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Doxorubicin

More information: STITCH, PubChem (stereo-specific compounds: 1, 2, 3) and possibly Wikipedia

ATC Codes: L01DB01, L01DB03

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 37 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Neutropenia Neutropenia common — 1.6% - 95.8% x x x x x x x x x x x x x
Leukopenia Leukopenia uncommon — 1.5% - 98.1% x x x x x x x x x x x x x x x
Alopecia Alopecia common — 6.7% - 95.5% x x x x x x x x x x x x x x x x x x x x
Alopecia reversible
Nausea Nausea postmarketing — 0% - 92.4% x x x x x x x x x x x x x x x x x x x x
Vomiting Vomiting common — 0% - 92.4% x x x x x x x x x x x x x x x x x x x x
Asthenia Fatigue 0% - 46% x x x x x x
Asthenia postmarketing — 0% - 51.5% x x x x x x x x x x x x x
Fatigue Fatigue 0% - 46% x x x x x x
Immunodeficiency Immunodeficiency very common
Opportunistic infection Opportunistic infection very common x
Injection site reaction Injection site reaction 2-20% x x x x x x x
Mucosal inflammation Mucosal inflammation postmarketing, 0% - 58.5% x x x x x x x x x x x x x x x x x
Anaemia Anaemia uncommon — 0% - 72.2% x x x x x x x x x x x x x x x
Neuropathy peripheral Neuropathy peripheral 1% - 45% x x
Neuropathy common, 0.6% - 9.2% x x
Neuritis uncommon, 0.8% - 8% x
Constipation Constipation very common, 0% - 31% x x x x x x
Amenorrhoea Amenorrhoea 0% - 71.8% x x x x x x x x x x
Skin discolouration Skin discolouration common, 6.1% x x x x
Pharyngitis Pharyngitis common, 0% - 17.9% x x x x x
Dry skin Dry skin common, 5.5% - 5.9% x x x x
Thrombocytopenia Thrombocytopenia uncommon — 0% - 51.4% x x x x x x x x x x x x x x x x x x
Menopausal symptoms Hot flush postmarketing, 0% - 69.1% x x x x x x x x x x x x
Hot flush Hot flush postmarketing, 0% - 69.1% x x x x x x x x x x x x
Dyspepsia Dyspepsia common, 0% - 14% x x x x
Somnolence Somnolence common, 5.1% x x x x x
Drowsiness
Hypochromic anaemia Hypochromic anaemia common, 3.5% - 9.6% x x x
Anxiety Anxiety common x x x
Arthralgia Arthralgia common x x
Musculoskeletal discomfort Arthralgia common x x
Myalgia common x x x x
Back pain Back pain common, 0.9% - 11.7% x x x x x
Cachexia Cachexia common x x
Cardiovascular disorder Cardiovascular disorder common x
Chest pain Chest pain common x x x x x
Retrosternal pain x
Dysphagia Dysphagia common x x x x
Dermatitis exfoliative Dermatitis exfoliative common x x x x
Diarrhoea Diarrhoea postmarketing — 0% - 50.7% x x x x x x x x x x x x x x x x x x x x
Dysgeusia Dysgeusia common x x x x
Dyspnoea Dyspnoea common, 1% - 23.4% x x x x x
Dysuria Dysuria common x x
Epistaxis Epistaxis common x x x x x
Flatulence Flatulence common x x
Gastritis Gastritis common x x
Gingivitis Gingivitis common x x
Headache Headache common, 0% - 14.9% x x x x x
Hyperbilirubinaemia Hyperbilirubinaemia common x x x
Hypertension Hypertension common x x
Hypotension Hypotension common x x x x x
Orthostatic hypotension Orthostatic hypotension common x x
Muscle spasms Cramps of lower extremities common x x
Muscle spasms postmarketing, common x x
Breast pain Breast pain common x x x
Hypertonia Hypertonia common x x
Musculoskeletal pain Musculoskeletal pain common x x
Nasopharyngitis Nasopharyngitis common x
Pain in extremity Pain in extremity common x
Paraesthesia Paraesthesia common, 0% - 11.7% x x x
Retinitis Retinitis common x x x
Skin disorder Skin disorder common x x x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x x x x x x
Skin ulcer Skin ulcer common x x
Hyperhidrosis Sweating common x x x
Upper respiratory tract infection Upper respiratory tract infection common x x
Urinary tract infection Urinary tract infection common x x x
Vaginal inflammation Vaginal inflammation common x x
Vaginal infection Vaginal inflammation common x x
Dry mouth Dry mouth common x
Ventricular arrhythmia Ventricular arrhythmia common x x x x
Oedema peripheral Oedema peripheral common x x x
Leg edema x x
Stomatitis Mouth ulceration common x x x x
Stomatitis postmarketing — 0% - 41.4% x x x x x x x x x x x x x x x x x x x x
Mouth ulceration Mouth ulceration common x x x x
Ulcerative stomatitis x
Muscular weakness Muscular weakness common x x
Myasthenia x
Bone pain Bone pain common x x x
Rash pustular Vesiculobullous rash common x x x
Rash pustular x
Dermatitis bullous Vesiculobullous rash common x x x
Blister x x x
Bullous eruption x x
Myalgia Myalgia common x x x x
Blood creatinine increased Blood creatinine increased common x
Serum creatinine increased common x
Creatinine increased
Vision blurred Vision blurred common x x
Rash maculo-papular Rash maculo-papular common x x x
Musculoskeletal chest pain Musculoskeletal chest pain common x
Metastases to liver Metastases to liver common
Hepatic cancer metastatic Metastases to liver common
Cough Cough increased common, 0% - 11.5% x x x x
Cough 0% - 12% x x x x
Ejection fraction decreased Ejection fraction decreased common x
Left ventricular ejection fraction decreased x
Cardiotoxicity Cardiotoxicity uncommon — 18-65% x
Acute cardiac toxicity
Insomnia Insomnia common x x x x
Dizziness Dizziness common, 0% - 10.2% x x x x x
Syncope x x
Mucous membrane disorder Mucous membrane disorder very common, 0% - 14.5% x x x x
Herpes zoster Herpes zoster common, 0% - 9% x x x x x x
Candida infection Oral candidiasis common, 0.8% - 5.6% x x x x
Candida infection x x x
Oral candidiasis Oral candidiasis common, 0.8% - 5.6% x x x x
Eye disorder Eye disorder 3% x x x
Neuralgia Neuralgia 0% - 20% x
Oedema Oedema uncommon, common x x x
Weight decreased Weight decreased common, 0% - 4% x x x x x x x
Decreased appetite Anorexia postmarketing — 0% - 21.7% x x x x x x x x x x x x x x x x x x x
Decreased appetite x
Laboratory test abnormal Laboratory test abnormal 0% - 5.8%
Arrhythmia Arrhythmia 0.5-3% x x x x x
Infection Infection postmarketing — 0% - 25.9% x x x x x x x x x x x x x x x x x x
Secondary infection
Lethargy Lethargy 0% - 72.7% x x x x x x x
Dermatitis Rash postmarketing — 0% - 28.5% x x x x x x x x x x x x x x x x
Dermatitis x x x
Rash Rash postmarketing — 0% - 28.5% x x x x x x x x x x x x x x x x
Eruption x
Febrile neutropenia Febrile neutropenia 0% - 6.1% x x x x x x x x x
Body temperature increased Body temperature increased postmarketing — 0% - 30.6% x x x x x x x x x x x x x x x x x x x x
Scrotal erythema Scrotal erythema common, 1% x
Sepsis Sepsis postmarketing — 0.9% - 1.2% x x x x x x x x x x x x x
Septicemia x x x x x x
Abdominal pain Abdominal pain postmarketing — 0% - 8.2% x x x x x x x x x x x x x
Gastrointestinal pain Abdominal pain postmarketing — 0% - 8.2% x x x x x x x x x x x x x
Shock Shock postmarketing, 0.9% - 1% x x x x x x x x x x x x x
Syncope x x
Neuritis Neuritis uncommon, 0.8% - 8% x
Peripheral motor neuropathy postmarketing x
Breast disorder Breast disorder 1% x x
Pain Pain postmarketing — 1.2% - 7.4% x x x x x x x x x x x x x
Stinging x
Amblyopia Amblyopia uncommon x
Cardiac failure congestive Cardiac failure congestive uncommon x x x x x x x x x
Nail disorder Nail disorder uncommon x x x
Palpitations Palpitations uncommon x x
Rhinitis Rhinitis uncommon x x x
Anaphylactic shock Anaphylactoid reaction uncommon x x
Anaphylactic shock postmarketing x x x x x x x x x x x x x x x
Anaphylactoid reaction Anaphylactoid reaction uncommon x x
Abdominal distension Enlargement abdomen uncommon x x
Pancytopenia Myelosuppression uncommon x x x x x x x x x x x
Pancytopenia
Bone marrow depression
Cardiomyopathy Cardiomyopathy uncommon x x x x x
Ovarian cancer Ovarian cancer uncommon
Herpes simplex Herpes simplex common, 0% - 6% x x x x
Myelodysplastic syndrome Myelodysplastic syndrome 0.3-0.6%
Myelodysplasia x
Leukaemia Leukaemia 0% - 1-10% x x x x x x
Leukemia secondary x x x x x x
Venous thrombosis Venous thrombosis postmarketing, uncommon x
Embolism venous Venous thromboembolism postmarketing, uncommon x
Thromboembolism postmarketing x x x x x x
Neoplasm malignant Neoplasm malignant postmarketing x
Coma Coma postmarketing x x x x
Conjunctivitis Conjunctivitis postmarketing — 0% - 38.4% x x x x x x x x x x x x x x x x x
Other conjunctivitis x
Connective tissue disorder Connective tissue disorder postmarketing x x
Cyst Cyst postmarketing x
Dehydration Dehydration postmarketing, common x x x x x x x x x x x x x x x x x
Toxic epidermal necrolysis Toxic epidermal necrolysis very rare, postmarketing x x
Erythema multiforme Erythema multiforme very rare, postmarketing x x x
Stevens-Johnson syndrome very rare, postmarketing x x
Oesophagitis Oesophagitis postmarketing, common x x x x x x x x x x x x x x x x x x
Flushing Flushing postmarketing — 1% - 5% x x x x x x x x x x x
Gastrointestinal disorder Gastrointestinal disorder postmarketing x x x x x x
Haematochezia Haematochezia postmarketing x
Blood disorder Blood disorder postmarketing x
Haemorrhage Haemorrhage postmarketing x x x x x x x x x x x x x x
Haemoglobin Haemorrhage postmarketing x x x x x x x x x x x x x x
Hypersensitivity Hypersensitivity postmarketing, common x x x x x x x x x x x x x x x x x
Immune system disorder Immune system disorder postmarketing x x x x x
Keratitis Keratitis postmarketing, 0% - 38.4% x x x x x x x x x x x x
Acute myeloid leukaemia Acute myeloid leukaemia postmarketing x
Acute leukaemia Acute myeloid leukaemia postmarketing x
Myeloid leukaemia
Mediastinal disorder Mediastinal disorder postmarketing x x x x x x
Oral neoplasm Oral neoplasm postmarketing x
Neoplasm Neoplasm postmarketing x
Phlebitis Phlebitis postmarketing — 0.3% - 4.8% x x x x x x x x x
Pneumonia Pneumonia postmarketing, common x x x x x x x x
Polyp Polyp postmarketing x
Pruritus Pruritus postmarketing, common x x x x x x x x x x x x x
Pulmonary embolism Pulmonary embolism postmarketing, uncommon x x x x x
Convulsion Convulsion postmarketing, uncommon x x x x x x
Cardiogenic shock Cardiogenic shock postmarketing x
Stevens-Johnson syndrome Stevens-Johnson syndrome very rare, postmarketing x x
Embolism Thromboembolism postmarketing x x x x x x
Thrombophlebitis Thrombophlebitis postmarketing, uncommon x x x x x x x x x x
Ulcer Ulcer postmarketing x x x x x x x x x x x x
Erythema Erythema postmarketing x x x x x x x x x
Redness x
Urethral disorder Urinary tract disorder postmarketing x x x x x x
Urinary tract disorder Urinary tract disorder postmarketing x x x x x x
Urticaria Urticaria postmarketing x x x x x x x x x x x x x x x x
Angiopathy Angiopathy postmarketing x x x x x x
Weight increased Weight increased postmarketing x x x x x
Chills Chills postmarketing — 0.3% - 6.4% x x x x x x x x x x x x x x x x x x
Rigors x
Burning sensation Burning sensation postmarketing x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased postmarketing — common x x
Alanine aminotransferase increased Alanine aminotransferase increased postmarketing, common x x x
Malnutrition Malnutrition postmarketing x x x x x x x x
Skin hyperpigmentation Skin hyperpigmentation postmarketing x x x x x x x x x x x x x x x
Malaise Malaise postmarketing — 0.4% - 4.8% x x x x x x x x x x x
Discomfort Malaise postmarketing — 0.4% - 4.8% x x x x x x x x x x x
Feeling abnormal Malaise postmarketing — 0.4% - 4.8% x x x x x x x x x x x
Confusional state x x
Ill-defined disorder Malaise postmarketing — 0.4% - 4.8% x x x x x x x x x x x
Peripheral motor neuropathy Peripheral motor neuropathy postmarketing x
Palmar-plantar erythrodysaesthesia syndrome Acral erythema postmarketing x x x
Hand and foot syndrome secondary to sickle cell anaemia x
Caecitis Caecitis postmarketing x
Phlebosclerosis Phlebosclerosis postmarketing x x x
Tumour necrosis Tumour necrosis postmarketing, uncommon x
Gastritis erosive Gastric erosions postmarketing x x x
Photosensitivity reaction Photosensitivity postmarketing x x x x x x x x x x x x x
Chemical cystitis Chemical cystitis postmarketing x x x x
Lacrimation increased Lacrimation postmarketing, common x x x x x x x x x
Embolism arterial Embolism arterial postmarketing x x
Blood uric acid increased Hyperuricaemia postmarketing x x x x x x x
Hyperuricaemia Hyperuricaemia postmarketing x x x x x x x
Infestation Infestation NOS postmarketing x x x x x x
Necrotising colitis Necrotising colitis postmarketing x
Recall phenomenon Radiation recall reaction (dermatologic) postmarketing x x x x x x x x x x x x x
Abscess Abscess x
Lactic acidosis Lactic acidosis
Agranulocytosis Agranulocytosis x
Albuminuria Albuminuria x x
Aplastic anaemia Aplastic anaemia
Angina pectoris Angina pectoris x
Anuria Anuria
Ascites Ascites x
Asthma Asthma x x
Ataxia Ataxia x
Atrioventricular block Atrioventricular block x x x
Azoospermia Azoospermia x x x x
Oligospermia x x x
Balanitis Balanitis x
Mental disorder Mental disorder x x
Blister Blister x x x
Bone disorder Bone disorder x
Bronchitis Bronchitis x
Bundle branch block Bundle branch block x x x x x x x
Skin candida Skin candida x
Vulvovaginal candidiasis Vaginal moniliasis x x
Vulvovaginal mycotic infection Vaginal moniliasis x x
Congestive cardiomyopathy Congestive cardiomyopathy
Cellulitis Cellulitis x x x x
Neck pain Neck pain x
Cholangitis sclerosing Cholangitis sclerosing x
Colitis Colitis x x x
Confusional state Confusional state x x
Cryptococcosis Cryptococcosis x x
Cystitis Cystitis x
Bladder pain Cystitis x
Cystitis noninfective Cystitis x
Delirium Delirium x
Drug eruption Drug eruption
Dermatitis atopic Dermatitis atopic x
Dermatitis contact Dermatitis contact x
Fungal skin infection Fungal skin infection x x
Diabetes mellitus Diabetes mellitus x
Diplopia Diplopia
Dysarthria Dysarthria
Osteoarthritis Dysarthria
Arthropathy
Dyskinesia Dyskinesia
Ecchymosis Ecchymosis x
Eczema Eczema
Effusion Effusion x
Eosinophilia Eosinophilia x
Eructation Eructation x
Erythema nodosum Erythema nodosum x
Extravasation Extravasation x x x x x
Faecalith Faecalith x
Faecaloma Faecalith x
Folliculitis Folliculitis x x x
Furuncle Furunculosis x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage x
Gingival bleeding Gingival bleeding x
Glossitis Glossitis x x x
Glycosuria Glycosuria x
Cardiac arrest Cardiac arrest x x
Heart disease congenital Heart malformation
Cardiac disorder Cardiac disorder x x x x
Cardiomegaly Cardiomegaly x
Cardiac failure Cardiac failure x x
Haematemesis Haematemesis
Haematuria Haematuria x x
Hemiplegia Hemiplegia x
Haemoptysis Haemoptysis x
Hepatitis Hepatitis x x
Hepatomegaly Hepatomegaly
Hepatosplenomegaly Hepatosplenomegaly x
Oral herpes Herpes labialis x x
Hiccups Hiccups x
Hydronephrosis Hydronephrosis x
Hypercalcaemia Hypercalcaemia x x
Hyperaesthesia Hyperaesthesia x
Hyperglycaemia Hyperglycaemia x x x
Hyperkalaemia Hyperkalaemia x x
Hyperlipidaemia Hyperlipidaemia x
Hypernatraemia Hypernatraemia x
Hyperventilation Hyperventilation x
Hypoaesthesia Hypoaesthesia x x
Hypocalcaemia Hypocalcaemia x x x
Hypoglycaemia Hypoglycaemia x
Hypokalaemia Hypokalaemia x x x x
Hyponatraemia Hyponatraemia x x x
Hypoproteinaemia Hypoproteinaemia x
Body temperature decreased Body temperature decreased x
Hypothermia Body temperature decreased x
Immunology test Immune status
Inflammation Inflammation
Influenza Influenza x
Jaundice Jaundice x x
Jaundice cholestatic Jaundice cholestatic x
Arthropathy Arthropathy
Ketosis Ketosis x
Renal failure acute Renal failure acute x
Laryngitis Laryngitis x
Acute lymphocytic leukaemia Acute lymphocytic leukaemia x x x x x
Myeloid leukaemia Myeloid leukaemia
Leukoplakia oral Leukoplakia oral x
Vaginal discharge Leukorrhea x
Lung disorder Lung disorder
Lymphangitis Lymphangitis x
Lymphoedema Lymphoedema x
Lymphopenia Lymphopenia x x
Mastitis Mastitis x
Melaena Melaena x
Premature menopause Premature menopause
Multi-organ failure Multi-organ failure
Hypotonia Hypotonia x
Muscle relaxant therapy Hypotonia x
Fungal infection Fungal infection x x
Myocarditis Myocarditis x
Myositis Myositis x
Necrosis Necrosis x x x x x x x x
Nervous system disorder Nervous system disorder x x
Nervousness Nervousness x
Tension Nervousness x
Nocturia Nocturia x
Nystagmus Nystagmus
Oliguria Oliguria x x
Optic neuritis Optic neuritis x x x
Otitis media Otitis media x
Pancreatitis Pancreatitis x
Pelvic pain Pelvic pain x
Drug hypersensitivity Penicillin allergy x x
Pericardial effusion Pericardial effusion x x x
Pericarditis Pericarditis x
Tooth abscess Abscess periodontal x
Petechiae Petechiae x x
Pleural effusion Pleural effusion x
Pneumothorax Pneumothorax x
Supraventricular extrasystoles Supraventricular extrasystoles
Proctitis Proctitis x
Prostatic disorder Prostatic disorder
Psoriasis Psoriasis x
Pulmonary oedema Pulmonary oedema
Purpura Purpura x
Vascular purpura Purpura x
Radiation injury Radiation injury x
Anorectal disorder Rectal disorder
Renal failure Renal failure x
Scotoma Scotoma x
Seborrhoeic dermatitis Seborrhoeic dermatitis
Septic shock Septic shock x x x x
Salivary hypersecretion Salivary hypersecretion x
Sinusitis Sinusitis x x
Skin mass Skin nodule x
Gastric ulcer Gastric ulcer x
Aphthous stomatitis Aphthous stomatitis x x x
Cerebrovascular accident Cerebrovascular accident
Syncope Syncope x x
Loss of consciousness Syncope x x
Tachycardia Tachycardia x x x x
Sinus tachycardia Sinus tachycardia x x
Testicular disorder Testicular disorder
Thrombosis Thrombosis x x
Tinnitus Tinnitus x
Toxoplasmosis Toxoplasmosis x x x
Tumour lysis syndrome Tumour lysis syndrome x
Ureteric obstruction Ureteric obstruction
Urethral obstruction Urethral obstruction x
Pollakiuria Pollakiuria
Vasodilation procedure Vasodilation x
Ventricular tachycardia Ventricular tachycardia x x x
Vertigo Vertigo x
Viral infection Viral infection x
Tachyarrhythmia Tachyarrhythmia x