Venoocclusive liver disease

Definition: A disorder characterized by damage of the hepatic sinusoidal endothelial cells of the hepatic venules that leads to venular occlusion and hepatocellular necrosis. It is usually the side effect of high dose chemotherapy in preparation for stem cell transplantation. Less frequently it may be caused by ingestion of plant alkaloids. The clinical signs and symptoms include hyperbilirubinemia, hepatomegaly, and fluid retention.

Synonyms (terms occurring on more labels are shown first): hepatic veno-occlusive disease, HVOD, venoocclusive liver disease, sinusoidal obstruction syndrome, veno-occlusive liver disease, hepatic veno- occlusive disease, veno occlusive liver disease, Hepatic venoocclusive disease

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