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ATC Code: C08CA03

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3
Headache Headache 9.4% - 13.7% 14.1% x x x
Dizziness Dizziness 7.3% - 8.2% 4.4% x x x
Syncope x x x
Asthenia Fatigue 3.9% - 6.3% 0.3% x x x
Asthenia 1.2% 0% x x x
Fatigue Fatigue 3.9% - 6.3% 0.3% x x x
Oedema Oedema 2.9% - 7.2% 3% x x
Polyuria Polyuria common x
Urine output increased Polyuria common x
Abdominal discomfort Abdominal discomfort 1.7% - 3.9% 1.7% x x x
Palpitations Palpitations 1.5% - 4% 1.4% x x x
Chest pain Chest pain 2.4% - 2.9% 2.4% x x x
Flushing Flushing very common, 1.2% - 2.6% 0% x x x
Nausea Nausea 1.8% - 3.1% 1.7% x x x
Dyspnoea Dyspnoea 1.8% - 2.2% 1% x x x
Diarrhoea Diarrhoea 1.1% - 1.9% 2% x x x
Dermatitis Rash 0.7% - 1.5% 0.3% x x x
Rash Rash 0.7% - 1.5% 0.3% x x x
Tachycardia Tachycardia 0.5% - 1.5% 0.3% x x x
Pollakiuria Pollakiuria 1% - 1.5% 0% x x
Vomiting Vomiting 0.2% - 1.1% 0.3% x x x
Hypotension Hypotension uncommon x x x
Arthralgia Arthralgia very rare x
Musculoskeletal discomfort Arthralgia very rare x
Back pain Back pain very rare x
Gynaecomastia Gynaecomastia very rare x
Pain in extremity Pain in extremity very rare x
Muscle spasms Muscle spasms very rare x
Cramp muscle x x
Erectile dysfunction Erectile dysfunction very rare x x x
Anaphylactic shock Anaphylactic shock x
Anaemia Anaemia x
Angina pectoris Angina pectoris x
Angioedema Angioedema x
Anxiety Anxiety x
Atrial fibrillation Atrial fibrillation x x x
Mental disorder Mental disorder x
Breast disorder Breast disorder x
Transient ischaemic attack Transient ischaemic attack x x x
Connective tissue disorder Connective tissue disorder x
Constipation Constipation x x x
Cough Cough x x x
Libido decreased Libido decreased x x
Disturbance in sexual arousal Libido decreased x x
Depression Depression x
Dermatitis atopic Dermatitis atopic x
Somnolence Drowsiness x x
Somnolence x
Eye disorder Eye disorder x
Gastrointestinal disorder Gastrointestinal disorder x
Digestion impaired x x
Gingival hyperplasia Gingival hyperplasia x
Cardiac disorder Cardiac disorder x
Cardiac failure Cardiac failure x x x
Hepatitis Hepatitis x
Hyperhidrosis Hyperhidrosis x x x
Hypoaesthesia Hypoaesthesia x
Numbness x x
Immune system disorder Immune system disorder x
Lethargy Lethargy x x x
Leukopenia Leukopenia x x x
Mediastinal disorder Mediastinal disorder x
Myocardial infarction Myocardial infarction x x x
Acute coronary syndrome Myocardial infarction x x x
Nervous system disorder Nervous system disorder x
Nervousness Nervousness x x x
Tension Nervousness x x x
Sensory loss Numbness x x
Nocturia Nocturia x x
Paraesthesia Paraesthesia x x x
Tingling sensation x x
Pruritus Pruritus x x x
Cerebrovascular accident Cerebrovascular accident x x x
Shock Syncope x x x
Syncope Syncope x x x
Loss of consciousness Syncope x x x
Thrombocytopenia Thrombocytopenia x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Urticaria Urticaria x x
Angiopathy Angiopathy x
Ventricular fibrillation Ventricular fibrillation x x
Weight increased Weight increased x
Dry mouth Dry mouth x x x
Ventricular arrhythmia Ventricular arrhythmia x
Oedema peripheral Oedema peripheral x
Malnutrition Malnutrition x
Photosensitivity reaction Photosensitivity reaction x
Skin disorder Unspecified disorder of skin and subcutaneous tissue x
Malaise Malaise x
Discomfort Malaise x
Feeling abnormal Malaise x
Ill-defined disorder Malaise x
Dyspepsia Digestion impaired x x
Decreased appetite Decreased appetite x
Oropharyngeal discomfort Throat sore x x
Oropharyngeal pain Throat sore x x
Hepatobiliary disease Hepatobiliary disease x
Fluid retention Fluid retention x
Vision blurred Vision blurred x
Bradycardia Bradycardia x
Visual impairment Visual disturbance x x
Visual impairment x
Liver function test abnormal Raised liver function tests x x
Insomnia Insomnia x x x


Information about indications was extracted from the indications and usage sections of the labels.


Side effects:46
Source:FDA Structured Product Label


Side effects:46
Source:FDA Structured Product Label

Color scheme:


    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    no frequency information
    not found on label