Doxorubicin hydrochloride

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

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Side effect Data for drug Placebo Labels (show all 22)
1 2 3 4 5 6 7 8 9 10
Alopecia def 8.9% - 95.5% x x x x x x x x x x
Nausea def 16.9% - 92.4% x x x x x x x x x x
Vomiting def 7.8% - 92.4% x x x x x x x x x x
Leukopenia def 58.6% - 80.3% x x x x x x x x
Neutropenia def 6.1% - 80.3% x x x x x x x x x
Anaemia def 5.8% - 72.2% x x x x x x x x
Amenorrhoea def 0% - 71.8% x x x x x x x
Mucosal inflammation def 8.9% - 58.5% x x x x x x x x x
Thrombocytopenia def 5.4% - 48.8% x x x x x x x x
Lethargy def 1.9% - 45.8% x x x x
Hot flush def 4% - 38.9% x x x x x x x
Diarrhoea def 0.8% - 24.8% x x x x x x x x x x
Infection def 1.6% - 21.5% x x x x x x x x x
Conjunctivitis def 0% - 14.8% x x x x x x x x x
Keratitis def 0% - 14.8% x x x x x x x
Asthenia def 6.5% - 9.9% x x x x x x
Body temperature increased def postmarketing, 0% - 9.1% x x x x x x x x x x
Rash def 0.3% - 8.9% x x x x x x x x
Pruritus def 0.3% - 8.9% x x x x x x x x
Stomatitis def 5.2% - 6.8% x x x x x x x x x x
Febrile neutropenia def 6.1% x x x x x
Candidiasis def 1.3% - 5.5% x x
Oral candidiasis def 1.3% - 5.5% x x
Ichthyosis def 0% - 4.7% x x x x x x
Anorexia def 0% - 2.9% x x x x x x x x x
Acute myeloid leukaemia def postmarketing, 0.8% x x x x x x x
Anaphylactic shock def postmarketing x x x x x x x x
Connective tissue disorder def postmarketing x
Dehydration def postmarketing x x x x x x x x
Embolism def postmarketing x
Toxic epidermal necrolysis def postmarketing x
Erythema multiforme def postmarketing x x
Flushing def postmarketing x x x x x
Blood disorder def postmarketing x
Haemorrhage def postmarketing x x x x x x x x
Leukaemia def postmarketing x x x x x x x x x
Myeloid leukaemia def postmarketing x x x x x x
Mediastinal disorder def postmarketing x
Pain def postmarketing x x x x x x x x
Phlebitis def postmarketing x x x
Pulmonary embolism def postmarketing x
Shock def postmarketing x x x x x x x
Muscle spasms def postmarketing x
Thrombophlebitis def postmarketing x x x x
Ulcer def postmarketing x x x x x x x
Erythema def postmarketing x x x x x x x x x
Urticaria def postmarketing x x x x x x x x x
Chills def postmarketing x x x x x x x x x
Burning sensation def postmarketing x x x x x
Necrolysis epidermal postmarketing x
Skin hyperpigmentation def postmarketing x x x x x x x x
Photosensitivity def postmarketing x x x x x x x x
Dissecting aortic aneurysm, thoracic postmarketing x
Abdominal pain def x x x x x x x x
Abscess def x
Ageusia def
Aggression def x
Agranulocytosis def x
Albuminuria def x
Amblyopia def
Hypochromic anaemia def x
Angina pectoris def
Anxiety def x
Arrhythmia def x x x x
Arthralgia def x
Ascites def x
Ataxia def
Azoospermia def x x x
Balanitis def x
Blepharitis def
Blister def x x x
Bronchitis def x
Bundle branch block def x x x
Cachexia def x
Skin candida def x
Vaginal moniliasis x
Cellulitis def x x x x
Neck pain def
Cholangitis def x
Cholangitis sclerosing def x
Colitis def x x x
Coma def x
Confusional state def x
Constipation def x x
Convulsion def x
Cough def x
Cryptococcosis def x
Dysphagia def x
Delirium def x
Dermatitis def x x
Dermatitis exfoliative def x
Dermatitis contact def
Fungal skin infection def x
Diabetes mellitus def x
Dizziness def x
Drug abuse def
Dysgeusia def x
Dyspepsia def x x
Dysuria def x
Ear pain def x
Ecchymosis def x
Oedema def x
Effusion def x
Eosinophilia def x
Epistaxis def x
Eructation def
Erythema nodosum def x
Oesophageal disorder def x
Oesophagitis def x x x x x x x x x
Extravasation def x x x
Fatigue def x
Faecalith def x
Flatulence def x
Folliculitis def
Pathological fracture def x
Furunculosis def x
Gastritis def x
Gastrointestinal disorder def x
Gastrointestinal haemorrhage def x
Gingival bleeding def
Gingivitis def x
Glossitis def x
Glycosuria def x
Cardiac arrest def x
Cardiomegaly def x
Cardiac failure def x x x x
Cardiac failure congestive def x x x x
Haematuria def x
Hemiplegia def x
Haemolysis def x
Haemoptysis def
Hepatitis def x
Hepatosplenomegaly x
Herpes NOS def x
Herpes simplex def x
Herpes zoster def x
Hiccups def
Hydronephrosis def
Hyperbilirubinaemia def x
Hypercalcaemia def x
Hyperaesthesia def
Hyperglycaemia def x
Hyperkalaemia def x
Hyperlipidaemia def x
Hypernatraemia def x
Hypertension def
Hyperventilation def x
Hypoaesthesia def
Hypocalcaemia def x
Hypoglycaemia def x
Hypokalaemia def x
Hyponatraemia def x
Hypoproteinaemia def x
Orthostatic hypotension def
Body temperature decreased def x
Incontinence def x
Inflammation def
Influenza def x
Intestinal obstruction def x
Jaundice def x
Jaundice cholestatic def x
Ketosis def x
Renal failure acute def x
Laryngitis def
Lymphocytic leukaemia def x x x x x x x x
Acute lymphocytic leukaemia def x x x x x x x
Leukoplakia def x
Leukoplakia oral def x
Leukorrhea def x
Lymphangitis x
Lymphoedema def x
Lymphopenia def
Mastitis def
Breast pain def
Melaena def
Premature menopause def
Hypertonia def x
Hypotonia def x
Myelodysplastic syndrome def x
Myocarditis def x
Myositis def x
Nail disorder def
Necrosis def x x x x x x
Nervous system disorder def x
Nervousness def
Neuralgia def x x
Neuritis def x
Nodule def
Nocturia def
Obstruction def x x
Oligospermia def x x x
Oliguria def
Optic neuritis def x
Otitis def x
Otitis media def x
Pallor def x
Palpitations def x
Pancreatitis def x
Paraesthesia def x x
Pelvic pain def x
Penicillin allergy x
Pericardial effusion def x
Pericarditis def x
Abscess periodontal def
Neuropathy peripheral def x
Petechiae def x
Pharyngitis def x
Pleural disorder def x
Pleural effusion def x
Pneumonia def x
Pneumothorax def x
Proctitis def x
Prurigo def x
Psoriasis def x
Purpura def
Renal failure def x x
Retinitis def x
Rhinitis def x
Salivation def
Kaposi's sarcoma def x
Scotoma def x
Seizures def x
Septicemia def x x x x
Septic shock def x x
Salivary hypersecretion def
Sinusitis def x
Skin disorder def
Skin nodule def
Skin ulcer def x
Gastric ulcer def
Aphthous stomatitis def x
Ulcerative stomatitis x
Sweating def x
Tachycardia def x x x
Sinus tachycardia def x x
Thromboembolism def x x
Thrombosis def x x
Tinnitus def x
Tooth impacted def x
Toxoplasmosis def x
Tumour lysis syndrome def
Ureteric obstruction def
Urethral obstruction def x
Uric acid level increased x
Pollakiuria def x
Urinary incontinence def x
Urinary tract infection def x
Vaginal inflammation def
Vasodilation def x
Vertigo def x
Viral infection def x
Visual impairment def x
Weight increased def x x x
Weight decreased def x x
Dry mouth def x
Tachyarrhythmia x x
Encephalopathy def x
Fever chills
Hepatic failure def x
Micturition urgency def x
Ventricular arrhythmia def x
Agitation def x
Mood swings x
Rash pustular def x
Oedema peripheral def x
Onycholysis def x
Hypochloraemia def
Hypophosphataemia def x
Hypokinesia def x
Mouth ulceration def x
Migraine def x
Peripheral sensory neuropathy def x
Generalised oedema
Oedema genital def x
Injection site haemorrhage x
Bleeding vaginal def x
Hypermagnesaemia
Hypomagnesaemia def x
Injection site inflammation
Injection site reaction def
Kidney function abnormal
Mucous membrane disorder x x
Muscular weakness def
Skin necrosis x
Bone pain def x
Retrosternal pain
Eye pain def x
Injection site pain x
Phosphatase alkaline increased
Prothrombin level increased x
Vesiculobullous rash x
Skin discolouration def x
Dry skin def x
Deep thrombophlebitis x
Oesophageal ulcer def x
Polyneuropathy def x
Rash macular x
Sickness x
Injection site infection
Malaise def x x x x
Myalgia def x
Increased appetite x
Rectal tenesmus def x
Thinking abnormal
Rash erythematous x
Peripheral motor neuropathy def x
Acral erythema x x
Hypoxia def x x
Disease progression def x
Sepsis def x x x x x
Rectal haemorrhage def x
Kaposi's sarcoma AIDS related def x
Breast cancer stage IV def
Solid tumour def x
Blood bilirubin increased def
Dry eye x
Redness def x
Phlebosclerosis x
Anaphylactoid reaction
Gastric erosions x x
Hypolipidaemia def x
Enlargement abdomen def x
Dysaesthesia def x
Lacrimation def x x x x
Rash maculo-papular def x
Rigors
Left ventricular ejection fraction x x x x
Bradycardia def
Transaminases increased
Neuropathy def x x
Blindness def x
Lymphadenopathy def x
Rash generalised x
Coordination abnormal
Face oedema def x
Palmar-plantar erythrodysaesthesia syndrome def x x
Cough increased x x
Gait disturbance def
Stinging x
Aspiration x
Acne def x
Hyperuricaemia def x x x x
Second primary malignancy def x
Infestation NOS x
Hand and foot syndrome secondary to sickle cell anaemia x
Myelosuppression def x x x x x
Leukemia secondary x x x x
Serum bilirubin increased
Cardiomyopathy def x x
Insomnia def x
Myasthenia def
Ileus def x
Urine output x
Death x x x
Parosmia def
Voice disturbance
Dysphonia def
Cytolysis def x
Soft tissue necrosis x
Radiation recall reaction (dermatologic) def x x x x
Weakness def
Somnolence def x
Proctitis ulcerative x
Vaginal haemorrhage def
Indication Labels
Acute lymphocytic leukaemia def x x x
Acute myeloid leukaemia def x x x
Adjuvant therapy def x
Bladder carcinoma def x x
Bladder neoplasm def x x
Bone sarcoma def x x x
Brain neoplasm def x
Breast cancer def x x x x x x
Breast cancer stage IV def x
Bronchial carcinoma def x x x
Carcinoma def x x x x x
Carcinoma breast def x x x
Carcinoma stomach def x x x x
Carcinoma testes x
Gastric cancer def x
Gastric disorder def x
Generalized illness def x
Head and neck cancer def x
Leukaemia def x x x x
Liver carcinoma def x
Lung neoplasm malignant def x x
Lymphoma def x x x x x
Malignant melanoma def x
Malignant neoplasm of pancreas def x
Menopause def x
Metastasis def x
Multiple myeloma def x x
Myeloblastic leukemia x x x
Neoplasm def x x x x x x x x x
Neoplasm malignant def x x x x x x x x x x
Neuroblastoma def x x x x
Osteosarcoma def x
Ovarian cancer def x x
Ovarian carcinoma x x
Ovarian disorder def x
Prostate cancer def x
Prostatic disorder def x
Regressive behaviour def x x x x
Renal carcinoma def x
Sarcoma def x x x x x x
Small cell lung cancer stage unspecified def x
Solid tumour def x x
Squamous cell carcinoma def x x
Thymoma def x
Thyroid carcinoma def x x x x
Transitional cell carcinoma def x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Codes: L01DB01, L01DB03

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. Epirubicin : 41 side effects (FDA XML label)
  2. DOXORUBICIN HYDROCHLORIDE / ADRIAMYCIN RDF : 41 side effects (Drugs@FDA)
  3. epirubicin : 42 side effects (FDA XML label)
  4. doxorubicin : 49 side effects (FDA XML label)
  5. epirubicin : 50 side effects (FDA XML label)
  6. EPIRUBICIN HYDROCHLORIDE / EPIRUBICIN HYDROCHLORIDE FOR INJECTION : 57 side effects (Health Canada)
  7. Doxorubicin : 62 side effects (BC Cancer)
  8. DOXORUBICIN HYDROCHLORIDE / DOXORUBICIN HYDROCHLORIDE FOR INJECTION USP : 65 side effects (Health Canada)
  9. DOXORUBICIN HYDROCHLORIDE / DOXORUBICIN HYDROCHLORIDE INJECTION : 66 side effects (Health Canada)
  10. DOXORUBICIN HYDROCHLORIDE / DOXIL : 214 side effects (Drugs@FDA)