotaemia Azotaemia x
Sepsis Sepsis x x x
Punctate keratitis Punctate keratitis x x x
Hepatobiliary disease Hepatobiliary disease x x x x
Fluid retention Fluid retention x
Water retention x
Epidermolysis Epidermolysis x
Atrophy Atrophy x
Corneal perforation Corneal perforation x x
Corneal erosion Corneal erosion x x
Platelet count decreased Platelet count decreased x
Lacrimation increased Lacrimation x x
Rash maculo-papular Rash maculo-papular 0% - 2% x
Agitation Hyperkinesia x
Hyperkinesia Hyperkinesia x
Bradycardia Bradycardia x
Lymphadenopathy Lymphadenopathy x x x
Coordination abnormal Coordination abnormal x
Gait disturbance Gait disturbance x
Blood creatinine abnormal Creatinine abnormal NOS x
Eyelids pruritus Eyelids pruritus x
Infestation Infestation NOS
Sleep disorder Sleep disorder x
Eye allergy Eye allergy x
Corneal infiltrates Corneal infiltrates x x
Dermatitis atopic Allergic skin reaction x x
Muscular weakness Myasthenia x
Corneal thinning Corneal thinning x x
Excoriation Abrasion NOS x
Conjunctival hyperaemia Conjunctival hyperaemia x
Vaginal haemorrhage Vaginal haemorrhage x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

DICLOFENAC

Side effects:6
Source:FDA Structured Product Label

DICLOFENAC

Side effects:9
Source:FDA Structured Product Label

Diclofenac

Side effects:13
Source:FDA Structured Product Label

Diclofenac

Side effects:16
Source:FDA Structured Product Label

diclofenac

Side effects:23
Source:FDA Structured Product Label

DICLOFENAC

Side effects:32
Source:FDA Structured Product Label

DICLOFENAC SODIUM / VOLTAREN OPHTHA

Side effects:46
Source:Health Canada

DICLOFENAC

Side effects:61
Source:FDA Structured Product Label

DICLOFENAC POTASSIUM / SANDOZ-DICLOFENAC RAPIDE

Side effects:91
Source:Health Canada

Diclofenac

Side effects:98
Source:FDA Structured Product Label

diclofenac

Side effects:100
Source:FDA Structured Product Label

DICLOFENAC

Side effects:101
Source:FDA Structured Product Label

Diclofenac sodium / DICLOFENAC TABLETS

Side effects:104
Source:medicines.org.au

Diclofenac

Side effects:105
Source:FDA Structured Product Label

VOLTAREN / Voltaren, Suppository

Side effects:109
Source:Medsafe

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label