Cardiac failure

Definition: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Synonyms (terms occurring on more labels are shown first): heart failure, cardiac failure, cardiac insufficiency, HEART FAILURES, weak heart, cardiac failure NOS

More information: PubMed search and possibly Wikipedia or Medpedia

Proteins predicted to cause Cardiac failure: CYP2C9, PTGS2 (inhibition), DRD5 (activation) (19 predictions in total) Show drugs for which this side effect directly occurs

Drugs with this side effect as MedDRA Preferred Term Corticotropin Cardiac failure: postmarketing Imagent Cardiac failure Pentostatin Cardiac failure Raltitrexed Cardiac failure Tacrine Hydrochloride Capsules Cardiac failure: infrequent Tolcapone Cardiac failure acamprosate calcium Cardiac failure: rare acebutolol (acebutolol hydrochloride) Cardiac failure allopurinol Cardiac failure alprostadil Cardiac failure amantadine Cardiac failure ambrisentan Cardiac failure: postmarketing amiodarone Cardiac failure: 2% - 2.21% amphotericin b Cardiac failure amsacrine Cardiac failure anagrelide hydrochloride Cardiac failure apomorphine Cardiac failure aprotinin Cardiac failure: postmarketing aripiprazole Cardiac failure: infrequent arsenic trioxide Cardiac failure atenolol Cardiac failure: 0.01% - 24% azacitidine Cardiac failure azilect Cardiac failure: infrequent bendamustine Cardiac failure betaxolol Cardiac failure bexarotene Cardiac failure bicalutamide Cardiac failure bisoprolol fumarate Cardiac failure: postmarketing bortezomib Cardiac failure: postmarketing bromazepam Cardiac failure bromocriptine Cardiac failure buspirone Cardiac failure: rare busulfan Cardiac failure cabergoline Cardiac failure capecitabine Cardiac failure carbamazepine Cardiac failure: rare carboplatin Cardiac failure: postmarketing carteolol Cardiac failure cefaclor Cardiac failure cefdinir Cardiac failure: postmarketing cefpodoxime Cardiac failure celecoxib Cardiac failure: postmarketing cetirizine Cardiac failure cidofovir anhydrous Cardiac failure cilazapril (cilazapril monohydrate) Decompensation cardiac citalopram Cardiac failure: postmarketing, infrequent clomipramine Cardiac failure: rare clonazepam Cardiac failure clonidine Cardiac failure clozapine Cardiac failure: postmarketing cortisone Cardiac failure cubicin Cardiac failure cyanocobalamin Cardiac failure cyclophosphamide Cardiac failure: postmarketing Decompensation cardiac cycloserine Cardiac failure cyclosporine Cardiac failure: postmarketing cyproterone acetate Cardiac failure dantrolene Cardiac failure daunorubicin Cardiac failure decitabine Cardiac failure: 5.05% deferiprone Cardiac failure delavirdine mesylate Cardiac failure desipramine Cardiac failure dexamethasone Cardiac failure dextrose Cardiac failure diazepam Cardiac failure diazoxide Cardiac failure diclofenac Cardiac failure: postmarketing diltiazem Cardiac failure disopyramide Cardiac failure docetaxel Cardiac failure dofetilide Cardiac failure donepezil Cardiac failure: infrequent, frequent doxazosin Cardiac failure doxorubicin hydrochloride Cardiac failure duloxetine Cardiac failure: rare, infrequent efavirenz Cardiac failure: postmarketing epoprostenol sodium Cardiac failure eprosartan (eprosartan mesylate) Cardiac failure: postmarketing eptifibatide Cardiac failure esmolol hydrochloride Cardiac failure: postmarketing estramustine phosphate sodium Cardiac failure etodolac Cardiac failure: postmarketing etoposide Cardiac failure exemestane Cardiac failure felbamate Cardiac failure fenoldopam Cardiac failure fexofenadine hydrochloride Cardiac failure: postmarketing flecainide Cardiac failure fludarabine Cardiac failure: postmarketing fludrocortisone Cardiac failure fluorouracil Cardiac failure fluoxetine Cardiac failure: infrequent flurbiprofen Cardiac failure: postmarketing fluvoxamine maleate Cardiac failure: infrequent fondaparinux sodium Cardiac failure: postmarketing formoterol fumarate Cardiac failure fosphenytoin sodium Cardiac failure gabapentin Cardiac failure: rare, infrequent gadobenic acid Cardiac failure gadodiamide Cardiac failure galantamine Cardiac failure: infrequent gemcitabine Cardiac failure: postmarketing glatiramer acetate Cardiac failure: postmarketing gliclazide Cardiac failure goserelin Cardiac failure: 1% - 5% guanfacine Cardiac failure: postmarketing heparin Cardiac failure hydrocortisone Cardiac failure hydromorphone Cardiac failure ibuprofen Cardiac failure: postmarketing ibutilide Cardiac failure ifosfamide Cardiac failure iloprost Cardiac failure imatinib mesylate Cardiac failure: postmarketing, infrequent imipramine Cardiac failure imiquimod Cardiac failure: postmarketing indomethacin Cardiac failure insulin recombinant human Cardiac failure invanz Cardiac failure iodine Cardiac failure iodixanol Cardiac failure: postmarketing iopamidol Decompensation cardiac iopromide Cardiac failure: postmarketing ioversol Decompensation cardiac ioxaglic acid Decompensation cardiac irbesartan Cardiac failure isosorbide-5-mononitrate Cardiac failure itraconazole Cardiac failure ketoprofen Cardiac failure: postmarketing ketorolac Cardiac failure labetalol Cardiac failure lenalidomide Cardiac failure letrozole Cardiac failure: postmarketing leuprolide acetate Cardiac failure levobunolol Cardiac failure levofloxacin Cardiac failure levothyroxine Cardiac failure linezolid Cardiac failure liothyronine Cardiac failure mannitol Cardiac failure Decompensation cardiac maraviroc Cardiac failure maxaquin Cardiac failure mefenamic acid Cardiac failure megestrol Cardiac failure meloxicam Cardiac failure: postmarketing memantine hydrochloride Cardiac failure: postmarketing, frequent meropenem Cardiac failure methadone Cardiac failure methyldopa Cardiac failure methylnaltrexone bromide Cardiac failure methylprednisolone Cardiac failure metoclopramide Cardiac failure: postmarketing mexiletine Cardiac failure: postmarketing mirtazapine Cardiac failure: rare mitomycin Cardiac failure mitoxantrone Cardiac failure moricizine Cardiac failure moxifloxacin hydrochloride Cardiac failure mycophenolic acid Cardiac failure nadolol Cardiac failure naltrexone Cardiac failure: postmarketing naproxen Cardiac failure: postmarketing nefazodone Cardiac failure: rare nexavar Cardiac failure nifedipine Cardiac failure nilotinib (nilotinib hydrochloride monohydrate) Cardiac failure nilutamide Cardiac failure nimodipine Cardiac failure nisoldipine Cardiac failure octreotide (octreotide acetate) Cardiac failure olanzapine Cardiac failure: rare, infrequent oxaprozin Cardiac failure oxcarbazepine Cardiac failure oxycodone Cardiac failure paclitaxel Cardiac failure: postmarketing pantoprazole Cardiac failure paroxetine Cardiac failure: rare, postmarketing penicillin g Cardiac failure pergolide mesylate Cardiac failure: frequent phenytoin Cardiac failure pindolol Cardiac failure: 1% piroxicam Cardiac failure plavix Cardiac failure porfimer sodium Cardiac failure posaconazole Cardiac failure pramipexole dihydrochloride monohydrate Cardiac failure: postmarketing prednisolone Cardiac failure prednisone Cardiac failure pregabalin Cardiac failure: postmarketing, infrequent procainamide hydrochloride Cardiac failure propafenone hydrochloride Cardiac failure: 1% - 4% propofol Cardiac failure: postmarketing propoxyphene Cardiac failure propranolol Cardiac failure: postmarketing quetiapine (quetiapine fumarate) Cardiac failure: rare refludan Cardiac failure repaglinide Cardiac failure: postmarketing riluzole Cardiac failure: infrequent rimantadine Cardiac failure rivastigmine Cardiac failure: frequent rofecoxib Cardiac failure: postmarketing ropinirole Cardiac failure: infrequent rosiglitazone maleate Cardiac failure: postmarketing rotigotine Cardiac failure selegiline Cardiac failure sensipar Cardiac failure: postmarketing sildenafil Cardiac failure sirolimus Cardiac failure sitaxsentan sodium Cardiac failure sotalol hydrochloride Cardiac failure: postmarketing, 1% sprycel Cardiac failure: 0% - 4% sulindac Cardiac failure sutent Cardiac failure tacrolimus Cardiac failure telmisartan Cardiac failure: postmarketing terazosin Cardiac failure thalidomide Cardiac failure tigecycline Cardiac failure timolol Cardiac failure: 3% - 8% tizanidine Cardiac failure: rare tolmetin sodium Cardiac failure toremifene Cardiac failure tracleer Cardiac failure: postmarketing trazodone Cardiac failure: postmarketing treprostinil (treprostinil sodium) Cardiac failure tretinoin Cardiac failure triamcinolone Cardiac failure troglitazone Cardiac failure trusopt Cardiac failure ursodiol Cardiac failure valdecoxib Cardiac failure venlafaxine Cardiac failure: rare venofer Cardiac failure: postmarketing verapamil Cardiac failure voriconazole Cardiac failure: postmarketing zalcitabine Cardiac failure zidovudine Cardiac failure zinecard Cardiac failure zonisamide Cardiac failure

Drugs with this indication enoxaparin sodium epinephrine doxorubicin hydrochloride acetazolamide amlodipine benazepril bumetanide candesartan cilexetil captopril carvedilol chlorothiazide chlorthalidone cilazapril (cilazapril monohydrate) digoxin enalapril sodium ethacrynic acid fosinopril sodium furosemide hydrochlorothiazide hydroflumethiazide idarubicin indapamide inamrinone isoproterenol lisinopril metolazone metoprolol milrinone nitroglycerin pamidronate disodium phenobarbital pioglitazone (pioglitazone hydrochloride) polythiazide quinapril ramipril spironolactone trandolapril triamterene valsartan amiloride dobutamine torsemide perindopril erbumine zoledronic acid nebivolol eplerenone conivaptan hydrochloride tolvaptan streptokinase natrecor