| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 
| Cardiac failure | Cardiac failure | rare — 27.5% | 29.6% | x |  |  | x |  |  |  |  |  | x |  | x |  | x | x | x | x |  | x | x | 
| Hypotension | Hypotension | postmarketing, 27.4% | 23.2% | x |  | x | x |  |  |  | x |  | x |  | x |  | x | x | x | x |  |  |  | 
| Orthostatic hypotension | Orthostatic hypotension | common, 27.4% | 23.2% |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Bradycardia | Bradycardia | common, 1.5% - 15.9% | 0.4% - 6.7% | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Atrioventricular block first degree | Atrioventricular block first degree | 5.3% | 1.9% | x | x |  | x |  |  |  |  |  | x |  | x | x |  | x | x | x |  | x |  | 
| Abdominal pain | Abdominal pain | common |  | x | x |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Stomach ache | common |  |  |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x | 
| Gastrointestinal pain | Abdominal pain | common |  | x | x |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Asthenia | Fatigue | common, very common |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Asthenia |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Fatigue | Fatigue | common, very common |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypertension | Hypertension | common |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Abdominal pain upper | Stomach ache | common |  |  |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x | 
| Dyspnoea exertional | Dyspnoea exertional | common |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Peripheral coldness | Cold hands & feet | common |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Peripheral coldness | postmarketing, common |  |  |  | x | x |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Atrioventricular block complete | Atrioventricular block complete | 4.7% | 4.7% | x |  |  | x |  |  |  |  |  | x |  | x | x | x | x | x | x |  | x |  | 
| Muscle spasms | Cramp muscle | uncommon, common |  |  | x |  |  | x |  |  |  |  | x |  |  |  |  |  |  |  |  | x | x | 
| Muscle spasms | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dizziness | Dizziness | common, 1.8% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Syncope | postmarketing, common |  |  | x | x | x | x |  | x | x |  | x |  |  |  |  |  |  |  | x | x | x | 
| Lightheadedness |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Vertigo | Vertigo | 1.8% | 1% | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Atrioventricular block | Atrioventricular block | uncommon |  | x |  | x |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Block heart | postmarketing |  |  |  |  |  |  | x |  |  | x |  |  |  |  | x |  |  |  | x |  |  | 
| Dermatitis | Rash | rare — common |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Rash | Rash | rare — common |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Cardiogenic shock | Cardiogenic shock | postmarketing, uncommon |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Acute myocardial infarction | Acute myocardial infarction | postmarketing, uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Disturbance in attention | Cerebration impaired | uncommon |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mental disability | Cerebration impaired | uncommon |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Agranulocytosis | Agranulocytosis | postmarketing, rare |  | x |  | x |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Alopecia | Alopecia | rare |  |  | x |  |  | x |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Alopecia reversible | very rare, postmarketing |  |  |  |  |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Anxiety | Anxiety | postmarketing, rare |  |  | x | x | x | x |  | x | x |  | x |  |  |  |  |  |  |  | x | x | x | 
| Arrhythmia | Arrhythmia | rare |  |  |  |  |  | x |  |  |  |  | x |  |  |  |  |  |  |  | x | x | x | 
| Arterial insufficiency | Arterial insufficiency | postmarketing, common |  |  |  | x |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Arthralgia | Arthralgia | very rare — common |  |  | x |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Musculoskeletal discomfort | Arthralgia | very rare — common |  |  | x |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  | x |  |  | 
| Bronchospasm | Bronchospasm | postmarketing — uncommon |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Catatonia | Catatonia | postmarketing |  | x |  | x |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Chest pain | Chest pain | postmarketing |  |  |  | x | x |  |  | x | x |  | x |  |  |  |  |  |  |  | x | x |  | 
| Precordial pain | very rare, uncommon |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Confusional state | Confusional state | very rare, postmarketing |  | x | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Feeling abnormal | Confusional state | very rare, postmarketing |  | x | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Conjunctivitis | Conjunctivitis | rare |  |  | x |  |  | x |  |  |  |  | x |  |  |  |  |  |  |  |  | x | x | 
| Constipation | Constipation | postmarketing — common |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Libido decreased | Libido decreased | postmarketing |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Disturbance in sexual arousal | Libido decreased | postmarketing |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Depression | Depression | postmarketing — uncommon |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Diarrhoea | Diarrhoea | rare, common |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dysgeusia | Dysgeusia | postmarketing |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  | 
| Taste bitter |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Dyspnoea | Dyspnoea | postmarketing, common |  | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Oedema | Oedema | rare, uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Flatulence | Flatulence | postmarketing, common |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hallucination | Hallucination | very rare, postmarketing |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Headache | Headache | postmarketing, common |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Dyspepsia | Heartburn | postmarketing, common |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hepatitis | Hepatitis | very rare, postmarketing |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Laryngospasm | Laryngospasm | postmarketing |  | x |  | x |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Musculoskeletal pain | Musculoskeletal pain | very rare, postmarketing |  |  |  |  |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Nausea | Nausea | postmarketing, common |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Nervousness | Nervousness | postmarketing, rare |  |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  | x |  | x | 
| Tension | Nervousness | postmarketing, rare |  |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  | x |  | x | 
| Nightmare | Nightmare | postmarketing — uncommon |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Palpitations | Palpitations | postmarketing — common |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Paraesthesia | Paraesthesia | postmarketing — uncommon |  |  |  | x | x | x |  | x | x |  | x |  |  |  |  |  |  |  | x | x | x | 
| Peyronie's disease | Peyronie's disease | very rare, postmarketing |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Pruritus | Pruritus | postmarketing, common |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Psoriasis | Psoriasis | postmarketing |  | x |  |  |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x |  | 
| Psoriasis flare-up | very rare |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Raynaud's phenomenon | Raynaud's disease | postmarketing |  |  |  | x |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x |  |  | 
| Hyperhidrosis | Sweating | postmarketing |  |  |  |  | x |  |  | x | x |  | x |  |  |  |  |  |  |  |  |  |  | 
| Sweating increased | very rare — uncommon |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | 
| Hyperhidrosis | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Shock | Syncope | postmarketing, common |  |  | x | x | x | x |  | x | x |  | x |  |  |  |  |  |  |  | x | x | x | 
| Shock |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Syncope | Syncope | postmarketing, common |  |  | x | x | x | x |  | x | x |  | x |  |  |  |  |  |  |  | x | x | x | 
| Loss of consciousness | Syncope | postmarketing, common |  |  | x | x | x | x |  | x | x |  | x |  |  |  |  |  |  |  | x | x | x | 
| Tinnitus | Tinnitus | very rare, postmarketing |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Urticaria | Urticaria | postmarketing — uncommon |  |  | x |  |  | x |  |  |  |  | x |  |  |  |  |  |  |  |  | x | x | 
| Vomiting | Vomiting | postmarketing — common |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Wheezing | Wheezing | postmarketing |  |  |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Dry mouth | Dry mouth | very rare — rare |  |  | x | x |  | x | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | 
| Mood swings | Mood swings | postmarketing |  | x |  | x |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Affect lability | Mood swings | postmarketing |  | x |  | x |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Oedema peripheral | Oedema peripheral | postmarketing, common |  |  |  | x |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Disorientation | Disorientation | postmarketing |  | x |  | x |  |  |  | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Erectile dysfunction | Erectile dysfunction | very rare — rare |  |  | x |  |  | x |  | x | x |  |  |  |  |  |  |  |  |  | x |  | x | 
| Purpura non-thrombocytopenic | Purpura non-thrombocytopenic | postmarketing |  | x |  | x |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Dry eye | Dry eye | postmarketing |  |  |  |  |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  |  | 
| Vision blurred | Vision blurred | postmarketing |  |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Photosensitivity reaction | Photosensitivity | postmarketing |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x |  | 
| Photosensitivity reaction | very rare |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Respiratory distress | Respiratory distress | postmarketing |  | x |  | x |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Altered state of consciousness | Depressed level of consciousness | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Depressed level of consciousness | Depressed level of consciousness | rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Alertness decreased |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Sexual dysfunction | Sexual dysfunction | rare |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Obstructive airways disorder | Obstructive airways disorder | rare, uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Amnesia | Short-term memory loss | postmarketing, rare |  | x |  | x |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Amnesia | very rare |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Blood triglycerides increased | Blood triglycerides increased | postmarketing |  |  |  |  |  |  |  |  |  |  |  | x |  | x | x | x | x | x |  | x | x | 
| Thrombocytopenic purpura | Thrombocytopenic purpura | postmarketing |  | x |  | x |  |  | x | x | x | x |  | x | x | x | x | x | x | x | x |  | x | 
| Insomnia | Insomnia | postmarketing — uncommon |  |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Somnolence | Somnolence | postmarketing — uncommon |  |  | x | x |  | x |  | x | x |  | x |  |  |  |  |  |  |  | x | x | x | 
| Angina pectoris | Angina pectoris | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Arthritis | Arthritis | very rare |  |  |  |  |  |  | x |  |  | x | x | x | x | x | x | x | x | x |  | x | x | 
| Deafness | Deafness | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hearing impaired | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Diabetes mellitus | Diabetes mellitus | very rare |  | x |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x | 
| Diabetes mellitus exacerbated |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Gangrene | Gangrene | very rare |  |  | x |  |  | x |  |  |  |  | x | x |  | x | x | x | x | x |  | x | x | 
| Intermittent claudication | Intermittent claudication | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Claudication |  |  | x |  |  | x |  | x |  |  | x | x | x | x | x | x | x | x | x |  | x |  | 
| Personality disorder | Personality disorder | very rare |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x | x | 
| Retroperitoneal fibrosis | Retroperitoneal fibrosis | very rare |  |  |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x |  | x | x | 
| Rhinitis | Rhinitis | very rare, rare |  |  | x |  |  | x | x |  |  |  | x | x |  | x | x | x | x | x |  | x | x | 
| Thrombocytopenia | Thrombocytopenia | very rare, postmarketing |  |  | x |  | x | x |  |  |  |  | x |  |  |  |  |  |  |  | x | x | x | 
| Weight increased | Weight increased | very rare, uncommon |  |  | x |  | x | x | x |  |  | x | x | x | x | x | x | x | x | x |  | x | x | 
| Liver function test abnormal | Liver function test abnormal | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Memory impairment | Memory impairment | very rare |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hearing impaired | Auditory disorder NOS | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Hearing impaired | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | 
| Conduction disorder | Conduction disorder | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiovascular disorder | Unspecified circulatory system disorder | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Libido disorder | Libido disorder | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Mental disorder | Mental disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Breast disorder | Breast disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiac output decreased | Cardiac output decreased |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Cerebrovascular disorder | Cerebrovascular disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Coma | Coma |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Connective tissue disorder | Connective tissue disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cyanosis | Cyanosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eye disorder | Eye disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Body temperature increased | Body temperature increased |  |  | x |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x | 
| Gastrointestinal disorder | Gastrointestinal disorder |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Cardiac arrest | Cardiac arrest |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiac disorder | Cardiac disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Cardiac failure congestive | Cardiac failure congestive |  |  |  |  |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x |  | 
| Hypersensitivity | Hypersensitivity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hypoglycaemia | Hypoglycaemia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Immune system disorder | Immune system disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eye pruritus | Eye pruritus |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  | 
| Jaundice | Jaundice |  |  |  |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x |  |  |  | 
| Leukopenia | Leukopenia |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Hepatic cirrhosis | Hepatic cirrhosis |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Mediastinal disorder | Mediastinal disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Nervous system disorder | Nervous system disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Pain | Pain |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ache |  |  | x |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x | 
| Pneumonia | Pneumonia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Rales | Rales |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Skin lesion | Skin lesion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Sleep disorder | Sleep disturbance |  |  | x |  |  |  | x | x |  |  | x |  | x | x | x | x | x | x | x |  |  | x | 
| Status asthmaticus | Status asthmaticus |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Cerebrovascular accident | Cerebrovascular accident |  |  |  |  | x |  |  |  | x | x |  |  |  |  |  |  |  |  |  |  |  |  | 
| Tachycardia | Tachycardia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Angiopathy | Angiopathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Ventricular tachycardia | Ventricular tachycardia |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Hepatic function abnormal | Hepatic function abnormal |  |  |  |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x |  |  |  | 
| Skin disorder | Unspecified disorder of skin and subcutaneous tissue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Eye irritation | Eye irritation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  | 
| Oropharyngeal discomfort | Throat sore |  |  | x |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x | 
| Oropharyngeal pain | Throat sore |  |  | x |  |  |  |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x | 
| Dermatitis psoriasiform | Dermatitis psoriasiform |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Hepatobiliary disease | Hepatobiliary disease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Abnormal dreams | Vivid dreams |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Sinus arrest | Sinus arrest |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Visual impairment | Visual disturbance |  |  | x |  |  | x |  | x |  |  | x | x | x | x | x | x | x | x | x |  | x |  | 
| Visual impairment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Menopausal symptoms | Hot flush |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Hot flush | Hot flush |  |  |  |  |  | x |  |  |  |  |  | x |  |  |  |  |  |  |  |  | x |  | 
| Emotional distress | Emotional distress |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Coronary artery disease | Coronary artery disease |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Loss of libido | Loss of libido |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |