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Cyclophosphamide

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01AA01

Side effects

Options: Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9
Anorexia 33% x x x x x x x x x
Renal tubular necrosis 1-5% x x x x x
Sweating 0.1-1% x
Jaundice 1% x x x x x x x x x
Ureteritis 1% x x x x x
Hemorrhagic colitis 1% x x x x x x x x x
Congenital anomaly postmarketing x x
Pancreatitis acute postmarketing x x x x
Alveolitis allergic postmarketing x x
Amenorrhoea postmarketing x x x x x
Anaphylactic shock postmarketing x x x x x x x x x
Arthralgia postmarketing x x
Ascites postmarketing x x x x
Asthenia postmarketing x x x x x x x x
Atrial fibrillation postmarketing x x
Azoospermia postmarketing x x x x
Bladder cancer postmarketing x x
Blister postmarketing x x
Bronchospasm postmarketing x x
Obliterative bronchiolitis postmarketing x x
Neoplasm malignant postmarketing, 1% x x x
Renal cell carcinoma postmarketing x x
Cardiac tamponade postmarketing x x x
Chest pain postmarketing x x
Cholestasis postmarketing x x
Colitis postmarketing x x
Infection postmarketing x x x x x x x
Confusional state postmarketing x x x
Conjunctivitis postmarketing x x
Constipation postmarketing x x x x
Muscle contracture postmarketing x x
Cough postmarketing x x
Deafness postmarketing x x
Dermatitis postmarketing x x x x
Scleroderma postmarketing x x
Disseminated intravascular coagulation postmarketing x x x x
Dizziness postmarketing, 1% x x x x x x
Dysgeusia postmarketing x x
Dyspnoea postmarketing x x x x
Oedema postmarketing x x x x x
Enteritis postmarketing x x
Toxic epidermal necrolysis postmarketing, 1% x x x x x x x x
Erythema multiforme postmarketing x x
Fatigue postmarketing x x x x
Foetal death postmarketing x x
Microsomia postmarketing x x
Body temperature increased postmarketing x x x x x x x x
Flushing postmarketing x x x x
Gastroenteritis postmarketing x x
Gastrointestinal haemorrhage postmarketing x x
Headache postmarketing x x x x x x
Cardiac arrest postmarketing x x
Cardiac failure postmarketing x x
Haematuria postmarketing x x x x
Haemolytic uraemic syndrome postmarketing x x x x
Hepatic encephalopathy postmarketing x x x
Venoocclusive liver disease postmarketing x x
Hepatitis postmarketing x x
Hepatomegaly postmarketing x x x x
Herpes zoster postmarketing x x
Hyperhidrosis postmarketing x x
Hypersensitivity postmarketing x x x x
Hypertension postmarketing x x
Pulmonary hypertension postmarketing x x
Hypoaesthesia postmarketing x x
Hyponatraemia postmarketing x x x x x
Hypotension postmarketing x x
Infertility postmarketing x x x x x
Inflammation postmarketing x x x x
Premature labour postmarketing x x
Lymphoma postmarketing x x
Multi-organ failure postmarketing x x
Myelodysplastic syndrome postmarketing x x
Myocardial infarction postmarketing x x x x
Myocarditis postmarketing x x x x x x
Nail disorder postmarketing x x
Nasal congestion postmarketing x x x
Necrosis postmarketing x x x
Neoplasm postmarketing x x
Neuralgia postmarketing x x
Oligomenorrhoea postmarketing x x
Oligospermia postmarketing x x x x
Ovarian disorder postmarketing x x
Pain postmarketing x x x x x x x x
Palpitations postmarketing x x
Pancytopenia postmarketing x x x
Paraesthesia postmarketing x x
Pericardial effusion postmarketing x x
Pericarditis postmarketing x x x x
Neuropathy peripheral postmarketing x x
Phlebitis postmarketing x x
Pleural effusion postmarketing x x
Pneumonia postmarketing x x x x x x
Pregnancy postmarketing x x
Pruritus postmarketing x x x x
Pulmonary oedema postmarketing x x
Pulmonary embolism postmarketing x x
Pulmonary veno-occlusive disease postmarketing x x
Renal failure postmarketing x x
Acute respiratory distress syndrome postmarketing x x
Rhabdomyolysis postmarketing x x x
Convulsion postmarketing x x x
Cardiogenic shock postmarketing x x
Septic shock postmarketing x x
Muscle spasms postmarketing x x x
Spinal cord disorder postmarketing x x
Stevens-Johnson syndrome postmarketing x x x x x x x
Stomatitis postmarketing x x x x x
Swelling postmarketing x x x
Tachycardia postmarketing x x x
Thrombosis postmarketing x x
Tinnitus postmarketing x x
Tremor postmarketing x x
Tuberculosis postmarketing x x
Tumour lysis syndrome postmarketing x x x
Erythema postmarketing x x
Urticaria postmarketing x x x
Vasculitis postmarketing x x
Venous thrombosis postmarketing x x
Ventricular fibrillation postmarketing x x
Ventricular tachycardia postmarketing x x
Hepatitis viral postmarketing x x
Water intoxication postmarketing x x x
Encephalopathy postmarketing x x
Chills postmarketing x x
Hepatic failure postmarketing x x
Ventricular arrhythmia postmarketing x x
Acute leukaemia postmarketing x x
Cystitis haemorrhagic postmarketing x x x x x
Hepatic function abnormal postmarketing x x x
Hepatitis cholestatic postmarketing x x
Swelling face postmarketing x x
Pulmonary haemorrhage postmarketing x x
Renal tubular disorder postmarketing x x
Hypogeusia postmarketing x x
Polyneuropathy postmarketing x x
Malignant neoplasm of renal pelvis postmarketing x x
Ureteric cancer postmarketing x x
Testicular atrophy postmarketing x x
Nephrogenic diabetes insipidus postmarketing x x
Interstitial lung disease postmarketing x x
Fatal outcomes postmarketing x x
Malaise postmarketing x x x x x x
Myalgia postmarketing x x
Neurotoxicity postmarketing x x
Hepatotoxicity postmarketing, 1% x x x x
Peripheral ischaemia postmarketing x x
Hepatic enzyme increased postmarketing x x
Sepsis postmarketing x x
Organising pneumonia postmarketing x x
Caecitis postmarketing x x
Fluid retention postmarketing x x
Cystitis interstitial postmarketing x x
Blood bilirubin increased postmarketing x x
Mucosal inflammation postmarketing x x x x
Bladder necrosis postmarketing x x
Dysaesthesia postmarketing x x
Lacrimation postmarketing x x
Arrhythmia supraventricular postmarketing x x
Bradycardia postmarketing x x
Respiratory distress postmarketing x x
Toxic skin eruption postmarketing x x
Influenza like illness postmarketing x x
Blood glucose increased postmarketing x x
Blood glucose decreased postmarketing x x
Nephropathy toxic postmarketing x x
Stillbirth postmarketing x x
Hot flush postmarketing x x
Hyperuricaemia postmarketing x x x x x
C-reactive protein increased postmarketing x x
Ovarian failure postmarketing x x x
Blood lactate dehydrogenase increased postmarketing x x
Myelosuppression postmarketing x x x x x
Nasal discomfort postmarketing x x
Carditis postmarketing x x
Myocardial haemorrhage postmarketing x x
Cardiomyopathy postmarketing x x x
Cytolytic hepatitis postmarketing x x
Respiratory failure postmarketing x x
Rhinorrhoea postmarketing x x x
Sarcoma postmarketing x x
Hearing impaired postmarketing x x
Parosmia postmarketing x x
Renal impairment postmarketing x x
Radiation recall reaction (dermatologic) postmarketing x x x
Parotid gland inflammation postmarketing x x
Oropharyngeal pain postmarketing x x
Infusion site reactions postmarketing x x
Thrombotic microangiopathy postmarketing x x
Posterior reversible encephalopathy syndrome postmarketing x x
Visual impairment postmarketing x x
Agranulocytosis x
Alopecia x x x x x x x x x
Anaemia x x x x x x x
Haemolytic anaemia x
Arrhythmia x x
Bacterial infection x
Cystitis x x x x x x
Dermatomyositis x
Diabetes mellitus x x
Diarrhoea x x x x x x x x
Diuresis x x
Enterocolitis x
Rash x x x x x x x x
Extravasation x x
Fibrosis x x
Heart malformation x
Cardiac failure congestive x x x
Pericardial haemorrhage x x
Haemorrhage x x x
Hyperbilirubinaemia x x
Hyperglycaemia x
Hyperkalaemia x x
Inappropriate antidiuretic hormone secretion x x x x x x x
Renal failure acute x
Myeloid leukaemia x
Leukopenia x x x x x x
Methaemoglobinaemia x
Myeloproliferative disorder x
Myopia x
Myxoedema x x
Nausea x x x x x x x x x
Prurigo x
Radiation injury x
Rales x
Rhinitis x
Cardiomyopathy secondary NOS x
Shock x
Pigmentation skin x
Sneezing x
Telangiectasia x
Thrombocytopenia x x x x x x x
Thromboembolism x x
Ulcer x
Ureteric obstruction x
Viral infection x
Vomiting x x x x x x x x x
Wegener's granulomatosis x
Weight increased x x x
Wound x
Agitation x
Mouth ulceration x x x x x x x
Growth retardation x
Impaired healing x
Injection site pain x
Sinus congestion x
Menstruation irregular x
Skin hyperpigmentation x x
Interstitial pneumonia x x x x x x
Obstipation x
Abdominal discomfort x x x x x x x
Discomfort x
Tenderness x
Nail changes x
Microscopic hematuria x
Lung fibrosis interstitial x x x x x x x
Redness x
Vision blurred x x
Platelet count decreased x
Chemical cystitis x
Ovarian atrophy x
Lupus erythematosus x
Prolonged menses x
Bladder spasm x
Bladder fibrosis x x x x
Water retention x x x
Fluid overload x
Urine flow decreased x
Nephrotoxicity x
Drug interaction x
Bladder carcinoma x
Hypoxemia x
Sweating increased x
Febrile neutropenia x
Generalized urticaria x
Dry cough x
Myopericarditis x
Oral mucosa sore x x x x x x x
Cardiotoxicity x x x x x
Pulmonary toxicity x x x x
Venoocclusive disease x x
Hypothrombinaemia x
Urine output x
Palmar-plantar erythema x
Myocardial necrosis x x
Acute cardiac toxicity x
Wound healing normal x
Decompensation cardiac x
Bacterial colonisation x x
Metastatic neoplasm x x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

cyclophosphamide

Side effects:27
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE

Side effects:29
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE ANHYDROUS

Side effects:29
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE / CYTOXAN TAB 50MG

Side effects:35
Source:Health Canada

Cyclophosphamide

Side effects:90
Source:BC Cancer

CYCLOPHOSPHAMIDE / PROCYTOX TAB 25MG

Side effects:84
Source:Health Canada

CYCLOPHOSPHAMIDE ANHYDROUS

Side effects:196
Source:FDA Structured Product Label

CYCLOPHOSPHAMIDE ANHYDROUS

Side effects:200
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label