| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 
| Neutropenia | Neutropenia | common — 1.6% - 95.8% |  |  |  | x | x | x |  | x | x |  |  | x |  | x | x | x | x |  | x | x |  | 
| Leukopenia | Leukopenia | uncommon — 1.5% - 98.1% |  |  | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x |  | x |  |  | 
| Alopecia | Alopecia | common — 6.7% - 95.5% |  | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Alopecia reversible |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Nausea | Nausea | postmarketing — 0% - 92.4% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Vomiting | Vomiting | common — 0% - 92.4% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Asthenia | Fatigue | 0% - 46% |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Asthenia | postmarketing — 0% - 51.5% |  |  | x |  |  | x |  | x | x | x | x | x | x |  |  |  | x | x | x | x | x | 
| Fatigue | Fatigue | 0% - 46% |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Immunodeficiency | Immunodeficiency | very common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Opportunistic infection | Opportunistic infection | very common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Injection site reaction | Injection site reaction | 2-20% |  |  |  | x | x | x |  |  |  |  |  | x |  |  | x | x |  |  |  |  | x | 
| Mucosal inflammation | Mucosal inflammation | postmarketing, 0% - 58.5% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  | x | 
| Anaemia | Anaemia | uncommon — 0% - 72.2% |  |  |  | x | x | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | 
| Neuropathy peripheral | Neuropathy peripheral | 1% - 45% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Neuropathy | common, 0.6% - 9.2% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neuritis | uncommon, 0.8% - 8% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Constipation | Constipation | very common, 0% - 31% |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Amenorrhoea | Amenorrhoea | 0% - 71.8% |  |  |  | x | x |  | x | x | x |  | x |  | x | x | x | x | x | x |  |  |  | 
| Skin discolouration | Skin discolouration | common, 6.1% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Pharyngitis | Pharyngitis | common, 0% - 17.9% |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Dry skin | Dry skin | common, 5.5% - 5.9% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Thrombocytopenia | Thrombocytopenia | uncommon — 0% - 51.4% |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Menopausal symptoms | Hot flush | postmarketing, 0% - 69.1% |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x |  | x |  |  |  | 
| Hot flush | Hot flush | postmarketing, 0% - 69.1% |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x |  | x |  |  |  | 
| Dyspepsia | Dyspepsia | common, 0% - 14% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Somnolence | Somnolence | common, 5.1% |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Drowsiness |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Hypochromic anaemia | Hypochromic anaemia | common, 3.5% - 9.6% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Anxiety | Anxiety | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Arthralgia | Arthralgia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Musculoskeletal discomfort | Arthralgia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Myalgia | common |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  | x | 
| Back pain | Back pain | common, 0.9% - 11.7% |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Cachexia | Cachexia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cardiovascular disorder | Cardiovascular disorder | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | 
| Chest pain | Chest pain | common |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Retrosternal pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dysphagia | Dysphagia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Dermatitis exfoliative | Dermatitis exfoliative | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Diarrhoea | Diarrhoea | postmarketing — 0% - 50.7% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dysgeusia | Dysgeusia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Dyspnoea | Dyspnoea | common, 1% - 23.4% |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  | x | x | x | 
| Dysuria | Dysuria | common |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x | 
| Epistaxis | Epistaxis | common |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Flatulence | Flatulence | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gastritis | Gastritis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gingivitis | Gingivitis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Headache | Headache | common, 0% - 14.9% |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Hyperbilirubinaemia | Hyperbilirubinaemia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Hypertension | Hypertension | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hypotension | Hypotension | common |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Orthostatic hypotension | Orthostatic hypotension | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscle spasms | Cramps of lower extremities | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Muscle spasms | postmarketing, common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Breast pain | Breast pain | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Hypertonia | Hypertonia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Musculoskeletal pain | Musculoskeletal pain | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Nasopharyngitis | Nasopharyngitis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pain in extremity | Pain in extremity | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Paraesthesia | Paraesthesia | common, 0% - 11.7% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x | 
| Retinitis | Retinitis | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Skin disorder | Skin disorder | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Unspecified disorder of skin and subcutaneous tissue | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  | x | x | 
| Skin ulcer | Skin ulcer | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hyperhidrosis | Sweating | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Upper respiratory tract infection | Upper respiratory tract infection | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Urinary tract infection | Urinary tract infection | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Vaginal inflammation | Vaginal inflammation | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vaginal infection | Vaginal inflammation | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dry mouth | Dry mouth | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ventricular arrhythmia | Ventricular arrhythmia | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Oedema peripheral | Oedema peripheral | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Leg edema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Stomatitis | Mouth ulceration | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Stomatitis | postmarketing — 0% - 41.4% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Mouth ulceration | Mouth ulceration | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Ulcerative stomatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Muscular weakness | Muscular weakness | common |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x | 
| Myasthenia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bone pain | Bone pain | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Rash pustular | Vesiculobullous rash | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Rash pustular |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dermatitis bullous | Vesiculobullous rash | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Blister |  |  | x |  |  |  |  |  | x | x |  | x |  |  |  |  |  |  | x |  |  |  | 
| Bullous eruption |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Myalgia | Myalgia | common |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  | x | 
| Blood creatinine increased | Blood creatinine increased | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Serum creatinine increased | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Creatinine increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vision blurred | Vision blurred | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Rash maculo-papular | Rash maculo-papular | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Musculoskeletal chest pain | Musculoskeletal chest pain | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Metastases to liver | Metastases to liver | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatic cancer metastatic | Metastases to liver | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cough | Cough increased | common, 0% - 11.5% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Cough | 0% - 12% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Ejection fraction decreased | Ejection fraction decreased | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Left ventricular ejection fraction decreased |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiotoxicity | Cardiotoxicity | uncommon — 18-65% |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Acute cardiac toxicity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Insomnia | Insomnia | common |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  | x | 
| Dizziness | Dizziness | common, 0% - 10.2% |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | 
| Syncope |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Mucous membrane disorder | Mucous membrane disorder | very common, 0% - 14.5% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Herpes zoster | Herpes zoster | common, 0% - 9% |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Candida infection | Oral candidiasis | common, 0.8% - 5.6% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Candida infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Oral candidiasis | Oral candidiasis | common, 0.8% - 5.6% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Eye disorder | Eye disorder | 3% |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | x |  |  | x | 
| Neuralgia | Neuralgia | 0% - 20% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Oedema | Oedema | uncommon, common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x |  | x | 
| Weight decreased | Weight decreased | common, 0% - 4% |  |  | x |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | 
| Decreased appetite | Anorexia | postmarketing — 0% - 21.7% |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | 
| Decreased appetite |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Laboratory test abnormal | Laboratory test abnormal | 0% - 5.8% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Arrhythmia | Arrhythmia | 0.5-3% |  |  |  |  |  |  | x |  | x | x |  | x |  |  |  |  | x | x |  |  |  | 
| Infection | Infection | postmarketing — 0% - 25.9% |  | x | x | x | x | x |  | x | x |  |  | x | x | x | x | x | x | x | x | x | x | 
| Secondary infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Lethargy | Lethargy | 0% - 72.7% |  |  |  | x | x |  |  | x |  |  |  |  |  | x | x | x |  |  |  |  | x | 
| Dermatitis | Rash | postmarketing — 0% - 28.5% |  |  | x | x | x |  |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x | 
| Dermatitis |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Rash | Rash | postmarketing — 0% - 28.5% |  |  | x | x | x |  |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x | 
| Eruption |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Febrile neutropenia | Febrile neutropenia | 0% - 6.1% |  |  |  | x | x |  | x | x |  |  | x | x |  | x | x | x | x |  |  |  |  | 
| Body temperature increased | Body temperature increased | postmarketing — 0% - 30.6% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Scrotal erythema | Scrotal erythema | common, 1% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Sepsis | Sepsis | postmarketing — 0.9% - 1.2% |  |  | x |  |  |  |  | x | x | x |  | x | x | x | x | x | x | x |  | x | x | 
| Septicemia |  |  |  |  |  | x |  |  | x | x |  | x |  |  | x | x | x | x | x |  |  |  | 
| Abdominal pain | Abdominal pain | postmarketing — 0% - 8.2% |  |  | x | x | x |  |  |  | x | x | x |  |  | x | x | x | x | x | x |  | x | 
| Gastrointestinal pain | Abdominal pain | postmarketing — 0% - 8.2% |  |  | x | x | x |  |  |  | x | x | x |  |  | x | x | x | x | x | x |  | x | 
| Shock | Shock | postmarketing, 0.9% - 1% |  |  | x | x | x |  |  | x | x | x | x |  | x | x | x | x | x | x |  |  |  | 
| Syncope |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neuritis | Neuritis | uncommon, 0.8% - 8% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Peripheral motor neuropathy | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Breast disorder | Breast disorder | 1% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pain | Pain | postmarketing — 1.2% - 7.4% |  |  |  | x | x | x |  | x | x |  |  | x | x | x | x | x | x | x | x |  | x | 
| Stinging |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Amblyopia | Amblyopia | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiac failure congestive | Cardiac failure congestive | uncommon |  |  |  |  |  | x | x | x | x |  | x |  | x |  |  |  |  | x |  | x | x | 
| Nail disorder | Nail disorder | uncommon |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  | x | 
| Palpitations | Palpitations | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Rhinitis | Rhinitis | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Anaphylactic shock | Anaphylactoid reaction | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Anaphylactic shock | postmarketing |  | x | x | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x |  |  | x | 
| Anaphylactoid reaction | Anaphylactoid reaction | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Abdominal distension | Enlargement abdomen | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Pancytopenia | Myelosuppression | uncommon |  | x | x |  | x |  | x | x |  | x | x |  |  | x | x | x | x | x |  | x | x | 
| Pancytopenia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bone marrow depression |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiomyopathy | Cardiomyopathy | uncommon |  |  |  |  |  | x | x |  |  | x | x |  |  |  |  |  | x | x |  | x |  | 
| Ovarian cancer | Ovarian cancer | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Herpes simplex | Herpes simplex | common, 0% - 6% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | 
| Myelodysplastic syndrome | Myelodysplastic syndrome | 0.3-0.6% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Myelodysplasia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Leukaemia | Leukaemia | 0% - 1-10% |  |  |  | x | x |  | x |  |  |  |  |  |  | x | x | x |  | x |  |  |  | 
| Leukemia secondary |  |  |  |  | x | x |  |  | x |  |  | x |  |  | x | x | x |  |  |  |  |  | 
| Venous thrombosis | Venous thrombosis | postmarketing, uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Embolism venous | Venous thromboembolism | postmarketing, uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Thromboembolism | postmarketing |  |  |  |  |  |  |  |  | x | x | x |  | x | x | x | x |  | x |  |  |  | 
| Neoplasm malignant | Neoplasm malignant | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Coma | Coma | postmarketing |  | x | x |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Conjunctivitis | Conjunctivitis | postmarketing — 0% - 38.4% |  |  | x | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | 
| Other conjunctivitis |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Connective tissue disorder | Connective tissue disorder | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Cyst | Cyst | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dehydration | Dehydration | postmarketing, common |  |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Toxic epidermal necrolysis | Toxic epidermal necrolysis | very rare, postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Erythema multiforme | Erythema multiforme | very rare, postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Stevens-Johnson syndrome | very rare, postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Oesophagitis | Oesophagitis | postmarketing, common |  | x | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | x | 
| Flushing | Flushing | postmarketing — 1% - 5% |  | x |  | x | x | x | x | x |  |  | x |  | x | x | x | x | x | x |  |  | x | 
| Gastrointestinal disorder | Gastrointestinal disorder | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  |  | x | 
| Haematochezia | Haematochezia | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Blood disorder | Blood disorder | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Haemorrhage | Haemorrhage | postmarketing |  | x | x | x | x |  |  | x | x | x | x |  | x | x | x | x | x | x |  |  |  | 
| Haemoglobin | Haemorrhage | postmarketing |  | x | x | x | x |  |  | x | x | x | x |  | x | x | x | x | x | x |  |  |  | 
| Hypersensitivity | Hypersensitivity | postmarketing, common |  | x | x | x | x |  | x |  | x | x |  |  | x | x | x | x | x | x | x | x | x | 
| Immune system disorder | Immune system disorder | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x |  | x |  |  | x | 
| Keratitis | Keratitis | postmarketing, 0% - 38.4% |  |  | x | x | x |  |  | x | x | x |  |  | x | x | x | x |  | x |  |  |  | 
| Acute myeloid leukaemia | Acute myeloid leukaemia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Acute leukaemia | Acute myeloid leukaemia | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Myeloid leukaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mediastinal disorder | Mediastinal disorder | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  | x | x | 
| Oral neoplasm | Oral neoplasm | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neoplasm | Neoplasm | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Phlebitis | Phlebitis | postmarketing — 0.3% - 4.8% |  |  |  |  |  |  |  | x | x | x | x |  | x | x | x | x | x | x |  |  | x | 
| Pneumonia | Pneumonia | postmarketing, common |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | x | x | x | x | 
| Polyp | Polyp | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pruritus | Pruritus | postmarketing, common |  |  | x | x | x |  |  |  |  | x |  | x |  | x | x | x | x |  | x | x | x | 
| Pulmonary embolism | Pulmonary embolism | postmarketing, uncommon |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x |  | x |  | x | x | 
| Convulsion | Convulsion | postmarketing, uncommon |  | x | x |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Cardiogenic shock | Cardiogenic shock | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Stevens-Johnson syndrome | Stevens-Johnson syndrome | very rare, postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Embolism | Thromboembolism | postmarketing |  |  |  |  |  |  |  |  | x | x | x |  | x | x | x | x |  | x |  |  |  | 
| Thrombophlebitis | Thrombophlebitis | postmarketing, uncommon |  |  |  |  |  |  |  | x | x | x | x |  | x | x | x | x | x | x |  | x | x | 
| Ulcer | Ulcer | postmarketing |  | x | x | x | x | x | x | x |  |  | x |  | x | x | x | x | x | x |  |  |  | 
| Erythema | Erythema | postmarketing |  |  |  | x | x |  | x | x |  |  |  |  | x | x | x | x | x | x |  |  | x | 
| Redness |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urethral disorder | Urinary tract disorder | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  |  | x | 
| Urinary tract disorder | Urinary tract disorder | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  |  | x | 
| Urticaria | Urticaria | postmarketing |  | x | x | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x |  |  | x | 
| Angiopathy | Angiopathy | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  |  | x | 
| Weight increased | Weight increased | postmarketing |  |  | x |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | 
| Chills | Chills | postmarketing — 0.3% - 6.4% |  | x | x | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | 
| Rigors |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Burning sensation | Burning sensation | postmarketing |  |  |  | x | x |  |  | x |  |  | x |  | x | x | x | x | x | x |  |  |  | 
| Aspartate aminotransferase increased | Aspartate aminotransferase increased | postmarketing — common |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x | 
| Alanine aminotransferase increased | Alanine aminotransferase increased | postmarketing, common |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | x | 
| Malnutrition | Malnutrition | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  | x | x | 
| Skin hyperpigmentation | Skin hyperpigmentation | postmarketing |  | x | x | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x |  |  | x | 
| Malaise | Malaise | postmarketing — 0.4% - 4.8% |  |  | x |  |  |  |  | x | x | x | x | x | x |  |  |  | x | x | x |  | x | 
| Discomfort | Malaise | postmarketing — 0.4% - 4.8% |  |  | x |  |  |  |  | x | x | x | x | x | x |  |  |  | x | x | x |  | x | 
| Feeling abnormal | Malaise | postmarketing — 0.4% - 4.8% |  |  | x |  |  |  |  | x | x | x | x | x | x |  |  |  | x | x | x |  | x | 
| Confusional state |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | x | 
| Ill-defined disorder | Malaise | postmarketing — 0.4% - 4.8% |  |  | x |  |  |  |  | x | x | x | x | x | x |  |  |  | x | x | x |  | x | 
| Peripheral motor neuropathy | Peripheral motor neuropathy | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Palmar-plantar erythrodysaesthesia syndrome | Acral erythema | postmarketing |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  | x |  |  |  |  | 
| Hand and foot syndrome secondary to sickle cell anaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Caecitis | Caecitis | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Phlebosclerosis | Phlebosclerosis | postmarketing |  | x |  |  |  |  | x |  |  | x | x |  |  |  |  |  | x |  |  |  |  | 
| Tumour necrosis | Tumour necrosis | postmarketing, uncommon |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Gastritis erosive | Gastric erosions | postmarketing |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  | 
| Photosensitivity reaction | Photosensitivity | postmarketing |  |  | x | x | x |  | x | x | x | x |  |  | x | x | x | x |  | x |  |  |  | 
| Chemical cystitis | Chemical cystitis | postmarketing |  |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x | x |  |  |  | 
| Lacrimation increased | Lacrimation | postmarketing, common |  | x | x |  |  |  | x |  | x | x | x |  |  |  |  |  | x |  | x |  | x | 
| Embolism arterial | Embolism arterial | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  | x |  |  |  | 
| Blood uric acid increased | Hyperuricaemia | postmarketing |  |  |  |  |  |  | x |  | x |  | x |  | x | x | x | x | x | x |  |  |  | 
| Hyperuricaemia | Hyperuricaemia | postmarketing |  |  |  |  |  |  | x |  | x |  | x |  | x | x | x | x | x | x |  |  |  | 
| Infestation | Infestation NOS | postmarketing |  |  |  |  |  | x |  |  |  |  |  |  | x | x | x | x |  | x |  |  | x | 
| Necrotising colitis | Necrotising colitis | postmarketing |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Recall phenomenon | Radiation recall reaction (dermatologic) | postmarketing |  |  | x | x | x |  | x | x | x |  |  | x | x | x | x | x | x |  |  |  |  | 
| Abscess | Abscess |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lactic acidosis | Lactic acidosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Agranulocytosis | Agranulocytosis |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Albuminuria | Albuminuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Aplastic anaemia | Aplastic anaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Angina pectoris | Angina pectoris |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Anuria | Anuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ascites | Ascites |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Asthma | Asthma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ataxia | Ataxia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Atrioventricular block | Atrioventricular block |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x |  |  |  |  |  | 
| Azoospermia | Azoospermia |  |  |  |  |  |  |  | x |  | x |  | x |  | x |  |  |  | x | x |  |  |  | 
| Oligospermia |  |  |  |  |  |  |  | x |  | x |  |  |  |  |  |  |  |  |  |  |  |  | 
| Balanitis | Balanitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mental disorder | Mental disorder |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Blister | Blister |  |  | x |  |  |  |  |  | x | x |  | x |  |  |  |  |  |  | x |  |  |  | 
| Bone disorder | Bone disorder |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bronchitis | Bronchitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bundle branch block | Bundle branch block |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x |  | x |  | 
| Skin candida | Skin candida |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vulvovaginal candidiasis | Vaginal moniliasis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Vulvovaginal mycotic infection | Vaginal moniliasis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Congestive cardiomyopathy | Congestive cardiomyopathy |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Cellulitis | Cellulitis |  |  | x |  |  |  |  |  | x | x |  | x |  |  |  |  |  | x | x |  |  |  | 
| Neck pain | Neck pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cholangitis sclerosing | Cholangitis sclerosing |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Colitis | Colitis |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | 
| Confusional state | Confusional state |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | x | 
| Cryptococcosis | Cryptococcosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Cystitis | Cystitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Bladder pain | Cystitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cystitis noninfective | Cystitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Delirium | Delirium |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Drug eruption | Drug eruption |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dermatitis atopic | Dermatitis atopic |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dermatitis contact | Dermatitis contact |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Fungal skin infection | Fungal skin infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Diabetes mellitus | Diabetes mellitus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Diplopia | Diplopia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dysarthria | Dysarthria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Osteoarthritis | Dysarthria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Arthropathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dyskinesia | Dyskinesia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ecchymosis | Ecchymosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Eczema | Eczema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Effusion | Effusion |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eosinophilia | Eosinophilia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eructation | Eructation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Erythema nodosum | Erythema nodosum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Extravasation | Extravasation |  |  | x |  |  |  |  | x |  | x | x | x |  |  |  |  |  | x | x |  |  | x | 
| Faecalith | Faecalith |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Faecaloma | Faecalith |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Folliculitis | Folliculitis |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  | x | 
| Furuncle | Furunculosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Gastrointestinal haemorrhage | Gastrointestinal haemorrhage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gingival bleeding | Gingival bleeding |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Glossitis | Glossitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Glycosuria | Glycosuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiac arrest | Cardiac arrest |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Heart disease congenital | Heart malformation |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Cardiac disorder | Cardiac disorder |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  |  |  | x |  |  | x | 
| Cardiomegaly | Cardiomegaly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Cardiac failure | Cardiac failure |  |  |  |  |  |  |  | x |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Haematemesis | Haematemesis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Haematuria | Haematuria |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Hemiplegia | Hemiplegia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Haemoptysis | Haemoptysis |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Hepatitis | Hepatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Hepatomegaly | Hepatomegaly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Hepatosplenomegaly | Hepatosplenomegaly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Oral herpes | Herpes labialis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Hiccups | Hiccups |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hydronephrosis | Hydronephrosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypercalcaemia | Hypercalcaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Hyperaesthesia | Hyperaesthesia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperglycaemia | Hyperglycaemia |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  | 
| Hyperkalaemia | Hyperkalaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hyperlipidaemia | Hyperlipidaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypernatraemia | Hypernatraemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperventilation | Hyperventilation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypoaesthesia | Hypoaesthesia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hypocalcaemia | Hypocalcaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Hypoglycaemia | Hypoglycaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypokalaemia | Hypokalaemia |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x | 
| Hyponatraemia | Hyponatraemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hypoproteinaemia | Hypoproteinaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Body temperature decreased | Body temperature decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypothermia | Body temperature decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Immunology test | Immune status |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Inflammation | Inflammation |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Influenza | Influenza |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Jaundice | Jaundice |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Jaundice cholestatic | Jaundice cholestatic |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Arthropathy | Arthropathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ketosis | Ketosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Renal failure acute | Renal failure acute |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Laryngitis | Laryngitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Acute lymphocytic leukaemia | Acute lymphocytic leukaemia |  |  |  |  | x |  |  | x | x |  |  |  |  | x |  |  | x |  | x |  |  |  | 
| Myeloid leukaemia | Myeloid leukaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Leukoplakia oral | Leukoplakia oral |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vaginal discharge | Leukorrhea |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lung disorder | Lung disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lymphangitis | Lymphangitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lymphoedema | Lymphoedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lymphopenia | Lymphopenia |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Mastitis | Mastitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Melaena | Melaena |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Premature menopause | Premature menopause |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Multi-organ failure | Multi-organ failure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypotonia | Hypotonia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Muscle relaxant therapy | Hypotonia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Fungal infection | Fungal infection |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Myocarditis | Myocarditis |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Myositis | Myositis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Necrosis | Necrosis |  |  | x | x |  |  |  | x | x | x | x | x |  |  |  |  |  | x |  |  |  | x | 
| Nervous system disorder | Nervous system disorder |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Nervousness | Nervousness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Tension | Nervousness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nocturia | Nocturia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nystagmus | Nystagmus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Oliguria | Oliguria |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Optic neuritis | Optic neuritis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Otitis media | Otitis media |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pancreatitis | Pancreatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pelvic pain | Pelvic pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Drug hypersensitivity | Penicillin allergy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Pericardial effusion | Pericardial effusion |  |  |  |  |  |  | x |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  | 
| Pericarditis | Pericarditis |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Tooth abscess | Abscess periodontal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Petechiae | Petechiae |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pleural effusion | Pleural effusion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Pneumothorax | Pneumothorax |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Supraventricular extrasystoles | Supraventricular extrasystoles |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Proctitis | Proctitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Prostatic disorder | Prostatic disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Psoriasis | Psoriasis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pulmonary oedema | Pulmonary oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Purpura | Purpura |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Vascular purpura | Purpura |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Radiation injury | Radiation injury |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Anorectal disorder | Rectal disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Renal failure | Renal failure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Scotoma | Scotoma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Seborrhoeic dermatitis | Seborrhoeic dermatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Septic shock | Septic shock |  |  |  |  |  | x |  |  | x |  |  |  |  |  | x | x | x | x | x |  |  |  | 
| Salivary hypersecretion | Salivary hypersecretion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Sinusitis | Sinusitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Skin mass | Skin nodule |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gastric ulcer | Gastric ulcer |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Aphthous stomatitis | Aphthous stomatitis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Cerebrovascular accident | Cerebrovascular accident |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Syncope | Syncope |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Loss of consciousness | Syncope |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Tachycardia | Tachycardia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Sinus tachycardia | Sinus tachycardia |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x |  |  |  |  | 
| Testicular disorder | Testicular disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Thrombosis | Thrombosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Tinnitus | Tinnitus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Toxoplasmosis | Toxoplasmosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | 
| Tumour lysis syndrome | Tumour lysis syndrome |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  |  |  | 
| Ureteric obstruction | Ureteric obstruction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urethral obstruction | Urethral obstruction |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pollakiuria | Pollakiuria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Vasodilation procedure | Vasodilation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Ventricular tachycardia | Ventricular tachycardia |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x |  |  |  | 
| Vertigo | Vertigo |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Viral infection | Viral infection |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Tachyarrhythmia | Tachyarrhythmia |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | x | x |  |  |  | 
| Peripheral vascular disorder | Peripheral vascular disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatic failure | Hepatic failure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Agitation | Agitation |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Mood swings | Mood swings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Affect lability | Mood swings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Onycholysis | Onycholysis |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypochloraemia | Hypochloraemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperphosphataemia | Hyperphosphataemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypophosphataemia | Hypophosphataemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cystitis haemorrhagic | Cystitis haemorrhagic |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Hypokinesia | Hypokinesia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatic function abnormal | Hepatic function abnormal |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Migraine | Migraine |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Peripheral sensory neuropathy | Peripheral sensory neuropathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Blood urea increased | Blood urea increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Diarrhoea haemorrhagic | Diarrhoea haemorrhagic |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Generalised oedema | Generalised oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Fluid retention | Generalised oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Oedema genital | Oedema genital |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ventricular extrasystoles | Ventricular extrasystoles |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | 
| Injection site haemorrhage | Injection site haemorrhage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypermagnesaemia | Hypermagnesaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hypomagnesaemia | Hypomagnesaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Injection site inflammation | Injection site inflammation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Renal impairment | Kidney function abnormal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood lactate dehydrogenase increased | Lactic dehydrogenase activity increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatocellular injury | Hepatocellular injury |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Liver injury | Hepatocellular injury |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Liver function test abnormal | Liver function test abnormal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Skin necrosis | Skin necrosis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  |  | 
| Skin exfoliation | Skin necrosis |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  |  | 
| Skin scaly |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Eye pain | Eye pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Injection site pain | Injection site pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood alkaline phosphatase increased | Phosphatase alkaline increased |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  | 
| Prothrombin level increased | Prothrombin level increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Hyporeflexia | Hyporeflexia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood thromboplastin decreased | Thromboplastin decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Oesophageal ulcer | Oesophageal ulcer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Polyneuropathy | Polyneuropathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Leukoderma | Leukoderma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pseudolymphoma | Pseudolymphoma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Injection site infection | Injection site infection |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Oral pain | Oral pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Dyspnoea exertional | Dyspnoea exertional |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Heart sounds abnormal | Gallop rhythm |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Increased appetite | Increased appetite |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Abdominal pain upper | Abdominal pain upper |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Proctalgia | Rectal tenesmus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Rectal tenesmus | Rectal tenesmus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Anorectal discomfort | Rectal tenesmus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Thinking abnormal | Thinking abnormal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mental disability | Thinking abnormal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Abnormal dreams | Abnormal dreams |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Rash erythematous | Rash erythematous |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Neurotoxicity | Neurotoxicity |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gravitational oedema | Gravitational oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urine abnormality | Urine abnormality |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Urine analysis abnormal | Urine abnormality |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ventricular dysfunction | Ventricular dysfunction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Rectal haemorrhage | Rectal haemorrhage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Hepatobiliary disease | Hepatobiliary disease |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dry eye | Dry eye |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Hypolipidaemia | Hypolipidaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Red blood cell abnormality | Red blood cell abnormality |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Feeling hot | Warmth |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dysaesthesia | Dysaesthesia | 0% - 10% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Electrocardiogram QRS complex abnormal | QRS voltage decreased |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  | x |  |  |  | 
| Bradycardia | Bradycardia |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x |  |  |  | 
| Transaminases increased | Transaminases increased |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Blindness | Blindness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Lymphadenopathy | Lymphadenopathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Electrocardiogram ST segment depression | Electrocardiogram ST segment depression |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | x |  |  |  | 
| Coordination abnormal | Coordination abnormal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Influenza like illness | Influenza like illness |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Paralysis | Paralysis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Face oedema | Face oedema |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gait disturbance | Gait disturbance |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Drug interaction | Drug interaction |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood bilirubin increased | Bilirubin total increased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Serum bilirubin increased |  |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Thrombocytosis | Thrombocytosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hand and foot syndrome secondary to sickle cell anaemia | Hand and foot syndrome secondary to sickle cell anaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Local reaction | Local reaction |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | x | 
| Bladder stenosis | Bladder constriction |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x |  |  |  | 
| Neutropenic sepsis | Neutropenic sepsis |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Gastrointestinal toxicity | Gastrointestinal toxicity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Ileus | Ileus |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Pigmentation disorder | Abnormal pigmentation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ocular toxicity | Ocular toxicity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  | 
| Urine output | Urine output |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Sensitisation | Sensitisation |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Parosmia | Parosmia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Rash papular | Rash papular |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dysphonia | Dysphonia |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Pneumocystis jirovecii pneumonia | Pneumocystis jirovecii pneumonia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ageusia | Ageusia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Proctitis ulcerative | Proctitis ulcerative |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Metastatic neoplasm | Metastatic neoplasm |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Metastatic disease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vaginal haemorrhage | Vaginal haemorrhage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Visual impairment | Abnormal vision |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |