Tacrolimus

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10
Diarrhoea def 2% - 72% x x x x x x x x x x
Insomnia def 0% - 68% x x x x x x x x x x
Headache def 9% - 64% x x x x x x x x x x
Pain def 0% - 63% x x x x x x x x
Abdominal pain def 1% - 59% x x x x x x x x
Body temperature increased def 2% - 56% x x x x x x x x
Hypertension def 0% - 56% x x x x x x x x x x
Tremor def 20% - 56% x x x x x x x x x
Hypophosphataemia def 21% - 53% x x x x x x x
Asthenia def 0% - 52% x x x x x x x
Infection def postmarketing, 1% - 49% x x x x x x x x x
Oedema def postmarketing, 0% - 48% x x x x x x x x
Oedema peripheral def 0% - 48% x x x x x x x x
Hypomagnesaemia def 9% - 48% x x x x x x x x x
Anaemia def postmarketing, 1% - 47% x x x x x x x x
Hyperglycaemia def 15% - 47% x x x x x x x x x
Nausea def 1% - 47% x x x x x x x x x x
Hyperkalaemia def 9% - 45% x x x x x x x x x
Creatinine increased def 19% - 45% x x x x x x x
Constipation def 21% - 43% x x x x x x x x x x
Paraesthesia def 1% - 40% x x x x x x x x x x
Kidney function abnormal 23% - 40% x x x x x x x x
Hyperlipidaemia def 10% - 38% x x x x x x x
Effusion def postmarketing, 30% - 36% x x x x x x
Pleural disorder def 30% - 36% x x x x x x
Pleural effusion def 30% - 36% x x x x x x
Pruritus def 7% - 36% x x x x x x x x
Urinary tract infection def 1% - 35% x x x x x x x x
Anorexia def 5% - 34% x x x x x x x x x x
Hypokalaemia def 13% - 34% x x x x x x x
Influenza def 22% - 34% x x x x x x x
Leukocytosis def 8% - 32% x x x x x x x
Atelectasis def 4% - 30% x x x x x x
Back pain def 0% - 30% x x x x x x x x
Blood urea increased 9% - 30% x x x x x x
Dyspnoea def 4% - 29% x x x x x x x x
Vomiting def 1% - 29% x x x x x x x x x x
Post procedural pain 27% - 29% x x
Dyspepsia def 2% - 28% x x x x x x x x
Ascites def 7% - 27% x x x x x x
Arthralgia def 1% - 25% x x x x x x x x
Diabetes mellitus def 3.31% - 24% x x x x x x x
Rash def 1% - 24% x x x x x x x x
Thrombocytopenia def 14% - 24% x x x x x x x
Graft dysfunction postmarketing, 18% - 24% x x x
Chest pain def 13% - 19% x x x x x x x x
Dizziness def 16% - 19% x x x x x x x x
Oliguria def 12% - 19% x x x x x x x
Cough def 3% - 18% x x x x x x x x
Cough increased 3% - 18% x x x x x x x x
Leukopenia def 10% - 17% x x x x x x x
Skin infection def 9% - 16% x
Asthma def 4% - 13% x x x x x x x x
Hypersensitivity def 9% - 13% x x x x x x x x
Pharyngitis def 4% - 12% x x x x x x x x
Erythema def 7% - 12% x
Otitis def 2% - 11% x x x x x x x x
Otitis media def 2% - 11% x x x x x x x
Sinusitis def 6% - 7% x x x x x x x x
Rash pustular def 2% - 7% x
Lack of drug effect 6% x
Bronchitis def 4% x x x x x x x
Dermatitis def 0% - 4% x x x x x x x x
Fungal skin infection def 2% - 4% x x x x x x x x
Folliculitis def 2% - 4% x
Gastroenteritis def postmarketing, 2% - 4% x x x x x x
Herpes NOS def 1% - 4% x x x x x x x x
Herpes simplex def 3% - 4% x x x x x x x x
Rhinitis def 2% - 4% x x x x x x x x
Urticaria def 3% - 4% x
Alcohol intolerance def 0% - 4% x
Conjunctivitis def 3% x
Pneumonia def 1% - 3% x x x x x x x x
Acne def 2% - 3% x x x x x x x x
Varicella def 1% - 2% x
Dermatitis contact def 2% x
Dysmenorrhoea def 1% - 2% x
Herpes zoster def 1% - 2% x x x x
Neoplasm def postmarketing, 1% - 2% x x x x
Skin disorder def 2% x x x x x x x x
Neoplasm skin def 1% - 2% x x x x
Tooth disorder def 1% - 2% x
Common wart def 1% - 2% x
Vesiculobullous rash 1% - 2% x
Myalgia def 1% - 2% x x x x x x x x
Tingling skin 1% - 2% x
Rash maculo-papular def 1% - 2% x
Lymphadenopathy def 1% - 2% x
Varicella zoster 1% - 2% x
Tingling sensation def 1% - 2% x
Abscess def 1% x x x x x x x x
Alopecia def 1% x x x x x x x x
Cellulitis def 1% x x x x x x x
Cyst def 0% - 1% x
Dermatitis exfoliative def 0% - 1% x x x x x
Ear pain def 0% - 1% x x x x x x x
Eczema def 0% - 1% x
Abscess periodontal def 1% x
Dry skin def 1% x
Face oedema def 1% x
Arrhythmia def postmarketing x x x x x x x
Atrial fibrillation def postmarketing x x x
Atrial flutter def postmarketing x x x
Mental disorder def postmarketing x x x
Carcinoma def postmarketing x
Basal cell carcinoma def postmarketing x
Squamous cell carcinoma def postmarketing x
Carpal tunnel syndrome def postmarketing x x x
Cerebral infarction def postmarketing x x x
Colitis def postmarketing x x x x
Cystitis def postmarketing x x x x x x x x
Deafness def postmarketing x x x x x x x
Disseminated intravascular coagulation def postmarketing x x x
Enterocolitis def postmarketing x x x
Toxic epidermal necrolysis def postmarketing x x x
Liver fatty def postmarketing x x x
Flushing def postmarketing x x x
Cardiac flutter postmarketing x x x
Gastrooesophageal reflux disease def postmarketing x x x
Glycosuria def postmarketing x x x x x x x
Cardiac arrest def postmarketing x x x
Hemiparesis postmarketing x x x
Venoocclusive liver disease def postmarketing x x x
Hypertrophy def postmarketing x x x x x x x x
Impetigo def postmarketing x
Bullous impetigo postmarketing x
Infarction def postmarketing x x x
Ischaemia def postmarketing x x x
Nephropathy def postmarketing x x x x x x x
Renal failure acute def postmarketing x x x x x x x x
Progressive multifocal leukoencephalopathy def postmarketing x x x
Liver disorder def postmarketing x x x
Lung disorder def postmarketing x x x x x x x x
Lymphoma def postmarketing x x x
Malignant melanoma def postmarketing x
Mutism def postmarketing x x x
Myocardial infarction def postmarketing x x x
Necrosis def postmarketing x x x x x x x
Neutropenia def postmarketing x x x
Osteomyelitis def postmarketing x
Pancreatitis def postmarketing x x x x x x x
Pancytopenia def postmarketing x x x
Pericardial effusion def postmarketing x x x
Purpura def postmarketing x x x x x x x
Thrombotic thrombocytopenic purpura def postmarketing x x x
Quadriplegia def postmarketing x x x
Aplasia pure red cell def postmarketing x x
Renal failure def postmarketing x x x x x x x x
Acute respiratory distress syndrome def postmarketing x x x
Rosacea def postmarketing x
Seizures def postmarketing x x
Septicemia def postmarketing x
Speech disorder def postmarketing x x x
Gastric disorder def postmarketing x x x x x x x
Gastric ulcer def postmarketing x x x x x x x
Syncope def postmarketing x x x x
Thrombosis def postmarketing x x x x x x x
Torsade de pointes def postmarketing x x x x x
Ulcer def postmarketing x x x x x x x x
Micturition disorder def postmarketing x x x
Venous thrombosis def postmarketing x x x
Ventricular fibrillation def postmarketing x x x
Weight decreased def postmarketing x x x
Encephalopathy def postmarketing x x x x x x x
Photophobia def postmarketing x x x
Cystitis haemorrhagic postmarketing x x x
Mouth ulceration def postmarketing x x x x
Amylase increased postmarketing x x x x x
Necrolysis epidermal postmarketing x x x
Ventricular extrasystoles def postmarketing x x x
Myocardial ischaemia def postmarketing x x x
Hepatocellular injury postmarketing x x x x x x
Hepatic necrosis def postmarketing x x x
Blindness cortical def postmarketing x x x
Interstitial lung disease def postmarketing x x x
Cardiac fibrillation postmarketing x x x
Lung infiltration postmarketing x x x
Ventricular dysfunction def postmarketing x x x x
Aplasia postmarketing x x
Bile duct stenosis def postmarketing x x x
Pancreatitis haemorrhagic postmarketing x x x
Pancreatitis necrotising def postmarketing x x x
Leukoencephalopathy def postmarketing x x x x x x x
Red cell aplasia postmarketing x x
Uraemic syndrome postmarketing x x x x x
Extrasystoles def postmarketing x x x
Renal impairment def postmarketing x
Blindness def postmarketing x x x
Respiratory distress def postmarketing x x x
Impaired gastric emptying postmarketing x x x
Feeling hot and cold postmarketing x x x
Feeling jittery postmarketing x x x
Hot flush def postmarketing x x x
Thrombocytopenic purpura def postmarketing x x x x x x x
Graft loss postmarketing x
Primary graft dysfunction def postmarketing x x x
Organ failure postmarketing x x x
Respiratory failure def postmarketing x x x
Cardiac hypertrophy def postmarketing x x x x x x x
Hearing impaired def postmarketing x x x x x x x
Cytolysis def postmarketing x x x
Feeling hot postmarketing x x x
Eczema herpeticum 0% x
Acidosis def x x x x x x x
Albuminuria def x x x x x x x
Alkalosis def x x x x x x x
Amblyopia def x x x x x x x
Amnesia def x x x x x x x
Hypochromic anaemia def x x x x x x
Angina pectoris def x x x x x x x
Anxiety def x x x x x x x x
Blepharitis def x
Coagulopathy def x x x x x x
Bone disorder def x
Bursitis def x
Neoplasm malignant def x x
Candidiasis def x x x x x x x x
Skin candida def x
Oral candidiasis def x x x x x x x
Vaginal moniliasis x
Cardiovascular disorder def x x x
Neck pain def x
Cholangitis def x x x x x x x
Coma def x x
Confusional state def x x x x x x x
Convulsion def x x x x x x x
Cytomegalovirus infection def x
Dysphagia def x x x x x x x
Dehydration def x x x x x x x x
Delirium def x x
Dental caries def x
Type 1 diabetes mellitus def x
Duodenitis def x x x
Dysarthria def x
Dysgeusia def x
Dysuria def x x x x x x x
Ear disorder def x
Ecchymosis def x x x x x x x x
Epistaxis def x
Oesophagitis def x x x x x x x
Fasting def x
Flatulence def x x x x x x x
Furunculosis def x
Gastritis def x x x x x x x x
Gastrointestinal disorder def x x x x
Gastrointestinal haemorrhage def x x x x x x
Gout def x x x
Hallucination def x x x x x x x
Cardiac disorder def x
Cardiac failure def x x x
Cardiac failure congestive def x x x
Cardiac valve disease def x
Haematuria def x x x x x x x
Hemiplegia def x
Haemorrhage def x x x x x x x
Hepatitis def x x x x x x x
Hernia def x x x x x x x x
Hiccups def x x x
Hirsutism def x x x x x x x
Hydronephrosis def x x x x x x x
Hyperbilirubinaemia def x x x x x x x x
Hypercalcaemia def x x x x x x x
Hypercholesterolaemia def x x x x x x x x
Hypocalcaemia def x x x x x x x
Hypoglycaemia def x x x x x x x
Hyponatraemia def x x x x x x x
Hypoproteinaemia def x x x x x x x
Hypotension def x x x x x x x
Orthostatic hypotension def x x x x x x x
Hypothyroidism def x
Immunosuppression def x x
Incontinence def x x x x x x x
Jaundice def x x x x x x x
Jaundice cholestatic def x x x x x x x
Arthropathy def x x x x x x x x
Laryngitis def x
Cramps of lower extremities x x x x x x x
Lymphoproliferative disorder def x
Cramp muscle def x x x x x x x x
Hypertonia def x x x x x x x x
Myoclonus def x x x x x x x
Nail disorder def x
Nervous system disorder def x x x
Nervousness def x x x x x x x
Neuralgia def x x x
Nocturia def x x x x x x x
Nystagmus def x
Osteoporosis def x x x x x x x
Otitis externa def x
Pancreatic pseudocyst def x x x
Peritonitis def x x x x x x x
Phlebitis def x x x x x x x
Pneumothorax def x x x x x x x
Polycythaemia def x x x x x x x
Psychotic disorder def x x x x x x x
Pulmonary oedema def x x x x x x x
Emphysema def x x x
Pyuria def x x x x x x x
Rectal disorder def x x x x x x x x
Respiratory disorder def x x x x x x x
Seborrhoeic dermatitis def x
Skin ulcer def x x x x x x
Muscle spasms def x x x x x x x
Stomatitis def x x x x x x x x
Cerebrovascular accident def x x x
Sweating def x x x x x x x x
Tachycardia def x x x x x x x x
Thrombophlebitis def x x x x x x x
Tinnitus def x x x x x x x
Unintended pregnancy def x
Pollakiuria def x x x x x x x
Urinary incontinence def x x x x x x
Vaginal inflammation def x x x x x x x x
Angiopathy def x x x x x x
Vasodilation def x x x x x x x x
Vertigo def x x x x
Visual impairment def x x x x x x x
Weight increased def x x x x x x x
Dry mouth def x
Urinary retention def x x x
Peripheral vascular disorder def x x x x x x
Chills def x x x x x x x x
Paralysis flaccid x x x x
Agitation def x x x x x x x
Mood swings x x x x x x x
Hyperphosphataemia def x x x x x x x
Cataract def x
Epstein-Barr virus infection def x
Migraine def x x
Urge incontinence def x x x
Conjunctival oedema x
Generalised oedema x x x x x x x
Gamma-glutamyltransferase increased def x x x x x x x
Gastrointestinal perforation x x x x x x
Impaired healing x x x x x
Skin hypertrophy x
Renal tubular disorder def x x x x x x x
Liver function test abnormal x x x x x
Eye pain def x
Phosphatase alkaline increased x x x x x x x
Skin discolouration def x x x x x x x x
Spasm generalised x x x x x x x
Tendon disorder x
Deep thrombophlebitis x x x x x x x
Photosensitivity reaction def x x x x x x x x
Leukoderma def x
Malaise def x
Increased appetite x x x x x x
Function kidney decreased x x x
Elevated mood x x x
Thinking abnormal x x x x x x
Abnormal dreams x x x x x x x
Respiratory depression x x x
Hepatitis granulomatous x x x
Serum iron decreased x x x x x x
Haematocrit increased x x x
Sepsis def x x x x x x x
Quadriparesis x x x
Monoparesis x x x
Dry eye x
Cushingoid x
Pseudocyst x x x
Anaphylactoid reaction x
Pneumonia due to Streptococcus, group b x x x
Photosensitivity def x x x x x x x x
Haemoglobin abnormal x x x
Enlargement abdomen def x x x x x x x
Gastrooesophagitis x x x
Dystonia def x
Bladder spasm def x x x
Bradycardia def x x x
Electrocardiogram ST segment x x x
QRS complex def x x x
Electrocardiogram QRS complex x x x
Neuropathy def x x x x x x x
Echocardiogram abnormal x x x
Coordination abnormal x x x x x x x
Electrocardiogram abnormal x x x x x x x
Paralysis def x x x x
Fluid overload def x x x x x x x
Haemorrhagic stroke x x x
Prothrombin level decreased x x x x x x x
Writing impaired x x x
Nephropathy toxic x x x x x x
Skin carcinoma def x
Mobility decreased x x x
Hyperuricaemia def x x x x x x x
Iron low x x x x x x x
Psychomotor skills impaired x x x
Myasthenia def x x x x x x x
Temperature intolerance x x x
Ileus def x x x x x x x
Sensitisation def x
Feeling abnormal x x x
Cardiopulmonary failure x x x
Breast neoplasm def x
Voice disturbance x x x x x
Phototoxicity def x
Renal tubular necrosis x x x x x x
Oesophagitis ulcerative x x x
Somnolence def x x x x x x x
Indication Labels
Anaphylactic shock def x x x x x x
Arthritis def x
Atopy def x
Dermatitis def x
Dermatitis atopic def x
Drug interaction def x
Rheumatoid arthritis def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Codes: D11AH01, L04AD02

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. TACROLIMUS / PROGRAF : 14 side effects (Drugs@FDA)
  2. tacrolimus / Prograf : 23 side effects (FDA MedWatch)
  3. TACROLIMUS : 157 side effects (FDA XML label)
  4. TACROLIMUS / PROGRAF : 185 side effects (Drugs@FDA)
  5. TACROLIMUS / PROGRAF : 188 side effects (Drugs@FDA)
  6. TACROLIMUS / PROGRAF : 204 side effects (Drugs@FDA)
  7. TACROLIMUS / PROGRAF : 214 side effects (Health Canada)
  8. TACROLIMUS : 311 side effects (FDA XML label)
  9. tacrolimus : 311 side effects (FDA XML label)
  10. TACROLIMUS ANHYDROUS : 318 side effects (FDA XML label)