Cyclophosphamide

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4
Anaphylactic shock def postmarketing x x x x
Anaemia def postmarketing x x x x
Asthenia def postmarketing x x x
Diabetes mellitus def postmarketing x x
Dizziness def postmarketing x x x
Body temperature increased def postmarketing x x x x
Fibrosis def postmarketing x x x x
Headache def postmarketing x x x
Cardiac failure def postmarketing x x x
Cardiac failure congestive def postmarketing x x
Pericardial haemorrhage postmarketing x
Hypoprothrombinaemia def postmarketing x x
Inappropriate antidiuretic hormone secretion def postmarketing x x x x
Infection def postmarketing x x x x
Leukopenia def postmarketing x x x
Myocarditis def postmarketing x x x
Pericarditis def postmarketing x x
Pneumonia def postmarketing x x x x
Pulmonary fibrosis def postmarketing x x x x
Thrombocytopenia def postmarketing x x x x
Interstitial pneumonia postmarketing x x x
Malaise def postmarketing x x
Lung fibrosis interstitial postmarketing x x x x
Death postmarketing x x x x
Pancreatitis acute def x
Adenovirus infection def x
Aggression def x
Alopecia def x x x x
Amenorrhoea def x x
Aplastic anaemia def x
Anorexia def x x x x
Arrhythmia def x x
Ascites def x
Azoospermia def x
Bacterial infection def x
Cardiac tamponade def x
Colitis def x x x x
Confusional state def x
Constipation def x
Cough def x
Cystitis def x x x
Dermatitis def x
Dermatomyositis def x
Diarrhoea def x x x
Disseminated intravascular coagulation def x
Diuresis def x x
Dyspnoea def x x
Dysuria def x
Oedema def x x
Toxic epidermal necrolysis def x x x
Rash def x x x
Extravasation def x
Fatigue def x
Fertilization def x
Flushing def x
Gastrooesophageal reflux disease def x
Cardiac disorder def x
Haematuria def x x
Haemolytic uraemic syndrome def x
Haemorrhage def x x
Hepatic encephalopathy def x
Hepatomegaly def x
Hyperbilirubinaemia def x
Hyperglycaemia def x
Hyperkalaemia def x x
Hypersensitivity def x x
Hyponatraemia def x x
Infarction def x
Inflammation def x
Jaundice def x x x x
Renal failure acute def x
Methaemoglobinaemia def x
Myocardial infarction def x
Myopia def x
Myxoedema def x
Nasal congestion def x
Nausea def x x x x
Necrosis def x x x
Neutropenia def x x x
Obstruction def x
Oligospermia def x
Pain def x x x
Pancreatitis def x
Pancytopenia def x
Pigmentation def x x
Pruritus def x x
Rales x
Renal failure def x
Rhabdomyolysis def x
Cardiomyopathy secondary NOS x
Shock def x x
Pigmentation skin def x x
Sneezing def x
Muscle spasms def x
Stevens-Johnson syndrome def x
Stomatitis def x x
Sweating def x
Swelling def x
Tachycardia def x
Thromboembolism def x
Ulcer def x x x
Erythema def x
Ureteric obstruction def x
Ureteritis def x x
Uric acid level increased x
Pollakiuria def x
Urinary tract infection def x
Urticaria def x x
Viral infection def x
Vomiting def x x x x
Water intoxication def x
Weight increased def x x
Encephalopathy def x
Agitation def x
Acute leukaemia def x
Cystitis haemorrhagic x x
Hepatic function abnormal x
Hemorrhagic colitis x x x x
Necrolysis epidermal x x x
Renal tubular disorder def x x
Injection site pain x
Sinus congestion x
Skin hyperpigmentation def x
Obstipation x
Tachypnoea def x
Abdominal discomfort x x
Discomfort def x x x
Tenderness def x
Mucosal ulceration x x x
Productive cough def x
Microscopic hematuria x
Plantar erythema x
Left ventricular dysfunction def x
Ventricular dysfunction def x
Recurrent urinary tract infection x
Fluid retention x
Clot blood def x
Uraemic syndrome x
Redness def x
Mucosal inflammation def x x
Atrophy def x
Renal impairment def x x
Electrolyte imbalance def x
Vision blurred def x
Ovarian atrophy x
Lupus erythematosus def x
Prolonged menses x
Bladder spasm def x
Water retention x x
Fluid overload def x
Urine flow decreased x
Sterility def x
Drug interaction def x
Hypoxemia def x
Intoxication x
Hyperuricaemia def x x
Febrile neutropenia def x
Generalized urticaria x
Malignant urinary tract neoplasm def x
Second primary malignancy def x
Myelosuppression def x x
Cardiomyopathy def x x
Pulmonary toxicity x x
Venoocclusive disease def x
Pain during injection x
Rhinorrhoea def x
Urine output x
Myocardial necrosis x x
Vasoconstriction x
Cytolysis def x x
Renal tubular necrosis x x
Radiation recall reaction (dermatologic) def x
Weakness def x
Decompensation cardiac x
Metastatic neoplasm def x
Indication Labels
Adenocarcinoma def x
Bladder cancer def x
Brain neoplasm malignant def x
Breast cancer def x
Cancer in remission x x
Carcinoma def x
Carcinoma breast def x
Cervix carcinoma def x
Chronic lymphocytic leukaemia def x x x
Chronic myeloid leukaemia def x x x
Diffuse large B-cell lymphoma def x x x
Diffuse lymphoma def x
Endometrial cancer def x
Fungal infection def x x
Gestational trophoblastic tumour def x
Leukaemia def x x x x
Leukaemia monocytic x x
Lung neoplasm malignant def x
Lymphoblastic lymphoma def x x x
Lymphocytic leukaemia def x x x
Lymphoma def x x x x
Lymphoproliferative disorder def x x x
Mediastinal disorder def x
Multiple myeloma def x x
Mycosis fungoides def x x
Myeloid leukaemia def x x x
Neoplasm def x
Neoplasm malignant def x x x
Nephropathy def x
Nephrotic syndrome def x
Neuroblastoma def x x
Nodular lymphoma def x
Osteosarcoma def x
Ovarian adenocarcinoma def x
Ovarian cancer def x
Ovarian disorder def x
Retinoblastoma def x x
Rhabdomyosarcoma def x
Sarcoma def x
Testicular disorder def x
Testis cancer def x
Thymoma def x
Waldenstrom's macroglobulinaemia def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: L01AA01

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. CYCLOPHOSPHAMIDE / CYTOXAN TAB 50MG : 36 side effects (Health Canada)
  2. cyclophosphamide : 38 side effects (FDA XML label)
  3. CYCLOPHOSPHAMIDE / PROCYTOX TAB 25MG : 104 side effects (Health Canada)
  4. Cyclophosphamide : 123 side effects (BC Cancer)