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Docetaxel

More information: STITCH, PubChem (stereo-specific compounds: 1, 2) and possibly Wikipedia

ATC Code: L01CD02

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 26 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Agranulocytosis Agranulocytosis 10% - 87% x
Neutropenia Neutropenia very common, 1% - 95.5% x x x x x x x x x x x x x x x x x x x x
Gastrointestinal disorder Gastrointestinal disorder 45% x x x x x x x
Reaction gastrointestinal x x x x x x x x x x x
Lymphopenia Lymphopenia 40% - 98% x
Amenorrhoea Amenorrhoea 27.2% - 59.9% x x x x x x x x x x x x x x
Alopecia Alopecia very rare, 0% - 98% x x x x x x x x x x x x x x x x x x x x
Mucosal inflammation Mucosal inflammation 40% x x x x x x x x x x x x
Nervous system disorder Nervous system disorder 32% x x x x x x x
Connective tissue disorder Connective tissue disorder 27% x x x x x x
Menstruation irregular Menstruation irregular 19.9% - 33.6% x x x
Blood alkaline phosphatase increased Phosphatase alkaline increased 1% - 51% x x
Blood alkaline phosphatase increased 0.3% - 4% x
Lethargy Lethargy 1% - 62.9% x x x x x x x x x x x x x
Stomatitis Stomatitis 0% - 68% x x x x x x x x x x x x x x x x x x x
Nausea Nausea 1% - 87.2% x x x x x x x x x
Anaemia Anaemia 1% - 96.8% x x x x x x x x x x x x x x x x x x x
Diarrhoea Diarrhoea 0.9% - 77.8% x x x x x x x x x x x x x x x x x x x
Vomiting Vomiting postmarketing, 1% - 73.2% x x x x x x x x x
Dysphagia Dysphagia 0.6% - 26% x x x x x x x x x x x x
Odynophagia Odynophagia 0.6% - 26% x x x x x x x x x x x x
Mental disorder Mental disorder 12% x x x x x x
Cancer pain Cancer pain 0.6% - 21% x x x x x x x x x x x
Febrile neutropenia Febrile neutropenia 2% - 26% x x x x x x x x x x x x x x x x x x x
Eye disorder Eye disorder postmarketing, 21% x x x x x x x
Mediastinal disorder Mediastinal disorder postmarketing, 20% x x x x x x x
Decreased appetite Anorexia postmarketing, 0% - 54% x x x x x x x x x x x x x x x x x x
Decreased appetite 4% - 10% x x x x x x x x
Oesophagitis Oesophagitis postmarketing — 0.6% - 26% x x x x x x x x x x x x x x x x x x
Asthenia Asthenia 1% - 43% x x x x x x x x x x x x x x x x x x x
Fatigue 2.7% - 81.3% x x x x x x x x x x x x x x x x x
Paraesthesia Paraesthesia 1% - 15% x x x x x x x x
Neutropenic infection Neutropenic infection 1.19% - 15.9% x x x x x x x x x x x x x
Haemoglobin decreased Haemoglobin decreased 4% - 13% x x x
Arthralgia Arthralgia 0% - 39.7% x x x x x x x x x x x x x x x x x x x
Musculoskeletal discomfort Arthralgia 0% - 39.7% x x x x x x x x x x x x x x x x x x x
Myalgia 0% - 50.9% x x x x x x x x x x x x x x x x x x x
Oedema peripheral Edema of lower extremities 1% - 14% x x x x
Oedema peripheral 0% x
Infection Infection postmarketing, 0% - 37% x x x x x x x x x x x x x x x x x x x
Injection site reaction Injection site reaction 6% x x x x
Blood bilirubin increased Blood bilirubin increased 2% - 23% x x x x x x x
Fatigue Fatigue 2.7% - 81.3% x x x x x x x x x x x x x x x x x
Muscle spasms Cramp muscle 1% - 15% x x x x x x x x
Neuropathy peripheral Neuropathy peripheral 1% - 10% x x x x x x x x
Neuropathy 0% - 44.8% x x x x x x x x x x x x x x x x x
Thrombocytopenia Thrombocytopenia rare, 0% - 47% x x x x x x x x x x x x x x x x x x x x
Gastrointestinal pain Gastrointestinal pain 1% - 15% x x x x x x x x x x x x
Abdominal pain postmarketing — 0% - 9% x x x x x x x x x x x x x x x x x x
Parosmia Parosmia 0% - 20% x x x x x x x x x x x
Dermatitis Dermatitis 1% - 9% x x x x x x x x
Rash 0% - 25.9% x x x x x x x x x x x x x x x x x x x
Oropharyngeal discomfort Throat sore 1% - 11% x x x x
Oropharyngeal pain Throat sore 1% - 11% x x x x
Headache Headache 1% - 8% x x x x x x x x
Extravasation Extravasation 3.3% - 5.6% x x x x x x x x x x x x x x x x x x x
Inflammation Inflammation 3.3% - 5.6% x x x x x x x x x x x x x x x x x x x
Swelling Swelling 3.3% - 5.6% x x x x x x x x x x x x x x x x x x x
Erythema Redness 3.3% - 5.6% x x x x x x x x x x x x x x x x x x
Erythema postmarketing x x x x x x x x
Pain in extremity Pain in extremity 1% - 8% x x x x x x x x
Dizziness Dizziness 0% - 16% x x x x x x x x x x x x x
Syncope postmarketing — 0% - 1% x x x x x x x x x x x x x x x x x x
Lightheadedness x x x
Body temperature increased Body temperature increased 0% - 37% x x x x x x x x x x x x x x x x x x x
Drug fever x x x x x x x x x x x x x x
Dyspepsia Heartburn 0% - 13% x x x x x x x
Dyspepsia 1% - 5% x x x x x x x x
Weight decreased Weight decreased 0% - 27% x x x x x x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased 0.5% - 42% x x x x x x x x x x x x x x x x x x
Rash erythematous Rash erythematous 4% x x x x x x x x
Skin hyperpigmentation Skin hyperpigmentation postmarketing, 3.3% - 5.6% x x x x x x x x x x x x x x x x x x x
Back pain Back pain 1% - 7% x x x x x x x x x x x x x x x x x x x
Abdominal pain upper Abdominal pain upper 1% - 6% x x x x x x x x
Candida infection Oral candidiasis 1% - 7% x x x x x x x x
Oral candidiasis Oral candidiasis 1% - 7% x x x x x x x x
Myalgia Myalgia 0% - 50.9% x x x x x x x x x x x x x x x x x x x
Nail discolouration Nail discolouration 1% - 4% x x x x x x x x
Arrhythmia Arrhythmia postmarketing — 0% - 6% x x x x x x x x x x x x x x x x x x x
Hyperbilirubinaemia Hyperbilirubinaemia 2% - 6% x x x x
Leukopenia Leukopenia 2% - 3% x x x x x x x x x x x x x x x
Hypertension Hypertension postmarketing — 1.6% - 2% x x x x x x x x x x x x x x x x x x x
Alanine aminotransferase increased Alanine aminotransferase increased 2% - 1.3% x x x x x
Constipation Constipation postmarketing — 0% - 38% x x x x x x x x x x x x x x x x x x
Oedema Oedema 0% - 27% x x x x x x x x x x x x x x
Rash Rash 0% - 25.9% x x x x x x x x x x x x x x x x x x x
Eruption x x x x x x x x x x x x x x x x
Localized rash x x x x x x x x x x x x x x x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage postmarketing — 0% - 5% x x x x x x x x x x x x x x x x
Pharyngitis Pharyngitis 0% - 65% x x x x x x x x x x x x x x x x
Myocardial ischaemia Myocardial ischaemia 0% - 2.7% x x x x x x x x x x x x
Skin exfoliation Skin exfoliation 0% - 25.9% x x x x x x x x x x x x x x x x
Fluid retention Fluid retention postmarketing, 0% - 52.2% x x x x x x x x x x x x x x x x x x x
Dyspnoea Dyspnoea postmarketing — 0.3% - 9% x x x x x x x x x x x x x x x x x x x
Onycholysis Onycholysis postmarketing, 1% - 5% x x x x x x x x x x x x x x x x x x
Skin toxicity Skin toxicity 0% - 1% x x x x x x x x x x x x x x x
Cardiac failure Cardiac failure 0% - 2.17% x x x x x x x x x x x x x x x x x x x
Abdominal pain Abdominal pain postmarketing — 0% - 9% x x x x x x x x x x x x x x x x x x
Anaphylactic shock Anaphylactic shock postmarketing, rare x x x x x x x x x x x x x
Atrial fibrillation Atrial fibrillation postmarketing, rare x x x x x x x x x x x x x
Chest pain Chest pain postmarketing — common x x x x x x x x x x x x x x x x x x
Colitis Colitis very rare, postmarketing x x x x x x x x x x x x x x x x x x
Confusional state Confusional state postmarketing, rare x x x x x x x x x x x x x
Feeling abnormal Confusional state postmarketing, rare x x x x x x x x x x x x x
Conjunctivitis Conjunctivitis postmarketing — 0% - 1.1% x x x x x x x x x x x x x x x x x x x
Dehydration Dehydration postmarketing — 1% - 8% x x x x x x x x x x x x x x x x x x
Scleroderma Scleroderma very rare, postmarketing x x x x x x x x
Disseminated intravascular coagulation Disseminated intravascular coagulation postmarketing x x x x x x x x x x x x x
Duodenal ulcer Duodenal ulcer very rare, postmarketing x x x x x x x x x x x x x
Enterocolitis Enterocolitis postmarketing x
Toxic epidermal necrolysis Toxic epidermal necrolysis very rare, postmarketing x x x x x x x x x x x x x x
Erythema multiforme Erythema multiforme very rare, postmarketing x x x x x x x x x x x x x x x x x
Stevens-Johnson syndrome very rare, postmarketing x x x x x x x x x x x x x x x x x x
Cardiac failure congestive Cardiac failure congestive postmarketing, uncommon x x x x x x x x
Haemorrhage Haemorrhage postmarketing, rare x x x x x x x x x x x x x x x x x x x x
Haemoglobin Haemorrhage postmarketing, rare x x x x x x x x x x x x x x x x x x x x
Hepatitis Hepatitis very rare, postmarketing x x x x x x x x x x x x x x x x x x
Hypersensitivity Hypersensitivity postmarketing, 0% - 10.4% x x x x x x x x x x x x x x x x x x x
Hyponatraemia Hyponatraemia postmarketing x x x x x x x
Intestinal obstruction Intestinal obstruction very rare, postmarketing x x x x x x x x x x x x x x x x x x
Dacryostenosis acquired Lacrimal duct obstruction postmarketing, rare x x x x x x x x x x x x x x x x x
Acute myeloid leukaemia Acute myeloid leukaemia very rare, postmarketing x x x x x x x x x x x x x x x
Acute leukaemia Acute myeloid leukaemia very rare, postmarketing x x x x x x x x x x x x x x x
Acute leukaemia x x x x
Liver disorder Liver disorder very rare, postmarketing x x x x x x x x
Hepatocellular injury Liver disorder very rare, postmarketing x x x x x x x x
Foetor hepaticus Liver disorder very rare, postmarketing x x x x x x x x
Cutaneous lupus erythematosus Cutaneous lupus erythematosus postmarketing x x x x x x x x x
Lymphatic disorder Lymphatic disorder postmarketing x x x
Cystoid macular oedema Cystoid macular oedema postmarketing x x x x x x
Multi-organ failure Multi-organ failure postmarketing x x x x x x x x x x x x x
Myelodysplastic syndrome Myelodysplastic syndrome very rare, postmarketing x x x x x x x x
Myocardial infarction Myocardial infarction very rare, postmarketing x x x x x x x x x x x x x x x x x x
Acute coronary syndrome Myocardial infarction very rare, postmarketing x x x x x x x x x x x x x x x x x x
Neoplasm Neoplasm postmarketing x x
Pain Pain postmarketing — 0% - 2% x x x x x x x x x x x x x x x x x x x
Pain localised postmarketing, common x x x x
Pneumonia Pneumonia postmarketing, 22% x x x x x x x x x x x x
Pulmonary oedema Pulmonary oedema postmarketing, rare x x x x x x x x x x x x x x x x x x
Pulmonary embolism Pulmonary embolism very rare, postmarketing x x x x x x x x x x x x x
Pulmonary fibrosis Pulmonary fibrosis postmarketing, rare x x x x x x x x x x x x x x x x x
Renal failure Renal failure postmarketing, rare x x x x x x x x x x x x x
Renal impairment postmarketing, rare x x x x x x x x x x x x x x x x x x
Acute respiratory distress syndrome Acute respiratory distress syndrome postmarketing, rare x x x x x x x x x x x x x x x x x x
Scotoma Scotoma postmarketing x x x x x x x x x x x x x x x x
Convulsion Convulsion postmarketing, rare x x x x x x x x x x x x x x x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome very rare, postmarketing x x x x x x x x x x x x x x x x x x
Shock Syncope postmarketing — 0% - 1% x x x x x x x x x x x x x x x x x x
Syncope Syncope postmarketing — 0% - 1% x x x x x x x x x x x x x x x x x x
Loss of consciousness Syncope postmarketing — 0% - 1% x x x x x x x x x x x x x x x x x x
Loss of consciousness postmarketing, rare x x x x x x x x x x x x x x x x x x
Tachycardia Tachycardia postmarketing — 1% - 1.4% x x x x x x x x x x x x x x x
Thrombophlebitis Thrombophlebitis very rare, postmarketing x x x x x x x x x x x x x x x
Photopsia Photopsia postmarketing x x x x x x x x x x x x x x x x
Deep vein thrombosis Deep vein thrombosis very rare, postmarketing x x x x x x x x x x x x x
Gastrointestinal perforation Gastrointestinal perforation very rare, postmarketing x x x x x x x x x x x x x x x x x x
Lacrimation increased Lacrimation increased postmarketing — 5% - 12% x x x x x x x x x x x x x x x x x x x
Lacrimation postmarketing — 0% - 9.3% x x x x x x x x x x x x x
Tearing eyes x
Acute pulmonary oedema Acute pulmonary oedema postmarketing, rare x x x x x x x x x x x x x
Malnutrition Malnutrition postmarketing, 22% x x x x x x x x x x
Colitis ischaemic Colitis ischaemic very rare, postmarketing x x x x x x x x x x x x x x x x x x
Interstitial lung disease Interstitial pneumonia postmarketing, rare x x x x x x x x x x x x x x x x x x
Interstitial lung disease postmarketing x x x x x x x x
Radiation pneumonitis Radiation pneumonitis postmarketing x x x x x x x x x x x x x
Dermatitis bullous Bullous eruption very rare, postmarketing x x x x x x x x x x x x x x x x x x
Sepsis Sepsis postmarketing x x x x x x x x x x x x x x
Neutropenic colitis Neutropenic enterocolitis very rare, postmarketing x x x x x x x x x x x x x x x x x
Systemic lupus erythematosus Lupus erythematosus very rare, postmarketing x x x x
Visual impairment Visual disturbance postmarketing x x x x x x x x x x x x x x x x
Palmar-plantar erythrodysaesthesia syndrome Hand and foot syndrome secondary to sickle cell anaemia postmarketing x x x x x x x x x x x
Hand and foot syndrome secondary to sickle cell anaemia Hand and foot syndrome secondary to sickle cell anaemia postmarketing x x x x x x x x x x x
Respiratory failure Respiratory failure postmarketing x x x x x x x x
Ileus Ileus very rare, postmarketing x x x x x x x x x x x x x x x x x x
Recall phenomenon Recall phenomenon very rare, postmarketing x x x x x x x x x x x x x
Radiation recall reaction (dermatologic) x
Renal impairment Renal impairment postmarketing, rare x x x x x x x x x x x x x x x x x x
Angina pectoris Angina unstable x x x x x x x x x x
Angina unstable Angina unstable x x x x x x x x x x
Ascites Ascites x x x x x x x x
Ataxia Ataxia x
Atrial flutter Atrial flutter x x x x x x x x x x
Bone disorder Bone disorder x x x x x
Breast disorder Breast disorder x x x x
Bronchospasm Bronchospasm x x x x x x
Bronchopneumonia Bronchopneumonia x
Congestive cardiomyopathy Congestive cardiomyopathy
Cough Cough 0% - 9% x x x x x x x x x x x x x x x x
Cyst Cyst x x x x
Dysgeusia Dysgeusia postmarketing — 0% - 29.5% x x x x x x x x x x x x x x x x x x
Effusion Effusion x x
Enteritis Enteritis x x x x x x x x x x
Epistaxis Epistaxis 0% - 5% x x x x x x x x x x x x x x x x
Flushing Flushing 0% x x x x x x x x x x x x x x x x x x x
Cardiac disorder Cardiac disorder x x x x x x x
Haemorrhoids Haemorrhoids x
Coma hepatic Coma hepatic x
Hypoaesthesia Hypoaesthesia x x x x x x x
Hypotension Hypotension postmarketing — 0% x x x x x x x x x x x x x x x x x x x
Orthostatic hypotension Orthostatic hypotension x
Immune system disorder Immune system disorder x x x x
Jaundice Jaundice x
Lacrimal disorder Lacrimal disorder 0% x x x x x x x x x x
Lacrimal structural disorder Lacrimal disorder 0% x x x x x x x x x x
Lymphoedema Lymphoedema postmarketing, 0% - 54.5% x x x x x x x x x x x x x x x
Nail disorder Nail disorder postmarketing, 0% - 50% x x x x x x x x x x x x x x x x x x
Nail changes 0% - 46.4% x x x x x x x x x x x x x x x
Nasopharyngitis Nasopharyngitis x x x x x x
Rhinorrhoea x x x x x x
Necrosis Necrosis x
Neuralgia Neuralgia x
Oliguria Oliguria x x x x x
Otitis media Otitis media x
Palpitations Palpitations 0% x x x
Pericardial effusion Pericardial effusion x x x x x x
Phlebitis Phlebitis 0% - 8% x x x x x x x x x x x x x x x x x x x
Pleural effusion Pleural effusion x x x x x x x x x x x x x x
Polyp Polyp x x x x
Prurigo Prurigo x x x x
Pruritus Pruritus x x x x x x x x x x x x x x x x x x x
Rhinitis Rhinitis 0% x x x
Skin disorder Skin disorder x x x
Unspecified disorder of skin and subcutaneous tissue x x x x x x
Sinus tachycardia Sinus tachycardia 0% x x x x x x x x x x x x x
Supraventricular tachycardia Supraventricular tachycardia x
Urethral disorder Urinary tract disorder x x x x
Urinary tract disorder Urinary tract disorder x x x x
Angiopathy Angiopathy x x x x x x x
Weight increased Weight increased 0% - 6% x x x x x x x x x x x x x x x x x x
Dry mouth Dry mouth 0% - 4% x x x x x x x x
Chills Chills 0% x x x x x x x x x x x x x x x x x x x
Rigors 0% x x x x
Hepatic failure Hepatic failure x
Burning sensation Burning sensation x
Lower respiratory tract infection Lower respiratory tract infection x
Migraine Migraine x
Diarrhoea haemorrhagic Diarrhoea haemorrhagic x
Large intestine perforation Large intestine perforation x x x x x x x x x x
Liver function test abnormal Liver function test abnormal x x x x x x x x x x x
Raised liver function tests x x
Bone pain Bone pain x x x x x x x
Dry skin Dry skin 0% - 6% x x x x x x x x x x x
Oesophageal ulcer Oesophageal ulcer x
Polyneuropathy Polyneuropathy x
Injection site infection Injection site infection x
Chest discomfort Chest tightness x x x x x x x x x x x x x x x x x x x
Neuritis Peripheral motor neuropathy x x x x
Peripheral motor neuropathy Peripheral motor neuropathy x x x x
Neurotoxicity Neurotoxicity x x x x x x x x
Eye irritation Eye irritation x
Ototoxicity Ototoxicity x x x x x
Hepatotoxicity Hepatotoxicity x x x x x x
Hearing impaired Auditory disorder NOS x
Hearing impaired x x x x
Onychomadesis Onychomadesis x
Hepatobiliary disease Hepatobiliary disease x x x x
Dysaesthesia Dysaesthesia x x x x x x x x
Liver function test normal Liver function test normal x x x x x
Non-cardiac chest pain Non-cardiac chest pain x x x
Blood pressure increased Blood pressure increased x
Rash generalised Rash generalised x x x x x x
Necrotising colitis Necrotizing enterocolitis x
Necrotising enterocolitis neonatal Necrotizing enterocolitis x
Influenza like illness Influenza like illness x x x x x x
Prothrombin level decreased Prothrombin level decreased x
Dermatitis atopic Cutaneous hypersensitivity x
Menopausal symptoms Hot flush 0% x x x x x x x
Hot flush Hot flush 0% x x x x x x x
Breast cancer Carcinoma breast x x x x
Advanced breast cancer x x x x x x x
Lung neoplasm malignant Carcinoma of lung x x x x x
Drug interaction Drug interaction x
Infestation Infestation NOS x x x x x
Pancytopenia Myelosuppression x
Embolism Thromboembolic event x x x x x
Laryngeal pain Pharyngolaryngeal pain x x x x x x
Cardiotoxicity Cardiotoxicity x x
Neutropenic sepsis Neutropenic sepsis x x x x x
Insomnia Insomnia 0% x x x x x x x x
Infusion site reaction Infusion site reaction x x x x x
Ovarian cancer Ovarian cancer x
Nail toxicity Nail toxicity x x
Rhinorrhoea Rhinorrhoea x x x x x x
Death Death x x x x
Deafness Hearing impaired x x x x
Exfoliative rash Exfoliative rash x x x x
Ageusia Ageusia x
Fluid imbalance Fluid imbalance x
Somnolence Somnolence x x x x
Metastatic neoplasm Metastatic disease x

Indications

Information about indications was extracted from the indications and usage sections of the labels.