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Ifosfamide

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01AA06

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5
Alopecia Alopecia 1-83% - 83% x x x x x
Nausea Nausea 58% x x x x x
Vomiting Vomiting 58% - 56-81% x x x x x
Haematuria Haematuria 46% - 6-92% x x x x x
Frank hematuria 12% x x
Microscopic hematuria x x x
Neurotoxicity CNS toxicity 12% x x x
Neurotoxicity x
Thrombocytopenia Thrombocytopenia 10% x x x x x
Nephropathy toxic Nephrotoxicity 6% x x
Nephropathy toxic x x
Renal failure Renal impairment 6% x x x
Renal failure 1% x
Renal impairment Renal impairment 6% x x x
Cystitis haemorrhagic Cystitis haemorrhagic 1-10% x x
Hepatic function abnormal Hepatic function abnormal 3% x x
Phlebitis Phlebitis 2% x x x
Body temperature increased Body temperature increased postmarketing, 1% - 8% x x x x x
Fever of unknown origin 1% x x x
Thrombophlebitis Thrombophlebitis 1% x x
Decreased appetite Anorexia 1% x x x x
Coagulopathy Coagulopathy 1% x x
Dermatitis Dermatitis 1% x x x x x
Rash postmarketing x
Diarrhoea Diarrhoea 1% x x x x
Encephalitis Encephalitis 1% x x
Asthenia Fatigue 1% x x x
Asthenia x x
Fatigue Fatigue 1% x x x
Hypersensitivity Hypersensitivity postmarketing, 1% x x x x x
Neuropathy peripheral Neuropathy peripheral 1% x x
Salivary hypersecretion Salivation 1% x x
Salivary hypersecretion postmarketing x
Stomatitis Stomatitis 1% x x x x
Polyneuropathy Polyneuropathy postmarketing, 1% x x x x x
Malaise Malaise 1% x x x
Discomfort Malaise 1% x x x
Feeling abnormal Malaise 1% x x x
Confusional state x x x x
Ill-defined disorder Malaise 1% x x x
Convulsion Convulsions generalised 1% x x
Convulsion postmarketing x x x x x
Constipation Constipation postmarketing, 1% x x x x
Hypertension Hypertension postmarketing, 1% x x x x
Hypotension Hypotension postmarketing, 1% x x x x
Cardiotoxicity Cardiotoxicity postmarketing, 1% x x x x
Abdominal pain Abdominal pain postmarketing x
Gastrointestinal pain Abdominal pain postmarketing x
Agranulocytosis Agranulocytosis postmarketing x
Alveolitis allergic Alveolitis allergic postmarketing x
Amenorrhoea Amenorrhoea postmarketing x x
Amnesia Amnesia postmarketing x
Anaphylactic shock Anaphylactic shock postmarketing x
Haemolytic anaemia Haemolytic anaemia postmarketing x
Anaemia neonatal Anaemia neonatal postmarketing x
Angina pectoris Angina pectoris postmarketing x
Angioedema Angioedema postmarketing x
Arrhythmia Arrhythmia postmarketing x x
Arthralgia Arthralgia postmarketing x
Musculoskeletal discomfort Arthralgia postmarketing x
Myalgia postmarketing x
Atrial fibrillation Atrial fibrillation postmarketing x
Atrial flutter Atrial flutter postmarketing x
Azoospermia Azoospermia postmarketing x x
Oligospermia postmarketing x
Mental disorder Mental disorder postmarketing x
Breast disorder Breast disorder postmarketing x
Bronchospasm Bronchospasm postmarketing x
Neoplasm malignant Neoplasm malignant postmarketing x
Renal cell carcinoma Renal cell carcinoma postmarketing x
Congestive cardiomyopathy Congestive cardiomyopathy postmarketing x
Catatonia Catatonia postmarketing x
Chest pain Chest pain postmarketing x
Cholestasis Cholestasis postmarketing x
Colitis Colitis postmarketing x
Infection Infection postmarketing, 8% x x x x x
Conjunctivitis Conjunctivitis postmarketing x
Connective tissue disorder Connective tissue disorder postmarketing x
Cough Cough postmarketing x
Cyst Cyst postmarketing x
Deafness Deafness postmarketing x
Hearing impaired postmarketing x
Delirium Delirium postmarketing x
Delusion Delusion postmarketing x
Disseminated intravascular coagulation Disseminated intravascular coagulation postmarketing x
Dysarthria Dysarthria postmarketing x
Osteoarthritis Dysarthria postmarketing x
Dyspnoea Dyspnoea postmarketing x
Echolalia Echolalia postmarketing x
Oedema Oedema postmarketing x
Endocrine disorder Endocrine disorder postmarketing x
Enterocolitis Enterocolitis postmarketing x
Enuresis Enuresis postmarketing x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing x
Rash Rash postmarketing x
Extrapyramidal disorder Extrapyramidal disorder postmarketing x
Eye disorder Eye disorder postmarketing x
Fanconi syndrome Fanconi syndrome postmarketing x x x x x
Renal tubular disorder Fanconi syndrome postmarketing x x x x x
Faecal incontinence Faecal incontinence postmarketing x
Microsomia Microsomia postmarketing x
Flushing Flushing postmarketing x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage postmarketing x
Cardiac arrest Cardiac arrest postmarketing x
Cardiac disorder Cardiac disorder postmarketing x
Cardiac failure Cardiac failure postmarketing x x x
Haemolytic uraemic syndrome Haemolytic uraemic syndrome postmarketing x
Venoocclusive liver disease Venoocclusive liver disease postmarketing x
Herpes zoster Herpes zoster postmarketing x
Hyperglycaemia Hyperglycaemia postmarketing x
Hyperhidrosis Hyperhidrosis postmarketing x
Pulmonary hypertension Pulmonary hypertension postmarketing x
Hypocalcaemia Hypocalcaemia postmarketing x
Hypokalaemia Hypokalaemia postmarketing x
Immune system disorder Immune system disorder postmarketing x
Inappropriate antidiuretic hormone secretion Inappropriate antidiuretic hormone secretion postmarketing x x
Infertility Infertility postmarketing x
Inflammation Inflammation postmarketing x x
Renal failure chronic Renal failure chronic postmarketing x x x
Bundle branch block left Bundle branch block left postmarketing x
Left ventricular failure Left ventricular failure postmarketing x
Pulmonary oedema Left ventricular failure postmarketing x
Pulmonary oedema postmarketing, 1% x x x
Acute lymphocytic leukaemia Acute lymphocytic leukaemia postmarketing x
Acute myeloid leukaemia Acute myeloid leukaemia postmarketing x
Acute leukaemia Acute myeloid leukaemia postmarketing x
Acute leukaemia postmarketing x
Acute promyelocytic leukaemia Acute promyelocytic leukaemia postmarketing x
Progressive multifocal leukoencephalopathy Progressive multifocal leukoencephalopathy postmarketing x
Lymphoma Lymphoma postmarketing x
Non-Hodgkin's lymphoma Lymphoma postmarketing x
Non-Hodgkin's lymphoma postmarketing x
Mediastinal disorder Mediastinal disorder postmarketing x
Premature menopause Premature menopause postmarketing x
Methaemoglobinaemia Methaemoglobinaemia postmarketing x
Dyskinesia Movement disorder postmarketing x
Movement disorder Movement disorder postmarketing x
Multi-organ failure Multi-organ failure postmarketing x
Mutism Mutism postmarketing x x
Fungal infection Fungal infection postmarketing x
Myelodysplastic syndrome Myelodysplastic syndrome postmarketing x
Myocardial infarction Myocardial infarction postmarketing x
Acute coronary syndrome Myocardial infarction postmarketing x
Myocarditis Myocarditis postmarketing x
Nail disorder Nail disorder postmarketing x
Neoplasm Neoplasm postmarketing x
Nervous system disorder Nervous system disorder postmarketing x
Neuralgia Neuralgia postmarketing x
Osteomalacia Osteomalacia postmarketing x
Ovarian disorder Ovarian disorder postmarketing x
Pain Pain postmarketing x
Pain in extremity Pain in extremity postmarketing x
Palpitations Palpitations postmarketing x
Pancreatitis Pancreatitis postmarketing, 1% x x x
Pancytopenia Pancytopenia postmarketing x
Myelosuppression postmarketing x x x
Paraesthesia Paraesthesia postmarketing x
Pericardial effusion Pericardial effusion postmarketing x
Pericarditis Pericarditis postmarketing x
Petechiae Petechiae postmarketing x
Pleural effusion Pleural effusion postmarketing x
Pneumonia Pneumonia postmarketing x
Polyp Polyp postmarketing x
Polyuria Polyuria postmarketing x
Urine output increased Polyuria postmarketing x
Supraventricular extrasystoles Supraventricular extrasystoles postmarketing x
Pruritus Pruritus postmarketing x
Pulmonary embolism Pulmonary embolism postmarketing x
Pulmonary fibrosis Pulmonary fibrosis postmarketing x
Acute respiratory distress syndrome Acute respiratory distress syndrome postmarketing x
Rhabdomyolysis Rhabdomyolysis postmarketing x
Rickets Rickets postmarketing x
Cardiogenic shock Cardiogenic shock postmarketing x
Septic shock Septic shock postmarketing x
Status epilepticus Status epilepticus postmarketing x
Erythema multiforme Stevens-Johnson syndrome postmarketing x
Stevens-Johnson syndrome Stevens-Johnson syndrome postmarketing x
Swelling Swelling postmarketing x
Tinnitus Tinnitus postmarketing x
Tubulointerstitial nephritis Tubulointerstitial nephritis postmarketing x
Tumour lysis syndrome Tumour lysis syndrome postmarketing x
Erythema Erythema postmarketing x
Urethral disorder Urinary tract disorder postmarketing x
Urinary tract disorder Urinary tract disorder postmarketing x
Urticaria Urticaria postmarketing x
Angiopathy Angiopathy postmarketing x
Vasculitis Vasculitis postmarketing x
Ventricular fibrillation Ventricular fibrillation postmarketing x
Ventricular tachycardia Ventricular tachycardia postmarketing x
Vertigo Vertigo postmarketing x
Hepatitis viral Hepatitis viral postmarketing x
Chills Chills postmarketing x
Polydipsia Polydipsia postmarketing x
Hepatic failure Hepatic failure postmarketing x
Bundle branch block right Bundle branch block right postmarketing x
Hypophosphataemia Hypophosphataemia postmarketing x
Panic attack Panic attack postmarketing x
Deep vein thrombosis Deep vein thrombosis postmarketing x
Swelling face Swelling face postmarketing x
Ventricular extrasystoles Ventricular extrasystoles postmarketing x
Growth retardation Growth retardation postmarketing x
Skin necrosis Skin necrosis postmarketing x
Skin exfoliation Skin necrosis postmarketing x
Portal vein thrombosis Portal vein thrombosis postmarketing x
Nephrogenic diabetes insipidus Nephrogenic diabetes insipidus postmarketing x x
Malnutrition Malnutrition postmarketing x
Skin hyperpigmentation Skin hyperpigmentation postmarketing x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing x
Interstitial lung disease Interstitial pneumonia postmarketing, 1% x x x
Interstitial lung disease postmarketing x
Lung fibrosis interstitial x
Metabolic acidosis Metabolic acidosis postmarketing, 31% x x x x x
Rash macular Rash macular postmarketing x
Myalgia Myalgia postmarketing x
Muscle twitching Muscle twitching postmarketing x
Asterixis Asterixis postmarketing x
Perseveration Perseveration postmarketing x
Tenderness Tenderness postmarketing x
Eye irritation Eye irritation postmarketing x
Mucosal ulceration Mucosal ulceration postmarketing x
Mucosal inflammation Mucosal ulceration postmarketing x
Mucosal inflammation postmarketing x
Aminoaciduria Aminoaciduria postmarketing x
Hypoxia Hypoxia postmarketing x
Sepsis Sepsis postmarketing x
Caecitis Caecitis postmarketing x
Hepatobiliary disease Hepatobiliary disease postmarketing x
Leukoencephalopathy Leukoencephalopathy postmarketing x
Hepatitis fulminant Hepatitis fulminant postmarketing x
Mania Mania postmarketing x
Myocardial depression Myocardial depression postmarketing x
Capillary leak syndrome Capillary leak syndrome postmarketing x
Vision blurred Vision blurred postmarketing x x x
Dysaesthesia Dysaesthesia postmarketing x
Bradycardia Bradycardia postmarketing x
Electrocardiogram QRS complex abnormal Electrocardiogram QRS complex abnormal postmarketing x
Electrocardiogram T wave inversion Electrocardiogram T wave inversion postmarketing x
Bradyphrenia Bradyphrenia postmarketing x
Gait disturbance Gait disturbance postmarketing x
Ejection fraction decreased Ejection fraction decreased postmarketing x
Ovarian failure Ovarian failure postmarketing x
Infestation Infestation NOS postmarketing x
Blood oestrogen decreased Blood oestrogen decreased postmarketing x
Blood gonadotrophin increased Blood gonadotrophin increased postmarketing x
Electrocardiogram ST segment abnormal Electrocardiogram ST segment abnormal postmarketing x
Urinary retention Feeling of residual urine postmarketing x
Myocardial haemorrhage Myocardial haemorrhage postmarketing x
Cardiomyopathy Cardiomyopathy postmarketing x
Hepatitis Cytolytic hepatitis postmarketing x
Haematotoxicity Haematotoxicity postmarketing x
Urine phosphorus increased Urine phosphate increased postmarketing x x x
Febrile bone marrow aplasia Febrile bone marrow aplasia postmarketing x
Respiratory failure Respiratory failure postmarketing x
Ileus Ileus postmarketing x
Sarcoma Sarcoma postmarketing x
Hearing impaired Hearing impaired postmarketing x
Ovulation disorder Ovulation disorder postmarketing x
Psychotic disorder Paranoia postmarketing x
Paranoia Paranoia postmarketing x
Recall phenomenon Radiation recall reaction (dermatologic) postmarketing x
Posterior reversible encephalopathy syndrome Posterior reversible encephalopathy syndrome postmarketing x
Logorrhoea Logorrhoea postmarketing x
Visual impairment Visual impairment postmarketing x
Acidosis Acidosis x x x
Renal tubular acidosis Renal tubular acidosis x x x x
Road traffic accident Renal tubular acidosis x x x x
Anaemia Anaemia x x x x
Coma Coma x x x x
Confusional state Confusional state x x x x
Dizziness Dizziness x x x x
Dysuria Dysuria x x x x
Extravasation Extravasation x
Hallucination Hallucination x x x x
Haematemesis Haematemesis x x
Haemorrhage Haemorrhage x x
Haemoglobin Haemorrhage x x
Incontinence Incontinence x
Nephropathy Nephropathy x
Renal failure acute Renal failure acute x x
Renal neoplasm Renal neoplasm x
Leukopenia Leukopenia x x x x
Necrosis Necrosis x
Obstruction Obstruction x
Pelvic neoplasm Pelvic neoplasm x
Proteinuria Proteinuria x x x x
Protein urine present Proteinuria x x x x
Pollakiuria Pollakiuria x x x x
Urinary incontinence Urinary incontinence x
Ventricular arrhythmia Ventricular arrhythmia x x
Stupor Stupor x
Depressed level of consciousness Stupor x
Agitation Agitation x
Brain cancer metastatic Brain cancer metastatic x
Metastases to central nervous system Brain cancer metastatic x
Disorientation Disorientation x x x x
Hallucination, auditory Hallucination, auditory x
Hepatotoxicity Hepatotoxicity x
Arrhythmia supraventricular Arrhythmia supraventricular x
Electrocardiogram ST segment Electrocardiogram ST segment x x
Drug interaction Drug interaction x
Blood creatinine increased Serum creatinine increased x x
Major depression Psychosis depressive x x x x
Febrile neutropenia Febrile neutropenia x x
Cerebral arteriosclerosis Cerebral arteriosclerosis x
Pulmonary toxicity Pulmonary toxicity x
Rash papular Rash papular x
Renal rickets Renal rickets x x x x
Renal tubular necrosis Renal tubular necrosis x x
Somnolence Somnolence x x x x
Hypertonic bladder Bladder irritation x x
Bladder irritation Bladder irritation x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

IFOSFAMIDE

Side effects:51
Source:FDA Structured Product Label

IFOSFAMIDE

Side effects:51
Source:FDA Structured Product Label

IFOSFAMIDE / IFOSFAMIDE FOR INJECTION, USP

Side effects:63
Source:Health Canada

ifosfamide

Side effects:65
Source:BC Cancer

IFOSFAMIDE

Side effects:232
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label