Letrozole

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Hide MedDRA Preferred Terms

MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 14)
1 2 3 4 5 6 7 8 9 10
Back pain def Back pain def 0.286% - 70.5% x x x x x x x x x
Pain def Pain def postmarketing, 0.0408% - 70.5% x x x x x x x x x x
Hypercholesterolaemia def Hypercholesterolaemia def 0.4% - 52.3% x x x x x x x x x x
Flushing def Flushing def 0% - 33.5% x x x x x x x x x
Menopausal symptoms def Hot flush def 0% - 33.5% x x x x x x x x x x
Hot flush def Hot flush def 0% - 33.5% x x x x x x x x x x
Arthralgia def Arthralgia def 3% - 25.2% x x x x x x x x x x
Musculoskeletal discomfort Arthralgia def 3% - 25.2% x x x x x x x x x x
Myalgia def 0.7% - 8.9% x x x x x x x x
Arthritis def Arthritis def 3.47% - 25.2% x x x x x x x x
Pain in extremity def Leg pain 14% - 22% x x x x x x x x x
Pain in arm 14% - 22% x x x x x x x x x
Pain in extremity def 0.2% - 10% x x x x x x x x
Musculoskeletal pain def Musculoskeletal pain def 14% - 22% x x x x x x x x x x
Bone pain def Bone pain def 0.2% - 22% x x x x x x x x x
Dyspnoea def Dyspnoea def 5% - 18% x x x x x x x x x x
Nausea def Nausea def 0.2% - 17% x x x x x x x x x x
Night sweats def Night sweats def 0% - 14.6% x x x x x x
Hyperhidrosis def Sweating def 0% - 14.6% x x x x x x x x x x
Sweating increased x x x x x x x x x
Cough def Cough def 5% - 13% x x x x x x x x x x
Asthenia def Fatigue def 0.2% - 13% x x x x x x x x x x
Asthenia def 0.2% - 9.6% x x x x x x x x x
Weakness def 6% x x x x x x x x x
Fatigue def Fatigue def 0.2% - 13% x x x x x x x x x x
Weight increased def Weight increased def 1.1% - 12.9% x x x x x x x x x x
Dermatitis def Rash def 4% - 12% x x x x x x x x x x
Rash def Rash def 4% - 12% x x x x x x x x x x
Headache def Headache def 0.368% - 12% x x x x x x x x x x
Rash vesicular Rash vesicular 4% - 12% x x x x x x x x x
Rash erythematous Rash erythematous 4% - 12% x x x x x x x x x
Rash maculo-papular def Rash maculo-papular def 4% - 12% x x x x x x x x x
Constipation def Constipation def 0.1% - 10% x x x x x x x x x x
Lethargy def Lethargy def 0.2% - 9.6% x x x x x x
Malaise def Malaise def 0.2% - 9.6% x x x x x x
Sickness x x x x x x x x x
Discomfort def Malaise def 0.2% - 9.6% x x x x x x
Feeling abnormal Malaise def 0.2% - 9.6% x x x x x x
Ill-defined disorder Malaise def 0.2% - 9.6% x x x x x x
Vomiting def Vomiting def 0.1% - 9% x x x x x x x x x x
Somnolence def Somnolence def 2% - 9% x x x x x x x x x x
Myalgia def Myalgia def 0.7% - 8.9% x x x x x x x x
Chest pain def Chest pain def 3% - 8% x x x x x x x x x x
Diarrhoea def Diarrhoea def 4% - 8% x x x x x x x x x x
Hypertension def Hypertension def 5% - 8% x x x x x x x x x
Lymphoedema def Lymphoedema def 7% x x x x x x x x x
Breast pain def Breast pain def 0.0408% - 7% x x x x x x x x x
Weight decreased def Weight decreased def 0.3% - 7% x x x x x x x x x
Insomnia def Insomnia def 7% x x x x x x x x x x
Oedema def Oedema def 0.1% - 6.7% x x x x x x x x x x
Musculoskeletal chest pain Chest wall pain def 6% x x x x x x x x
Infection def Infection def 3% - 6% x x x x x x x x x
Influenza def Influenza def 6% x x x x x x x x x
Urinary tract infection def Urinary tract infection def 6% x x x x x x x x
Viral infection def Viral infection def 3% - 6% x x x x x x x x x
Haemorrhage def Haemorrhage def 0.0408% - 5.6% x x x x x x x x x x
Haemoglobin def Haemorrhage def 0.0408% - 5.6% x x x x x x x x x x
Vaginal haemorrhage def Bleeding vaginal def 0.0408% - 5.6% x x x x x x x x x x
Vaginal haemorrhage def x x x x x x x x
Osteoporosis def Osteoporosis def 0.4% - 5.1% x x x x x x x x
Decreased appetite Anorexia def 0.0408% - 5% x x x x x x x x x x
Decreased appetite x
Dizziness def Dizziness def 0.0408% - 5% x x x x x x x x x x
Dyspepsia def Dyspepsia def 3% - 5% x x x x x x x x x x
Oedema peripheral def Oedema peripheral def 3% - 5% x x x x x x x x x x
Leg edema 3% - 5% x x x x x x x x x
Gravitational oedema Gravitational oedema 3% - 5% x x x x x x x x x
Vulvovaginal discomfort Vaginal irritation 0.0817% - 4.53% x x x x x x
Osteopenia def Osteopenia def 0% - 3.6% x x x x
Alopecia def Alopecia def 0% - 3.4% x x x x x x x x x x
Pruritus def Pruritus def 1% - 3% x x x x x x x x x
Embolism def Thromboembolic event 2.08% - 2.9% x x x x x x x x x
Embolism def x x x x x x x x x
Thromboembolism def x
Cerebrovascular accident def Cerebrovascular accident def 2.1% - 2.9% x x x x x x x x x
Cataract def Cataract def postmarketing, 0.654% - 2% x x x x x
Infarction def Infarction def 0.98% - 1.51% x x x x x x x x x
Myocardial infarction def Myocardial infarction def 0.98% - 1.51% x x x x x x x x x
Acute coronary syndrome def Myocardial infarction def 0.98% - 1.51% x x x x x x x x x
Angina pectoris def Angina pectoris def 1.06% - 1.31% x x x x x x x x x
Endometrial hyperplasia def Endometrial hyperplasia def 0.3% - 0.6% x x x x
Hyperplasia def Hyperplasia def 0.3% - 0.6% x x x x
Ischaemia def Ischaemia def 0.2% - 0.245% x x x x x x x x x
Myocardial ischaemia def Myocardial ischaemia def 0.2% - 0.245% x x x x x x x x x
Anaphylactic shock def Anaphylactic shock def postmarketing x x x x
Angioedema def Angioedema def postmarketing x x x x
Dysgeusia def Dysgeusia def postmarketing x x x x x
Toxic epidermal necrolysis def Toxic epidermal necrolysis def postmarketing x x x x
Necrolysis epidermal postmarketing x x x x
Erythema multiforme def Erythema multiforme def postmarketing x x x x
Body temperature increased def Body temperature increased def postmarketing x x x x x
Cardiac failure def Cardiac failure def postmarketing x x x x x
Hepatitis def Hepatitis def postmarketing x x x x
Hypoaesthesia def Hypoaesthesia def postmarketing x x x x x
Irritability def Irritability def postmarketing x x x x x
Leukopenia def Leukopenia def postmarketing x x x x x
Nervousness def Nervousness def postmarketing x x x x x
Tension def Nervousness def postmarketing x x x x x
Palpitations def Palpitations def postmarketing x x x x x
Paraesthesia def Paraesthesia def postmarketing x x x x x
Stomatitis def Stomatitis def postmarketing x x x x x
Tachycardia def Tachycardia def postmarketing x x x x x
Thirst def Thirst def postmarketing x x x x x
Thrombosis def Thrombosis def postmarketing x x x x x x x x x
Erythema def Erythema def postmarketing x x x x
Pollakiuria def Pollakiuria def postmarketing x x x x x
Urticaria def Urticaria def postmarketing x x x x x
Dry mouth def Dry mouth def postmarketing x x x x x
Arterial thrombosis Arterial thrombosis postmarketing x x x x x
Vaginal discharge def Vaginal discharge def postmarketing x x x x x x
Increased appetite Increased appetite postmarketing x x x x x x
Memory impairment def Memory impairment def postmarketing x x x x x
Eye irritation Eye irritation postmarketing x x x x x
Hepatic enzyme increased Hepatic enzyme increased postmarketing x x x x
Vision blurred def Vision blurred def postmarketing x x x x x x x
Dysaesthesia def Dysaesthesia def postmarketing x x x x x
Cancer pain def Cancer pain def postmarketing x x x x x
Abdominal pain def Abdominal pain def x
Gastrointestinal pain def Abdominal pain def x
Anxiety def Anxiety def x x x x x x x x x
Mental disorder def Mental disorder def x x x x x x x
Breast disorder def Breast disorder def x x x x x x x x
Cardiovascular disorder def Cardiovascular disorder def x x x x
Transient ischaemic attack def Transient ischaemic attack def x x x x x x x x x
Connective tissue disorder def Connective tissue disorder def x x x x x x x x
Coronary artery disease def Coronary heart disease def x x x x x x x x x
Effusion def Effusion def x x x x x x x x x
Endocrine disorder def Endocrine disorder def x
Hormone level abnormal Endocrine disorder def x
Gastrointestinal disorder def Gastrointestinal disorder def x x x x x x x
Cardiac disorder def Cardiac disorder def x x x x x x x x x
Hemiparesis Hemiparesis x x x x x x x x x
Hypercalcaemia def Hypercalcaemia def x x x x x x x x x
Nephropathy def Nephropathy def x x x x x x
Mediastinal disorder def Mediastinal disorder def x x x x x x x x
Menopause def Menopause def x x x x
Metabolic disorder def Metabolic disorder def x x x x x x
Musculoskeletal disorder def Musculoskeletal disorder def x x x x x x
Neoplasm def Neoplasm def x x x x x x x x x
Nervous system disorder def Nervous system disorder def x x x x x x x
Phlebitis def Phlebitis def x
Pleural disorder def Pleural disorder def x x x x x x x x x
Pleural effusion def Pleural effusion def x x x x x x x x x
Pulmonary embolism def Pulmonary embolism def x x x x x x x x x
Respiratory disorder def Respiratory disorder def x x x x x x
Skin disorder def Skin disorder def x x x x x x x
Embolism venous Thromboembolism def x
Thrombophlebitis def Thrombophlebitis def x x x x x x x x x
Angiopathy def Angiopathy def x x x x x x x
Venous thrombosis def Venous thrombosis def x x x x x x x x x
Vertigo def Vertigo def x x x x x x x x x
Portal vein thrombosis def Portal vein thrombosis def x x x x x x x x x
Endometrial cancer def Endometrial cancer def x x
Haemorrhagic stroke Haemorrhagic stroke x x x x x x x
Cerebral haemorrhage def Haemorrhagic stroke x x x x x x x
Aortic dissection def Dissecting aortic aneurysm, thoracic x x x x x x x x
Lipids increased Lipids increased x x x x
Infestation Infestation NOS x x x x x x x x x
Oestrogen deficiency Oestrogen deficiency x x x x x x x
Oestrogenic effect Oestrogenic effect x x x x x x x x x
Becker's muscular dystrophy def Becker's muscular dystrophy def x x x x x x x
Indication Labels
Adjuvant therapy def x x x x x x x
Breast cancer def x x x x x x x x x x
Breast cancer stage IV def x x x x x x x
Disease progression def x x x x x x x x x
Neoplasm malignant def x x x x x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: L02BG04

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. Letrozole : 36 side effects (BC Cancer)
  2. LETROZOLE / FEMARA : 76 side effects (Drugs@FDA)
  3. LETROZOLE / FEMARA : 87 side effects (Drugs@FDA)
  4. LETROZOLE / FEMARA : 98 side effects (Drugs@FDA)
  5. LETROZOLE / FEMARA : 104 side effects (Drugs@FDA)
  6. LETROZOLE / FEMARA : 127 side effects (Drugs@FDA)
  7. LETROZOLE : 132 side effects (FDA XML label)
  8. LETROZOLE : 140 side effects (FDA XML label)
  9. LETROZOLE : 140 side effects (FDA XML label)
  10. LETROZOLE : 141 side effects (FDA XML label)