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Cyclophosphamide

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01AA01

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9
Decreased appetite Anorexia 33% x x x x x x x x x
Renal tubular necrosis Renal tubular necrosis 1-5% x x x x x
Hyperhidrosis Sweating 0.1-1% x
Hyperhidrosis postmarketing x x
Sweating increased x
Jaundice Jaundice 1% x x x x x x x x x
Ureteritis Ureteritis 1% x x x x x
Enterocolitis haemorrhagic Hemorrhagic colitis 1% x x x x x x x x x
Congenital anomaly Congenital anomaly postmarketing x x
Developmental delay Congenital anomaly postmarketing x x
Pancreatitis acute Pancreatitis acute postmarketing x x x x
Alveolitis allergic Alveolitis allergic postmarketing x x
Amenorrhoea Amenorrhoea postmarketing x x x x x
Anaphylactic shock Anaphylactic shock postmarketing x x x x x x x x x
Arthralgia Arthralgia postmarketing x x
Musculoskeletal discomfort Arthralgia postmarketing x x
Myalgia postmarketing x x
Ascites Ascites postmarketing x x x x
Asthenia Asthenia postmarketing x x x x x x x x
Fatigue postmarketing x x x x
Atrial fibrillation Atrial fibrillation postmarketing x x
Azoospermia Azoospermia postmarketing x x x x
Oligospermia postmarketing x x x x
Bladder cancer Bladder cancer postmarketing x x
Bladder carcinoma x
Blister Blister postmarketing x x
Dermatitis bullous Blister postmarketing x x
Bronchospasm Bronchospasm postmarketing x x
Obliterative bronchiolitis Obliterative bronchiolitis postmarketing x x
Neoplasm malignant Neoplasm malignant postmarketing, 1% x x x
Renal cell carcinoma Renal cell carcinoma postmarketing x x
Cardiac tamponade Cardiac tamponade postmarketing x x x
Chest pain Chest pain postmarketing x x
Cholestasis Cholestasis postmarketing x x
Colitis Colitis postmarketing x x
Infection Infection postmarketing x x x x x x x
Confusional state Confusional state postmarketing x x x
Feeling abnormal Confusional state postmarketing x x x
Malaise postmarketing x x x x x x
Conjunctivitis Conjunctivitis postmarketing x x
Constipation Constipation postmarketing x x x x
Obstipation x
Muscle contracture Muscle contracture postmarketing x x
Cough Cough postmarketing x x
Dry cough x
Deafness Deafness postmarketing x x
Hearing impaired postmarketing x x
Dermatitis Dermatitis postmarketing x x x x
Rash x x x x x x x x
Scleroderma Scleroderma postmarketing x x
Disseminated intravascular coagulation Disseminated intravascular coagulation postmarketing x x x x
Dizziness Dizziness postmarketing, 1% x x x x x x
Dysgeusia Dysgeusia postmarketing x x
Dyspnoea Dyspnoea postmarketing x x x x
Oedema Oedema postmarketing x x x x x
Enteritis Enteritis postmarketing x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing, 1% x x x x x x x x
Erythema multiforme Erythema multiforme postmarketing x x
Stevens-Johnson syndrome postmarketing x x x x x x x
Fatigue Fatigue postmarketing x x x x
Foetal death Foetal death postmarketing x x
Microsomia Microsomia postmarketing x x
Body temperature increased Body temperature increased postmarketing x x x x x x x x
Flushing Flushing postmarketing x x x x
Gastroenteritis Gastroenteritis postmarketing x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage postmarketing x x
Headache Headache postmarketing x x x x x x
Cardiac arrest Cardiac arrest postmarketing x x
Cardiac failure Cardiac failure postmarketing x x
Decompensation cardiac x
Haematuria Haematuria postmarketing x x x x
Microscopic hematuria x
Haemolytic uraemic syndrome Haemolytic uraemic syndrome postmarketing x x x x
Hepatic encephalopathy Hepatic encephalopathy postmarketing x x x
Venoocclusive liver disease Venoocclusive liver disease postmarketing x x
Hepatitis Hepatitis postmarketing x x
Cytolytic hepatitis postmarketing x x
Hepatomegaly Hepatomegaly postmarketing x x x x
Herpes zoster Herpes zoster postmarketing x x
Hypersensitivity Hypersensitivity postmarketing x x x x
Hypertension Hypertension postmarketing x x
Pulmonary hypertension Pulmonary hypertension postmarketing x x
Hypoaesthesia Hypoaesthesia postmarketing x x
Hyponatraemia Hyponatraemia postmarketing x x x x x
Hypotension Hypotension postmarketing x x
Infertility Infertility postmarketing x x x x x
Inflammation Inflammation postmarketing x x x x
Premature labour Premature labour postmarketing x x
Lymphoma Lymphoma postmarketing x x
Non-Hodgkin's lymphoma Lymphoma postmarketing x x
Multi-organ failure Multi-organ failure postmarketing x x
Myelodysplastic syndrome Myelodysplastic syndrome postmarketing x x
Myocardial infarction Myocardial infarction postmarketing x x x x
Myocardial necrosis x x
Acute coronary syndrome Myocardial infarction postmarketing x x x x
Myocarditis Myocarditis postmarketing x x x x x x
Nail disorder Nail disorder postmarketing x x
Nail changes x
Nasal congestion Nasal congestion postmarketing x x x
Necrosis Necrosis postmarketing x x x
Neoplasm Neoplasm postmarketing x x
Neuralgia Neuralgia postmarketing x x
Oligomenorrhoea Oligomenorrhoea postmarketing x x
Ovarian disorder Ovarian disorder postmarketing x x
Pain Pain postmarketing x x x x x x x x
Palpitations Palpitations postmarketing x x
Pancytopenia Pancytopenia postmarketing x x x
Myelosuppression postmarketing x x x x x
Paraesthesia Paraesthesia postmarketing x x
Pericardial effusion Pericardial effusion postmarketing x x
Pericarditis Pericarditis postmarketing x x x x
Neuropathy peripheral Neuropathy peripheral postmarketing x x
Phlebitis Phlebitis postmarketing x x
Pleural effusion Pleural effusion postmarketing x x
Pneumonia Pneumonia postmarketing x x x x x x
Pregnancy Pregnancy postmarketing x x
Pruritus Pruritus postmarketing x x x x
Pulmonary oedema Pulmonary oedema postmarketing x x
Pulmonary embolism Pulmonary embolism postmarketing x x
Pulmonary veno-occlusive disease Pulmonary veno-occlusive disease postmarketing x x
Renal failure Renal failure postmarketing x x
Renal impairment postmarketing x x
Acute respiratory distress syndrome Acute respiratory distress syndrome postmarketing x x
Rhabdomyolysis Rhabdomyolysis postmarketing x x x
Convulsion Convulsion postmarketing x x x
Cardiogenic shock Cardiogenic shock postmarketing x x
Septic shock Septic shock postmarketing x x
Muscle spasms Muscle spasms postmarketing x x x
Spinal cord disorder Spinal cord disorder postmarketing x x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x x x x x x x
Stomatitis Stomatitis postmarketing x x x x x
Mouth ulceration x x x x x x x
Oral mucosa sore x x x x x x x
Swelling Swelling postmarketing x x x
Tachycardia Tachycardia postmarketing x x x
Thrombosis Thrombosis postmarketing x x
Tinnitus Tinnitus postmarketing x x
Tremor Tremor postmarketing x x
Tuberculosis Tuberculosis postmarketing x x
Tumour lysis syndrome Tumour lysis syndrome postmarketing x x x
Erythema Erythema postmarketing x x
Redness x
Urticaria Urticaria postmarketing x x x
Generalized urticaria x
Vasculitis Vasculitis postmarketing x x
Venous thrombosis Venous thrombosis postmarketing x x
Ventricular fibrillation Ventricular fibrillation postmarketing x x
Ventricular tachycardia Ventricular tachycardia postmarketing x x
Hepatitis viral Hepatitis viral postmarketing x x
Water intoxication Water intoxication postmarketing x x x
Encephalopathy Encephalopathy postmarketing x x
Chills Chills postmarketing x x
Hepatic failure Hepatic failure postmarketing x x
Ventricular arrhythmia Ventricular arrhythmia postmarketing x x
Acute leukaemia Acute leukaemia postmarketing x x
Myeloid leukaemia x
Cystitis haemorrhagic Cystitis haemorrhagic postmarketing x x x x x
Hepatic function abnormal Hepatic function abnormal postmarketing x x x
Hepatitis cholestatic Hepatitis cholestatic postmarketing x x
Swelling face Swelling face postmarketing x x
Pulmonary haemorrhage Pulmonary haemorrhage postmarketing x x
Renal tubular disorder Renal tubular disorder postmarketing x x
Hypogeusia Hypogeusia postmarketing x x
Polyneuropathy Polyneuropathy postmarketing x x
Malignant neoplasm of renal pelvis Malignant neoplasm of renal pelvis postmarketing x x
Ureteric cancer Ureteric cancer postmarketing x x
Testicular atrophy Testicular atrophy postmarketing x x
Nephrogenic diabetes insipidus Nephrogenic diabetes insipidus postmarketing x x
Interstitial lung disease Interstitial lung disease postmarketing x x
Interstitial pneumonia x x x x x x
Lung fibrosis interstitial x x x x x x x
Malaise Malaise postmarketing x x x x x x
Discomfort Malaise postmarketing x x x x x x
Discomfort x
Ill-defined disorder Malaise postmarketing x x x x x x
Myalgia Myalgia postmarketing x x
Neurotoxicity Neurotoxicity postmarketing x x
Hepatotoxicity Hepatotoxicity postmarketing, 1% x x x x
Peripheral ischaemia Peripheral ischaemia postmarketing x x
Hepatic enzyme increased Hepatic enzyme increased postmarketing x x
Sepsis Sepsis postmarketing x x
Organising pneumonia Organising pneumonia postmarketing x x
Caecitis Caecitis postmarketing x x
Fluid retention Fluid retention postmarketing x x
Water retention x x x
Cystitis interstitial Cystitis interstitial postmarketing x x
Blood bilirubin increased Blood bilirubin increased postmarketing x x
Mucosal inflammation Mucosal inflammation postmarketing x x x x
Bladder necrosis Bladder necrosis postmarketing x x
Dysaesthesia Dysaesthesia postmarketing x x
Lacrimation increased Lacrimation postmarketing x x
Arrhythmia supraventricular Arrhythmia supraventricular postmarketing x x
Bradycardia Bradycardia postmarketing x x
Respiratory distress Respiratory distress postmarketing x x
Toxic skin eruption Toxic skin eruption postmarketing x x
Influenza like illness Influenza like illness postmarketing x x
Blood glucose increased Blood glucose increased postmarketing x x
Blood glucose decreased Blood glucose decreased postmarketing x x
Nephropathy toxic Nephropathy toxic postmarketing x x
Nephrotoxicity x
Stillbirth Stillbirth postmarketing x x
Menopausal symptoms Hot flush postmarketing x x
Hot flush Hot flush postmarketing x x
Blood uric acid increased Hyperuricaemia postmarketing x x x x x
Hyperuricaemia Hyperuricaemia postmarketing x x x x x
C-reactive protein increased C-reactive protein increased postmarketing x x
Ovarian failure Ovarian failure postmarketing x x x
Blood lactate dehydrogenase increased Blood lactate dehydrogenase increased postmarketing x x
Nasal discomfort Nasal discomfort postmarketing x x
Carditis Carditis postmarketing x x
Myocardial haemorrhage Myocardial haemorrhage postmarketing x x
Cardiomyopathy Cardiomyopathy postmarketing x x x
Cardiomyopathy secondary NOS x
Respiratory failure Respiratory failure postmarketing x x
Nasopharyngitis Rhinorrhoea postmarketing x x x
Rhinorrhoea Rhinorrhoea postmarketing x x x
Sarcoma Sarcoma postmarketing x x
Hearing impaired Hearing impaired postmarketing x x
Parosmia Parosmia postmarketing x x
Renal impairment Renal impairment postmarketing x x
Recall phenomenon Radiation recall reaction (dermatologic) postmarketing x x x
Parotid gland inflammation Parotid gland inflammation postmarketing x x
Oropharyngeal pain Oropharyngeal pain postmarketing x x
Thrombotic microangiopathy Thrombotic microangiopathy postmarketing x x
Posterior reversible encephalopathy syndrome Posterior reversible encephalopathy syndrome postmarketing x x
Visual impairment Visual impairment postmarketing x x
Agranulocytosis Agranulocytosis x
Alopecia Alopecia x x x x x x x x x
Anaemia Anaemia x x x x x x x
Haemolytic anaemia Haemolytic anaemia x
Arrhythmia Arrhythmia x x
Bacterial infection Bacterial infection x
Cystitis Cystitis x x x x x x
Bladder pain Cystitis x x x x x x
Bladder spasm x
Cystitis noninfective Cystitis x x x x x x
Dermatomyositis Dermatomyositis x
Diabetes mellitus Diabetes mellitus x x
Diarrhoea Diarrhoea x x x x x x x x
Polyuria Diuresis x x
Enterocolitis Enterocolitis x
Rash Rash x x x x x x x x
Extravasation Extravasation x x
Fibrosis Fibrosis x x
Heart disease congenital Heart malformation x
Cardiac failure congestive Cardiac failure congestive x x x
Pericardial haemorrhage Pericardial haemorrhage x x
Haemorrhage Haemorrhage x x x
Haemoglobin Haemorrhage x x x
Hyperbilirubinaemia Hyperbilirubinaemia x x
Hyperglycaemia Hyperglycaemia x
Hyperkalaemia Hyperkalaemia x x
Inappropriate antidiuretic hormone secretion Inappropriate antidiuretic hormone secretion x x x x x x x
Renal failure acute Renal failure acute x
Myeloid leukaemia Myeloid leukaemia x
Leukopenia Leukopenia x x x x x x
Methaemoglobinaemia Methaemoglobinaemia x
Myeloproliferative disorder Myeloproliferative disorder x
Myopia Myopia x
Myxoedema Myxoedema x x
Nausea Nausea x x x x x x x x x
Prurigo Prurigo x
Radiation injury Radiation injury x
Rales Rales x
Rhinitis Rhinitis x
Shock Shock x
Pigmentation disorder Pigmentation skin x
Sneezing Sneezing x
Telangiectasia Telangiectasia x
Thrombocytopenia Thrombocytopenia x x x x x x x
Embolism Thromboembolism x x
Embolism venous Thromboembolism x x
Ulcer Ulcer x
Ureteric obstruction Ureteric obstruction x
Viral infection Viral infection x
Vomiting Vomiting x x x x x x x x x
Granulomatosis with polyangiitis Wegener's granulomatosis x
Weight increased Weight increased x x x
Wound Wound x
Agitation Agitation x
Mouth ulceration Mouth ulceration x x x x x x x
Growth retardation Growth retardation x
Impaired healing Impaired healing x
Injection site pain Injection site pain x
Sinus congestion Sinus congestion x
Menstruation irregular Menstruation irregular x
Skin hyperpigmentation Skin hyperpigmentation x x
Abdominal discomfort Abdominal discomfort x x x x x x x
Tenderness Tenderness x
Vision blurred Vision blurred x x
Platelet count decreased Platelet count decreased x
Chemical cystitis Chemical cystitis x
Ovarian atrophy Ovarian atrophy x
Systemic lupus erythematosus Lupus erythematosus x
Menorrhagia Prolonged menses x
Bladder spasm Bladder spasm x
Bladder fibrosis Bladder fibrosis x x x x
Fluid overload Fluid overload x
Urine flow decreased Urine flow decreased x
Drug interaction Drug interaction x
Hypoxia Hypoxemia x
Febrile neutropenia Febrile neutropenia x
Myopericarditis Myopericarditis x
Cardiotoxicity Cardiotoxicity x x x x x
Acute cardiac toxicity x
Pulmonary toxicity Pulmonary toxicity x x x x
Venoocclusive disease Venoocclusive disease x x
Hypothrombinaemia Hypothrombinaemia x
Urine output Urine output x
Palmar-plantar erythrodysaesthesia syndrome Palmar-plantar erythema x
Wound healing normal Wound healing normal x
Bacterial disease carrier Bacterial colonisation x x
Metastatic neoplasm Metastatic neoplasm x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

cyclophosphamide

Side effects:27
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE

Side effects:29
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE ANHYDROUS

Side effects:29
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE / CYTOXAN TAB 50MG

Side effects:35
Source:Health Canada

Cyclophosphamide

Side effects:90
Source:BC Cancer

CYCLOPHOSPHAMIDE / PROCYTOX TAB 25MG

Side effects:84
Source:Health Canada

CYCLOPHOSPHAMIDE ANHYDROUS

Side effects:196
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE ANHYDROUS

Side effects:200
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label