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Melphalan

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: L01AA03

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7
Injection site reaction Injection site reaction 50% x
Anaemia Anaemia very common x x x x x x
Leukopenia Leukopenia very common x x x x x x
Muscle atrophy Muscle atrophy very common x x
Nausea Nausea very common x x x x x x x
Thrombocytopenia Thrombocytopenia very common x x x x x x
Pancytopenia Bone marrow depression very common x x
Pancytopenia x x x x x
Myelosuppression x x
Myalgia Myalgia very common x x
Musculoskeletal discomfort Myalgia very common x x
Feeling hot Sensation of warmth very common x x x x
Blood creatine phosphokinase increased Blood creatine phosphokinase increased very common x
Muscle fibrosis Muscle fibrosis very common x x
Paraesthesia Tingling sensation very common x x x x
Alopecia Alopecia common, very common x x x x x x x
Diarrhoea Diarrhoea rare, very common x x x x x x
Vomiting Vomiting rare, very common x x x x x x x
Compartment syndrome Compartment syndrome common x x
Plasma cell myeloma Plasma cell myeloma common x
Plasmacytoma Plasma cell myeloma common x
Neuropathy peripheral Neuropathy 2% x
Anaphylactic shock Anaphylactic shock rare, 2% x x x x x x x
Haemolytic anaemia Haemolytic anaemia rare x x x x x x x
Oedema Oedema rare x x x x x x
Dermatitis Rash rare x x x x x
Dermatitis x
Rash Rash rare x x x x x
Hepatitis Hepatitis rare x x x x x x
Hypersensitivity Hypersensitivity rare x x x x x x x
Immune system disorder Immune system disorder rare x
Jaundice Jaundice rare x x x x x x
Liver disorder Liver disorder rare x x x x x x
Hepatocellular injury Liver disorder rare x x x x x x
Foetor hepaticus Liver disorder rare x x x x x x
Pruritus Pruritus rare x x x x x
Pulmonary fibrosis Pulmonary fibrosis rare x x x x x x x
Stomatitis Stomatitis rare x x x x
Mouth ulceration x x x x
Urticaria Urticaria rare x x x x x x
Liver function test abnormal Liver function test abnormal rare x x x x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue rare x
Interstitial lung disease Interstitial pneumonia rare x x x x x x
Amenorrhoea Amenorrhoea x
Decreased appetite Anorexia x
Arrhythmia Arrhythmia x
Atrial fibrillation Atrial fibrillation x
Bronchospasm Bronchospasm x x x
Neoplasm malignant Neoplasm malignant x x x
Chest pain Chest pain x
Infection Infection x x
Connective tissue disorder Connective tissue disorder x
Cough Cough x
Cystitis Cystitis x
Bladder pain Cystitis x
Cystitis noninfective Cystitis x
Dyspnoea Dyspnoea x x x
Extravasation Extravasation x
Asthenia Fatigue x
Fatigue Fatigue x
Flushing Flushing x x
Gastrointestinal disorder Gastrointestinal disorder x
Digestion impaired x x
Cardiac arrest Cardiac arrest x x x x x x
Haemorrhage Haemorrhage x
Haemoglobin Haemorrhage x
Venoocclusive liver disease Venoocclusive liver disease x
Hyponatraemia Hyponatraemia x
Hypotension Hypotension x x x
Infertility Infertility x
Renal failure acute Renal failure acute x
Leukaemia Leukaemia x
Lymphoma Lymphoma x
Non-Hodgkin's lymphoma Lymphoma x
Mediastinal disorder Mediastinal disorder x
Neoplasm Neoplasm x
Neutropenia Neutropenia x x
Pain Pain x x
Rales Rales x
Rhabdomyolysis Rhabdomyolysis x x
Convulsion Convulsion x
Skin ulcer Skin ulcer x x
Tachycardia Tachycardia x x x
Ulcer Ulcer x
Ureteric obstruction Ureteric obstruction x
Urethral disorder Urinary tract disorder x
Urinary tract disorder Urinary tract disorder x
Vasculitis Vasculitis x x x x x
Wound Wound x
Acute leukaemia Acute leukaemia x
Mouth ulceration Mouth ulceration x x x x
Impaired healing Impaired healing x
Skin necrosis Skin necrosis x x
Skin exfoliation Skin necrosis x x
Arterial thrombosis Arterial thrombosis x
Dyspepsia Digestion impaired x x
Muscle necrosis Muscle necrosis x x
Hepatobiliary disease Hepatobiliary disease x
Radiation myelopathy Radiation myelopathy x
Muscle injury Muscle damage x
Transaminases increased Transaminases increased x
Respiratory distress Respiratory distress x
Dermatitis atopic Cutaneous hypersensitivity x x x x
Blood uric acid increased Hyperuricaemia x
Hyperuricaemia Hyperuricaemia x
Febrile neutropenia Febrile neutropenia x
Local reaction Local reaction x
Pulmonary toxicity Pulmonary toxicity x
Venoocclusive disease Venoocclusive disease x x x
Hypertonic bladder Bladder irritation x
Bladder irritation Bladder irritation x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

MELPHALAN / ALKERAN

Side effects:18
Source:FDA

MELPHALAN

Side effects:25
Source:FDA Structured Product Label

MELPHALAN

Side effects:37
Source:FDA Structured Product Label

MELPHALAN / ALKERAN

Side effects:51
Source:Health Canada

Melphalan

Side effects:65
Source:BC Cancer

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label