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Chronic myeloid leukaemia

Definition: A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and imatinib therapy delay disease progression and prolong overall survival.

Synonyms (terms occurring on more labels are shown first): chronic myeloid leukemia, chronic myelogenous leukemia, chronic myelocytic leukemia, chronic myelogenous leukaemia, chronic myeloid leukaemia, chronic granulocytic leukemia, chronic myelocytic leukaemia

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