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Nilotinib

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XE08

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Thrombocytopenia Thrombocytopenia very common, 9% - 42% x x x x x
Hyperbilirubinaemia Hyperbilirubinaemia very common x x x x
Neutropenia Neutropenia very common, 11% - 42% x x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue 0% - 36% x x x x x
Lipase increased Lipase increased very common, 4% - 18% x x x x x
Blood phosphorus decreased Blood phosphorus decreased very common x x x
Hypophosphataemia Hypophosphataemia uncommon — 6% - 17% x x x x x
Malnutrition Malnutrition 1% - 17% x x x x x
Anaemia Anaemia common, 4% - 27% x x x x x
Blood bilirubin increased Blood bilirubin increased common — 1% - 9% x x x x x
Mediastinal disorder Mediastinal disorder 0% - 27% x x x x x
Angiopathy Angiopathy 1% - 11% x x x x x
Infection Infection 0% - 24% x x x x x
Infestation Infestation NOS 0% - 24% x x x x x
Abdominal distension Abdominal distension uncommon, common x x x x x
Amnesia Amnesia common x x x x
Angina pectoris Angina pectoris uncommon, common x x x x x
Decreased appetite Anorexia common x x x
Decreased appetite uncommon — 0% - 8% x x x x x
Anxiety Anxiety uncommon, common x x x x x
Arrhythmia Arrhythmia common x x x x
Atrial fibrillation Atrial fibrillation uncommon, common x x x x x
Atrioventricular block Atrioventricular block common x x x x
Back pain Back pain common x x x x x
Neck pain Neck pain common x x x
Chest pain Chest pain uncommon, common x x x x x
Chest discomfort common x x x x
Confusional state Confusional state common x x x x
Feeling abnormal Confusional state common x x x x
Malaise uncommon, common x x x x x
Conjunctivitis Conjunctivitis uncommon, common x x x x x
Connective tissue disorder Connective tissue disorder common, 0% - 19% x x x x x
Contusion Contusion common x x x x
Cough Cough common x x x x x
Dermatitis Dermatitis common x x x x
Rash 0% - 37% x x x x x
Diabetes mellitus Diabetes mellitus common x x x x x
Dizziness Dizziness common x x x x x
Syncope uncommon x x x x
Dysgeusia Dysgeusia common x x x x
Dyspnoea Dyspnoea common x x x x x
Ear pain Ear pain common x x x x
Eczema Eczema common x x x x x
Eosinophilia Eosinophilia common x x x x
Epistaxis Epistaxis uncommon, common x x x x x
Eye haemorrhage Eye haemorrhage uncommon, common x x x x
Body temperature increased Body temperature increased common x x x x x
Flank pain Flank pain uncommon, common x x x x
Flatulence Flatulence common x x x x x
Flushing Flushing common x x x x x
Cardiac flutter Cardiac flutter common x x x x
Folliculitis Folliculitis common x x x x
Hypercalcaemia Hypercalcaemia common x x x x
Hypercholesterolaemia Hypercholesterolaemia common, 0% - 1% x x x x
Hyperglycaemia Hyperglycaemia common, 1% - 12% x x x x x
Hyperhidrosis Hyperhidrosis common x x x x x
Hyperkalaemia Hyperkalaemia uncommon — 1% - 6% x x x x x
Hyperlipidaemia Hyperlipidaemia common x x x x
Hypertension Hypertension common x x x x x
Hypertriglyceridaemia Hypertriglyceridaemia common x x x x
Blood triglycerides increased Hypertriglyceridaemia common x x x x
Hypoaesthesia Hypoaesthesia uncommon, common x x x x x
Hyponatraemia Hyponatraemia uncommon — 1% - 7% x x x x
Eye pruritus Eye pruritus common x x x x
Lymphopenia Lymphopenia common x x x x
Musculoskeletal pain Musculoskeletal pain uncommon, common x x x x x
Nasopharyngitis Nasopharyngitis common x x x x x
Night sweats Night sweats common x x x x x
Pain Pain uncommon, common x x x x
Palpitations Palpitations common x x x x x
Pancreatitis Pancreatitis uncommon, common x x x x x
Pancytopenia Pancytopenia uncommon, common x x x x x
Myelosuppression x x x x x
Paraproteinaemia Paraproteinaemia common x x x x
Paraesthesia Paraesthesia uncommon, common x x x x x
Neuropathy peripheral Neuropathy peripheral common x x x x x
Pharyngitis Pharyngitis uncommon, common x x x x x
Rhinitis Rhinitis common x x x x
Tachycardia Tachycardia common x x x x
Tinnitus Tinnitus common x x x
Upper respiratory tract infection Upper respiratory tract infection common x x x x
Pollakiuria Pollakiuria uncommon, common x x x x x
Micturition urgency uncommon x x x x
Urticaria Urticaria common x x x x x
Vertigo Vertigo common x x x x x
Weight increased Weight increased common x x x x x
Weight decreased Weight decreased common x x x x x
Xerophthalmia Xerophthalmia common x x x x
Hyperphosphataemia Hyperphosphataemia common x x x x
Hepatic function abnormal Hepatic function abnormal common x x x x
Periorbital oedema Periorbital oedema uncommon, common x x x x x
Ventricular extrasystoles Ventricular extrasystoles common x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased common x x x x x
Hypomagnesaemia Hypomagnesaemia common x x x x
Electrocardiogram QT prolonged Electrocardiogram QT prolonged common x x x x x
Dry skin Dry skin common, 0% - 10% x x x x x
Haemoglobin decreased Haemoglobin decreased uncommon, common x x x x
Malaise Malaise uncommon, common x x x x x
Discomfort Malaise uncommon, common x x x x x
Ill-defined disorder Malaise uncommon, common x x x x x
Dyspnoea exertional Dyspnoea exertional common x x x x x
Abdominal discomfort Abdominal discomfort common x x x x x
Disorientation Disorientation common x x x x
Dysphoria Dysphoria common x x x x
Chest discomfort Chest discomfort common x x x x
Dry eye Dry eye uncommon, common x x x x x
Extrasystoles Extrasystoles common x x x
Electrolyte imbalance Electrolyte imbalance common x x x
Skin papilloma Skin papilloma common x x x x
Bradycardia Bradycardia uncommon, common x x x x x
Musculoskeletal chest pain Musculoskeletal chest pain common x x x x
Non-cardiac chest pain Non-cardiac chest pain common x x x x
Blood glucose increased Blood glucose increased common x
Febrile neutropenia Febrile neutropenia common x x x x x
Blood insulin increased Blood insulin increased common x x x
Blood alkaline phosphatase increased Blood alkaline phosphatase increased common x x x x x
Phosphatase alkaline increased 0% - 1% x x
Amylase increased Blood amylase increased common x x x x x
Blood creatine phosphokinase increased Blood creatine phosphokinase increased common x
Insomnia Insomnia common x x x x x
Oral papilloma Oral papilloma common x x x x
Deafness Hearing impaired common x x x x
Hearing impaired Hearing impaired common x x x x
Dysphonia Dysphonia common x x x x
Mental disorder Mental disorder 0% - 12% x x x x x
Dyspepsia Dyspepsia common, 0% - 6% x x x x x
Alanine aminotransferase increased Alanine aminotransferase increased common — 3% - 9% x x x x x
Nervous system disorder Nervous system disorder very common, 1% - 35% x x x x x
Erythema Erythema common, 0% - 6% x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased common — 1% - 3% x x x x x
Oedema peripheral Oedema peripheral common, 0% - 17% x x x x
Rash Rash 0% - 37% x x x x x
Diarrhoea Diarrhoea 0% - 30% x x x x x
Hypocalcaemia Hypocalcaemia uncommon — 1% - 5% x x x x x
Hypokalaemia Hypokalaemia uncommon — 1% - 9% x x x x x
Bone pain Bone pain common, 0% - 6% x x x x x
Blood albumin decreased Albumin low 0% - 4% x x
Headache Headache 1% - 22% x x x x x
Asthenia Fatigue very common, 0% - 17% x x x x x
Asthenia common, 0% - 9% x x x x x
Fatigue Fatigue very common, 0% - 17% x x x x x
Gastrointestinal disorder Gastrointestinal disorder very common, 1% - 37% x x x x x
Arthralgia Arthralgia 0% - 9% x x x x x
Musculoskeletal discomfort Arthralgia 0% - 9% x x x x x
Myalgia 1% - 12% x x x x x
Nausea Nausea 0% - 34% x x x x x
Muscle spasms Muscle spasms 0% - 29% x x x x x
Vomiting Vomiting 0% - 18% x x x x x
Arteriosclerosis Arteriosclerosis uncommon x x x x
Arthritis Arthritis uncommon x x x x
Blepharitis Blepharitis uncommon x x x x x
Blister Blister uncommon x x x x
Dermatitis bullous Blister uncommon x x x x
Bronchitis Bronchitis uncommon x x x x
Candida infection Candida infection uncommon x x x x
Oral candidiasis uncommon x x x x
Oral candidiasis Oral candidiasis uncommon x x x x
Pleuritic pain Pleuritic pain uncommon x x x x
Cholestasis Cholestasis uncommon x x x
Conjunctival haemorrhage Conjunctival haemorrhage uncommon x x x x
Conjunctivitis allergic Conjunctivitis allergic uncommon x x x x
Cyanosis Cyanosis uncommon x x x x
Dehydration Dehydration uncommon x x x x
Sensitivity of teeth Sensitivity of teeth uncommon x x x x
Drug eruption Drug eruption uncommon x x x x
Diplopia Diplopia uncommon x x x x
Dysuria Dysuria uncommon x x x x x
Ecchymosis Ecchymosis uncommon x x x x
Localised oedema Localised oedema uncommon x x x x
Enterocolitis Enterocolitis uncommon x x x x
Erythema multiforme Erythema multiforme uncommon x x x x
Erythema nodosum Erythema nodosum uncommon x x x x
Gastritis Gastritis uncommon x x x x
Gastroenteritis Gastroenteritis uncommon x x x x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease uncommon x x x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage uncommon x x x x x
Gingivitis Gingivitis uncommon x x x x
Gout Gout uncommon x x x x
Gynaecomastia Gynaecomastia uncommon x x x x x
Cardiomegaly Cardiomegaly uncommon x x
Cardiac failure Cardiac failure uncommon x x x x x
Cardiac murmur Cardiac murmur uncommon x x x x
Haematemesis Haematemesis uncommon x x x x
Haematoma Haematoma uncommon x x x x x
Haematuria Haematuria uncommon x x x x
Haemorrhoids Haemorrhoids uncommon x x x x
Hepatitis Hepatitis uncommon x
Hepatitis toxic Hepatitis toxic uncommon x x x x
Hepatomegaly Hepatomegaly uncommon x x x x
Herpes virus infection Herpes virus infection uncommon x x x
Hyperaemia Hyperaemia uncommon x x x x
Hyperaesthesia Hyperaesthesia uncommon x x x x x
Hyperparathyroidism secondary Hyperparathyroidism secondary uncommon x x x x
Pulmonary hypertension Pulmonary hypertension uncommon x x x x
Hypertensive crisis Hypertensive crisis uncommon x x x x
Hyperthyroidism Hyperthyroidism uncommon x x x x
Hypoglycaemia Hypoglycaemia uncommon x x x x
Hypotension Hypotension uncommon x x x x
Hypothyroidism Hypothyroidism uncommon x x x x
Intermittent claudication Intermittent claudication uncommon x x
Jaundice Jaundice uncommon x x x x x
Lethargy Lethargy uncommon x x x x
Leukocytosis Leukocytosis uncommon x x x x
Breast pain Breast pain uncommon x x x x
Melaena Melaena uncommon x x x x
Myocardial infarction Myocardial infarction uncommon x x x x x
Acute coronary syndrome Myocardial infarction uncommon x x x x x
Nocturia Nocturia uncommon x x x x
Optic neuritis Optic neuritis uncommon x x x x
Papilloedema uncommon x x x x
Papilloedema Papilloedema uncommon x x x x
Pericardial effusion Pericardial effusion uncommon x x x x x
Pericarditis Pericarditis uncommon x x x x x
Petechiae Petechiae uncommon x x x x
Pleural effusion Pleural effusion uncommon x x x x x
Pleurisy Pleurisy uncommon x x x x x
Pneumonia Pneumonia uncommon x x x x
Psoriasis Psoriasis uncommon x x x x
Pulmonary oedema Pulmonary oedema uncommon x x x x
Renal failure Renal failure uncommon x x x x
Restless legs syndrome Restless legs syndrome uncommon x x x x
Shock haemorrhagic Shock haemorrhagic uncommon x x x x
Skin ulcer Skin ulcer uncommon x x x x
Gastric ulcer Gastric ulcer uncommon x x x x x
Stomatitis Stomatitis uncommon x x x x x
Mouth ulceration uncommon x x x x
Shock Syncope uncommon x x x x
Syncope Syncope uncommon x x x x
Loss of consciousness Syncope uncommon x x x x
Loss of consciousness uncommon x x x x
Thrombosis Thrombosis uncommon x x x x
Thyroiditis Thyroiditis uncommon x x x x
Tinea pedis Tinea pedis uncommon x x x x
Tremor Tremor uncommon x x x x x
Urinary incontinence Urinary incontinence uncommon x x x x
Urinary tract infection Urinary tract infection uncommon x x x x
Wheezing Wheezing uncommon x x x
Dry mouth Dry mouth uncommon x x x x x
Chills Chills uncommon x x x x x
Micturition urgency Micturition urgency uncommon x x x x
Photopsia Photopsia uncommon x x x x
Photophobia Photophobia uncommon x x x x
Mouth ulceration Mouth ulceration uncommon x x x x
Migraine Migraine uncommon x x x x x
Skin atrophy Skin atrophy uncommon x x x x
Blood urea increased Blood urea increased uncommon x x x x
Swelling face Swelling face uncommon x x x x x
Globulins decreased Globulins decreased uncommon x x x x
Haemorrhage intracranial Haemorrhage intracranial uncommon x x x x
Retroperitoneal haemorrhage Retroperitoneal haemorrhage uncommon x x x x
Skin hypertrophy Skin hypertrophy uncommon x x x x
Muscular weakness Muscular weakness uncommon x x x x x
Eye pain Eye pain uncommon x x x x x
Skin discolouration Skin discolouration uncommon x x x x
Joint swelling Joint swelling uncommon x x x x
Eyelid oedema Eyelid oedema uncommon x x x x
Skin hyperpigmentation Skin hyperpigmentation uncommon x x x x
Interstitial lung disease Interstitial lung disease uncommon x x x x
Oesophageal pain Oesophageal pain uncommon x x x x
Increased appetite Increased appetite uncommon x x x x
Disturbance in attention Disturbance in attention uncommon x x x
Visual acuity reduced Visual acuity reduced uncommon x x x x
Eye irritation Eye irritation uncommon x x x x
Hepatotoxicity Hepatotoxicity uncommon x x x x
Blood creatinine increased Blood creatinine increased uncommon x x
Creatinine increased 0% - 1% x x x x x
Gravitational oedema Gravitational oedema uncommon x x x x
Skin exfoliation Skin exfoliation uncommon x x x x
Dermal cyst Dermal cyst uncommon x x x x
Pain of skin Pain of skin uncommon x x x x
Subcutaneous abscess Subcutaneous abscess uncommon x x x x
Furuncle Furuncle uncommon x x x
Dyslipidaemia Dyslipidaemia uncommon x x x
Erectile dysfunction Erectile dysfunction uncommon x x x x x
Ventricular dysfunction Ventricular dysfunction uncommon x x x x
Sepsis Sepsis uncommon x x x x
Arterial occlusive disease Arterial occlusion uncommon x
Rectal haemorrhage Rectal haemorrhage uncommon x x x x
Eye swelling Eye swelling uncommon x x x x
Anal abscess Anal abscess uncommon x x x x
Chorioretinopathy Chorioretinopathy uncommon x x x x
Vision blurred Vision blurred uncommon x x x x x
Photosensitivity reaction Photosensitivity uncommon x x x x
Dysaesthesia Dysaesthesia uncommon x x x x
Sebaceous hyperplasia Sebaceous hyperplasia uncommon x x x x
Blood pressure increased Blood pressure increased uncommon x
Influenza like illness Influenza like illness uncommon x x x x
Chromaturia Chromaturia uncommon x x x x
Face oedema Face oedema uncommon x x x x x
Blood glucose decreased Blood glucose decreased uncommon x x
Throat irritation Throat irritation uncommon x x x x
Blood uric acid increased Hyperuricaemia uncommon x x x x
Hyperuricaemia Hyperuricaemia uncommon x x x x
Thrombocytosis Thrombocytosis uncommon x x x x
Blood parathyroid hormone increased Blood parathyroid hormone increased uncommon x x x x
Blood lactate dehydrogenase increased Blood lactate dehydrogenase increased uncommon x x x x
Blood bilirubin unconjugated increased Blood bilirubin unconjugated increased uncommon x x x x
Blood insulin decreased Blood insulin decreased uncommon x x x
Gastrointestinal ulcer perforation Gastrointestinal ulcer perforation uncommon x x x x
Laryngeal pain Pharyngolaryngeal pain uncommon x x x x
Insulin C-peptide decreased Insulin C-peptide decreased uncommon x x x x
Hyperkeratosis Hyperkeratosis uncommon x x x x
Peripheral artery stenosis Arterial stenosis limb uncommon x
Subileus Subileus uncommon x x x x
Musculoskeletal stiffness Musculoskeletal stiffness uncommon x x x
Troponin increased Troponin increased uncommon x x x x
Peripheral arterial occlusive disease Peripheral arterial occlusive disease uncommon x x x
Brain oedema Brain oedema uncommon x x x x
Ocular surface disease Ocular surface disease uncommon x x x x
Exfoliative rash Exfoliative rash uncommon x x x x
Coronary artery disease Coronary artery disease uncommon x x x x
Oropharyngeal pain Oropharyngeal pain uncommon x x x x
Oesophagitis ulcerative Oesophagitis ulcerative uncommon x x x x
Feeling hot Feeling hot uncommon x x x x
Hiatus hernia Hiatus hernia uncommon x x x x
Visual impairment Visual impairment uncommon x x x
Abdominal pain Abdominal pain 0% - 10% x x x x x
Gastrointestinal pain Abdominal pain 0% - 10% x x x x x
Constipation Constipation 0% - 12% x x x x x
Pain in extremity Pain in extremity 1% - 7% x x x x x
Pruritus Pruritus 0% - 24% x x x x x
Myalgia Myalgia 1% - 12% x x x x x
Tumour lysis syndrome Tumour lysis syndrome rare x x x
Alopecia Alopecia common, 0% - 14% x x x x x
Appetite disorder Appetite disorder x
Breast disorder Breast disorder x x x x x
Transient ischaemic attack Transient ischaemic attack x
Cyst Cyst x
Oedema Oedema x
Endocrine disorder Endocrine disorder x x x x x
Eye disorder Eye disorder x x x x x
Cardiac disorder Cardiac disorder x x x x x
Haemorrhage Haemorrhage x x
Haemoglobin Haemorrhage x x
Herpes simplex Herpes simplex x
Hypersensitivity Hypersensitivity x x x x
Immune system disorder Immune system disorder x x x x
Influenza Influenza x
Bundle branch block left Bundle branch block left x
Leukopenia Leukopenia x x
Menorrhagia Menorrhagia x x x x
Neoplasm Neoplasm x x x x
Polyp Polyp x
Torsade de pointes Torsade de pointes x x x
Urethral disorder Urinary tract disorder x x x x x
Urinary tract disorder Urinary tract disorder x x x x x
Oesophageal ulcer Oesophageal ulcer x
Abdominal pain upper Abdominal pain upper x x x x
Nipple swelling Nipple swelling x x x x
Hepatobiliary disease Hepatobiliary disease x x x x x
Fluid retention Fluid retention x x
Breast induration Breast induration x x x x
Diastolic dysfunction Diastolic dysfunction x
Blood potassium decreased Blood potassium decreased x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

nilotinib / nilotinib

Side effects:225
Source:EMA

NILOTINIB

Side effects:305
Source:FDA Structured Product Label

Nilotinib / Tasigna, Capsule

Side effects:309
Source:Medsafe

nilotinib / TASIGNA

Side effects:312
Source:medicines.org.au

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label