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Palmar-plantar erythrodysaesthesia syndrome

Definition: Chemotherapy-induced dermal side effects that are associated with the use of various CYTOSTATIC AGENTS. Symptoms range from mild ERYTHEMA and/or PARESTHESIA to severe ulcerative dermatitis with debilitating pain involving typically palmoplantar and intertriginous areas. These cutaneous manifestations are sometimes accompanied by nail anomalies.

Synonyms (terms occurring on more labels are shown first):

More information: PubMed search and possibly Wikipedia

Drugs with this side effect as MedDRA Preferred Term

  • capecitabine
    • Hand and foot syndrome secondary to sickle cell anaemia: 1% - 60%
  • cyclophosphamide
    • Palmar-plantar erythema
  • docetaxel
    • Hand and foot syndrome secondary to sickle cell anaemia: postmarketing
  • doxorubicin
    • Acral erythema: postmarketing
    • Hand and foot syndrome secondary to sickle cell anaemia
  • etoposide
    • Palmar-plantar erythema
  • fosinopril
    • Acral erythema
  • idarubicin
    • Acral erythema
  • irinotecan
    • Hand and foot syndrome secondary to sickle cell anaemia: 0% - 20.3%