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Sorafenib

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XE05

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4
Hypoalbuminaemia Hypoalbuminaemia 0% - 58% 0% - 47% x x
Decreased appetite Decreased appetite very common x
Anorexia postmarketing, 0% - 29% 0% - 18% x x x x
Arthralgia Arthralgia postmarketing, very common x x x x
Musculoskeletal discomfort Arthralgia postmarketing, very common x x x x
Myalgia postmarketing, common x x x x
Body temperature increased Body temperature increased postmarketing, very common x x x x
Leukopenia Leukopenia postmarketing, very common x x x
Amylase increased Amylase increased postmarketing, very common x x x x
Tumour pain Tumour pain postmarketing, very common x x x x
Cerebral haemorrhage Cerebral haemorrhage postmarketing, very common x x x x
Lymphopenia Lymphopenia postmarketing — 6% - 47% 6% - 42% x x x
Diarrhoea Diarrhoea postmarketing, 0% - 55% 0% - 25% x x x x
Asthenia Fatigue postmarketing, 1% - 46% 1% - 45% x x x x
Asthenia postmarketing — 0% - 6% 1% - 2% x x x x
Fatigue Fatigue postmarketing, 1% - 46% 1% - 45% x x x x
Dyspnoea Dyspnoea 1% - 14% 1% - 12% x x
Anaemia Anaemia postmarketing, common x x x x
Dysphagia Dysphagia postmarketing, common x x x x
Dermatitis exfoliative Dermatitis exfoliative postmarketing, common x x x x
Dysgeusia Dysgeusia postmarketing, common x x x
Dyspepsia Dyspepsia postmarketing, common x x x x
Flushing Flushing postmarketing, common x x x x
Folliculitis Folliculitis postmarketing, common x x x x
Glossodynia Glossodynia postmarketing, common x x x x
Hyponatraemia Hyponatraemia postmarketing, common x x x x
Hypothyroidism Hypothyroidism postmarketing, common x x x x
Infarction Infarction postmarketing, common x x x x
Proteinuria Proteinuria postmarketing, common x x x x
Protein urine present Proteinuria postmarketing, common x x x x
Renal failure Renal failure postmarketing, common x x x x
Muscle spasms Muscle spasms postmarketing, common x x x
Thrombocytopenia Thrombocytopenia postmarketing, common x x x x
Dry mouth Dry mouth postmarketing, common x x x x
Myocardial ischaemia Myocardial ischaemia postmarketing, common x x x x
Myalgia Myalgia postmarketing, common x x x x
Erectile dysfunction Erectile dysfunction postmarketing, common x x x x
Influenza like illness Influenza like illness postmarketing, common x x x x
Hyperkeratosis Hyperkeratosis postmarketing, common x x x
Nasopharyngitis Rhinorrhoea postmarketing, common x x x x
Rhinorrhoea Rhinorrhoea postmarketing, common x x x x
Haemorrhage Haemorrhage postmarketing — 0% - 15% 1% - 8% x x x x
Haemoglobin Haemorrhage postmarketing — 0% - 15% 1% - 8% x x x x
Pain Pain postmarketing — 0% - 31% 0% - 26% x x x x
Hepatic function abnormal Hepatic function abnormal 1% - 11% 1% - 8% x x
Abdominal pain Abdominal pain 0% - 7% 1% - 3% x x x
Gastrointestinal pain Abdominal pain 0% - 7% 1% - 3% x x x
Neutropenia Neutropenia postmarketing — 1% - 11% 1% - 14% x x x
Vomiting Vomiting postmarketing, 0% - 16% 0% - 12% x x x x
Skin exfoliation Skin exfoliation postmarketing, 0% - 40% 0% - 16% x x x x
Cholangitis Cholangitis postmarketing — common x x x x
Cholecystitis Cholecystitis postmarketing — common x x x x
Erythema multiforme Erythema multiforme uncommon x x
Stevens-Johnson syndrome postmarketing x x x
Erythema multiforme minor x
Interstitial lung disease Interstitial pneumonia uncommon x x
Interstitial lung disease postmarketing, uncommon x x x
Blood bilirubin increased Blood bilirubin increased uncommon x x x
Dermatitis Rash postmarketing, 0% - 40% 0% - 16% x x x x
Rash Rash postmarketing, 0% - 40% 0% - 16% x x x x
Hypertension Hypertension postmarketing, 1% - 17% 0% - 2% x x x x
Nausea Nausea postmarketing, 0% - 24% 0% - 20% x x x x
Stomatitis Stomatitis postmarketing — 0% - 11% 0% - 5% x x x x
Mouth ulceration x
Weight decreased Weight decreased postmarketing, 0% - 30% 0% - 10% x x x x
Mucosal inflammation Mucosal inflammation postmarketing — 0% - 11% 0% - 5% x x x x
Neuropathy peripheral Neuropathy 0% - 13% 0% - 6% x x
Anaphylactic shock Anaphylactic shock postmarketing, uncommon x x x
Dehydration Dehydration postmarketing, uncommon x x x x
Eczema Eczema postmarketing, uncommon x x x x
Gastritis Gastritis postmarketing, uncommon x x x x
Gynaecomastia Gynaecomastia postmarketing, uncommon x x x x
Hypertensive crisis Hypertensive crisis postmarketing, uncommon x x x x
Hyperthyroidism Hyperthyroidism postmarketing, uncommon x x x
Jaundice Jaundice postmarketing, uncommon x x x x
Pneumonia Pneumonia postmarketing, uncommon x x x
Tinnitus Tinnitus postmarketing, uncommon x x x x
Urticaria Urticaria postmarketing, uncommon x x x x
Radiation pneumonitis Radiation pneumonitis postmarketing, uncommon x x x
Leukoencephalopathy Leukoencephalopathy postmarketing, uncommon x x x
Respiratory distress Respiratory distress postmarketing, uncommon x x x
International normalised ratio abnormal International normalised ratio abnormal postmarketing, uncommon x x x x
Headache Headache postmarketing, 0% - 10% 0% - 6% x x x x
Pruritus Pruritus postmarketing, 0% - 19% 0% - 11% x x x x
Angioedema Angioedema postmarketing x x x
Mental disorder Mental disorder postmarketing x x x
Bone disorder Bone disorder postmarketing x
Breast disorder Breast disorder postmarketing x x x
Skin cancer Skin cancer postmarketing x x x
Infection Infection postmarketing, very common x x x x
Connective tissue disorder Connective tissue disorder postmarketing x x x
Endocrine disorder Endocrine disorder postmarketing x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing x x x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease postmarketing x x x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x x x x
Gastrointestinal symptom NOS x x
Cardiac disorder Cardiac disorder postmarketing x x x
Cardiac failure congestive Cardiac failure congestive postmarketing, common x x x x
Hypersensitivity Hypersensitivity postmarketing, uncommon x x x x
Hypocalcaemia Hypocalcaemia postmarketing, common x x x
Hypokalaemia Hypokalaemia postmarketing, common x x x
Immune system disorder Immune system disorder postmarketing x x x
Keratoacanthoma Keratoacanthoma postmarketing x x x
Mediastinal disorder Mediastinal disorder postmarketing x x x x
Nephrotic syndrome Nephrotic syndrome postmarketing, rare x x x x
Nervous system disorder Nervous system disorder postmarketing x x x x
Pancreatitis Pancreatitis postmarketing, uncommon x x x x
Rhabdomyolysis Rhabdomyolysis postmarketing x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x x
Erythema Erythema postmarketing, very common x x x x
Urethral disorder Urinary tract disorder postmarketing x x
Urinary tract disorder Urinary tract disorder postmarketing x x
Angiopathy Angiopathy postmarketing x x x x
Hepatic failure Hepatic failure rare x
Hypophosphataemia Hypophosphataemia postmarketing — 11% - 35% 3% - 11% x x x x
Peripheral sensory neuropathy Peripheral sensory neuropathy postmarketing x x x
Leukocytoclastic vasculitis Allergic cutaneous angiitis postmarketing x
Leukocytoclastic vasculitis postmarketing x
Malnutrition Malnutrition postmarketing x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing x x x x
Hepatobiliary disease Hepatobiliary disease postmarketing x x x x
Lipase increased Lipase increased postmarketing, very common x x x x
Squamous cell carcinoma of skin Squamous cell carcinoma of skin postmarketing x x
Infestation Infestation NOS postmarketing x x x
Prothrombin level abnormal Prothrombin level abnormal postmarketing x x x
Blood potassium decreased Potassium low postmarketing x
Drug-induced liver injury Drug-induced hepatitis postmarketing, rare x x x
Dysphonia Dysphonia postmarketing x x x
Hoarseness 0% - 5% 0% - 1% x x
Recall phenomenon Radiation recall reaction (dermatologic) postmarketing x x
Hepatic cancer Hepatocellular carcinoma postmarketing x
Hepatocellular carcinoma Hepatocellular carcinoma postmarketing x
Osteonecrosis of jaw Osteonecrosis of jaw postmarketing x
Constipation Constipation postmarketing, 0% - 15% 0% - 11% x x x x
Alopecia Alopecia postmarketing, 0% - 27% 0% - 3% x x x x
Arrhythmia Arrhythmia x x
Ascites Ascites x
Burning mouth syndrome Burning mouth syndrome x
Neoplasm malignant Carcinoma x
Squamous cell carcinoma Squamous cell carcinoma x
Transient ischaemic attack Transient ischaemic attack x x
Cough Cough x
Epistaxis Epistaxis x x
Varices oesophageal Varices oesophageal x x
Glossitis Glossitis x
Cardiac failure Cardiac failure x
Haematoma Haematoma x
Ischaemia Ischaemia x
Renal failure acute Renal failure acute x
Myocardial infarction Myocardial infarction x
Acute coronary syndrome Myocardial infarction x
Neoplasm Neoplasm x
Pain in extremity Pain in extremity x x
Pleural effusion Pleural effusion x
Aphthous stomatitis Aphthous stomatitis x
Completed suicide Suicide x
Dizziness Syncope x
Shock Syncope x
Syncope Syncope x
Loss of consciousness Syncope x
Embolism Thromboembolism x x
Embolism venous Thromboembolism x x
Vascular headache Vascular headache x
Urogenital disorder Urogenital disorder x
Mouth ulceration Mouth ulceration x
Tubulointerstitial nephritis Acute interstitial nephritis x
Gastrointestinal perforation Gastrointestinal perforation x x
Aspartate aminotransferase increased Aspartate aminotransferase increased x x
Alanine aminotransferase increased Alanine aminotransferase increased x
Dry skin Dry skin postmarketing, 0% - 11% 0% - 6% x x x x
Abdominal rigidity Abdominal rigidity x
Haemoglobin decreased Haemoglobin decreased x
Brain cancer metastatic Brain cancer metastatic x
Metastases to central nervous system Brain cancer metastatic x
Oesophageal pain Oesophageal pain x
Oral pain Oral pain x
Abdominal discomfort Abdominal discomfort x
Abdominal pain upper Abdominal pain upper x
Abdominal pain lower Abdominal pain lower x
Abdominal tenderness Abdominal tenderness x
Disease progression Disease progression x
Blood pressure systolic increased Blood pressure systolic increased x
Metastatic renal cell carcinoma Metastatic renal cell carcinoma x
Blood pressure increased Blood pressure increased x
Hepatic pain Hepatic pain x
Blood thyroid stimulating hormone increased Thyrotropin high x
Drug interaction Drug interaction x
Oesophageal discomfort Oesophageal discomfort x
Oropharyngeal discomfort Oropharyngeal discomfort x
Mood swings Mood alteration NOS x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

sorafenib / sorafenib

Side effects:117
Source:EMA

SORAFENIB (SORAFENIB TOSYLATE) / NEXAVAR

Side effects:119
Source:Health Canada

SORAFENIB

Side effects:131
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label