Letrozole
Side effects
Options:
Hide MedDRA Preferred Terms
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display all 29 labels
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
1
|
2
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3
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4
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5
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6
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7
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8
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9
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10
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11
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12
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13
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14
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15
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16
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17
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18
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19
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20
|
Flushing
|
Flushing
|
0.117% - 49.7%
|
0% - 43.3%
|
|
|
|
x
|
|
|
x
|
|
|
x
|
x
|
x
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x
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x
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x
|
x
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x
|
x
|
x
|
x
|
Musculoskeletal disorder
|
Musculoskeletal disorder
|
2.77% - 38.2%
|
1.94% - 32.5%
|
|
|
|
x
|
|
|
x
|
|
|
x
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x
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x
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x
|
x
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x
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x
|
x
|
x
|
x
|
x
|
Nervous system disorder
|
Nervous system disorder
|
2.54% - 33.7%
|
2.25% - 31.8%
|
|
|
x
|
x
|
x
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x
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x
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x
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x
|
x
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x
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x
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x
|
x
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x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal disorder
|
Gastrointestinal disorder
|
1.68% - 28.3%
|
1.63% - 28.4%
|
|
|
x
|
x
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x
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x
|
x
|
x
|
x
|
x
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x
|
x
|
x
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x
|
x
|
x
|
x
|
x
|
x
|
x
|
Skin disorder
|
Skin disorder
|
0.663% - 32.4%
|
0.622% - 30.6%
|
|
|
|
x
|
|
|
x
|
|
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x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
|
x
|
Unspecified disorder of skin and subcutaneous tissue
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Menopausal symptoms
|
Hot flush
|
very common, 3% - 38%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hot flush
|
Hot flush
|
very common, 3% - 38%
|
|
x
|
x
|
x
|
x
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x
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x
|
x
|
x
|
x
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x
|
x
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x
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x
|
x
|
x
|
x
|
x
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x
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x
|
x
|
Night sweats
|
Night sweats
|
10.7% - 17.4%
|
|
|
|
|
|
|
|
x
|
|
|
x
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x
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x
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x
|
x
|
x
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x
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x
|
x
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x
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x
|
Hyperhidrosis
|
Sweating
|
1-22%
|
|
x
|
|
|
|
|
|
|
|
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|
|
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Sweating increased
|
common, 0.039% - 24.2%
|
0% - 22.4%
|
|
x
|
x
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x
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x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
|
Nausea
|
Nausea
|
common, 0.117% - 17%
|
0.389% - 8.24%
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
|
x
|
Metabolic disorder
|
Metabolic disorder
|
0.936% - 21.5%
|
1.24% - 20.9%
|
|
|
|
x
|
|
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x
|
|
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Multiple fractures
|
Fracture
|
common, 4% - 13.8%
|
|
x
|
x
|
x
|
x
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x
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x
|
x
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x
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x
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x
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x
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x
|
x
|
x
|
x
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x
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x
|
x
|
x
|
x
|
Fracture
|
Fracture
|
common, 4% - 13.8%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthralgia
|
Arthralgia
|
very common, 0.975% - 25.2%
|
0.777% - 18.1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
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x
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x
|
x
|
x
|
x
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x
|
x
|
x
|
x
|
Musculoskeletal discomfort
|
Arthralgia
|
very common, 0.975% - 25.2%
|
0.777% - 18.1%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myalgia
|
common, 0.312% - 12-21%
|
0.233% - 4.74%
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
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x
|
x
|
x
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x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
Fatigue
|
common, 0.151% - 11-30%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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x
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x
|
x
|
x
|
x
|
x
|
x
|
Asthenia
|
0.151% - 33.6%
|
0.272% - 32.1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
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x
|
x
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x
|
x
|
x
|
x
|
Fatigue
|
Fatigue
|
common, 0.151% - 11-30%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspnoea
|
Dyspnoea
|
uncommon, 0.819% - 18%
|
0.7% - 5.32%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Headache
|
Headache
|
common, 0.204% - 20.1%
|
0.661% - 19.7%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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x
|
x
|
x
|
x
|
x
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x
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x
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x
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x
|
x
|
x
|
Lymphoedema
|
Lymphoedema
|
7%
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mental disorder
|
Mental disorder
|
0.819% - 12.5%
|
0.622% - 10.7%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pain
|
Pain
|
5% - 7%
|
|
x
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
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x
|
x
|
x
|
x
|
x
|
x
|
Abdominal pain
|
Abdominal pain
|
uncommon, 5% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gastrointestinal pain
|
Abdominal pain
|
uncommon, 5% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Chest pain
|
Chest pain
|
3% - 9%
|
|
x
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Musculoskeletal chest pain
|
Chest wall pain
|
6%
|
|
|
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Constipation
|
Constipation
|
common, 0.0251% - 11.3%
|
0.0777% - 11.8%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cough
|
Cough
|
uncommon, 5% - 13%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypertension
|
Hypertension
|
uncommon, 4% - 8%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vulvovaginal dryness
|
Vulvovaginal dryness
|
0% - 5.35%
|
0% - 4.94%
|
|
|
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vaginal dryness
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Back pain
|
Back pain
|
0.176% - 70.5%
|
0.272% - 4.35%
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Infection
|
Infection
|
1.56% - 6.48%
|
1.28% - 6.34%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dyspepsia
|
Dyspepsia
|
common, 3% - 6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dermatitis
|
Rash
|
common, 3% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash
|
Rash
|
common, 3% - 12%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Influenza
|
Influenza
|
4% - 6%
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Viral infection
|
Viral infection
|
3% - 6%
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vomiting
|
Vomiting
|
common, 0.0755% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Weight decreased
|
Weight decreased
|
uncommon, 0.125% - 7%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema peripheral
|
Oedema peripheral
|
common, 3% - 9-17%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Leg edema
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Edema of lower extremities
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Myalgia
|
Myalgia
|
common, 0.312% - 12-21%
|
0.233% - 4.74%
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Increased appetite
|
Increased appetite
|
common, 1%
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Infestation
|
Infestation NOS
|
1.56% - 6.48%
|
1.28% - 6.34%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Diarrhoea
|
Diarrhoea
|
common, 0.468% - 8%
|
0.311% - 5.56%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Bone pain
|
Bone pain
|
common, 0.1% - 22%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Decreased appetite
|
Anorexia
|
common, 0.0251% - 6%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Decreased appetite
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Insomnia
|
Insomnia
|
uncommon, 0.078% - 7%
|
0.0777% - 4.66%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arthritis
|
Arthritis
|
uncommon, 0.39% - 25.2%
|
0.194% - 4.82%
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Alopecia
|
Alopecia
|
common, 2.09% - 3.43%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pain in extremity
|
Pain in extremity
|
0.1% - 10%
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Leg pain
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Pain in arm
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Neoplasm malignant
|
Neoplasm malignant
|
1.33% - 4.86%
|
|
x
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lethargy
|
Lethargy
|
0.151% - 10.2%
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Malaise
|
Malaise
|
0.151% - 10.2%
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Discomfort
|
Malaise
|
0.151% - 10.2%
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Feeling abnormal
|
Malaise
|
0.151% - 10.2%
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Ill-defined disorder
|
Malaise
|
0.151% - 10.2%
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Osteopenia
|
Osteopenia
|
0.0502% - 3.55%
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dizziness
|
Dizziness
|
common, 0.0252% - 14.2%
|
0.233% - 13.3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Lightheadedness
|
0.0252% - 3.43%
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypercholesterolaemia
|
Hypercholesterolaemia
|
common, 0% - 52.3%
|
0.194% - 15.5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urinary tract infection
|
Urinary tract infection
|
uncommon, 3% - 6%
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Weight increased
|
Weight increased
|
common, 0.679% - 15.4%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Somnolence
|
Somnolence
|
uncommon, 2% - 9%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Depression
|
Depression
|
common, 0.351% - 4.86%
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Anxiety depression
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nephropathy
|
Nephropathy
|
0.468% - 5.07%
|
0.233% - 3.89%
|
|
|
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Osteoporosis
|
Osteoporosis
|
common, 0.125% - 6%
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Angiopathy
|
Angiopathy
|
2.3% - 53.6%
|
2.88% - 47.8%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cerebrovascular accident
|
Cerebrovascular accident
|
uncommon, 1.15% - 2.86%
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pruritus
|
Pruritus
|
uncommon, 1% - 5%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Breast pain
|
Breast pain
|
uncommon, 0.0252% - 7%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vaginal discharge
|
Vaginal discharge
|
uncommon, 2%
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Angina pectoris
|
Angina pectoris
|
0.176% - 24%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vulvovaginal discomfort
|
Vaginal irritation
|
0.0502% - 4.53%
|
|
|
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myocardial infarction
|
Myocardial infarction
|
0.276% - 15%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Acute coronary syndrome
|
Myocardial infarction
|
0.276% - 15%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cataract
|
Cataract
|
uncommon, 0.654% - 2.21%
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Embolism
|
Thromboembolism
|
0.6%
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Thromboembolic event
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Embolism venous
|
Thromboembolism
|
0.6%
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Anxiety
|
Anxiety
|
uncommon
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysgeusia
|
Dysgeusia
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oedema
|
Oedema
|
uncommon, 0.0251% - 18.4%
|
0.117% - 16.2%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Body temperature increased
|
Body temperature increased
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Leukopenia
|
Leukopenia
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Palpitations
|
Palpitations
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Stomatitis
|
Stomatitis
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tachycardia
|
Tachycardia
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Thirst
|
Thirst
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Thrombophlebitis
|
Thrombophlebitis
|
uncommon
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pollakiuria
|
Pollakiuria
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Urticaria
|
Urticaria
|
uncommon
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dry mouth
|
Dry mouth
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dry skin
|
Dry skin
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Memory impairment
|
Memory impairment
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Dysaesthesia
|
Dysaesthesia
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tumour pain
|
Tumour pain
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Mucosal dryness
|
Mucosal dryness
|
uncommon
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Vaginal haemorrhage
|
Vaginal haemorrhage
|
uncommon, 0.0252% - 13.1%
|
0.194% - 6.65%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Myocardial ischaemia
|
Myocardial ischaemia
|
0.245% - 0.368%
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Anaphylactic shock
|
Anaphylactic shock
|
very rare, postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Angioedema
|
Angioedema
|
very rare, postmarketing
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Carpal tunnel syndrome
|
Carpal tunnel syndrome
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
Toxic epidermal necrolysis
|
Toxic epidermal necrolysis
|
very rare, postmarketing
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Erythema multiforme
|
Erythema multiforme
|
very rare, postmarketing
|
|
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hepatitis
|
Hepatitis
|
very rare, postmarketing
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Pulmonary embolism
|
Pulmonary embolism
|
rare
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Arterial thrombosis
|
Arterial thrombosis
|
rare
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Trigger finger
|
Trigger finger
|
postmarketing
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
Vision blurred
|
Vision blurred
|
postmarketing
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cerebral infarction
|
Cerebrovascular infarction
|
rare
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Bone disorder
|
Bone disorder
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Breast disorder
|
Breast disorder
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cardiovascular disorder
|
Cardiovascular disorder
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Transient ischaemic attack
|
Transient ischaemic attack
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Connective tissue disorder
|
Connective tissue disorder
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Coronary artery disease
|
Coronary heart disease
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cyst
|
Cyst
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Endometrial hyperplasia
|
Endometrial hyperplasia
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Eye disorder
|
Eye disorder
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Cardiac disorder
|
Cardiac disorder
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Cardiac failure
|
Cardiac failure
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hemiparesis
|
Hemiparesis
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Haemorrhage
|
Haemorrhage
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Haemoglobin
|
Haemorrhage
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hypercalcaemia
|
Hypercalcaemia
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Hypoaesthesia
|
Hypoaesthesia
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Irritability
|
Irritability
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Mediastinal disorder
|
Mediastinal disorder
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Menopause
|
Menopause
|
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
|
x
|
x
|
|
|
x
|
Musculoskeletal pain
|
Musculoskeletal pain
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Neoplasm
|
Neoplasm
|
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Nervousness
|
Nervousness
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Tension
|
Nervousness
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Paraesthesia
|
Paraesthesia
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Phlebitis
|
Phlebitis
|
|
|
x
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Pleural effusion
|
Pleural effusion
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Polyp
|
Polyp
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Urethral disorder
|
Urinary tract disorder
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Urinary tract disorder
|
Urinary tract disorder
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Venous thrombosis
|
Venous thrombosis
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Vertigo
|
Vertigo
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Portal vein thrombosis
|
Portal vein thrombosis
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Malnutrition
|
Malnutrition
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Rash vesicular
|
Rash vesicular
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Rash erythematous
|
Rash erythematous
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Eye irritation
|
Eye irritation
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Gravitational oedema
|
Gravitational oedema
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Dermatitis psoriasiform
|
Dermatitis psoriasiform
|
|
|
|
|
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Hepatobiliary disease
|
Hepatobiliary disease
|
|
|
|
|
|
|
x
|
x
|
|
x
|
x
|
|
|
|
|
|
|
|
|
|
|
|
Rash maculo-papular
|
Rash maculo-papular
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
Endometrial cancer
|
Endometrial cancer
|
|
|
|
|
|
|
|
|
x
|
|
|
x
|
|
|
x
|
|
|
|
|
|
|
|
Haemorrhagic stroke
|
Haemorrhagic stroke
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cerebral haemorrhage
|
Haemorrhagic stroke
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Cancer pain
|
Cancer pain
|
|
|
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oestrogen deficiency
|
Oestrogen deficiency
|
|
|
|
|
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Oestrogenic effect
|
Oestrogenic effect
|
|
|
|
x
|
x
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 36 |
Source: | BC Cancer |
---|
Side effects: | 68 |
Source: | FDA |
---|
Side effects: | 76 |
Source: | FDA |
---|
Side effects: | 88 |
Source: | FDA |
---|
Side effects: | 90 |
Source: | Medsafe |
---|
Side effects: | 93 |
Source: | Medsafe |
---|
Side effects: | 95 |
Source: | FDA |
---|
Side effects: | 95 |
Source: | medicines.org.au |
---|
Side effects: | 95 |
Source: | medicines.org.au |
---|
Side effects: | 118 |
Source: | FDA |
---|
Side effects: | 119 |
Source: | FDA Structured Product Label |
---|
Side effects: | 119 |
Source: | FDA Structured Product Label |
---|
Side effects: | 120 |
Source: | FDA Structured Product Label |
---|
Side effects: | 120 |
Source: | FDA Structured Product Label |
---|
Side effects: | 120 |
Source: | FDA Structured Product Label |
---|
Side effects: | 121 |
Source: | FDA Structured Product Label |
---|
Side effects: | 128 |
Source: | FDA Structured Product Label |
---|
Side effects: | 129 |
Source: | FDA Structured Product Label |
---|
Side effects: | 129 |
Source: | FDA Structured Product Label |
---|
Side effects: | 130 |
Source: | FDA Structured Product Label |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
|
50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
|
0%
|
|
|
no frequency information
|
|
|
not found on label
|