MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
Thrombocytopenia
|
Thrombocytopenia
|
postmarketing, 5% - 85%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neutropenia
|
Neutropenia
|
20% - 80%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Anaemia
|
Anaemia
|
3% - 75%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypophosphataemia
|
Hypophosphataemia
|
5% - 28%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fluid retention
|
Fluid retention
|
very common, 1% - 50%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Generalised oedema
|
common, 0% - 7%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
Fatigue
|
very common, 0% - 26%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
common, 1% - 6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Fatigue
|
Fatigue
|
very common, 0% - 26%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pleural effusion
|
Pleural effusion
|
0% - 24%
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
Febrile neutropenia
|
Febrile neutropenia
|
1% - 20%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
Rash
|
0% - 21%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
0% - 21%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypocalcaemia
|
Hypocalcaemia
|
1% - 20%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal haemorrhage
|
Gastrointestinal haemorrhage
|
0% - 14%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Headache
|
Headache
|
very common, 0% - 33%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pneumonia
|
Pneumonia
|
3% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Infection
|
Infection
|
postmarketing, 0% - 15%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Diarrhoea
|
Diarrhoea
|
0% - 31%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Body temperature increased
|
Body temperature increased
|
very common, 0% - 18%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Flushing
|
Flushing
|
common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Palpitations
|
Palpitations
|
common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Muscle spasms
|
Muscle spasms
|
common, 0% - 21%
|
|
|
x
|
|
|
|
x
|
x
|
Tachycardia
|
Tachycardia
|
common
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Tinnitus
|
Tinnitus
|
common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Muscular weakness
|
Muscular weakness
|
common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal stiffness
|
Musculoskeletal stiffness
|
common
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypokalaemia
|
Hypokalaemia
|
0% - 15%
|
|
x
|
x
|
|
|
|
x
|
|
Dyspnoea
|
Dyspnoea
|
2% - 24%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nausea
|
Nausea
|
0% - 24%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pain
|
Pain
|
common, 1% - 10%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal pain
|
Musculoskeletal pain
|
0% - 22%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal pain
|
Abdominal pain
|
0% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
0% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chest pain
|
Chest pain
|
common, 0% - 13%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Localised oedema
|
Localised oedema
|
0% - 37%
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Cardiac failure
|
Cardiac failure
|
3%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Oedema
|
Oedema
|
0% - 36%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pitting edema
|
|
|
|
|
|
|
|
x
|
x
|
Alanine aminotransferase increased
|
Alanine aminotransferase increased
|
0% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
|
|
Myositis
|
Myositis
|
uncommon, 0% - 19%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Decreased appetite
|
Anorexia
|
1% - 3%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arrhythmia
|
Arrhythmia
|
common, 1% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Colitis
|
Colitis
|
2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Haemorrhage
|
Haemorrhage
|
0% - 26%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Haemoglobin
|
Haemorrhage
|
0% - 26%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vomiting
|
Vomiting
|
0% - 16%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myalgia
|
Myalgia
|
common, 0% - 13%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal discomfort
|
Myalgia
|
common, 0% - 13%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthralgia
|
common, 0% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Aspartate aminotransferase increased
|
Aspartate aminotransferase increased
|
0% - 8%
|
|
x
|
x
|
x
|
x
|
x
|
|
|
Arthralgia
|
Arthralgia
|
common, 0% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ascites
|
Ascites
|
0% - 2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Inflammation
|
Inflammation
|
1% - 5%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pericardial effusion
|
Pericardial effusion
|
common, 0% - 4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuropathy peripheral
|
Neuropathy peripheral
|
0% - 13%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neuropathy
|
0% - 13%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Weight increased
|
Weight increased
|
1% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Weight decreased
|
Weight decreased
|
0% - 14%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood creatinine increased
|
Creatinine increased
|
0% - 8%
|
|
x
|
x
|
x
|
x
|
x
|
|
|
Generalised oedema
|
Generalised oedema
|
common, 0% - 7%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood bilirubin increased
|
Blood bilirubin increased
|
0% - 8%
|
|
x
|
x
|
x
|
x
|
x
|
|
|
Amnesia
|
Amnesia
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Asthma
|
Asthma
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mental disorder
|
Mental disorder
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Breast disorder
|
Breast disorder
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Bronchospasm
|
Bronchospasm
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cholecystitis
|
Cholecystitis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cholestasis
|
Cholestasis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gynaecomastia
|
Gynaecomastia
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatitis
|
Hepatitis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypotension
|
Hypotension
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rhabdomyolysis
|
Rhabdomyolysis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
Syncope
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
0% - 14%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Shock
|
Syncope
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Syncope
|
Syncope
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Loss of consciousness
|
Syncope
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tendonitis
|
Tendonitis
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Thrombophlebitis
|
Thrombophlebitis
|
uncommon
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Tremor
|
Tremor
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vertigo
|
Vertigo
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Menstruation irregular
|
Menstruation irregular
|
uncommon
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Malaise
|
Malaise
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Discomfort
|
Malaise
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Feeling abnormal
|
Malaise
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Confusional state
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ill-defined disorder
|
Malaise
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood creatine phosphokinase increased
|
Blood creatine phosphokinase increased
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Temperature intolerance
|
Temperature intolerance
|
uncommon
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Constipation
|
Constipation
|
0% - 14%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cough
|
Cough
|
0% - 1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypertension
|
Hypertension
|
postmarketing — 0% - 2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cardiac failure congestive
|
Cardiac failure congestive
|
common, 0% - 4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Atrial fibrillation
|
Atrial fibrillation
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
Atrial flutter
|
Atrial flutter
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
|
Neoplasm malignant
|
Neoplasm malignant
|
postmarketing
|
|
|
|
|
|
|
x
|
x
|
Cardiovascular disorder
|
Cardiovascular disorder
|
postmarketing
|
|
|
|
|
|
|
|
x
|
Embolism
|
Embolism
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
postmarketing, rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cardiac disorder
|
Cardiac disorder
|
postmarketing
|
|
x
|
x
|
|
|
|
|
x
|
Mediastinal disorder
|
Mediastinal disorder
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nervous system disorder
|
Nervous system disorder
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary embolism
|
Pulmonary embolism
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
Aplasia pure red cell
|
Aplasia pure red cell
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Acute respiratory distress syndrome
|
Acute respiratory distress syndrome
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Thrombosis
|
Thrombosis
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
Angiopathy
|
Angiopathy
|
postmarketing
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Livedo reticularis
|
Livedo reticularis
|
rare
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Deep vein thrombosis
|
Deep vein thrombosis
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
Interstitial lung disease
|
Interstitial lung disease
|
postmarketing
|
|
x
|
x
|
|
|
|
x
|
x
|
Sepsis
|
Sepsis
|
postmarketing, 1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Abdominal distension
|
Abdominal distension
|
0% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Alopecia
|
Alopecia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Angina pectoris
|
Angina pectoris
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Anxiety
|
Anxiety
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Coagulopathy
|
Coagulopathy
|
|
|
|
|
x
|
x
|
|
|
|
Congestive cardiomyopathy
|
Congestive cardiomyopathy
|
|
|
|
|
|
|
x
|
x
|
x
|
Transient ischaemic attack
|
Transient ischaemic attack
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Confusional state
|
Confusional state
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Conjunctival haemorrhage
|
Conjunctival haemorrhage
|
|
|
|
|
|
|
|
|
x
|
Conjunctivitis
|
Conjunctivitis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Connective tissue disorder
|
Connective tissue disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Contusion
|
Contusion
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cyst
|
Cyst
|
|
|
|
|
|
|
|
x
|
x
|
Pancytopenia
|
Cytopenia
|
|
|
|
x
|
|
|
|
x
|
|
Pancytopenia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myelosuppression
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Libido decreased
|
Libido decreased
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Disturbance in sexual arousal
|
Libido decreased
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysphagia
|
Dysphagia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Drug eruption
|
Drug eruption
|
|
|
|
|
x
|
x
|
|
x
|
x
|
Dysgeusia
|
Dysgeusia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspepsia
|
Dyspepsia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ecchymosis
|
Ecchymosis
|
|
|
|
|
|
|
|
|
x
|
Eczema
|
Eczema
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Epistaxis
|
Epistaxis
|
|
|
|
|
|
|
|
x
|
x
|
Erythema multiforme
|
Erythema multiforme
|
|
|
|
|
|
|
x
|
x
|
x
|
Erythema nodosum
|
Erythema nodosum
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Oesophagitis
|
Oesophagitis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eye disorder
|
Eye disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eye haemorrhage
|
Eye haemorrhage
|
|
|
|
|
|
|
|
|
x
|
Anal fissure
|
Anal fissure
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastritis
|
Gastritis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gingival bleeding
|
Gingival bleeding
|
|
|
|
|
|
|
|
|
x
|
Cardiomegaly
|
Cardiomegaly
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Haematoma
|
Haematoma
|
|
|
|
|
|
|
|
|
x
|
Subdural haematoma
|
Subdural haematoma
|
|
|
|
|
|
|
|
x
|
x
|
Haematuria
|
Haematuria
|
|
|
|
|
|
|
|
|
x
|
Haemoptysis
|
Haemoptysis
|
|
|
|
|
|
|
|
|
x
|
Herpes virus infection
|
Herpes virus infection
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hyperhidrosis
|
Hyperhidrosis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypersensitivity
|
Hypersensitivity
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary hypertension
|
Pulmonary hypertension
|
0% - 2%
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Immune system disorder
|
Immune system disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Left ventricular failure
|
Left ventricular failure
|
|
|
|
|
x
|
x
|
|
|
|
Pulmonary oedema
|
Left ventricular failure
|
|
|
|
|
x
|
x
|
|
|
|
Pulmonary oedema
|
0% - 4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chronic myeloid leukaemia
|
Chronic myeloid leukaemia
|
|
|
|
x
|
|
|
|
|
|
Myocardial infarction
|
Myocardial infarction
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Acute coronary syndrome
|
Myocardial infarction
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Acute coronary syndrome
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myocarditis
|
Myocarditis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nail disorder
|
Nail disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Neoplasm
|
Neoplasm
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oligomenorrhoea
|
Oligomenorrhoea
|
|
|
|
|
x
|
x
|
|
|
|
Optic neuritis
|
Optic neuritis
|
|
|
x
|
x
|
|
|
|
x
|
x
|
Pancreatitis
|
Pancreatitis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Panniculitis
|
Panniculitis
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Pericarditis
|
Pericarditis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Petechiae
|
Petechiae
|
|
|
|
|
|
|
|
x
|
x
|
Polyp
|
Polyp
|
|
|
|
|
|
|
|
x
|
x
|
Proteinuria
|
Proteinuria
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Protein urine present
|
Proteinuria
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Prurigo
|
Prurigo
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Pruritus
|
Pruritus
|
0% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cor pulmonale
|
Cor pulmonale
|
|
|
x
|
x
|
|
|
|
x
|
x
|
Renal failure
|
Renal failure
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Convulsion
|
Convulsion
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Skin ulcer
|
Skin ulcer
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Stomatitis
|
Stomatitis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cerebrovascular accident
|
Cerebrovascular accident
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Subarachnoid haemorrhage
|
Subarachnoid haemorrhage
|
|
|
|
|
|
|
|
x
|
x
|
Tumour lysis syndrome
|
Tumour lysis syndrome
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Erythema
|
Erythema
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Upper respiratory tract infection
|
Upper respiratory tract infection
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Pollakiuria
|
Pollakiuria
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urethral disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urticaria
|
Urticaria
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Uterine haemorrhage
|
Uterine haemorrhage
|
|
|
|
|
|
|
|
|
x
|
Ventricular tachycardia
|
Ventricular tachycardia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Visual impairment
|
Disorder sight
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Visual disturbance
|
|
|
x
|
x
|
|
|
|
x
|
x
|
Visual impairment
|
|
|
|
x
|
|
|
|
x
|
x
|
Acute febrile neutrophilic dermatosis
|
Acute febrile neutrophilic dermatosis
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chills
|
Chills
|
common, 0% - 11%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ventricular arrhythmia
|
Ventricular arrhythmia
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Rash pustular
|
Rash pustular
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Oedema peripheral
|
Oedema peripheral
|
|
|
|
|
|
|
|
x
|
x
|
Periorbital oedema
|
Periorbital oedema
|
|
|
|
|
|
|
|
x
|
x
|
Conjunctival oedema
|
Conjunctival oedema
|
|
|
|
|
|
|
|
x
|
x
|
Swelling face
|
Swelling face
|
|
|
|
|
|
|
|
x
|
x
|
Oedema genital
|
Oedema genital
|
|
|
|
|
|
|
|
x
|
x
|
Scrotal oedema
|
Scrotal oedema
|
|
|
|
|
|
|
|
x
|
x
|
Tongue disorder
|
Tongue oedema
|
|
|
|
|
|
|
|
x
|
x
|
Tongue oedema
|
Tongue oedema
|
|
|
|
|
|
|
|
x
|
x
|
Haemorrhage intracranial
|
Haemorrhage intracranial
|
|
|
|
|
|
|
|
x
|
x
|
Electrocardiogram QT prolonged
|
Electrocardiogram QT prolonged
|
|
|
|
|
|
|
|
x
|
x
|
Electrocardiogram QT corrected interval prolonged
|
|
|
|
|
|
|
|
x
|
x
|
Dry skin
|
Dry skin
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Skin irritation
|
Skin irritation
|
|
|
|
|
|
|
x
|
x
|
x
|
Penile oedema
|
Penile oedema
|
|
|
|
|
|
|
|
x
|
x
|
Eyelid oedema
|
Eyelid oedema
|
|
|
|
|
|
|
|
x
|
x
|
Miliaria
|
Miliaria rubra
|
|
|
|
|
|
|
x
|
x
|
x
|
Malnutrition
|
Malnutrition
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Photosensitivity reaction
|
Photosensitivity reaction
|
|
|
|
|
x
|
x
|
|
|
|
Photosensitivity
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash macular
|
Rash macular
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Rash vesicular
|
Rash vesicular
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Affect lability
|
Affect lability
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Visual acuity reduced
|
Visual acuity reduced
|
|
|
x
|
x
|
|
|
|
x
|
x
|
Rash erythematous
|
Rash erythematous
|
|
|
|
|
x
|
x
|
|
x
|
x
|
Rash follicular
|
Rash follicular
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Urticaria vesiculosa
|
Urticaria vesiculosa
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Gravitational oedema
|
Gravitational oedema
|
|
|
|
|
|
|
|
x
|
x
|
Lung infiltration
|
Lung infiltration
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema mouth
|
Oedema mouth
|
|
|
|
|
|
|
|
x
|
x
|
Skin exfoliation
|
Skin exfoliation
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal ulcer
|
Gastrointestinal ulcer
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Epidural haemorrhage
|
Epidural haemorrhage
|
|
|
|
|
|
|
|
x
|
x
|
Genital rash
|
Genital rash
|
|
|
|
|
|
|
|
x
|
x
|
Hypoalbuminaemia
|
Hypoalbuminaemia
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
Left ventricular dysfunction
|
Left ventricular dysfunction
|
|
|
x
|
x
|
|
|
x
|
|
x
|
Ventricular dysfunction
|
Ventricular dysfunction
|
|
|
|
|
x
|
x
|
|
x
|
x
|
Cardiac failure acute
|
Cardiac failure acute
|
|
|
|
|
|
|
|
|
x
|
Oral disorder
|
Oral soft tissue disorder NOS
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatobiliary disease
|
Hepatobiliary disease
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eye swelling
|
Eye swelling
|
|
|
|
|
|
|
|
x
|
x
|
Macular oedema
|
Macular oedema
|
|
|
|
|
|
|
|
x
|
x
|
Ear haemorrhage
|
Ear haemorrhage
|
|
|
|
|
|
|
|
|
x
|
Skin swelling
|
Skin swelling
|
|
|
|
|
|
|
|
x
|
x
|
Protein-losing gastroenteropathy
|
Protein-losing gastroenteropathy
|
|
|
x
|
x
|
|
|
|
x
|
x
|
Dry eye
|
Dry eye
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mucosal inflammation
|
Mucosal inflammation
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vision blurred
|
Vision blurred
|
|
|
x
|
x
|
|
|
|
x
|
x
|
Milia
|
Milia
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Lipoedema
|
Lipoedema
|
|
|
|
|
|
|
|
x
|
x
|
Neutropenic colitis
|
Neutropenic colitis
|
|
|
x
|
x
|
|
|
x
|
x
|
x
|
Rash maculo-papular
|
Rash maculo-papular
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Orbital oedema
|
Orbital oedema
|
|
|
|
|
|
|
|
x
|
x
|
Intra-abdominal haematoma
|
Intra-abdominal haematoma
|
|
|
|
|
|
|
|
|
x
|
Rash generalised
|
Rash generalised
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Diastolic dysfunction
|
Diastolic dysfunction
|
|
|
|
|
|
|
x
|
x
|
x
|
Systemic lupus erythematosus rash
|
Systemic lupus erythematosus rash
|
|
|
|
|
x
|
x
|
x
|
|
|
Platelet aggregation abnormal
|
Platelet aggregation abnormal
|
|
|
|
|
x
|
x
|
|
|
|
Lip oedema
|
Lip oedema
|
|
|
|
|
|
|
|
x
|
x
|
Cerebral haematoma
|
Cerebral haematoma
|
|
|
|
|
|
|
|
x
|
x
|
Face oedema
|
Face oedema
|
|
|
|
|
|
|
|
x
|
x
|
Auricular swelling
|
Auricular swelling
|
|
|
|
|
|
|
|
x
|
x
|
Skin discolouration
|
Pigmentation disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pigmentation disorder
|
Pigmentation disorder
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Haemorrhagic stroke
|
Haemorrhagic stroke
|
|
|
|
|
|
|
|
x
|
x
|
Cerebral haemorrhage
|
Haemorrhagic stroke
|
|
|
|
|
|
|
|
x
|
x
|
Cerebral haemorrhage
|
|
|
|
|
|
|
|
x
|
x
|
Blood uric acid increased
|
Hyperuricaemia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hyperuricaemia
|
Hyperuricaemia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ejection fraction decreased
|
Ejection fraction decreased
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Eye oedema
|
Eye oedema
|
|
|
|
|
|
|
|
x
|
x
|
Scleral haemorrhage
|
Scleral haemorrhage
|
|
|
|
|
|
|
|
|
x
|
Generalised erythema
|
Generalised erythema
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Ventricular failure
|
Ventricular failure
|
|
|
|
|
|
|
x
|
x
|
x
|
Infestation
|
Infestation NOS
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Blood calcium decreased
|
Calcium low
|
|
|
|
|
|
|
|
x
|
|
Cardiomyopathy
|
Cardiomyopathy
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Insomnia
|
Insomnia
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
VIIth nerve paralysis
|
VIIth nerve paralysis
|
|
|
|
x
|
|
|
|
x
|
x
|
Erythrosis
|
Erythrosis
|
|
|
|
|
|
|
|
x
|
x
|
Troponin increased
|
Troponin increased
|
|
|
|
|
x
|
x
|
|
|
|
Enterocolitis infectious
|
Enterocolitis infectious
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ileus
|
Ileus
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
Rash papular
|
Rash papular
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Exfoliative rash
|
Exfoliative rash
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
Incision site oedema
|
Incision site oedema
|
|
|
|
|
|
|
|
x
|
x
|
Genital swelling
|
Genital swelling
|
|
|
|
|
|
|
|
x
|
x
|
Somnolence
|
Somnolence
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vaginal haemorrhage
|
Vaginal haemorrhage
|
|
|
|
|
|
|
|
|
x
|
Posterior reversible encephalopathy syndrome
|
Posterior reversible encephalopathy syndrome
|
|
|
|
|
x
|
x
|
|
|
|