Rosiglitazone
  
Side effects 
	
		
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| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 
| Anaemia | Anaemia | common, 7.1% |  | x | x | x | x | x | x | x | x | x | 
| Nasopharyngitis | Nasopharyngitis | 6.3% - 6.9% |  |  |  |  |  |  | x | x | x |  | 
| Upper respiratory tract infection | Upper respiratory tract infection | 4.3% - 9.9% | 8.7% |  |  |  |  |  | x | x | x |  | 
| Hypertension | Hypertension | 4.4% - 6.1% |  |  |  |  |  |  | x | x | x | x | 
| Headache | Headache | 5.4% - 20% | 5% | x | x | x | x | x | x | x | x | x | 
| Thrombocytopenia | Thrombocytopenia | common |  | x |  |  |  |  |  |  |  |  | 
| Back pain | Back pain | 4% - 9% | 3.8% |  | x | x | x | x | x | x | x | x | 
| Arthralgia | Arthralgia | 4.2% - 5% |  |  |  |  |  |  | x | x | x |  | 
| Musculoskeletal discomfort | Arthralgia | 4.2% - 5% |  |  |  |  |  |  | x | x | x |  | 
| Myalgia |  |  | x |  |  |  |  |  |  |  |  | 
| Hyperglycaemia | Hyperglycaemia | 3.9% - 10% | 5.7% |  | x | x | x | x | x | x | x | x | 
| Asthenia | Fatigue | 1.9% - 9% | 5% |  | x | x | x | x | x | x | x | x | 
| Fatigue | Fatigue | 1.9% - 9% | 5% |  | x | x | x | x | x | x | x | x | 
| Sinusitis | Sinusitis | 3% - 12% | 4.5% |  | x | x | x | x | x | x | x | x | 
| Diarrhoea | Diarrhoea | 2.3% - 35% | 3.3% |  | x | x | x | x | x | x | x | x | 
| Hypoglycaemia | Hypoglycaemia | 1% - 13% | 0.2% | x | x | x | x | x | x | x | x | x | 
| Anaphylactic shock | Anaphylactic shock | very rare, postmarketing |  | x |  |  |  |  | x | x | x | x | 
| Angioedema | Angioedema | very rare, postmarketing |  | x |  |  |  | x | x | x | x | x | 
| Dermatitis | Rash | very rare, postmarketing |  | x |  |  |  |  | x | x | x | x | 
| Rash | Rash | very rare, postmarketing |  | x |  |  |  |  | x | x | x | x | 
| Cardiac failure congestive | Cardiac failure congestive | postmarketing, rare |  | x |  | x | x | x | x | x | x | x | 
| Hepatitis | Hepatitis | postmarketing |  |  |  | x | x | x | x | x | x | x | 
| Pleural effusion | Pleural effusion | postmarketing |  |  |  | x | x | x | x | x | x | x | 
| Pruritus | Pruritus | very rare, postmarketing |  | x |  |  |  |  | x | x | x | x | 
| Pulmonary oedema | Pulmonary oedema | postmarketing, rare |  | x |  | x | x | x | x | x | x | x | 
| Erythema multiforme | Stevens-Johnson syndrome | postmarketing |  |  |  |  |  |  | x | x | x |  | 
| Stevens-Johnson syndrome | Stevens-Johnson syndrome | postmarketing |  |  |  |  |  |  | x | x | x |  | 
| Urticaria | Urticaria | very rare, postmarketing |  | x |  |  |  | x | x | x | x | x | 
| Hepatic failure | Hepatic failure | postmarketing |  |  | x | x | x | x | x | x | x | x | 
| Hepatic function abnormal | Hepatic function abnormal | rare |  | x |  |  |  |  |  |  |  |  | 
| Visual acuity reduced | Visual acuity reduced | postmarketing |  |  |  |  |  |  | x | x | x | x | 
| Macular oedema | Macular oedema | postmarketing, rare |  | x |  |  |  |  | x | x | x | x | 
| Diabetes mellitus | Worsening of diabetes | postmarketing |  |  |  |  |  |  | x | x | x |  | 
| Diabetes mellitus |  |  |  |  |  |  |  |  |  | x |  | 
| Weight increased | Weight increased | very rare |  | x |  |  |  |  |  |  | x | x | 
| Infection | Infection |  |  |  | x | x | x | x |  |  |  | x | 
| Connective tissue disorder | Connective tissue disorder |  |  | x |  |  |  |  |  |  |  |  | 
| Constipation | Constipation |  |  | x |  |  |  |  |  |  |  | x | 
| Dizziness | Dizziness |  |  | x |  |  |  |  |  |  |  |  | 
| Oedema | Oedema |  |  | x | x | x | x | x | x | x | x | x | 
| Eye disorder | Eye disorder |  |  | x |  |  |  |  |  |  |  |  | 
| Multiple fractures | Fracture |  |  | x |  |  |  |  | x | x | x | x | 
| Fracture | Fracture |  |  | x |  |  |  |  | x | x | x | x | 
| Gastrointestinal disorder | Gastrointestinal disorder |  |  | x |  |  |  |  |  |  |  |  | 
| Cardiac disorder | Cardiac disorder |  |  | x |  |  |  |  |  |  |  |  | 
| Cardiac failure | Cardiac failure |  |  | x |  | x | x | x |  |  | x | x | 
| Hyperbilirubinaemia | Hyperbilirubinaemia |  |  |  | x | x | x | x | x | x | x | x | 
| Hypercholesterolaemia | Hypercholesterolaemia |  |  | x |  |  |  |  |  |  |  |  | 
| Hyperlipidaemia | Hyperlipidaemia |  |  | x |  |  |  |  |  |  |  |  | 
| Hypertriglyceridaemia | Hypertriglyceridaemia |  |  | x |  |  |  |  |  |  |  |  | 
| Blood triglycerides increased | Hypertriglyceridaemia |  |  | x |  |  |  |  |  |  |  |  | 
| Immune system disorder | Immune system disorder |  |  | x |  |  |  |  |  |  |  |  | 
| Ischaemia | Ischaemia |  |  |  |  |  |  |  |  |  |  | x | 
| Leukopenia | Leukopenia |  |  |  |  |  |  |  |  |  |  | x | 
| Myocardial infarction | Myocardial infarction |  |  |  |  |  |  |  |  |  | x | x | 
| Acute coronary syndrome | Myocardial infarction |  |  |  |  |  |  |  |  |  | x | x | 
| Nausea | Nausea |  |  |  |  |  |  |  | x | x | x |  | 
| Nervous system disorder | Nervous system disorder |  |  | x |  |  |  |  |  |  |  |  | 
| Ligament sprain | Sprain |  |  |  |  |  |  |  |  |  |  | x | 
| Cerebrovascular accident | Cerebrovascular accident |  |  |  |  |  |  |  |  |  | x |  | 
| Oedema peripheral | Oedema peripheral |  |  |  |  |  |  |  |  |  |  | x | 
| Myocardial ischaemia | Myocardial ischaemia |  |  | x |  |  |  |  |  |  |  | x | 
| Ketonuria | Ketonuria |  |  |  |  |  |  |  | x | x | x |  | 
| Malnutrition | Malnutrition |  |  | x |  |  |  |  |  |  |  |  | 
| Myalgia | Myalgia |  |  | x |  |  |  |  |  |  |  |  | 
| Volume blood increased | Volume plasma increased |  |  |  | x | x | x | x | x | x | x | x | 
| Increased appetite | Increased appetite |  |  | x |  |  |  |  |  |  |  | x | 
| Hepatic enzyme increased | Hepatic enzyme increased |  |  | x |  |  |  |  |  |  |  |  | 
| Hepatobiliary disease | Hepatobiliary disease |  |  | x |  |  |  |  |  |  |  |  | 
| Fluid retention | Fluid retention |  |  | x |  |  |  |  |  |  |  |  | 
| Parotid gland enlargement | Parotid gland enlargement |  |  |  |  |  |  |  |  |  |  | x | 
| Anion gap increased | Anion gap increased |  |  |  |  |  |  |  | x | x | x |  | 
| Haematocrit decreased | Haematocrit decreased |  |  |  |  |  |  |  |  |  |  | x | 
| Blood cholesterol increased | High cholesterol |  |  | x |  |  |  |  |  |  |  | x | 
	 
 
  Indications
	Information about indications was extracted from the indications and usage sections of the labels.
	
 
	  
	  
		| Side effects: | 38 | 
|---|
		| Source: | EMA | 
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		| Side effects: | 13 | 
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		| Source: | FDA | 
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		| Side effects: | 18 | 
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		| Source: | FDA | 
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		| Side effects: | 18 | 
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		| Source: | FDA | 
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		| Side effects: | 20 | 
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		| Source: | FDA | 
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		| Side effects: | 34 | 
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		| Source: | FDA Structured Product Label | 
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		| Side effects: | 34 | 
|---|
		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 39 | 
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		| Source: | FDA Structured Product Label | 
|---|
		 
	  
	  
		| Side effects: | 40 | 
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		| Source: | Health Canada | 
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	Color scheme:
	  
	  standard – alternative
	  
	
	
|  |  | 100% | 
|  |  | 75% | 
|  |  | 50% | 
|  |  | 10% | 
|  |  | frequent (1% to 100%) | 
|  |  | infrequent (0.1% to 1%) | 
|  |  | rare (<0.1%) | 
|  |  | postmarketing | 
|  |  | 0% | 
|  |  | no frequency information | 
|  |  | not found on label |