Imatinib mesylate

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

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MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 20)
1 2 3 4 5 6 7 8 9 10
Oedema def Oedema def postmarketing — 2% - 86.1% x x x x x x x x x
Fluid retention Fluid retention 2% - 76% x x x x x x x x
Generalised oedema x x x x x x x x
Asthenia def Asthenia def 0.2% - 74.9% x x x x x x x x
Fatigue def 1% - 74.9% x x x x x x x x x
Weakness def x x x x x
Fatigue def Fatigue def 1% - 74.9% x x x x x x x x x
Nausea def Nausea def 3% - 73% x x x x x x x x x
Muscle spasms def Cramp muscle def postmarketing, 0.4% - 62% x x x x x x x x x
Diarrhoea def Diarrhoea def 3% - 58.2% x x x x x x x x x
Vomiting def Vomiting def 2% - 58% x x x x x x x x x
Abdominal pain def Abdominal pain def 1% - 57.2% x x x x x x x x x
Gastrointestinal pain def Abdominal pain def 1% - 57.2% x x x x x x x x x
Pain def Pain def 0.4% - 57.2% x x x x x x x x x
Haemorrhage def Haemorrhage def rare — 0.4% - 53% x x x x x x x x x
Haemoglobin def Haemorrhage def rare — 0.4% - 53% x x x x x x x x x
Dermatitis def Rash def rare — 3% - 49.8% x x x x x x x x x
Dermatitis def infrequent x x x x x x x
Rash def Rash def rare — 3% - 49.8% x x x x x x x x x
Eruption infrequent x x x x
Musculoskeletal pain def Musculoskeletal pain def 2% - 49% x x x x x x x x
Neutropenia def Neutropenia def 0% - 48% x x x x x x x x x
Anaemia def Anaemia def rare, 0% - 42% x x x x x x x x
Body temperature increased def Body temperature increased def postmarketing, 2% - 41% x x x x x x x x x
Arthralgia def Arthralgia def 1% - 40% x x x x x x x x x
Musculoskeletal discomfort Arthralgia def 1% - 40% x x x x x x x x x
Myalgia def 0% - 32.2% x x x x x x x x x
Headache def Headache def 0.6% - 36% x x x x x x x x x
Decreased appetite Anorexia def 0% - 35.8% x x x x x x x x x
Thrombocytopenia def Thrombocytopenia def 0% - 33% x x x x x x x x x
Myalgia def Myalgia def 0% - 32.2% x x x x x x x x x
Weight increased def Weight increased def postmarketing, 0.6% - 32% x x x x x x x x x
Cough def Cough def 0% - 27% x x x x x x x x x
Dyspepsia def Dyspepsia def 0% - 27% x x x x x x x x
Nasopharyngitis def Nasopharyngitis def 0% - 22% x x x x x x x x
Dyspnoea def Dyspnoea def postmarketing, 0.9% - 21% x x x x x x x x x
Leukopenia def Leukopenia def 0.7% - 19.6%
Infection def Infection def rare, 0% - 19% x x x x x x x x
Respiratory tract infection def Respiratory tract infection def 0% - 19% x x x x x x x
Upper respiratory tract infection def Upper respiratory tract infection def 0% - 19% x x x x x x x
Pruritus def Pruritus def 0.8% - 18.9% x x x x x x x x x
Night sweats def Night sweats def 0.2% - 17% x x x x x x x x x
Hyperhidrosis def Sweating def 0.2% - 17% x x x x x x x x x
Constipation def Constipation def 0.4% - 16% x x x x x x x x x
Dizziness def Dizziness def 0% - 16% x x x x x x x
Syncope def infrequent x x x
Pharyngitis def Pharyngitis def 0% - 15% x x x x
Alopecia def Alopecia def infrequent, 3.2% - 14.8% x x x
Insomnia def Insomnia def 0% - 14% x x x x x x x
Hypokalaemia def Hypokalaemia def 0.8% - 13% x x x x x x x x x
Pneumonia def Pneumonia def rare, 1% - 13% x x x x x x x x x
Anxiety def Anxiety def infrequent, 0% - 12% x x x x
Anguish def postmarketing
Chills def Rigors 0% - 12% x x x x x x x
Chest pain def Chest pain def 0.4% - 11% x x x x
Influenza def Influenza def 0% - 11% x x x x x x x
Sinusitis def Sinusitis def 0.4% - 11% x x x x
Flatulence def Flatulence def 0.1% - 10.1% x x x x x x
Lymphopenia def Lymphopenia def 0.7% - 10.1%
Gastrointestinal haemorrhage def Gastrointestinal haemorrhage def 0.4% - 8% x x x x x x x
Blood creatinine increased Creatinine increased def 0% - 8% x x x x x x x x
Aspartate aminotransferase increased def Aspartate aminotransferase increased def 0% - 7.1% x x x x x x x x
Alanine aminotransferase increased def Alanine aminotransferase increased def 0% - 7% x x x x x x x x x
Blood alkaline phosphatase increased def Phosphatase alkaline increased 0% - 5.5% x x x x x x
Blood bilirubin increased def Blood bilirubin increased def 0% - 3.8% x x x x x x x x
Abdominal distension def Abdominal distension def rare, infrequent x x x
Distention def rare x
Conjunctival haemorrhage Conjunctival haemorrhage infrequent x
Dehydration def Dehydration def infrequent x x x
Dermatitis exfoliative def Dermatitis exfoliative def infrequent x x x x
Flushing def Flushing def infrequent x x x
Gastritis def Gastritis def infrequent x x x
Gastroenteritis def Gastroenteritis def infrequent x x x
Gastrooesophageal reflux disease def Gastrooesophageal reflux disease def rare, infrequent x x x
Gout def Gout def infrequent x x x
Cardiac failure def Cardiac failure def postmarketing, infrequent x x x x x x
Haematuria def Haematuria def infrequent x x x
Hepatitis def Hepatitis def rare, infrequent x
Herpes virus infection def Herpes NOS def infrequent x x x
Herpes simplex def Herpes simplex def infrequent x x x
Herpes zoster def Herpes zoster def infrequent x x x x
Hypertension def Hypertension def infrequent x x x
Hypertrophy def Hypertrophy def infrequent x x x
Hypotension def Hypotension def infrequent x x x
Menorrhagia def Menorrhagia def infrequent x x x
Nail disorder def Nail disorder def infrequent x x x
Pancytopenia def Pancytopenia def infrequent x x x
Cytopenia def x x x x x x x x
Paraesthesia def Paraesthesia def rare, infrequent x x x
Neuropathy peripheral def Neuropathy peripheral def infrequent x x x
Neuropathy def infrequent x x x
Pigmentation disorder def Pigmentation def infrequent x x x x
Pigmentation skin def infrequent x x x
Psoriasis def Psoriasis def infrequent x x
Purpura def Purpura def infrequent x x x
Vascular purpura Purpura def infrequent x x x
Renal failure def Renal failure def infrequent x x x x x x x x
Sciatica def Sciatica def infrequent x x x
Gastric ulcer def Gastric ulcer def infrequent x x x
Shock def Syncope def infrequent x x x
Shock def postmarketing
Syncope def Syncope def infrequent x x x
Loss of consciousness def Syncope def infrequent x x x
Tachycardia def Tachycardia def infrequent x x x
Tinnitus def Tinnitus def infrequent x x x
Ulcer def Ulcer def rare, infrequent x x x
Pollakiuria def Pollakiuria def infrequent x x x
Vertigo def Vertigo def infrequent x x x
Weight decreased def Weight decreased def infrequent x x x
Hypophosphataemia def Hypophosphataemia def infrequent x x x
Stomatitis def Mouth ulceration def rare, infrequent x x x
Mouth ulceration def Mouth ulceration def rare, infrequent x x x
Migraine def Migraine def infrequent x x x
Blood creatine phosphokinase increased Creatine phosphokinase increased def infrequent x x x
Blood lactate dehydrogenase increased Lactic dehydrogenase activity increased infrequent x x x
Dry skin def Dry skin def infrequent x x x
Photosensitivity reaction def Photosensitivity reaction def infrequent x x x
Photosensitivity def infrequent x x x x
Musculoskeletal stiffness Muscle stiffness infrequent x x x
Stiffness infrequent x x x
Rash vesicular Rash vesicular rare, infrequent x x x
Memory impairment def Memory impairment def infrequent x x
Dermatitis bullous def Bullous eruption infrequent x
Blister def x
Sepsis def Sepsis def infrequent x x x
Peripheral coldness Peripheral coldness infrequent x
Dry eye Dry eye infrequent x x x
Sexual dysfunction Sexual dysfunction infrequent x x x
Feeling cold Coldness infrequent x
Acute generalised exanthematous pustulosis def Acute generalised exanthematous pustulosis def rare, infrequent x x
Breast enlargement Breast enlargement infrequent x x x
Somnolence def Somnolence def infrequent x x x
Delirium tremens def Delirium tremens def postmarketing
Aplastic anaemia def Aplastic anaemia def rare x x x
Angioedema def Angioedema def rare x x x
Ascites def Ascites def postmarketing x x x x x x x x x
Brain oedema def Edema cerebral def postmarketing, rare x x x x x x
Breast feeding def Breast feeding def postmarketing
Neoplasm malignant def Neoplasm malignant def postmarketing x
Carcinogenicity postmarketing
Cardiac tamponade def Cardiac tamponade def postmarketing x
Cytogenetic abnormality def Cytogenetic abnormality def postmarketing
Colitis def Colitis def rare x x x
Confusional state def Confusional state def rare x x
Feeling abnormal Confusional state def rare x x
Conjunctivitis def Conjunctivitis def rare x x x
Convulsion def Convulsion def rare x
Diverticulitis def Diverticulitis def rare, postmarketing x
Ehlers-Danlos syndrome def Ehlers-Danlos syndrome def postmarketing
Embolism def Embolism def rare, postmarketing x x
Eosinophilia def Eosinophilia def postmarketing
Toxic epidermal necrolysis def Toxic epidermal necrolysis def postmarketing
Erythema multiforme def Erythema multiforme def postmarketing
Assisted fertilisation Fertilization def postmarketing
Fibrosis def Fibrosis def rare x x x
Glaucoma def Glaucoma def rare x x
Cardiac disorder def Cardiac disorder def postmarketing
Hyperkalaemia def Hyperkalaemia def rare x x x
Hypersensitivity def Hypersensitivity def rare x x x
Hyponatraemia def Hyponatraemia def rare x x x
Intestinal obstruction def Intestinal obstruction def rare, postmarketing x x
Jaundice def Jaundice def postmarketing
Mastocytic leukaemia def Mastocytic leukaemia def postmarketing
Lymphoma def Lymphoma def postmarketing
Mastocytoma def Mastocytoma def postmarketing
Necrosis def Necrosis def rare, postmarketing x x x
Obstruction def Obstruction def rare, postmarketing x x
Osteonecrosis def Osteonecrosis def rare, postmarketing x
Necrosis ischaemic def rare, postmarketing x
Ovarian disorder def Ovarian disorder def postmarketing
Pancreatitis def Pancreatitis def rare x x
Optic neuritis def Papilloedema def postmarketing, rare x x x x
Papilloedema def Papilloedema def postmarketing, rare x x x x
Parity def Parity def rare x
Pericarditis def Pericarditis def rare, postmarketing x x
Pulmonary fibrosis def Pulmonary fibrosis def rare x x x
Retinal haemorrhage def Retinal haemorrhage def rare x x
Skin disorder def Skin disorder def rare x
Swelling def Swelling def rare x x x
Testicular disorder def Testicular disorder def postmarketing
Thrombosis def Thrombosis def rare, postmarketing x x
Erythema def Erythema def postmarketing
Angiopathy def Angiopathy def rare, postmarketing x x
Vitreous haemorrhage def Vitreous haemorrhage def rare, postmarketing x x
Acute febrile neutrophilic dermatosis def Acute febrile neutrophilic dermatosis def rare x
Neutrophilic dermatosis rare x
Hepatic failure def Hepatic failure def rare x x x x x x x x
Gastrointestinal perforation Gastrointestinal perforation rare, postmarketing x
Intracranial pressure increased def Intracranial pressure increased def postmarketing, rare x x x
Joint swelling Joint swelling rare x x x
Apoptosis def Apoptosis def postmarketing
Interstitial lung disease def Interstitial pneumonia rare x x x
Necrosis ischaemic def Necrosis ischaemic def rare, postmarketing x
Renal impairment def Function kidney decreased postmarketing
Disease progression def Disease progression def postmarketing
Macular oedema def Macular oedema def rare x x x
Systemic mastocytosis def Indolent systemic mastocytosis def postmarketing
Tumour necrosis def Tumour necrosis def rare, postmarketing x x
Vision blurred def Vision blurred def rare x x x
Liver disorder def Hepatic impairment postmarketing
Ileus def Ileus def rare, postmarketing x x
Death Death postmarketing
Metastatic neoplasm def Metastatic disease def postmarketing
Back pain def Back pain def x x x x x x
Blister def Blister def x
Varicella def Varicella def x
Dysgeusia def Dysgeusia def x x x x x x
Ecchymosis def Ecchymosis def x x x
Effusion def Effusion def x x x x x x x x x
Epistaxis def Epistaxis def x x x x x x
Gastrointestinal neoplasm def Gastrointestinal neoplasm def
Gynaecomastia def Gynaecomastia def x
Cardiac failure congestive def Cardiac failure congestive def x x x
Blood disorder def Blood disorder def
Hyperplasia def Hyperplasia def
Immunosuppression def Immunosuppression def
Inflammation def Inflammation def x
Nephropathy def Nephropathy def
Musculoskeletal disorder def Musculoskeletal disorder def
Myelodysplastic syndrome def Myelodysplasia x
Myeloproliferative disorder def Myeloproliferative disorder def
Nephrotic syndrome def Nephrosis def
Opportunistic infection def Opportunistic infection def
Papilloma def Papilloma def
Pericardial effusion def Pericardial effusion def x x x x x x
Petechiae def Petechiae def x x x x x
Pleural disorder def Pleural disorder def x x x x x x x x x
Pleural effusion def Pleural effusion def x x x x x x x x x
Alveolar proteinosis def Alveolar proteinosis def x
Pulmonary oedema def Pulmonary oedema def x x x x x x x x x
Rhinitis def Rhinitis def
Cardiogenic shock def Cardiogenic shock def
Tumour lysis syndrome def Tumour lysis syndrome def x
Viral infection def Viral infection def x
Oedema peripheral def Oedema peripheral def x x x x x x x
Edema of lower extremities x x x x x x x
Lower respiratory tract infection Lower respiratory tract infection
Periorbital oedema def Periorbital oedema def x x x
Blood urea increased Blood urea increased
Generalised oedema Generalised oedema x x x x x x x x
Renal tubular disorder def Renal tubular disorder def
Hepatic necrosis def Hepatic necrosis def x
Bone pain def Bone pain def
Lacrimation increased def Lacrimation increased def x x x x x x x
Lacrimation def x x x x x x
Acute hepatic failure def Acute hepatic failure def x x x x x x x x
Aphagia Aphagia
Vaginal discharge def Vaginal discharge def
Dyspnoea exertional Dyspnoea exertional
Tenderness def Tenderness def x x x
Hepatic enzyme increased Hepatic enzyme increased
Sexually active Sexually active
Oropharyngeal discomfort Throat sore def x x x
Oropharyngeal pain Throat sore def x x x
Pharyngolaryngeal pain def x x x x x x
Left ventricular dysfunction def Left ventricular dysfunction def
Ventricular dysfunction def Ventricular dysfunction def
Haematological malignancy def Haematological malignancy def
Face oedema def Face oedema def x x x x x x
Nephropathy toxic Nephropathy toxic
Drug interaction def Drug interaction def
Eye oedema Eye oedema
Febrile neutropenia def Febrile neutropenia def x
Cardiomyopathy def Cardiomyopathy def
Bone marrow necrosis Bone marrow necrosis x
Haematochezia def Blood in stool x
Cardiac hypertrophy def Cardiac hypertrophy def
Calcinosis def Deposit calcium def
Cell death def Cytolysis def x
Abdominal discomfort Gastrointestinal tract irritation
Gastrointestinal tract irritation Gastrointestinal tract irritation
Cerebral haemorrhage def Cerebral haemorrhage def x x x x x x
Indication Labels
Blast cell crisis def x x x x x x x
Chronic myeloid leukaemia def x x x x x x x x
Chronic phase chronic myeloid leukemia def x x x x x
Gastrointestinal stromal tumour def x x x x x x x x
Leukaemia def x x x x x x x x x
Myeloid leukaemia def x x x x x x x x
Neoplasm def x x x x x x x x
Philadelphia chromosome positive x x x x x x x
Sarcoma def x

Information

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01XE01

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. imatinib mesylate / Gleevec : 1 side effect (FDA MedWatch)
  2. IMATINIB MESYLATE / GLEEVEC : 48 side effects (Drugs@FDA)
  3. imatinib mesylate / Gleevec : 61 side effects (FDA MedWatch)
  4. Imatinib : 66 side effects (BC Cancer)
  5. imatinib mesylate / Gleevec : 73 side effects (FDA CDER)
  6. IMATINIB MESYLATE / GLEEVEC : 75 side effects (Drugs@FDA)
  7. IMATINIB MESYLATE / GLEEVEC : 78 side effects (Drugs@FDA)
  8. IMATINIB MESYLATE / GLEEVEC : 142 side effects (Drugs@FDA)
  9. IMATINIB MESYLATE / GLEEVEC : 158 side effects (Drugs@FDA)
  10. IMATINIB MESYLATE / GLEEVEC : 168 side effects (Drugs@FDA)