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Mitoxantrone

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: L01DB07

Side effects

Options: Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11
Nausea Nausea 0% - 76% 20% x x x x x x x x x x x
Upper respiratory tract infection Upper respiratory tract infection 51% - 53% 52% x x x x x x
Menstrual disorder Menstrual disorder 26-61% - 61% 26% x x x x x
Vomiting Vomiting 31% - 72% x x x x x x x x x x x
Haemoglobin decreased Haemoglobin decreased 43% - 48% x x x x
Body temperature increased Body temperature increased 18% - 78% x x x x x x x x x x x
Amenorrhoea Amenorrhoea 0% - 53% 3% x x x x x x x
Alopecia Alopecia 0% - 61% 31% x x x x x x x x x x x
Thrombocytopenia Thrombocytopenia 33-39% x x x x x x x
Sepsis Sepsis 18% - 36% x x x x x x x x x x
Urinary tract infection Urinary tract infection 29% - 32% 13% x x x x x x
Haemorrhage Haemorrhage 6% - 41% x x x x x x x
Haemoglobin Haemorrhage 6% - 41% x x x x x x x
Pain Pain 8-41% x
Asthenia Asthenia 0% - 24% x x x x x x x x x x x
Fatigue x x x x x x x x x x x
Decreased appetite Anorexia 22-25% x x x x x x x x x x x
Mucosal inflammation Mucosal inflammation 8% - 33% x x x x x x x x x x x
Blood urea increased Blood urea increased 22% x
Diarrhoea Diarrhoea 8% - 47% 11% x x x x x x x x x x x
Oedema Oedema 10-31% x x x x x x x
Hyperglycaemia Hyperglycaemia 10-31% x x x x x
Infection Infection 5% - 73% x x x x x x x
Leukopenia Leukopenia 9% - 9-100% 0% x x x x x x x x x x x
Stomatitis Stomatitis 8% - 33% 8% x x x x x x x x x x x
White blood cell count decreased White blood cell count decreased 14% - 100% x x x x
Constipation Constipation 10% - 14% 6% x x x x x x x x
Blood creatinine increased Serum creatinine increased 13% x
Dyspnoea Dyspnoea 0% - 20% x x x x x x x x x x x
Pharyngitis Pharyngitis 5% - 19% x x x x
Haematuria Haematuria 11% x x x x x
Fungal infection Fungal infection 6% - 15% x x x x
Onycholysis Onycholysis 11% x x x x x x
Hypocalcaemia Hypocalcaemia 10% x x x x x x x x x x
Ulcer Ulcer 10% x
Dyspepsia Dyspepsia 5-14% x x x x x
Abdominal pain Stomach ache 5% - 14% x x x x
Abdominal pain 4% - 15% x x x x x x x x x x x
Abdominal pain upper Stomach ache 5% - 14% x x x x
Epigastric pain 5% - 14% x x x x
Gastrointestinal pain Abdominal pain 4% - 15% x x x x x x x x x x x
Anaemia Anaemia 6% - 5-75% 2% x x x x x x x x x x x
Cough Cough 2% - 13% x x x x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage 2-16% x x x x x x x
Hyponatraemia Hyponatraemia 9% x x x x x
Pneumonia Pneumonia 0% - 9% x x x x x x x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased 3% - 15% 3% x x x x
Hyperhidrosis Sweating increased 9% x
Sweating x x x x
Hypokalaemia Hypokalaemia 7-10% x x x x x
Contusion Contusion 6-11% x x x x x x x
Aspartate aminotransferase increased Aspartate aminotransferase increased 8% - 9% 8% x x x x
Back pain Back pain 6% - 8% 5% x x x x x
Ecchymosis Ecchymosis 2% - 11% x x x x
Petechiae Petechiae 2% - 11% x x x x
Urine abnormality Urine abnormality 5% - 11% 6% x x x x
Urine analysis abnormal Urine abnormality 5% - 11% 6% x x x x
Electrocardiogram abnormal Electrocardiogram abnormal 5% - 11% 3% x x x x
Nephropathy toxic Nephropathy toxic 8% x x x
Erectile dysfunction Erectile dysfunction 7% x x x x x
Agranulocytosis Agranulocytosis 6% 2% x x x x x x
Arrhythmia Arrhythmia 3% - 18% 8% x x x x x x x x x x x
Headache Headache 6% - 13% 5% x x x x x x x
Proteinuria Proteinuria 6% x x x x x
Protein urine present Proteinuria 6% x x x x x
Sinusitis Sinusitis 3% - 6% 2% x x x x x
Alanine aminotransferase increased Alanine aminotransferase increased 5% - 6% 3% x x x x
Anxiety Anxiety 5% x x x x x x x x x x
Arthralgia Arthralgia 5% x x x x x
Musculoskeletal discomfort Arthralgia 5% x x x x x
Myalgia 5% x x x x x
Fungal skin infection Fungal skin infection 0% - 10% x x x x
Foot and mouth disease Foot and mouth disease 0% - 10% x x x x
Ischaemia Ischaemia 5% x
Jaundice Jaundice 0% - 8% x x x x x x
Rhinitis Rhinitis 0% - 10% x x x x x
Myalgia Myalgia 5% x x x x x
Blood glucose increased Glucose increased 5% - 10% x x x x
Hypertension Hypertension 4% x x x x x
Renal failure Renal failure 0% - 8% x x x x
Convulsion Convulsion 2% - 8% x x x x x
Menorrhagia Menorrhagia 0% - 7% x x x x
Vision blurred Vision blurred 3% x x x x x
Conjunctivitis Conjunctivitis 0% - 5% x x x x x
Anaphylactic shock Anaphylactic shock 1% x x x x x x x x x
Anaphylactoid reaction x x x x x x
Tumour lysis syndrome Tumour lysis syndrome 1% x x x x x x
Chest pain Chest pain x x x x x x x
Confusional state Confusional state x x x x x x
Feeling abnormal Confusional state x x x x x x
Malaise x x x x
Sudden death Sudden death x
Dehydration Dehydration x x x x
Somnolence Drowsiness x x x
Somnolence x x x
Endometritis Endometritis x x x x
Enteritis Enteritis x x x x
Dermatitis Rash x x x x x x x x x x
Rash Rash x x x x x x x x x x
Extravasation Extravasation x x x x x x x x x x x
Fatigue Fatigue x x x x x x x x x x x
Cardiac failure Cardiac failure x
Cardiac failure congestive Cardiac failure congestive x x x x x x x x x x
Hepatitis Hepatitis x x x x x x
Hyperkalaemia Hyperkalaemia x x x x x
Hypersensitivity Hypersensitivity x x x x x x x x x x x
Hypotension Hypotension x x x x x x x x x x
Infertility Infertility x x x x
Renal failure acute Renal failure acute x
Acute promyelocytic leukaemia Acute promyelocytic leukaemia x x
Non-Hodgkin's lymphoma Non-Hodgkin's lymphoma x
Myelodysplastic syndrome Myelodysplastic syndrome x x x
Myocardial infarction Myocardial infarction x x x x x x x
Acute coronary syndrome Myocardial infarction x x x x x x x
Necrosis Necrosis x x x x x x x x x x x
Metastasis Metastasis x
Neutropenia Neutropenia x x x x x x
Paraesthesia Paraesthesia x x x x x x
Phlebitis Phlebitis x x x x x x x x x x
Shock Shock x x
Skin disorder Skin disorder x x x x
Skin infection Skin infection x x x x
Swelling Swelling x x x x x x x x x
Tachycardia Tachycardia x x x x x x x
Tonsillitis Tonsillitis x x x x
Erythema Erythema x x x x x x x x x
Ureteric obstruction Ureteric obstruction x
Urticaria Urticaria x x x x x x x
Viral infection Viral infection x x x x
Weight increased Weight increased x x x x
Weight decreased Weight decreased x x x x
Chills Chills x x x x
Sinus bradycardia Sinus bradycardia x x x
Hyperphosphataemia Hyperphosphataemia x x x x x
Haemorrhage intracranial Haemorrhage intracranial x x x x
Myocardial ischaemia Myocardial ischaemia x x x x
Pancytopenia Bone marrow depression x x x x x x
Myelosuppression x x x x x x x x x x x
Bone pain Bone pain x x x x
Interstitial lung disease Interstitial pneumonia x x x x x x x
Malaise Malaise x x x x
Discomfort Malaise x x x x
Ill-defined disorder Malaise x x x x
Breast cancer stage IV Breast cancer stage IV x
Blood bilirubin increased Blood bilirubin increased x x x x x
Anaphylactoid reaction Anaphylactoid reaction x x x x x x
Platelet count decreased Platelet count decreased 0% - 33% x x x x
Lymphocyte count abnormal Lymphocyte abnormal x x x x
Bradycardia Bradycardia x x x
Blood urea abnormal Blood urea abnormal x x x x
Chromaturia Urine color abnormal x
Affective disorder Affective disorder x x x x
Platelet count abnormal Platelet count abnormal x x x x
Blood uric acid increased Hyperuricaemia x x x x x x
Hyperuricaemia Hyperuricaemia x x x x x x
Dysgeusia Taste altered x x x x
Blood creatinine abnormal Creatinine abnormal NOS x x x x
Febrile neutropenia Febrile neutropenia x x x x x
Local reaction Local reaction x
Hepatic enzyme increased Elevated liver enzyme levels x x x x x x
Blood potassium decreased Potassium low 0% - 10% x x x x
Cardiotoxicity Cardiotoxicity x x
Cardiomyopathy Cardiomyopathy x x x x x x x
Ejection fraction decreased Left ventricular ejection fraction decreased x x x x x
Nail pigmentation Nail pigmentation x x x x x x x
Urine output Urine output x
Pathogen resistance Cross resistance x

Indications

Information about indications was extracted from the indications and usage sections of the labels.

Mitozantrone (as hydrochloride) / Name of the drug

Side effects:50
Source:medicines.org.au

Mitoxantrone

Side effects:75
Source:BC Cancer

MITOXANTRONE

Side effects:111
Source:FDA Structured Product Label

MITOXANTRONE

Side effects:111
Source:FDA Structured Product Label

MITOXANTRONE

Side effects:111
Source:FDA Structured Product Label

MITOXANTRONE

Side effects:111
Source:FDA Structured Product Label

Color scheme:

standard – alternative

    100%
    75%
    50%
    10%
    frequent (1% to 100%)
    infrequent (0.1% to 1%)
    rare (<0.1%)
    postmarketing
    0%
    no frequency information
    not found on label