Pamidronate disodium

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 18)
1 2 3 4 5 6 7 8 9 10
Nausea def Nausea def rare, 0% - 63.5% 37.4% - 59.1% x x x x x x x x x
Anaemia def Anaemia def postmarketing — 0% - 47.8% 36.8% - 41.7% x x x x x x x x x
Vomiting def Vomiting def rare, 0% - 46.3% 19.8% - 39.1% x x x x x x x x x
Asthenia def Fatigue def 0% - 40.3% 28.3% - 29% x x x x x x x x x
Asthenia def 16.1% - 25.6% 17.1% - 19.2% x x x x x x x x
Fatigue def Fatigue def 0% - 40.3% 28.3% - 29% x x x x x x x x x
Body temperature increased def Body temperature increased def 18% - 38.5% 32.1% - 38% x x x x x x x x x
Constipation def Constipation def rare, 0% - 36% 31.7% - 38.6% x x x x x x x x x
Dyspnoea def Dyspnoea def postmarketing — 0% - 35.1% 21.4% - 24.4% x x x x x x x x x x
Infection def Infection def postmarketing — 0% - 32.2% 9.1% - 28.3% x x x x x x x x x
Respiratory tract infection def Respiratory tract infection def 0% - 32.2% 20.2% - 28.3% x x x
Upper respiratory tract infection def Upper respiratory tract infection def 0% - 32.2% 20.2% - 28.3% x x x
Decreased appetite Anorexia def rare, 1% - 31.1% 17.1% - 24.9% x x x x x x x x x
Diarrhoea def Diarrhoea def rare, 0% - 29.4% 26.8% - 30.6% x x x x x x x x x
Headache def Headache def rare, 24.4% - 27.2% 19.8% - 23.6% x x x x x x x x x
Myalgia def Myalgia def rare, 0% - 26.4% 15% - 22.5% x x x x x x x x x
Musculoskeletal discomfort Myalgia def rare, 0% - 26.4% 15% - 22.5% x x x x x x x x x
Arthralgia def rare, 10.7% - 15.3% 7% - 12.7% x x x x x x x x x
Cough def Cough def 25.3% - 26.3% 19.7% - 22.5% x x x x x x x x
Insomnia def Insomnia def rare, 0% - 25.1% 17.2% - 19.4% x x x x x x x x x
Abdominal pain def Abdominal pain def rare, 0% - 24.3% 16% - 18.1% x x x x x x x x x
Gastrointestinal pain def Abdominal pain def rare, 0% - 24.3% 16% - 18.1% x x x x x x x x x
Dyspepsia def Dyspepsia def rare, 0% - 22.6% 13.4% - 17.5% x x x x x x x x x
Agranulocytosis def Agranulocytosis def 19.3% - 20.5% 15.5% - 20.5% x x x x x x x
Urinary tract infection def Urinary tract infection def 15.6% - 20.2% 9.1% - 17.6% x x x x x x x x
Anxiety def Anxiety def 0% - 18% 9.1% - 16.8% x x x x x x
Hypokalaemia def Hypokalaemia def rare, 4% - 18% x x x x x x x x x
Hypophosphataemia def Hypophosphataemia def rare, 0% - 18% x x x x x x x x x
Thrombocytopenia def Thrombocytopenia def rare, 0% - 16.6% 14% - 17.1% x x x x x x x x x
Sinusitis def Sinusitis def 14.6% - 16.1% 10.4% - 16.6% x x x x x x
Arthralgia def Arthralgia def rare, 10.7% - 15.3% 7% - 12.7% x x x x x x x x x
Effusion def Effusion def 2.9% - 15% 4.3% - 9.1% x x x x x x
Pleural disorder def Pleural disorder def 2.9% - 15% 4.3% - 9.1% x x x x x x
Pleural effusion def Pleural effusion def 2.9% - 15% 4.3% - 9.1% x x x x x x
Hypocalcaemia def Hypocalcaemia def rare, 0% - 12% x x x x x x x x x
Hypomagnesaemia def Hypomagnesaemia def rare, 4% - 12% x x x x x x x x x
Atrial fibrillation def Atrial fibrillation def 0% - 6% x x x x x
Candidiasis def Candidiasis def 0% - 6% x x x x x x
Gastrointestinal haemorrhage def Gastrointestinal haemorrhage def 0% - 6% x x x
Haemorrhage def Haemorrhage def 0% - 6% x x x x x x
Haemoglobin def Haemorrhage def 0% - 6% x x x x x x
Hypertension def Hypertension def 0% - 6% x x x x x x x x x
Hypothyroidism def Hypothyroidism def 0% - 6% x x x x x
Rales Rales 0% - 6% x x x x x
Rhinitis def Rhinitis def 0% - 6% x x x x x
Dizziness def Syncope def 0% - 6% x x x x x
Dizziness def rare x x x x x x x x
Shock def Syncope def 0% - 6% x x x x x
Shock def postmarketing, rare x x x x x x x x x
Syncope def Syncope def 0% - 6% x x x x x
Loss of consciousness def Syncope def 0% - 6% x x x x x
Tachycardia def Tachycardia def 0% - 6% x x x x x
Cardiac fibrillation Cardiac fibrillation 0% - 6% x x x x x
Somnolence def Somnolence def rare, 0% - 6% x x x x x x x x
Leukopenia def Leukopenia def rare, 0% - 4% x x x x x x x x
Psychotic disorder def Psychotic disorder def 0% - 4% x x x x x
Azotaemia def Uremia def 0% - 4% x x x x x
Atrial flutter def Atrial flutter def 0% - 1% x x x x x
Oedema def Oedema def rare, 0% - 1% x x x x x x x x x
Cardiac flutter Cardiac flutter 0% - 1% x x x x x
Neutropenia def Neutropenia def 0% - 1% x x x x x
Stomatitis def Stomatitis def 0% - 1% x x x x x x
Anaphylactic shock def Anaphylactic shock def postmarketing, rare x x x x x x x x x
Anaphylactoid reaction rare x x
Angioedema def Angioedema def postmarketing x x x x x x x
Bronchospasm def Bronchospasm def rare x x x
Confusional state def Confusional state def postmarketing, rare x x x x x
Feeling abnormal Confusional state def postmarketing, rare x x x x x
Malaise def x x x x x x x x
Conjunctivitis def Conjunctivitis def postmarketing, rare x x x x
Episcleritis Episcleritis rare x x x x x x x x x
Dermatitis def Rash def postmarketing, rare x x x x x
Rash def Rash def postmarketing, rare x x x x x
Gastritis def Gastritis def rare x x x
Focal segmental glomerulosclerosis def Focal segmental glomerulosclerosis def postmarketing, rare x x x x
Hallucination def Hallucination def postmarketing, rare x x x x x
Cardiac failure congestive def Cardiac failure congestive def rare x x x
Haematuria def Haematuria def postmarketing, rare x x x x x
Herpes virus infection def Herpes NOS def postmarketing, rare x x x x x
Herpes simplex def Herpes simplex def postmarketing, rare x x x x x
Herpes zoster def Herpes zoster def postmarketing, rare x x x x x
Hyperkalaemia def Hyperkalaemia def postmarketing, rare x x x x x
Hypernatraemia def Hypernatraemia def postmarketing, rare x x x x x
Hypersensitivity def Hypersensitivity def postmarketing, rare x x x x x x x x x
Hypotension def Hypotension def postmarketing x x x x x x x x x
Inflammation def Inflammation def postmarketing x
Influenza def Influenza def postmarketing x x x x x
Iridocyclitis def Iridocyclitis def rare x x x
Iritis def Iritis def rare x x x x x x x x x
Nephropathy def Nephropathy def rare x x x
Renal failure acute def Renal failure acute def rare x x x
Left ventricular failure def Left ventricular failure def rare x x x
Pulmonary oedema def Left ventricular failure def rare x x x
Pulmonary oedema def rare x x x
Lethargy def Lethargy def rare x x x
Leukaemia def Leukaemia def rare x x x
Acute lymphocytic leukaemia def Acute lymphocytic leukaemia def rare x x x
Lymphopenia def Lymphopenia def rare x x x
Oral disorder def Oral disorder def postmarketing x x x
Muscle spasms def Cramp muscle def rare x x x
Nephrotic syndrome def Nephrotic syndrome def postmarketing, rare x x x x
Osteomyelitis def Osteomyelitis def postmarketing x
Osteonecrosis def Osteonecrosis def postmarketing, rare x x x x x x
Paraesthesia def Paraesthesia def rare x x x x x x x x
Periodontal disease def Periodontal disease def postmarketing x
Phlebitis def Phlebitis def rare x x x
Pneumonia def Pneumonia def rare x x x x x x x x
Pruritus def Pruritus def postmarketing, rare x x x x x x x x x
Renal failure def Renal failure def rare x x x
Insufficiency renal def x
Acute respiratory distress syndrome def Acute respiratory distress syndrome def rare x x x x x x x x
Scleritis def Scleritis def rare x x x x x x x x x
Convulsion def Seizures def rare x x x x x x x x x
Convulsion def 0% x x x x x
Swelling def Swelling def rare x x x x x x x x x
Tetany def Tetany def rare x x x
Thrombophlebitis def Thrombophlebitis def rare x x x
Uveitis def Uveitis def rare x x x x x x x x x
Agitation def Agitation def rare x x x
Liver function test abnormal Liver function test abnormal rare x x x
Glomerulosclerosis def Glomerulosclerosis def postmarketing, rare x x x x
Interstitial lung disease def Interstitial pneumonia rare x x x x x x x x
Xanthopsia Xanthopsia rare x x x
Hallucination, visual Hallucination, visual postmarketing, rare x x x x x
Pain def Generalized aching rare x x x x x x x x x
Induration def Induration def rare x x x x x x x x x
Erythema def Redness def rare x x x x x x x x x
Anaphylactoid reaction Anaphylactoid reaction rare x x
Electrolyte imbalance def Electrolyte imbalance def postmarketing x x x
Respiratory distress def Respiratory distress def rare x x x x x x x x
Fluid overload def Fluid overload def rare, 0% x x x x x x x x x
Blood creatinine increased Serum creatinine increased rare x x x x x x x
Ventricular failure Ventricular failure rare x x x
Local reaction Local reaction rare x x x
Infusion site reaction Infusion site reaction rare x x x
Osteonecrosis of jaw def Osteonecrosis of jaw def postmarketing, rare x x x x
Dysgeusia def Dysgeusia def 0% x x x x x
Nervousness def Nervousness def 0% x x x x x
Tension def Nervousness def 0% x x x x x
Chills def Rigors 0% x x x x x x x x x
Alopecia def Alopecia def x x x x x x
Amyloidosis def Amyloidosis def x x x x x
Amyotrophic lateral sclerosis def Amyotrophic lateral sclerosis def
Back pain def Back pain def x x x x x
Cholecystitis def Cholecystitis def x x x x x
Dehydration def Dehydration def x
Epilepsy def Epilepsy def x x x x x x
Flushing def Flushing def x x x
Eye pruritus Eye pruritus x x x x x
Arthropathy def Arthropathy def x x x x x
Osteoarthritis def Arthropathy def x x x x x
Musculoskeletal pain def Musculoskeletal pain def x x x x x
Proteinuria def Proteinuria def x
Protein urine present Proteinuria def x
Hyperhidrosis def Sweating def x x x x x
Sweating increased x x x x x
Malaise def Malaise def x x x x x x x x
Discomfort def Malaise def x x x x x x x x
Ill-defined disorder Malaise def x x x x x x x x
Neurological symptom Neurological symptom x x x x x
Bone lesion Bone lesion x
Cholecystitis infective Gangrenous cholecystitis x x x x x
Social avoidant behaviour Withdrawn x
Nephropathy toxic Nephropathy toxic x x x x x x x x
Nasopharyngitis def Rhinorrhoea def x x x x x
Rhinorrhoea def Rhinorrhoea def x x x x x
Indication Labels
Alkaline phosphatase serum increased x
Bone cancer metastatic def x x x x x x x x
Bone disorder def x x x x x x x x x
Bone formation increased x
Bone pain def x
Breast cancer def x x x x x x
Cardiac failure def x x x x x x
Cardiac output increased def x
Decompression sickness def x
Deformity x
Drug interaction def x
Hepatic function abnormal x
Hepatic impairment x
Hydraemia x x x x x x
Hypercalcaemia def x x x x x x x x x
Hypercalcaemia of malignancy def x x x x x x
Hyperparathyroidism def x x x x x x
Hypovolaemia def x x x x x x
Metastases to breast def x x x x x x
Metastasis def x x x x x x x x x
Multiple myeloma def x x x x x x x x x
Neoplasm def x x x x x x x x x
Neoplasm malignant def x x x x x x
Nervous system disorder def x
Osteitis def x
Osteitis deformans def x
Osteolytic lesion x x x x x x
Pain def x
Retinitis pigmentosa def x
Trapped nerve x
Urine output x x x x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: M05BA03

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. PAMIDRONIC ACID : 26 side effects (FDA XML label)
  2. PAMIDRONATE DISODIUM / AREDIA : 54 side effects (Drugs@FDA)
  3. PAMIDRONATE DISODIUM / AREDIA : 89 side effects (Drugs@FDA)
  4. PAMIDRONATE DISODIUM / PAMIDRONATE DISODIUM FOR INJECTION : 90 side effects (Health Canada)
  5. pamidronate disodium injection / Aredia : 91 side effects (FDA MedWatch)
  6. PAMIDRONATE DISODIUM / AREDIA : 93 side effects (Drugs@FDA)
  7. PAMIDRONATE DISODIUM / AREDIA : 94 side effects (Drugs@FDA)
  8. PAMIDRONATE DISODIUM / PAMIDRONATE DISODIUM OMEGA 6 MG/ML : 97 side effects (Health Canada)
  9. PAMIDRONATE DISODIUM / AREDIA 30MG : 102 side effects (Health Canada)
  10. PAMIDRONIC ACID : 109 side effects (FDA XML label)