Fludarabine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 14)
1 2 3 4 5 6 7 8 9 10
Asthenia def Asthenia def 13% - 31% x
Fatigue def postmarketing, 13% - 31% x x x x x x x x x x
Weakness def postmarketing, 13% - 31% x x x x x x x x x x
Fatigue def Fatigue def postmarketing, 13% - 31% x x x x x x x x x x
Body temperature increased def Body temperature increased def postmarketing, 11% - 26% x x x x x x x x x x
Fever chills x x x x x x
Cough def Cough def postmarketing, 0% - 21% x x x x x x x x x x
Cough increased 0% - 6% x
Decreased appetite Anorexia def postmarketing, 0% - 19% x x x x x x x x x x
Pain def Pain def postmarketing, 0% - 19% x x x x x x x x x
Infection def Infection def postmarketing, 4% - 17% x x x x x x x x x x
Respiratory tract infection def Respiratory tract infection def postmarketing, 9% - 14% x x x x x x x x
Hyperhidrosis def Sweating def 0% - 14% x
Sweating increased postmarketing, 0% - 14% x x x x x x x x
Upper respiratory tract infection def Upper respiratory tract infection def postmarketing, 9% - 14% x x x x x x x x
Rhinitis def Rhinitis def 3% - 11% x
Abdominal pain def Abdominal pain def 8% - 10% x
Gastrointestinal pain def Abdominal pain def 8% - 10% x
Back pain def Back pain def 4% - 9% x
Bronchitis def Bronchitis def postmarketing, 6% - 9% x x x x x x x x
Headache def Headache def postmarketing, 9% x x x x x x x x
Herpes virus infection def Herpes NOS def postmarketing, 7% - 8% x x x x x
Herpes simplex def Herpes simplex def 7% - 8% x
Influenza def Influenza def 5% - 8% x
Pneumonia def Pneumonia def postmarketing, 3% - 8% x x x x x x x x x x
Oedema def Oedema def postmarketing, 0% - 7% x x x x x x x x x x
Oedema peripheral def Oedema peripheral def 0% - 7% x
Diarrhoea def Diarrhoea def postmarketing, 5% - 6% x x x x x x x x x x
Skin disorder def Skin disorder def postmarketing, 0% - 6% x
Weight decreased def Weight decreased def 1% - 6% x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased 0% - 6% x
Chest pain def Chest pain def 0% - 5% x
Dyspnoea def Dyspnoea def postmarketing, 1% - 5% x x x x x x x x x
Dermatitis def Rash def postmarketing, 4% - 5% x x x x x x x x x x
Rash def Rash def postmarketing, 4% - 5% x x x x x x x x x x
Nausea def Nausea def postmarketing, 1% - 5% x x x x x x x x x x
Sinusitis def Sinusitis def postmarketing, 1% - 5% x x x x x x x x
Urinary tract infection def Urinary tract infection def postmarketing, 4% - 5% x x x x x x x x
Acidosis def Acidosis def postmarketing x x x x x x x x
Alopecia def Alopecia def postmarketing x x x x x x x
Alveolitis allergic def Alveolitis allergic def postmarketing x x x x x x x
Anaphylactic shock def Anaphylactic shock def postmarketing x x x x x x x
Anaemia def Anaemia def postmarketing x x x x x x x x
Haemolytic anaemia def Haemolytic anaemia def postmarketing x x x x x x x x
Anaemia haemolytic autoimmune def Anaemia haemolytic autoimmune def postmarketing x x x x x x
Aneurysm def Aneurysm def postmarketing x x x x x x x
Angina pectoris def Angina pectoris def postmarketing x x x x x x x
Arrhythmia def Arrhythmia def postmarketing x x x x x x x x x
Arthralgia def Arthralgia def postmarketing x x x x x x x
Musculoskeletal discomfort Arthralgia def postmarketing x x x x x x x
Myalgia def postmarketing x x x x x x x
Autoimmune disorder def Autoimmune disorder def postmarketing x
Neoplasm malignant def Neoplasm malignant def postmarketing x x
Skin cancer def Skin cancer def postmarketing x x
Cerebellar syndrome def Cerebellar syndrome def postmarketing x x x x x x x
Nervous system disorder def Cerebellar syndrome def postmarketing x x x x x x x
Nervous system disorder def postmarketing x
Transient ischaemic attack def Transient ischaemic attack def postmarketing x x x x x x x
Cholelithiasis def Cholelithiasis def postmarketing x x x x x x x
Coma def Coma def postmarketing x x x x x x x x
Confusional state def Confusional state def postmarketing x x x x x x x x
Feeling abnormal Confusional state def postmarketing x x x x x x x x
Malaise def postmarketing x x x x x x x x x x
Constipation def Constipation def postmarketing x x x x x x x
Cystitis def Cystitis def postmarketing x x x x x x x
Bladder pain def Cystitis def postmarketing x x x x x x x
Cystitis noninfective def Cystitis def postmarketing x x x x x x x
Cyst def Cyst def postmarketing x
Pancytopenia def Cytopenia def postmarketing x x x x x x
Pancytopenia def postmarketing x x x x x x
Bone marrow depression def postmarketing x x x x x x
Myelosuppression def postmarketing x x x x x x x x
Dysphagia def Dysphagia def postmarketing x x x x x x x
Dehydration def Dehydration def postmarketing x x x x x x x
Dysuria def Dysuria def postmarketing x x x x x x x
Effusion def Effusion def postmarketing x x x x x x x
Toxic epidermal necrolysis def Toxic epidermal necrolysis def postmarketing x x x
Necrolysis epidermal postmarketing x x x
Epistaxis def Epistaxis def postmarketing x x x x x x x
Erythema multiforme def Erythema multiforme def postmarketing x x
Oesophagitis def Oesophagitis def postmarketing x x x x x x x
Eye disorder def Eye disorder def postmarketing x
Fibrosis def Fibrosis def postmarketing x x x x x x x
Flank pain def Flank pain def postmarketing x x x x x x x
Gastrointestinal disorder def Gastrointestinal disorder def postmarketing x
Gastrointestinal haemorrhage def Gastrointestinal haemorrhage def postmarketing x x x x x x x x x
Cardiac disorder def Cardiac disorder def postmarketing x
Cardiac failure def Cardiac failure def postmarketing x x x x x x x x x
Cardiac failure congestive def Cardiac failure congestive def postmarketing x x x x x x x
Haematuria def Haematuria def postmarketing x x x x x x x x x x
Factor VIII deficiency def Factor VIII deficiency def postmarketing x x x
Haemoptysis def Haemoptysis def postmarketing x x x x x x x
Haemorrhage def Haemorrhage def postmarketing x x x x x x x x x
Haemoglobin def Haemorrhage def postmarketing x x x x x x x x x
Herpes zoster def Herpes zoster def postmarketing x x x x
Hyperglycaemia def Hyperglycaemia def postmarketing x x x x x x x
Hyperkalaemia def Hyperkalaemia def postmarketing x x x x x x x x
Hypersensitivity def Hypersensitivity def postmarketing x x x x x x x
Hypocalcaemia def Hypocalcaemia def postmarketing x x x x x x x x
Immune system disorder def Immune system disorder def postmarketing x
Infarction def Infarction def postmarketing x x x x x x x
Acute myeloid leukaemia def Acute myeloid leukaemia def postmarketing x x x
Acute leukaemia def Acute myeloid leukaemia def postmarketing x x x
Myeloid leukaemia def postmarketing x x x
Myeloid leukaemia def Myeloid leukaemia def postmarketing x x x
Progressive multifocal leukoencephalopathy def Progressive multifocal leukoencephalopathy def postmarketing x x x x x x
Lymphoproliferative disorder def Lymphoproliferative disorder def postmarketing x x x x
X-linked lymphoproliferative syndrome def Lymphoproliferative disorder def postmarketing x x x x
Mediastinal disorder def Mediastinal disorder def postmarketing x
Myelodysplastic syndrome def Myelodysplastic syndrome def postmarketing x x x x
Myocardial infarction def Myocardial infarction def postmarketing x x x x x x x
Acute coronary syndrome def Myocardial infarction def postmarketing x x x x x x x
Neoplasm def Neoplasm def postmarketing x x x x x x x x x x
Solid tumour def postmarketing x x x x x x x x
Neuritis def Neuritis def postmarketing x x x x
Neuropathy peripheral def Neuritis def postmarketing x x x x
Neuropathy peripheral def postmarketing x x x x x x x x
Neuropathy def postmarketing x x x x x x x x
Neutropenia def Neutropenia def postmarketing x x x x x x x x
Opportunistic infection def Opportunistic infection def postmarketing x x x x x x x x
Optic nerve disorder def Optic nerve disorder def postmarketing x x x x
Optic neuritis def Optic neuritis def postmarketing x x x x
Osteoporosis def Osteoporosis def postmarketing x x x x x x x
Paraesthesia def Paraesthesia def postmarketing x x x x x x x
Pemphigus def Pemphigus def postmarketing x x x
Pericardial effusion def Pericardial effusion def postmarketing x x x x x x x
Pharyngitis def Pharyngitis def postmarketing x x x x x x x
Phlebitis def Phlebitis def postmarketing x x x x x x x
Polyp def Polyp def postmarketing x
Proteinuria def Proteinuria def postmarketing x x x x x x x
Protein urine present Proteinuria def postmarketing x x x x x x x
Pruritus def Pruritus def postmarketing x x x x x x x
Pulmonary fibrosis def Pulmonary fibrosis def postmarketing x x x x x x
Purpura def Purpura def postmarketing x x x
Vascular purpura Purpura def postmarketing x x x
Renal failure def Renal failure def postmarketing x x x x x x x x x x
Acute respiratory distress syndrome def Acute respiratory distress syndrome def postmarketing x x x x x x
Seborrhoeic dermatitis def Seborrhoeic dermatitis def postmarketing x x x x x x x
Convulsion def Seizures def postmarketing x x x x
Stomatitis def Stomatitis def postmarketing x x x x x x x x x x
Cerebrovascular accident def Cerebrovascular accident def postmarketing x x x x x x x
Tachycardia def Tachycardia def postmarketing x x x x x x x
Supraventricular tachycardia def Supraventricular tachycardia def postmarketing x x x x x x x
Thrombocytopenia def Thrombocytopenia def postmarketing x x x x x x x x
Thrombosis def Thrombosis def postmarketing x x x x x x x
Tumour lysis syndrome def Tumour lysis syndrome def postmarketing x x x x x x x x x
Erythema def Erythema def postmarketing x x
Venous thrombosis def Venous thrombosis def postmarketing x x x x x x
Viral infection def Viral infection def postmarketing x x
Vomiting def Vomiting def postmarketing x x x x x x x x x x
Chills def Chills def postmarketing x x x x x x x x x x
Hepatic failure def Hepatic failure def postmarketing x x x x x x x
Agitation def Agitation def postmarketing x x x x x x x x
Hyperphosphataemia def Hyperphosphataemia def postmarketing x x x x x x x x
Cystitis haemorrhagic Cystitis haemorrhagic postmarketing x x x x x x
Hepatic function abnormal Hepatic function abnormal postmarketing x x x x x x x
Deep vein thrombosis def Deep vein thrombosis def postmarketing x x x x x x
Crystalluria Crystalluria postmarketing x x x x x x x x
Urate crystalluria postmarketing x x x x x x x x
Crystal urine Crystalluria postmarketing x x x x x x x x
Pulmonary haemorrhage def Pulmonary haemorrhage def postmarketing x x x x x x
Renal impairment def Kidney function abnormal postmarketing x x x x x x x
Liver function test abnormal Liver function test abnormal postmarketing x x x x x x x
Urinary hesitation Urinary hesitation postmarketing x x x x x x x
Metabolic acidosis def Metabolic acidosis def postmarketing x x x x x x x x
Malaise def Malaise def postmarketing x x x x x x x x x x
Discomfort def Malaise def postmarketing x x x x x x x x x x
Ill-defined disorder Malaise def postmarketing x x x x x x x x x x
Myalgia def Myalgia def postmarketing x x x x x x x
Lung infiltration Lung infiltration postmarketing x x x x x x x
Renal function test abnormal Renal function test abnormal postmarketing x x x x x x x
Hypoxia def Hypoxia def postmarketing x x x x x x x
Autoimmune thrombocytopenia Autoimmune thrombocytopenia postmarketing x x
Aplasia Aplasia postmarketing x x x x x x
Hepatobiliary disease def Hepatobiliary disease def postmarketing x x
Leukoencephalopathy def Leukoencephalopathy def postmarketing x x x x x
Mucosal inflammation def Mucosal inflammation def postmarketing x x x x x x x x x
Blindness def Blindness def postmarketing x x x x
Respiratory distress def Respiratory distress def postmarketing x x x x x x
Visual impairment def Visual disturbance postmarketing x x x x x x x x x x
Aortic dissection def Dissecting aortic aneurysm, thoracic postmarketing x
Blood uric acid Urate postmarketing x x x x x x x x
Blood uric acid increased Hyperuricaemia def postmarketing x x x x x x x x
Hyperuricaemia def Hyperuricaemia def postmarketing x x x x x x x x
Infestation Infestation NOS postmarketing x
Sleep disorder def Sleep disorder def postmarketing x x x x x x x
Thrombocytopenic purpura def Thrombocytopenic purpura def postmarketing x x x
Pulmonary toxicity Pulmonary toxicity postmarketing x x x x x x
Acquired haemophilia Acquired haemophilia postmarketing x x x
Respiratory failure def Respiratory failure def postmarketing x x x x x x
Skin toxicity Skin toxicity postmarketing x x x x x x x x
Death Death postmarketing x x x x x x
Deafness def Hearing impaired def postmarketing x x x x x x x x
Hearing impaired def Hearing impaired def postmarketing x x x x x x x x
Cell death def Cytolysis def postmarketing x x x x x x x x x x
Leukopenia def Leukopenia def x x
Myelofibrosis def Myelofibrosis def x x x x x
Myeloid metaplasia Myelofibrosis def x x x x x
Hypoaesthesia def Numbness def x
Sensory loss Numbness def x
Haemoglobin decreased def Haemoglobin decreased def x x x x x
Radial nerve palsy Wrist drop x
Evans syndrome def Evans syndrome def x
Platelet count decreased Platelet count decreased x x x x x
Neutrophil count decreased def Neutrophil count decreased def x x x x x
Absolute neutrophil count decreased x x x x x
Lung infection def Lung infection def x
Cerebral haemorrhage def Cerebral haemorrhage def x
Indication Labels
Chronic lymphocytic leukaemia def x x x x x x x x x
Chronic lymphocytic leukaemia refractory def x
Leukaemia def x x x x x x x x x x
Lymphocytic leukaemia def x x x x x x x x x
Lymphoma def x x
Renal impairment def x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: L01BB05

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. FLUDARABINE PHOSPHATE / FLUDARA : 74 side effects (Health Canada)
  2. FLUDARABINE PHOSPHATE / FLUDARABINE PHOSPHATE FOR INJECTION : 75 side effects (Health Canada)
  3. FLUDARABINE : 78 side effects (FDA XML label)
  4. FLUDARABINE : 80 side effects (FDA XML label)
  5. FLUDARABINE : 96 side effects (FDA XML label)
  6. fludarabine / Fludara : 121 side effects (FDA CDER)
  7. Fludarabine : 126 side effects (FDA XML label)
  8. Fludarabine : 128 side effects (FDA XML label)
  9. Fludarabine : 150 side effects (FDA XML label)
  10. fludarabine : 154 side effects (FDA XML label)