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Tacrolimus

More information: STITCH, PubChem (stereo-specific compounds: 1, 2) and possibly Wikipedia

ATC Codes: D11AH01, L04AD02

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 28 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Hypertriglyceridaemia Hypertriglyceridaemia common, 65% - 65.4% x x x x x x x
Blood triglycerides increased Hypertriglyceridaemia common, 65% - 65.4% x x x x x x x
Hypercholesterolaemia Hypercholesterolaemia common, 57% x x x x x x x x x x x x x x x
Hypertension Hypertension very common, 0% - 91.1% x x x x x x x x x x x x x x x
Renal impairment Kidney function abnormal 23% - 57% x x x x x x x x x x x
Renal impairment postmarketing, very common x x x x x x
Function kidney decreased x x x
Nausea Nausea very common, 0% - 47% 6.4% x x x x x x x x x x x x x x x x x x
Tremor Tremor very common, 4.5% - 56% 1.9% x x x x x x x x x x x x x x x
Pleural effusion Pleural effusion common, 30% - 36% x x x x x x x x x x x x x x
Constipation Constipation common, 13.6% - 43% x x x x x x x x x x x x x x x x x x
Asthenia Asthenia 0% - 52% 3.2% x x x x x x x x x x x x x x
Fatigue 1.79% - 15.9% x
Bacterial infection Bacterial infection 8.41% - 40.8% x x x x x
Cytomegalovirus infection Cytomegalovirus infection 6.25% - 32% x x x x x x x
Pain Pain common, 0% - 63% x x x x x x x x x x x x x x x x x x x
Insomnia Insomnia very common, 0% - 68% 5.1% x x x x x x x x x x x x x x x x x x
Abdominal pain Abdominal pain common, 1% - 59% 4.5% x x x x x x x x x x x x x x x x x x
Gastrointestinal pain Abdominal pain common, 1% - 59% 4.5% x x x x x x x x x x x x x x x x x x
Body temperature increased Body temperature increased 1% - 56% x x x x x x x x x x x x x x
Hypophosphataemia Hypophosphataemia common, 3% - 53% x x x x x x x x x x x x x x x
Influenza like illness Influenza-like symptoms 22% - 34% x x
Influenza like illness uncommon x x x
Procedural pain Post procedural pain 27% - 29% x x x x x x
Respiratory tract infection Respiratory tract infection 22% - 34.1% x
Influenza Influenza 16.2% - 28.7% 16.6% x x x x x x x x x x x
Diarrhoea Diarrhoea very common, 2% - 72% 5.1% x x x x x x x x x x x x x x x x x x
Loose stools common x x x
Hyperkalaemia Hyperkalaemia very common, 9% - 45% x x x x x x x x x x x x x x x
Incision site complication Incision site complication 23% - 28% x x x x x x
Headache Headache very common, 5% - 64% 8.9% x x x x x x x x x x x x x x x x x x
Blood creatinine increased Creatinine increased 19% - 45% x x x x x x x x x x x
Blood creatinine increased 16.3% - 23.1% x x x x x x x
Anaemia Anaemia common, 1% - 50% x x x x x x x x x x x x x x x x x x
Arthralgia Arthralgia common, 0% - 25% x x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia common, 0% - 25% x x x x x x x x x x x x
Myalgia postmarketing, 0% - 3% x x x x x x x x x x x x x x x
Infection Infection postmarketing, 1% - 76% x x x x x x x x x x x x x x x x x x x x
Diabetes mellitus Diabetes mellitus very common, 9% - 89.3% x x x x x x x x x x
Post transplant diabetes mellitus x x x x
Vomiting Vomiting common, 0% - 29% 1.3% x x x x x x x x x x x x x x x x x x
Hyperglycaemia Hyperglycaemia 9.3% - 47% x x x x x x x x x x x x
Hypomagnesaemia Hypomagnesaemia common, 1% - 48% x x x x x x x x x x x x x x x
Urinary tract infection Urinary tract infection 0% - 35% x x x x x x x x x x x x x x x
Fasting Fasting 15.7% - 25.9% x x x x
Thrombocytopenia Thrombocytopenia common, 14% - 24% x x x x x x x x x x x x x x x
Dyspnoea Dyspnoea common, 4% - 29% x x x x x x x x x x x x x x x x x x
Oedema Oedema common, 12% - 26% x x x x x x x x x x x x x x x x x x
Hyperlipidaemia Hyperlipidaemia common, 6.95% - 92.6% x x x x x x x x x x x x
Hypokalaemia Hypokalaemia common, 13% - 34% x x x x x x x x x x x x x x x
Graft dysfunction Graft dysfunction 13.6% - 24% x x x x x x x
Primary graft dysfunction postmarketing, common x x x x x x x x x x x
Back pain Back pain common, 0% - 30% 2.5% x x x x x x x x x x x x x x x x x
Bronchitis Bronchitis 0% - 18% x x x x x x x x x x x x
Paraesthesia Paraesthesia 0% - 40% x x x x x x x x x x x x x x x x x
Tingling skin 1% - 8% x x x
Blood urea increased Blood urea increased 9% - 30% x x x x x x x x x x x
Atelectasis Atelectasis 4% - 30% x x x x x x x x x x x
Pneumothorax Atelectasis 4% - 30% x x x x x x x x x x x
Pneumothorax x x x x x x x x x x x
Chest pain Chest pain 13% - 19% x x x x x x x x x x x x x x
Dizziness Dizziness common, 4.5% - 19% 3.8% x x x x x x x x x x x x x x x x x x
Syncope postmarketing x x x x x x x x x x x x
Oedema peripheral Oedema peripheral 0% - 48% x x x x x x x x x x x x x x x
Liver function test abnormal Liver function test abnormal very common x x x x x x x x x x x
Application site pruritus Application site pruritus very common x x
Application site pain Application site burn very common x x
Application site pain common x x
Application site burn Application site burn very common x x
Renal failure Renal impairment postmarketing, very common x x x x x x
Renal failure common x x x x x x x x x x x x x x x
Dyspepsia Dyspepsia 0% - 28% 3.2% x x x x x x x x x x x x x x x
Leukopenia Leukopenia common, 10% - 48% x x x x x x x x x x x x x x x
Oliguria Oliguria common, 12% - 19% x x x x x x x x x x x x x x x
Opportunistic infection Opportunistic infection 15% x x x x
Pruritus Pruritus common, 7% - 46% x x x x x x x x x x x x x x x x x x x x
Cough Cough increased 1% - 18% x x x x x x x x x x x x x x
Cough common x x x
Pericardial effusion Pericardial effusion postmarketing — 14% - 15% x x x x x x x x x x x x
Dermatitis Rash common, 1% - 24% x x x x x x x x x x x x x x x x x x x x
Dermatitis uncommon x x x x
Rash Rash common, 1% - 24% x x x x x x x x x x x x x x x x x x x x
Skin infection Skin infection 5% - 16% x x x x
Erythema Erythema 7% - 28% x x x x x
Hypersensitivity Hypersensitivity 4% - 13% x x x x x x x x x x x x x x
Ascites Ascites common, 7% - 27% x x x x x x x x x x x x x x x
Leukocytosis Leukocytosis common, 8% - 32% x x x x x x x x x x x x x x x
Decreased appetite Anorexia common, 5% - 34% x x x x x x x x x x x x x x x x x x
Decreased appetite common x x x
Injury Accidental injury 3% - 12.2% 5.1% x x x x x x x x x x x x x x
Fatigue Fatigue 1.79% - 15.9% x
Asthma Asthma uncommon, 4% - 13% x x x x x x x x x x x x x x x x x
Otitis media Otitis media 2% - 11% x x x x x x x x x x x x x
Sinusitis Sinusitis 1% - 8% x x x x x x x x x x x x x x
Drug ineffective Lack of drug effect 0% - 6% x x x
Neoplasm malignant Neoplasm malignant common x x x x x x x x x
Skin cancer Skin cancer common x x
Skin carcinoma x x x x
Cholestasis Cholestasis common x x x x
Confusional state Confusional state common x x x x x x x x x x x x x x x
Feeling abnormal Confusional state common x x x x x x x x x x x x x x x
Feeling abnormal uncommon x x x x x x x x x x x
Malaise x x x
Eye disorder Eye disorder postmarketing, common x x x x
Flatulence Flatulence common x x x x x x x x x x x x x x x
Abdominal bloating common x x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage common x x x x x x x x x x x x x x x
Hallucination Hallucination common x x x x x x x x x x x x x x x
Hepatitis Hepatitis common x x x x x x x x x x x x x x x
Oral herpes Herpes labialis common x
Herpes virus infection Herpes virus infection common x x
Hypocalcaemia Hypocalcaemia common x x x x x x x x x x x x x x x
Hyponatraemia Hyponatraemia common x x x x x x x x x x x x x x x
Inflammation Inflammation common x x x
Jaundice Jaundice postmarketing, common x x x x x x x x x x x x x x x
Kaposi's varicelliform eruption Kaposi's varicelliform eruption common x x
Lung disorder Lung disorder common x x x x x x x x x x x x x x x x x
Muscle spasms Cramp muscle common x x x x x x x x x x x x x x x x x
Cramps of lower extremities x x x x x x x x x x x
Generalised spasm x x x x x x x x x x x
Nasal congestion Nasal congestion common x x x
Nervous system disorder Nervous system disorder postmarketing — common x x x x x x x x x x x x
Nightmare Nightmare common x x x x
Pain in extremity Pain in extremity common x x x
Neuropathy peripheral Neuropathy peripheral common x x x x
Neuropathy x x x x x x x x x x x
Pharyngitis Pharyngitis common, 3% - 12% x x x x x x x x x x x x x x x x x
Convulsion Convulsion postmarketing, common x x x x x x x x x x x x x x x x x x
Stomatitis Stomatitis common x x x x x x x x x x x x x x x x x
Mouth ulceration postmarketing x x x x x x x x x x x
Tachycardia Tachycardia common x x x x x x x x x x x x x x x x x x
Tinnitus Tinnitus common x x x x x x x x x x x x x x x
Angiopathy Angiopathy common x x x x
Weight increased Weight increased common x x x x x x x x x x x x x x
Burning sensation Burning sensation common x x
Skin irritation Skin irritation common x x
Metabolic acidosis Metabolic acidosis common x x x x
Disorientation Disorientation common x x x
Discomfort Discomfort common x x x
Malaise x x x
Altered state of consciousness Consciousness abnormal common x x x
Vision blurred Vision blurred common x x x x
Depressed mood Depressed mood common x x x
Application site irritation Application site irritation common x x
Instillation site pain Application site pain common x x
Application site rash Application site rash common x x
Affective disorder Affective disorder common x x x
Fluid overload Fluid overload common x x x x x x x x x x x x x x x
Dysgraphia Writing impaired common x x x x x x x x x x x
Nephropathy toxic Nephropathy toxic common x x x x x x x x x x x x x x x
Nephrotoxicity x x x x
Hyperhidrosis Sweating increased common x x x
Hyperhidrosis x
Sweating x x x x x x x x x x x x x x
Blood uric acid increased Hyperuricaemia common x x x x x x x x x x x x x x x
Hyperuricaemia Hyperuricaemia common x x x x x x x x x x x x x x x
Blood alkaline phosphatase increased Blood alkaline phosphatase increased common x x x
Phosphatase alkaline increased x x x x x x x x x x x
Application site erythema Application site erythema common x x
Herpes dermatitis Herpes simplex dermatitis common x
Gastrointestinal ulcer perforation Gastrointestinal ulcer perforation common x x x
Application site warmth Application site warmth common x x
Anxiety Anxiety symptoms NOS common x x x
Anxiety x x x x x x x x x x x x x x x
Application site paraesthesia Application site paraesthesia common x x
Abdominal distension Abdominal bloating common x x x
Abdominal distension x
Enlargement abdomen x x x x x x x x x x x
Renal tubular necrosis Renal tubular necrosis common x x x x x x x x x x x x x x x
Rash pustular Rash pustular 2% - 7% x x x
Vesiculobullous rash 0% - 4% x x x
Urticaria Urticaria postmarketing, 1% - 6% x x x x
Conjunctivitis Conjunctivitis 0% - 3% x x x x
Fungal skin infection Fungal skin infection 0% - 4% x x x x x x x x x x x x x x
Folliculitis Folliculitis common, 0% - 6% x x x x x
Herpes simplex Herpes simplex common, 0% - 4% x x x x x x x x x x x x x x x x
Rhinitis Rhinitis 2% - 6% x x x x x x x x x x x x x x
Acne Acne uncommon, 0% - 7% x x x x x x x x x x x x x x
Haemorrhage Haemorrhage uncommon, common x x x x x x x x x x x x x x x
Haemoglobin Haemorrhage uncommon, common x x x x x x x x x x x x x x x
Ulcer Ulcer rare, common x x x x x x x x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing, common x x x x x
Skin disorder 1% - 4% x x x x x x x x x x x x x x
Dermatitis contact Dermatitis contact 1% - 4% x x x
Herpes zoster Herpes zoster 0% - 5% x x x x x x x x x x x
Varicella zoster 0% - 5% x x x
Pneumonia Pneumonia 0% - 3% x x x x x x x x x x x x x x
Alcohol intolerance Alcohol intolerance common, 0% - 7% x x x x x
Encephalopathy Encephalopathy uncommon, 2.5% x x x x x x x x x x x x x x
Alopecia Alopecia common, 0% - 1% x x x x x x x x x x x x x x x x x x
Cellulitis Cellulitis 0% - 1% x x x x x x x x x x x x x
Cyst Cyst 0% - 3% x x x x
Depression Depression 0% - 2% x x x
Dysmenorrhoea Dysmenorrhoea uncommon, 0% - 4% x x x x x x
Ear pain Ear pain 0% - 1% x x x x x x x x x x x x x
Eczema Eczema 0% - 2% x x x
Hyperaesthesia Hyperaesthesia common, 0% - 2% x x x x
Tooth abscess Abscess periodontal 0% - 1% x x x
Neoplasm skin Neoplasm skin 0% - 2% x x x x x x x x x x x
Sunburn Sunburn 0% - 2% x x x
Photosensitivity reaction Sunburn 0% - 2% x x x
Photosensitivity postmarketing, uncommon x x x x
Photosensitivity reaction x x x x x x x x x x x x x x
Phototoxicity x x x
Tooth disorder Tooth disorder 0% - 2% x x x
Dermatitis bullous Vesiculobullous rash 0% - 4% x x x
Dry skin Dry skin 0% - 7% x x x
Myalgia Myalgia postmarketing, 0% - 3% x x x x x x x x x x x x x x x
Rash maculo-papular Rash maculo-papular 0% - 3% x x x
Lymphadenopathy Lymphadenopathy 0% - 3% x x x
Face oedema Face oedema 1% - 2% x x x
Procedural complication Procedural complication 0% - 1% x x x
Hemiplegia Hemiplegia 0.8% x
Nystagmus Nystagmus 0.8% x
Delirium Delirium 0.2% - 1.2% x
Amnesia Amnesia uncommon x x x x x x x x x x x x x x
Anuria Anuria uncommon x x x x
Coagulopathy Coagulopathy uncommon x x x x x x x x x x x x x x x
Coma Coma postmarketing — 2.1% x x x x x
Dehydration Dehydration uncommon x x x x x x x x x x x x x x x x x x
Cardiac failure Cardiac failure uncommon x x x x x x x x x x x
Hypoglycaemia Hypoglycaemia uncommon x x x x x x x x x x x x x x x
Hypoproteinaemia Hypoproteinaemia uncommon x x x x x x x x x x x x x x x
Infarction Infarction uncommon x x x
Arthropathy Arthropathy uncommon x x x x x x x x x x x x x x x x x
Osteoarthritis Arthropathy uncommon x x x x x x x x x x x x x x x x x
Dysarthria postmarketing, 0.4% x x
Palpitations Palpitations uncommon x x x
Ileus paralytic Ileus paralytic uncommon x x x
Paresis Paresis uncommon x x x
Peritonitis Peritonitis postmarketing, uncommon x x x x x x x x x x x x x x x
Psychotic disorder Psychotic disorder uncommon x x x x x x x x x x x x x x
Shock Shock uncommon x x x
Syncope postmarketing x x x x x x x x x x x x
Uterine haemorrhage Uterine haemorrhage uncommon x x x
Ventricular arrhythmia Ventricular arrhythmia uncommon x x x
Hyperphosphataemia Hyperphosphataemia uncommon x x x x x x x x x x x x x x x
Cataract Cataract uncommon x x x x x x
Chest discomfort Chest pressure sensation of uncommon x x x
Chest tightness rare x x x
Pancreatitis acute Pancreatitis acute on chronic uncommon x x x
Ventricular hypertrophy Ventricular hypertrophy uncommon x x x
Arrhythmia supraventricular Arrhythmia supraventricular uncommon x x x
Haemorrhagic stroke Haemorrhagic stroke uncommon x x x x x x x x x x x
Cerebral haemorrhage Haemorrhagic stroke uncommon x x x x x x x x x x x
Amylase increased Blood amylase increased uncommon x x x
Amylase increased postmarketing x x x x x x x x x x x
Blood lactate dehydrogenase increased Blood lactate dehydrogenase increased uncommon x x x
Cardiomyopathy Cardiomyopathy uncommon x x x
Temperature intolerance Temperature intolerance uncommon x x x x x x x x x x x
Paralysis Paralysis uncommon, 0.4% x x x x
Dysarthria Dysarthria postmarketing, 0.4% x x
Paralysis flaccid Paralysis flaccid postmarketing, 0.4% x x x x x x x x x x
Stupor Stupor 0.2% x
Depressed level of consciousness Stupor 0.2% x
Agranulocytosis Agranulocytosis postmarketing, rare x x x x x x x
Haemolytic anaemia Haemolytic anaemia postmarketing, rare x x x x x x x
Arrhythmia Arrhythmia postmarketing x x x x x x x x x x x
Atrial fibrillation Atrial fibrillation postmarketing x x x x x x x x x
Atrial flutter Atrial flutter postmarketing x x x x x x x x x
Mental disorder Mental disorder postmarketing, common x x x x x x x x x x x x
Basal cell carcinoma Basal cell carcinoma postmarketing x x x
Squamous cell carcinoma Squamous cell carcinoma postmarketing x x x
Carpal tunnel syndrome Carpal tunnel syndrome postmarketing x x x x x x x x x
Cerebral infarction Cerebral infarction postmarketing x x x x x x x x x
Cholangitis Cholangitis postmarketing x x x x x x x x x x x x
Colitis Colitis postmarketing x x x x x x x x x x x x
Connective tissue disorder Connective tissue disorder postmarketing x x x x
Deafness Deafness postmarketing x x x x x x x x x x x
Hearing impaired very rare — uncommon x x x x x x x x x x x x x x x
Dysphagia Dysphagia postmarketing x x x x x x x x x x x x
Disseminated intravascular coagulation Disseminated intravascular coagulation postmarketing x x x x x x x x x
Enterocolitis Enterocolitis postmarketing x x x x x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis postmarketing, rare x x x x x x x x x x x x
Hepatic steatosis Liver fatty postmarketing x x x x x x x x
Hepatic steatosis postmarketing x
Flushing Flushing postmarketing, common x x x x x x x x x x x
Gastroenteritis Gastroenteritis postmarketing, 2% - 7.48% x x x x x x x x x x x x x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease postmarketing, uncommon x x x x x x x x x x x x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x x x x x x x x x x x x x
Glycosuria Glycosuria postmarketing x x x x x x x x x x x
Graft versus host disease Graft versus host disease postmarketing x
Deafness neurosensory Deafness neurosensory rare x x x
Cardiac arrest Cardiac arrest postmarketing, uncommon x x x x x x x x x x x x
Cardiac disorder Cardiac disorder postmarketing x x x x
Hemiparesis Hemiparesis postmarketing x x x x x x x x x
Haemolytic uraemic syndrome Haemolytic uraemic syndrome postmarketing, uncommon x x x x x x x x x x x x x x x
Venoocclusive liver disease Venoocclusive liver disease postmarketing, rare x x x x x x x x x x x x
Hirsutism Hirsutism rare x x x x x x x x x x x x x x
Pulmonary hypertension Pulmonary hypertension postmarketing x
Immune system disorder Immune system disorder postmarketing x x x x
Bullous impetigo Bullous impetigo postmarketing x x x
Intestinal obstruction Intestinal obstruction postmarketing x
Renal failure acute Renal failure acute postmarketing, common x x x x x x x x x x x x x x x x x
Leukaemia Leukaemia postmarketing x
Progressive multifocal leukoencephalopathy Progressive multifocal leukoencephalopathy postmarketing x x x x x x x x x x
Lymphoma Lymphoma postmarketing, common x x x x x x x x x
Non-Hodgkin's lymphoma Lymphoma postmarketing, common x x x x x x x x x
Lymphoproliferative disorder Lymphoproliferative disorder postmarketing x x x x
X-linked lymphoproliferative syndrome Lymphoproliferative disorder postmarketing x x x x
Mediastinal disorder Mediastinal disorder postmarketing x x x x
Malignant melanoma Malignant melanoma postmarketing x x x x
Multi-organ failure Multi-organ failure postmarketing, uncommon x x x x x x x x x x x x
Hypertonia Hypertonia rare x x x x x x x x x x x x x x x x x
Mutism Mutism postmarketing x x x x x x x x x
Myocardial infarction Myocardial infarction postmarketing x x x x x x x x x
Acute coronary syndrome Myocardial infarction postmarketing x x x x x x x x x
Neoplasm Neoplasm postmarketing x x x x x x x
Neutropenia Neutropenia postmarketing, uncommon x x x x x x x x x x x x
Optic atrophy Optic atrophy postmarketing x
Osteomyelitis Osteomyelitis postmarketing x x x
Pancreatic pseudocyst Pancreatic pseudocyst rare x x x x x x x x x x x
Pancreatitis Pancreatitis postmarketing x x x x x x x x x x x x
Pancytopenia Pancytopenia postmarketing, uncommon x x x x x x x x x x x x
Supraventricular extrasystoles Supraventricular extrasystoles postmarketing x
Thrombotic thrombocytopenic purpura Thrombotic thrombocytopenic purpura postmarketing, rare x x x x x x x x x x x x
Quadriplegia Quadriplegia postmarketing x x x x x x x x x
Aplasia pure red cell Aplasia pure red cell postmarketing, rare x x x x x x x x
Acute respiratory distress syndrome Acute respiratory distress syndrome postmarketing, rare x x x x x x x x x x x x
Rhabdomyolysis Rhabdomyolysis postmarketing x
Rosacea Rosacea postmarketing, common x x x x x
Sepsis Septicemia postmarketing x x x
Sepsis x x x x x x x x x x x
Speech disorder Speech disorder postmarketing x x x x x x x x
Status epilepticus Status epilepticus postmarketing x
Erythema multiforme Stevens-Johnson syndrome very rare, postmarketing x x x x x x x x x x x x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome very rare, postmarketing x x x x x x x x x x x x x x x
Gastric ulcer Gastric ulcer postmarketing x x x x x x x x x x x x
Syncope Syncope postmarketing x x x x x x x x x x x x
Loss of consciousness Syncope postmarketing x x x x x x x x x x x x
Supraventricular tachycardia Supraventricular tachycardia postmarketing x
Thirst Thirst rare x x x
Thrombosis Thrombosis rare x x x x x x x x x x x x x
Torsade de pointes Torsade de pointes very rare — uncommon x x x x x x x x x x x x x x
Micturition disorder Micturition disorder postmarketing x x x x x x x x
Urethral disorder Urinary tract disorder postmarketing x x x x
Urinary tract disorder Urinary tract disorder postmarketing x x x x
Ventricular fibrillation Ventricular fibrillation postmarketing x x x x x x x x x
Weight decreased Weight decreased postmarketing, uncommon x x x x x x x x x x x
Photophobia Photophobia postmarketing, common x x x x x x x x x x x x
Cystitis haemorrhagic Cystitis haemorrhagic very rare, postmarketing x x x x x x x x x x x x
Mouth ulceration Mouth ulceration postmarketing x x x x x x x x x x x
Ventricular extrasystoles Ventricular extrasystoles postmarketing x x x x x x x x x
Gastrointestinal perforation Gastrointestinal perforation postmarketing x x x x x x x x x x x x
Myocardial ischaemia Myocardial ischaemia postmarketing x x x x x x x x x
Hepatocellular injury Hepatocellular injury postmarketing, common x x x x x x x x x x x x x x
Liver injury Hepatocellular injury postmarketing, common x x x x x x x x x x x x x x
Hepatic necrosis Hepatic necrosis postmarketing x x x x x x x x x
Blindness cortical Blindness cortical postmarketing x x x x x x x x
Polyarthritis Polyarthritis postmarketing x
Skin hyperpigmentation Skin hyperpigmentation postmarketing x
Interstitial lung disease Interstitial lung disease postmarketing x x x x x x x
Application site oedema Application site oedema postmarketing x x
Hepatotoxicity Hepatotoxicity postmarketing x x x x x x x x x
Lung infiltration Lung infiltration postmarketing x x x x x x x x x
Activated partial thromboplastin time prolonged Activated partial thromboplastin time prolonged postmarketing x
Ventricular dysfunction Ventricular dysfunction postmarketing x x x x x x x
Netherton's syndrome Netherton's syndrome postmarketing x x x
Hepatobiliary disease Hepatobiliary disease postmarketing x x x x
Bile duct stenosis Bile duct stenosis very rare, postmarketing x x x x x x x x x
Pancreatitis haemorrhagic Pancreatitis haemorrhagic postmarketing x x x x x x x x
Pancreatitis necrotising Pancreatitis necrotising postmarketing x x x x x x x x
Leukoencephalopathy Leukoencephalopathy postmarketing x x x x x x x x x x x
Nerve injury Nerve compression postmarketing x x x x x x x x x
Nerve compression Nerve compression postmarketing x x x x x x x x x
Hepatic artery thrombosis Hepatic artery thrombosis rare x
Post transplant lymphoproliferative disorder Post transplant lymphoproliferative disorder postmarketing x
Electrocardiogram T wave abnormal Electrocardiogram T wave abnormal postmarketing x x x x x x x x
Blindness Blindness postmarketing, rare x x x x x x x x x x x x
Respiratory distress Respiratory distress postmarketing x x x x x x x x
Impaired gastric emptying Impaired gastric emptying postmarketing, uncommon x x x x x x x x x x x x
Nervousness Feeling jittery postmarketing, uncommon x x x x x x x x x x x
Nervousness x x x x x x x x x x x
Feeling jittery Feeling jittery postmarketing, uncommon x x x x x x x x x x x
Menopausal symptoms Hot flush postmarketing x x x x x x x x
Hot flush Hot flush postmarketing x x x x x x x x
Mobility decreased Mobility decreased rare x x x x x x x x x x x
Thrombocytopenic purpura Thrombocytopenic purpura postmarketing x x x x x x x x x x x
Graft loss Graft loss postmarketing x x x
Subileus Subileus rare x x x
Respiratory failure Respiratory failure postmarketing x x x x x x x x x
Deep vein thrombosis Venous thrombosis deep limb postmarketing, uncommon x x x x x x x x x x x
Deep vein thrombosis x
Hepatosplenic T-cell lymphoma Hepatosplenic T-cell lymphoma postmarketing x
Hearing impaired Hearing impaired very rare — uncommon x x x x x x x x x x x x x x x
Polyomavirus-associated nephropathy Polyomavirus-associated nephropathy postmarketing x x x
Feeling hot Feeling hot postmarketing x x x x x x x x
Sensation of warmth x x
Posterior reversible encephalopathy syndrome Posterior reversible encephalopathy syndrome postmarketing x x x x x x x
Factor II deficiency Hypoprothrombinaemia rare x x x
Hypoprothrombinaemia Hypoprothrombinaemia rare x x x
Cardiac hypertrophy Myocardial hypertrophy postmarketing x x x x x x x x x x x
Nephropathy Nephropathy very rare x x x x x x x x x x
Hepatic failure Hepatic failure very rare, postmarketing x x x x
Electrocardiogram QT prolonged Electrocardiogram QT prolonged very rare x x
Fat tissue increased Fat tissue increased very rare x x x
Echocardiogram abnormal Echocardiogram abnormal very rare x x x x x x x x x x x
Muscular weakness Myasthenia very rare x x x x x x x x x x x x x x
Abscess Abscess x x x x x x x x x x x x x x
Acidosis Acidosis x x x x x x x x x x x
Albuminuria Albuminuria x x x x x x x x x x x
Alkalosis Alkalosis x x x x x x x x x x x
Amblyopia Amblyopia x x x x x x x x x x x
Anaphylactic shock Anaphylactic shock x x x
Anaphylactoid reaction x x x x x x
Hypochromic anaemia Hypochromic anaemia x x x x x x x x x x x
Angina pectoris Angina pectoris x x x x x x x x x x x x
Aphasia Aphasia x
Arthritis Arthritis x x x
Bladder cancer Bladder cancer x
Blepharitis Blepharitis x x
Bone disorder Bone disorder x x x
Breast disorder Breast disorder x x x
Bursitis Bursitis x x x
Candida infection Candida infection x x x x x x x x
Oral candidiasis x x x x x x x x x x x x x x
Skin candida Skin candida x x
Oral candidiasis Oral candidiasis x x x x x x x x x x x x x x
Vulvovaginal candidiasis Vaginal moniliasis x x x
Vulvovaginal mycotic infection Vaginal moniliasis x x x
Hypertrophic cardiomyopathy Hypertrophic cardiomyopathy x
Cardiovascular disorder Cardiovascular disorder x x x x x x x x
Neck pain Neck pain x x x
Varicella Varicella x x
Anogenital warts Anogenital warts x
Cushing's syndrome Cushing's syndrome x x x x x x x x x x
Cystitis Cystitis x x x x x x x x x x x x x x
Bladder pain Cystitis x x x x x x x x x x x x x x
Bladder spasm x x x x x x x x
Cystitis noninfective Cystitis x x x x x x x x x x x x x x
Dental caries Dental caries x x x
Dermatitis exfoliative Dermatitis exfoliative 0% - 3% x x x x x x x x x x x x x
Diabetic nephropathy Diabetic nephropathy x
Duodenitis Duodenitis x x x x x x x x
Dysgeusia Dysgeusia x x x
Dysuria Dysuria x x x x x x x x x x x
Ear disorder Ear disorder x x x x
Ecchymosis Ecchymosis x x x x x x x x x x x x x x
Endocrine disorder Endocrine disorder x x x
Epistaxis Epistaxis x x x
Oesophagitis Oesophagitis x x x x x x x x x x x x
Furuncle Furunculosis x x x
Gastritis Gastritis x x x x x x x x x x x x x x x
Glomerulonephritis Glomerulonephritis x
Gout Gout x x x x x x x x
Cardiac failure congestive Cardiac failure congestive x x x x x x x x x
Cardiac valve disease Cardiac valve disease x x x
Haematuria Haematuria x x x x x x x x x x x x
Hernia Hernia x x x x x x x x x x x x x x
Hiccups Hiccups x x x x x x x x x
Hydronephrosis Hydronephrosis x x x x x x x x x x x
Hyperbilirubinaemia Hyperbilirubinaemia x x x x x x x x x x x x x x
Hypercalcaemia Hypercalcaemia x x x x x x x x x x x x
Hypoaesthesia Hypoaesthesia x
Hypotension Hypotension x x x x x x x x x x x x
Orthostatic hypotension Orthostatic hypotension x x x x x x x x x x x x
Hypothyroidism Hypothyroidism x x x
Hypotrichosis Hypotrichosis x
Impetigo Impetigo x
Jaundice cholestatic Jaundice cholestatic x x x x x x x x x x x
Congenital cystic kidney disease Polycystic kidney x
Laryngitis Laryngitis x x x
Myoclonus Myoclonus x x x x x x x x x x x
Nail disorder Nail disorder x x x
Nephrosclerosis Nephrosclerosis x
Tension Nervousness x x x x x x x x x x x
Neuralgia Neuralgia x x x x x x x x
Nocturia Nocturia x x x x x x x x x x x
Osteopenia Osteopenia x
Osteoporosis Osteoporosis x x x x x x x x x x x x
Ear infection Otitis x
Otitis externa Otitis externa x x x
Phlebitis Phlebitis x x x x x x x x x x x
Polycythaemia Polycythaemia x x x x x x x x x x x
Polyp Polyp x
Proteinuria Proteinuria x
Protein urine present Proteinuria x
Pulmonary oedema Pulmonary oedema x x x x x x x x x x x x
Emphysema Emphysema x x x x x x x x x
Pyuria Pyuria x x x x x x x x x x x
Anorectal disorder Rectal disorder x x x x x x x x x x x x x x
Kaposi's sarcoma Kaposi's sarcoma x
Seborrhoeic dermatitis Seborrhoeic dermatitis x x x
Skin ulcer Skin ulcer x x x x x x x x x x x x x x
Aphthous stomatitis Aphthous stomatitis x
Thrombophlebitis Thrombophlebitis x x x x x x x x x x x
Tinea versicolour Tinea versicolour x
Unintended pregnancy Unintended pregnancy x x x
Pollakiuria Pollakiuria x x x x x x x x x x x
Urinary incontinence Urinary incontinence x x x x x x x x x x x x
Vaginal inflammation Vaginal inflammation x x x x x x x x x x x x x x
Vaginal infection Vaginal inflammation x x x x x x x x x x x x x x
Vertigo Vertigo x x x x x x x x x x x
Dry mouth Dry mouth x x x
Mycosis fungoides Cutaneous T-cell lymphoma x
Urinary retention Urinary retention x x x x x x x x x
Peripheral vascular disorder Peripheral vascular disorder x x x x x x x x x x x
Chills Chills x x x x x x x x x x x x x x
Agitation Agitation x x x x x x x x x x x x
Mood swings Mood swings x x x x x x x x x x x x
Affect lability Mood swings x x x x x x x x x x x x
Epstein-Barr virus infection Epstein-Barr virus infection x
Migraine Migraine x x x x
Urge incontinence Urge incontinence x x x x x x x x
Drug level increased Drug level increased x
Conjunctival oedema Conjunctival oedema x x
Generalised oedema Generalised oedema x x x x x x x x x x x x
Fluid retention Generalised oedema x x x x x x x x x x x x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased x x x x x x x x x x x
Impaired healing Impaired healing x x x x x x x x x x x
Skin hypertrophy Skin hypertrophy x x x
Eye pain Eye pain x x x
Skin discolouration Skin discolouration x x x x x x x x x x x x x x
Tendon disorder Tendon disorder x x x
Malnutrition Malnutrition x x x x x x x x x x x x x x x
Leukoderma Leukoderma x x x
Malaise Malaise x x x
Ill-defined disorder Malaise x x x
Cardiac fibrillation Cardiac fibrillation x x x x x x x x
Increased appetite Increased appetite x x x x x x x x x x x
Elevated mood Elevated mood x x x x x x x x
Thinking abnormal Thinking abnormal x x x x x x x x x x x x x x
Mental disability Thinking abnormal x x x x x x x x x x x x x x
Abnormal dreams Abnormal dreams x x x x x x x x x x x
Neurotoxicity Neurotoxicity x x x x
Respiratory depression Respiratory depression x x x x x x x x
Pulmonary function test decreased Respiratory depression x x x x x x x x
Granulomatous liver disease Hepatitis granulomatous x x x x x x x x
Blood iron decreased Serum iron decreased x x x x x x x x x x x
Papillary thyroid cancer Papillary thyroid cancer x
Productive cough Productive cough x
Haematocrit increased Haematocrit increased x x x x x x x x x
Weight fluctuation Weight fluctuation x
Quadriparesis Quadriparesis x x x x x x x x
Monoparesis Monoparesis x x x x x x x x
Dry eye Dry eye x x x
Anaphylactoid reaction Anaphylactoid reaction x x x x x x
Pneumonia streptococcal Pneumonia due to Streptococcus, group b x x x x x x
Haemoglobin abnormal Haemoglobin abnormal x x x x x x x x
Gastrooesophagitis Gastrooesophagitis x x x x x x x x
Bladder spasm Bladder spasm x x x x x x x x
Bradycardia Bradycardia x x x x x x x x x
Electrocardiogram QRS complex abnormal Electrocardiogram QRS complex abnormal x x x x x x x x
Coordination abnormal Coordination abnormal x x x x x x x x x x x
Electrocardiogram abnormal Electrocardiogram abnormal x x x x x x x x x x x x
Prothrombin level decreased Prothrombin level decreased x x x x x x x x x x x
Hyperlactacidaemia Hyperlactacidaemia x
Hypertensive nephropathy Hypertensive nephropathy x
Infestation Infestation NOS x x x x x x
Electrocardiogram ST segment abnormal Electrocardiogram ST segment abnormal x x x x x x x x
Mental status changes Mental status changes x
Psychomotor skills impaired Psychomotor skills impaired x x x x x x x x
Cerebral ischaemia Cerebral ischaemia x
Eczema herpeticum Eczema herpeticum common, 0% - 2% x x x x x
Ileus Ileus x x x x x x x x x x x x
Cardiopulmonary failure Cardiopulmonary failure x x x x x x x x
Breast neoplasm Breast neoplasm x x x
Oesophagitis ulcerative Oesophagitis ulcerative x x x x x x x x
Rhinitis allergic Rhinitis allergic x
Thrombotic microangiopathy Thrombotic microangiopathy x
Somnolence Somnolence x x x x x x x x x x x x
Visual impairment Abnormal vision x x x x x x x x x x x x x x
Skin papilloma Warts x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

tacrolimus / tacrolimus

Side effects:37
Source:EMA

tacrolimus / tacrolimus

Side effects:40
Source:EMA

TACROLIMUS

Side effects:149
Source:FDA Structured Product Label

TACROLIMUS / PROTOPIC

Side effects:150
Source:FDA

TACROLIMUS ANHYDROUS

Side effects:153
Source:FDA Structured Product Label

TACROLIMUS / PROGRAF

Side effects:178
Source:FDA

TACROLIMUS / PROGRAF

Side effects:180
Source:FDA

TACROLIMUS / PROGRAF

Side effects:192
Source:Health Canada

PROGRAF / Prograf, Concentrate for infusion

Side effects:195
Source:Medsafe

tacrolimus / tacrolimus

Side effects:197
Source:EMA

tacrolimus / tacrolimus

Side effects:199
Source:EMA

TACROLIMUS ANHYDROUS

Side effects:224
Source:FDA Structured Product Label

tacrolimus / Prograf

Side effects:280
Source:FDA

TACROLIMUS / PROGRAF

Side effects:281
Source:FDA

TACROLIMUS ANHYDROUS

Side effects:288
Source:FDA Structured Product Label

ANHYDROUS TACROLIMUS

Side effects:288
Source:FDA Structured Product Label

tacrolimus

Side effects:293
Source:FDA Structured Product Label

TACROLIMUS ANHYDROUS

Side effects:295
Source:FDA Structured Product Label

TACROLIMUS ANHYDROUS

Side effects:300
Source:FDA Structured Product Label

TACROLIMUS ANHYDROUS

Side effects:303
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label