Aliskiren
Side effects
Options:
Hide MedDRA Preferred Terms
MedDRA Preferred Term
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Side effect
|
Data for drug
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Placebo
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Labels
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1
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2
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3
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4
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5
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6
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7
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8
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9
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Headache
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Headache
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6.71% - 11.2%
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x
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x
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x
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x
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Nasopharyngitis
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Nasopharyngitis
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4.42% - 6.16%
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x
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x
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x
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Arthralgia
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Arthralgia
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common
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x
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x
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x
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x
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Musculoskeletal discomfort
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Arthralgia
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common
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x
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x
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x
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x
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Dizziness
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Dizziness
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common
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x
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x
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x
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x
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x
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Hyperkalaemia
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Hyperkalaemia
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common
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x
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x
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x
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Back pain
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Back pain
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3.08% - 4.77%
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x
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x
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x
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Cough
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Cough
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uncommon, 2.83% - 9.48%
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x
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x
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x
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x
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x
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x
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x
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x
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Cough increased
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x
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x
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x
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Dry cough
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x
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Diarrhoea
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Diarrhoea
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common, 1.66% - 3.82%
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Oedema peripheral
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Oedema peripheral
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postmarketing — 3.08% - 5.56%
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x
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x
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x
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x
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x
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x
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Bronchitis
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Bronchitis
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0.948% - 3.1%
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x
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Toxic epidermal necrolysis
|
Toxic epidermal necrolysis
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postmarketing, uncommon
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x
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x
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x
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x
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Dermatitis
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Rash
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uncommon
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Rash
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Rash
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uncommon
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Hypotension
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Hypotension
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uncommon
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x
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x
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x
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Renal failure acute
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Renal failure acute
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uncommon
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x
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x
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x
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x
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x
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Palpitations
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Palpitations
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uncommon
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x
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x
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Pruritus
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Pruritus
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postmarketing, uncommon
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x
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x
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x
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x
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Erythema multiforme
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Stevens-Johnson syndrome
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postmarketing, uncommon
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x
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x
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x
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Stevens-Johnson syndrome
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Stevens-Johnson syndrome
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postmarketing, uncommon
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x
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x
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x
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Urticaria
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Urticaria
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postmarketing, uncommon
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x
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x
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x
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x
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Renal failure
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Renal impairment
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uncommon
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x
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x
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x
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Renal impairment
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Renal impairment
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uncommon
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x
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x
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x
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Anaphylactic shock
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Anaphylactic shock
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postmarketing
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x
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x
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x
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Angioedema
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Angioedema
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postmarketing, rare
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Colon cancer
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Colon cancer
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0.05%
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x
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Hypersensitivity
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Hypersensitivity
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postmarketing, rare
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x
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x
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x
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x
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x
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x
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x
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x
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Erythema
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Erythema
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postmarketing, rare
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x
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x
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x
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Hepatic function abnormal
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Hepatic function abnormal
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postmarketing
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x
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x
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Haemoglobin decreased
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Haemoglobin decreased
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rare
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x
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x
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x
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Blood creatinine increased
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Blood creatinine increased
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postmarketing, rare
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x
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x
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x
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x
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Creatinine increased
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x
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Serum creatinine increased
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x
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Haematocrit decreased
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Haematocrit decreased
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rare
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x
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x
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x
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Abdominal pain
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Abdominal pain
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x
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x
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x
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x
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Gastrointestinal pain
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Abdominal pain
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x
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x
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x
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x
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Anaemia
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Anaemia
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x
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x
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x
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x
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x
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x
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x
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x
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x
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Asthenia
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Asthenia
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x
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Fatigue
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x
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x
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Neck pain
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Neck pain
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x
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Connective tissue disorder
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Connective tissue disorder
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x
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x
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x
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Constipation
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Constipation
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x
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Dyspepsia
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Dyspepsia
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x
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x
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x
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x
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Oedema
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Oedema
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x
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x
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x
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x
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Epistaxis
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Epistaxis
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x
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Fatigue
|
Fatigue
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x
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x
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Gastrooesophageal reflux disease
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Gastrooesophageal reflux disease
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x
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x
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x
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x
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Gastrointestinal disorder
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Gastrointestinal disorder
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x
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x
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x
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x
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x
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Gout
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Gout
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x
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x
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x
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Cardiac disorder
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Cardiac disorder
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x
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x
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Hepatitis
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Hepatitis
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x
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Immune system disorder
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Immune system disorder
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x
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x
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x
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Influenza
|
Influenza
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x
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Jaundice
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Jaundice
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x
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Nephrolithiasis
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Calculus of kidney
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x
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x
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x
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Liver disorder
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Liver disorder
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x
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Hepatocellular injury
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Liver disorder
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x
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Foetor hepaticus
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Liver disorder
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x
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Mediastinal disorder
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Mediastinal disorder
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x
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x
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Myositis
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Myositis
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x
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x
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x
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Nausea
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Nausea
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x
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Nervous system disorder
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Nervous system disorder
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x
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x
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Pain in extremity
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Pain in extremity
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x
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Rhabdomyolysis
|
Rhabdomyolysis
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x
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x
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x
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Rhinitis
|
Rhinitis
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x
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Convulsion
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Convulsion
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x
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x
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Musculoskeletal pain
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Shoulder pain
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x
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Muscle spasms
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Muscle spasms
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x
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Swelling
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Swelling
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x
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x
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x
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x
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x
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Loss of consciousness
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Loss of consciousness
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x
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x
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x
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Upper respiratory tract infection
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Upper respiratory tract infection
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x
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x
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Blood uric acid increased
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Uric acid level increased
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x
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x
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x
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Raised serum uric acid
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x
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x
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x
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Urinary tract infection
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Urinary tract infection
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x
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Urethral disorder
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Urinary tract disorder
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|
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x
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x
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x
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Urinary tract disorder
|
Urinary tract disorder
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|
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|
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|
|
x
|
x
|
x
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Angiopathy
|
Angiopathy
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|
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x
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x
|
x
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Vertigo
|
Vertigo
|
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x
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Hepatic failure
|
Hepatic failure
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|
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|
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|
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|
x
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Periorbital oedema
|
Periorbital oedema
|
|
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x
|
x
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x
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|
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|
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|
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Blood urea increased
|
Blood urea increased
|
|
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x
|
x
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x
|
x
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|
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Swelling face
|
Swelling face
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|
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x
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|
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Skin disorder
|
Unspecified disorder of skin and subcutaneous tissue
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|
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x
|
x
|
x
|
x
|
x
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Diabetes mellitus
|
Diabetic
|
|
|
|
x
|
x
|
x
|
x
|
x
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|
|
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Hepatobiliary disease
|
Hepatobiliary disease
|
|
|
|
|
|
|
|
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|
x
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Grand mal convulsion
|
Tonic-clonic seizures
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|
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x
|
x
|
x
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|
|
|
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|
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Blood potassium increased
|
Serum potassium increased
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
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Drug effect increased
|
Increased effect
|
|
|
|
|
|
x
|
|
|
|
|
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Laryngeal pain
|
Pharyngolaryngeal pain
|
|
|
|
|
|
x
|
|
|
|
|
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Insomnia
|
Insomnia
|
|
|
|
|
|
x
|
|
|
|
|
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Hypertension
|
Uncontrolled hypertension
|
|
|
x
|
x
|
x
|
|
|
|
|
|
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Indications
Information about indications was extracted from the indications and usage sections of the labels.
Side effects: | 32 |
Source: | FDA Structured Product Label |
---|
Side effects: | 29 |
Source: | FDA |
---|
Side effects: | 33 |
Source: | FDA Structured Product Label |
---|
Side effects: | 39 |
Source: | Health Canada |
---|
Side effects: | 12 |
Source: | EMA |
---|
Side effects: | 12 |
Source: | EMA |
---|
Side effects: | 27 |
Source: | EMA |
---|
Side effects: | 34 |
Source: | EMA |
---|
Side effects: | 40 |
Source: | EMA |
---|
Color scheme:
standard – alternative
|
|
100%
|
|
|
75%
|
|
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50%
|
|
|
10%
|
|
|
frequent (1% to 100%)
|
|
|
infrequent (0.1% to 1%)
|
|
|
rare (<0.1%)
|
|
|
postmarketing
|
|
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0%
|
|
|
no frequency information
|
|
|
not found on label
|