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Tacrolimus

More information: STITCH, PubChem (stereo-specific compounds: 1, 2) and possibly Wikipedia

ATC Codes: D11AH01, L04AD02

Side effects

Options: Show MedDRA Preferred Terms,   display all 28 labels

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Hypertriglyceridaemia common, 65% - 65.4% x x x x x x x
Hypercholesterolaemia common, 57% x x x x x x x x x x x x x x x
Hypertension very common, 0% - 91.1% x x x x x x x x x x x x x x x
Kidney function abnormal 23% - 57% x x x x x x x x x x x
Nausea very common, 0% - 47% 6.4% x x x x x x x x x x x x x x x x x x
Tremor very common, 4.5% - 56% 1.9% x x x x x x x x x x x x x x x
Pleural effusion common, 30% - 36% x x x x x x x x x x x x x x
Constipation common, 13.6% - 43% x x x x x x x x x x x x x x x x x x
Asthenia 0% - 52% 3.2% x x x x x x x x x x x x x x
Bacterial infection 8.41% - 40.8% x x x x x
Cytomegalovirus infection 6.25% - 32% x x x x x x x
Pain common, 0% - 63% x x x x x x x x x x x x x x x x x x x
Insomnia very common, 0% - 68% 5.1% x x x x x x x x x x x x x x x x x x
Abdominal pain common, 1% - 59% 4.5% x x x x x x x x x x x x x x x x x x
Body temperature increased 1% - 56% x x x x x x x x x x x x x x
Hypophosphataemia common, 3% - 53% x x x x x x x x x x x x x x x
Influenza-like symptoms 22% - 34% x x
Post procedural pain 27% - 29% x x x x x x
Respiratory tract infection 22% - 34.1% x
Influenza 16.2% - 28.7% 16.6% x x x x x x x x x x x
Diarrhoea very common, 2% - 72% 5.1% x x x x x x x x x x x x x x x x x x
Hyperkalaemia very common, 9% - 45% x x x x x x x x x x x x x x x
Incision site complication 23% - 28% x x x x x x
Headache very common, 5% - 64% 8.9% x x x x x x x x x x x x x x x x x x
Creatinine increased 19% - 45% x x x x x x x x x x x
Anaemia common, 1% - 50% x x x x x x x x x x x x x x x x x x
Arthralgia common, 0% - 25% x x x x x x x x x x x x
Infection postmarketing, 1% - 76% x x x x x x x x x x x x x x x x x x x x
Diabetes mellitus very common, 9% - 89.3% x x x x x x x x x x
Vomiting common, 0% - 29% 1.3% x x x x x x x x x x x x x x x x x x
Blood creatinine increased 16.3% - 23.1% x x x x x x x
Hyperglycaemia 9.3% - 47% x x x x x x x x x x x x
Hypomagnesaemia common, 1% - 48% x x x x x x x x x x x x x x x
Urinary tract infection 0% - 35% x x x x x x x x x x x x x x x
Fasting 15.7% - 25.9% x x x x x
Thrombocytopenia common, 14% - 24% x x x x x x x x x x x x x x x
Dyspnoea common, 4% - 29% x x x x x x x x x x x x x x x x x x
Oedema common, 12% - 26% x x x x x x x x x x x x x x x x x x
Hyperlipidaemia common, 6.95% - 92.6% x x x x x x x x x x x x
Hypokalaemia common, 13% - 34% x x x x x x x x x x x x x x x
Graft dysfunction 13.6% - 24% x x x x x x x
Back pain common, 0% - 30% 2.5% x x x x x x x x x x x x x x x x x
Bronchitis 0% - 18% x x x x x x x x x x x x
Paraesthesia 0% - 40% x x x x x x x x x x x x x x x x x
Blood urea increased 9% - 30% x x x x x x x x x x x
Atelectasis 4% - 30% x x x x x x x x x x x
Chest pain 13% - 19% x x x x x x x x x x x x x x
Dizziness common, 4.5% - 19% 3.8% x x x x x x x x x x x x x x x x x x
Oedema peripheral 0% - 48% x x x x x x x x x x x x x x x
Liver function test abnormal very common x x x x x x x x x x
Application site pruritus very common x x
Application site burn very common x x
Renal impairment postmarketing, very common x x x x x x
Dyspepsia 0% - 28% 3.2% x x x x x x x x x x x x x x x
Leukopenia common, 10% - 48% x x x x x x x x x x x x x x x
Oliguria common, 12% - 19% x x x x x x x x x x x x x x x
Opportunistic infection 15% x x x x
Pruritus common, 7% - 46% x x x x x x x x x x x x x x x x x x x x
Cough increased 1% - 18% x x x x x x x x x x x x x x
Pericardial effusion postmarketing — 14% - 15% x x x x x x x x x x x x
Rash common, 1% - 24% x x x x x x x x x x x x x x x x x x x x
Skin infection 5% - 16% x x x x
Erythema 7% - 28% x x x x x
Hypersensitivity 4% - 13% x x x x x x x x x x x x x x
Ascites common, 7% - 27% x x x x x x x x x x x x x x x
Leukocytosis common, 8% - 32% x x x x x x x x x x x x x x x
Anorexia common, 5% - 34% x x x x x x x x x x x x x x x x x x
Accidental injury 3% - 12.2% 5.1% x x x x x x x x x x x x x x
Fatigue 1.79% - 15.9% x
Asthma uncommon, 4% - 13% x x x x x x x x x x x x x x x x
Otitis media 2% - 11% x x x x x x x x x x x x x
Sinusitis 1% - 8% x x x x x x x x x x x x x x
Lack of drug effect 0% - 6% x x x
Bile duct disorders common x x x
Neoplasm malignant common x x x x x x x x x x
Skin cancer common x x
Cholestasis common x x x x
Confusional state common x x x x x x x x x x x x x x x
Cough common x x x
Eye disorder postmarketing, common x x x x
Flatulence common x x x x x x x x x x x x x x x
Gastrointestinal haemorrhage common x x x x x x x x x x x x x x x
Hallucination common x x x x x x x x x x x x x x x
Hepatitis common x x x x x x x x x x x x x x x
Herpes labialis common x
Herpes virus infection common x x
Hypocalcaemia common x x x x x x x x x x x x x x x
Hyponatraemia common x x x x x x x x x x x x x x x
Inflammation common x x x
Jaundice postmarketing, common x x x x x x x x x x x x x x x
Kaposi's varicelliform eruption common x x
Lung disorder common x x x x x x x x x x x x x x x x x
Cramp muscle common x x x x x x x x x x x x x x x x x
Nasal congestion common x x x
Nervous system disorder postmarketing — common x x x x x x x x x x x x
Nightmare common x x x x
Pain in extremity common x x x
Neuropathy peripheral common x x x x
Pharyngitis common, 3% - 12% x x x x x x x x x x x x x x x x x
Renal failure common x x x x x x x x x x x x x x x
Convulsion postmarketing, common x x x x x x x x x x x x x x x x x x
Gastrointestinal signs and symptoms common x x x
Stomatitis common x x x x x x x x x x x x x x x x x
Tachycardia common x x x x x x x x x x x x x x x x x x
Tinnitus common x x x x x x x x x x x x x x x
Angiopathy common x x x x
Weight increased common x x x x x x x x x x x x x x
Burning sensation common x x
Skin irritation common x x
Metabolic acidosis common x x x x
Decreased appetite common x x x
Disorientation common x x x
Discomfort common x x x
Consciousness abnormal common x x x
Vision blurred common x x x x
Depressed mood common x x x
Application site irritation common x x
Application site pain common x x
Application site rash common x x
Affective disorder common x x x
Fluid overload common x x x x x x x x x x x x x x x
Writing impaired common x x x x x x x x x x x
Nephropathy toxic common x x x x x x x x x x x x x x x
Sweating increased common x x x
Hyperuricaemia common x x x x x x x x x x x x x x x
Febrile disorders common x x x
Urinary abnormalities common x x x
Gastrointestinal inflammatory conditions common x x x
Dyspeptic signs and symptoms common x x x
Ischaemic coronary artery disorders common x x x
Bladder and urethral symptoms common x x x
Asthenic conditions common x x x
Paraesthesias and dysaesthesias common x x x x x
Blood alkaline phosphatase increased common x x x
Application site erythema common x x
Herpes simplex dermatitis common x
Gastrointestinal ulcer perforation common x x x
Application site warmth common x x
Anxiety symptoms NOS common x x x
Application site paraesthesia common x x
Vascular hypotensive disorders common x x x
Abdominal bloating common x x x
Renal tubular necrosis common x x x x x x x x x x x x x x x
Loose stools common x x x
Rash pustular 2% - 7% x x x
Urticaria postmarketing, 1% - 6% x x x x
Conjunctivitis 0% - 3% x x x x
Fungal skin infection 0% - 4% x x x x x x x x x x x x x x
Folliculitis common, 0% - 6% x x x x x
Herpes simplex common, 0% - 4% x x x x x x x x x x x x x x x x
Rhinitis 2% - 6% x x x x x x x x x x x x x x
Acne uncommon, 0% - 7% x x x x x x x x x x x x x x
Haemorrhage uncommon, common x x x x x x x x x x x x x x x
Ulcer rare, common x x x x x x x x x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing, common x x x x
Polyomavirus infections 0.298% - 4.72% x x x x x
Dermatitis contact 1% - 4% x x x
Herpes zoster 0% - 5% x x x x x x x x x x x
Pneumonia 0% - 3% x x x x x x x x x x x x x x
Skin disorder 1% - 4% x x x x x x x x x x x x x x
Alcohol intolerance common, 0% - 7% x x x x x
Varicella zoster 0% - 5% x x x
Encephalopathy uncommon, 2.5% x x x x x x x x x x x x x x
Alopecia common, 0% - 1% x x x x x x x x x x x x x x x x x x
Cellulitis 0% - 1% x x x x x x x x x x x x x
Cyst 0% - 3% x x x x
Depression 0% - 2% x x x
Dysmenorrhoea uncommon, 0% - 4% x x x x x x
Ear pain 0% - 1% x x x x x x x x x x x x x
Eczema 0% - 2% x x x
Hyperaesthesia common, 0% - 2% x x x x
Abscess periodontal 0% - 1% x x x
Neoplasm skin 0% - 2% x x x x x x x x x x x
Sunburn 0% - 2% x x x
Tooth disorder 0% - 2% x x x
Vesiculobullous rash 0% - 4% x x x
Dry skin 0% - 7% x x x
Myalgia postmarketing, 0% - 3% x x x x x x x x x x x x x x x
Tingling skin 1% - 8% x x x
Rash maculo-papular 0% - 3% x x x
Lymphadenopathy 0% - 3% x x x
Face oedema 1% - 2% x x x
Procedural complication 0% - 1% x x x
Hemiplegia 0.8% x
Nystagmus 0.8% x
Delirium 0.2% - 1.2% x
Amnesia uncommon x x x x x x x x x x x x x x
Anuria uncommon x x x x
Coagulopathy uncommon x x x x x x x x x x x x x x x
Coma postmarketing — 2.1% x x x x x
Dehydration uncommon x x x x x x x x x x x x x x x x x x
Dermatitis uncommon x x x x
Cardiac failure uncommon x x x x x x x x x x x
Hypoglycaemia uncommon x x x x x x x x x x x x x x x
Hypoproteinaemia uncommon x x x x x x x x x x x x x x x
Infarction uncommon x x x
Arthropathy uncommon x x x x x x x x x x x x x x x x x
Palpitations uncommon x x x
Ileus paralytic uncommon x x x
Paresis uncommon x x x
Peritonitis postmarketing, uncommon x x x x x x x x x x x x x x x
Psychotic disorder uncommon x x x x x x x x x x x x x x
Shock uncommon x x x
Uterine haemorrhage uncommon x x x
Ventricular arrhythmia uncommon x x x
Hyperphosphataemia uncommon x x x x x x x x x x x x x x x
Cataract uncommon x x x x x x
Chest pressure sensation of uncommon x x x
Pancreatitis acute on chronic uncommon x x x
Ventricular hypertrophy uncommon x x x
Photosensitivity postmarketing, uncommon x x x x
Arrhythmia supraventricular uncommon x x x
Influenza like illness uncommon x x x
Haemorrhagic stroke uncommon x x x x x x x x x x x
Speech and language abnormalities uncommon x x x
Blood amylase increased uncommon x x x
Blood lactate dehydrogenase increased uncommon x x
Cardiomyopathy uncommon x x x
Temperature intolerance uncommon x x x x x x x x x x x
Feeling abnormal uncommon x x x x x x x x x x x
Paralysis uncommon, 0.4% x x x x
Dysarthria postmarketing, 0.4% x x
Paralysis flaccid postmarketing, 0.4% x x x x x x x x x x
Stupor 0.2% x
Agranulocytosis postmarketing, rare x x x x x x x x
Haemolytic anaemia postmarketing, rare x x x x x x x x
Arrhythmia postmarketing x x x x x x x x x x x
Atrial fibrillation postmarketing x x x x x x x x x
Atrial flutter postmarketing x x x x x x x x x
Mental disorder postmarketing, common x x x x x x x x x x x x
Basal cell carcinoma postmarketing x x x
Squamous cell carcinoma postmarketing x x x
Carpal tunnel syndrome postmarketing x x x x x x x x x
Cerebral infarction postmarketing x x x x x x x x x
Cholangitis postmarketing x x x x x x x x x x x x
Colitis postmarketing x x x x x x x x x x x x
Connective tissue disorder postmarketing x x x x
Deafness postmarketing x x x x x x x x x x x
Dysphagia postmarketing x x x x x x x x x x x x
Disseminated intravascular coagulation postmarketing x x x x x x x x x
Enterocolitis postmarketing x x x x x x x x
Toxic epidermal necrolysis postmarketing, rare x x x x x x x x x x x x
Liver fatty postmarketing x x x x x x x x
Flushing postmarketing, common x x x x x x x x x x x
Gastroenteritis postmarketing, 2% - 7.48% x x x x x x x x x x x x x
Gastrooesophageal reflux disease postmarketing, uncommon x x x x x x x x x x x x
Gastrointestinal disorder postmarketing x x x x x x x x x x x x x
Glycosuria postmarketing x x x x x x x x x x x
Graft versus host disease postmarketing x
Deafness neurosensory rare x x x
Cardiac arrest postmarketing, uncommon x x x x x x x x x x x x
Cardiac disorder postmarketing x x x x
Hemiparesis postmarketing x x x x x x x x x
Haemolytic uraemic syndrome postmarketing, uncommon x x x x x x x x x x x x x x x
Venoocclusive liver disease postmarketing, rare x x x x x x x x x x x x
Hirsutism rare x x x x x x x x x x x x x x
Pulmonary hypertension postmarketing x
Immune system disorder postmarketing x x x x
Bullous impetigo postmarketing x x x
Intestinal obstruction postmarketing x
Renal failure acute postmarketing, common x x x x x x x x x x x x x x x x x
Leukaemia postmarketing x
Progressive multifocal leukoencephalopathy postmarketing x x x x x x x x x x
Lymphoma postmarketing, common x x x x x x x x x x
Lymphoproliferative disorder postmarketing x x x x
Mediastinal disorder postmarketing x x x x
Malignant melanoma postmarketing x x x x
Multi-organ failure postmarketing, uncommon x x x x x x x x x x x x
Hypertonia rare x x x x x x x x x x x x x x x x x
Mutism postmarketing x x x x x x x x x
Myocardial infarction postmarketing x x x x x x x x x
Neoplasm postmarketing x x x x x x x
Neutropenia postmarketing, uncommon x x x x x x x x x x x x
Optic atrophy postmarketing x
Osteomyelitis postmarketing x x x
Pancreatic pseudocyst rare x x x x x x x x x x x
Pancreatitis postmarketing x x x x x x x x x x x x
Pancytopenia postmarketing, uncommon x x x x x x x x x x x x
Supraventricular extrasystoles postmarketing x
Thrombotic thrombocytopenic purpura postmarketing, rare x x x x x x x x x x x x
Quadriplegia postmarketing x x x x x x x x x
Aplasia pure red cell postmarketing, rare x x x x x x x x x
Acute respiratory distress syndrome postmarketing, rare x x x x x x x x x x x x
Rhabdomyolysis postmarketing x
Rosacea postmarketing, common x x x x x
Septicemia postmarketing x x x
Speech disorder postmarketing x x x x x x x x
Status epilepticus postmarketing x
Stevens-Johnson syndrome very rare, postmarketing x x x x x x x x x x x x x x x
Gastric ulcer postmarketing x x x x x x x x x x x x
Syncope postmarketing x x x x x x x x x x x x
Supraventricular tachycardia postmarketing x
Thirst rare x x x
Thrombosis rare x x x x x x x x x x x x x
Torsade de pointes very rare — uncommon x x x x x x x x x x x x x
Micturition disorder postmarketing x x x x x x x x
Urinary tract disorder postmarketing x x x x
Ventricular fibrillation postmarketing x x x x x x x x x
Weight decreased postmarketing, uncommon x x x x x x x x x x x
Photophobia postmarketing, common x x x x x x x x x x x x
Cystitis haemorrhagic very rare, postmarketing x x x x x x x x x x x x
Mouth ulceration postmarketing x x x x x x x x x x x
Amylase increased postmarketing x x x x x x x x x x x
Ventricular extrasystoles postmarketing x x x x x x x x x
Gastrointestinal perforation postmarketing x x x x x x x x x x x x
Myocardial ischaemia postmarketing x x x x x x x x x
Hepatocellular injury postmarketing, common x x x x x x x x x x x x x x
Hepatic necrosis postmarketing x x x x x x x x x
Blindness cortical postmarketing x x x x x x x x
Polyarthritis postmarketing x
Skin hyperpigmentation postmarketing x
Interstitial lung disease postmarketing x x x x x x x
Chest tightness rare x x x
Application site oedema postmarketing x x
Hepatotoxicity postmarketing x x x x x x x x x
Lung infiltration postmarketing x x x x x x x x x
Activated partial thromboplastin time prolonged postmarketing x
Ventricular dysfunction postmarketing x x x x x x x
Netherton's syndrome postmarketing x x x
Hepatobiliary disease postmarketing x x x x
Bile duct stenosis very rare, postmarketing x x x x x x x x x x
Pancreatitis haemorrhagic postmarketing x x x x x x x x
Pancreatitis necrotising postmarketing x x x x x x x x
Leukoencephalopathy postmarketing x x x x x x x x x x x
Nerve compression postmarketing x x x x x x x x x
Hepatic artery thrombosis rare x
Post transplant lymphoproliferative disorder postmarketing x
Electrocardiogram T wave abnormal postmarketing x x x x x x x x
Blindness postmarketing, rare x x x x x x x x x x x x
Respiratory distress postmarketing x x x x x x x x
Impaired gastric emptying postmarketing, uncommon x x x x x x x x x x x x
Feeling jittery postmarketing, uncommon x x x x x x x x x x x
Hot flush postmarketing x x x x x x x x
Mobility decreased rare x x x x x x