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Duloxetine

More information: STITCH, PubChem and possibly Wikipedia

ATC Code: N06AX21

Side effects

Options: Hide MedDRA Preferred Terms ,   display all 47 labels

MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Nausea Nausea 9% - 30% 7% - 11% x x x x x x x x x x x x x x x x x x x x
Headache Headache very common, 9% - 20% 8% - 15% x x x x x x x x x x x x x x x x x x x
Dry mouth Dry mouth 3% - 18% 3% - 6% x x x x x x x x x x x x x x x x x x x x
Constipation Constipation 2% - 15% 3% - 4% x x x x x x x x x x x x x x x x x x x x
Dizziness Dizziness 6% - 17% 5% - 7% x x x x x x x x x x x x x x x x x x x x
Syncope very rare, postmarketing x x x
Asthenia Fatigue 2% - 16% 5% - 8% x x x x x x x x x x x x x x x x x
Asthenia frequent, 2% - 8% 1% x x x x x x x x x x x x x
Fatigue Fatigue 2% - 16% 5% - 8% x x x x x x x x x x x x x x x x x
Insomnia Insomnia 5% - 16% 5% - 10% x x x x x x x x x x x x x x x x x
Somnolence Somnolence 5% - 21% 3% - 5% x x x x x x x x x x x x x x x x x x x x
Diarrhoea Diarrhoea 7% - 13% 5% - 8% x x x x x x x x x x x x x x x x x x x
Loose stools 2% - 3% 1% x x
Decreased appetite Decreased appetite 1% - 14% 1% - 2% x x x x x x x x x x x x x x x x x x x x
Anorexia 3% - 5% 1% x x x x x x x
Hyperhidrosis Hyperhidrosis 2% - 10% 1% - 2% x x x x x x x x x x x x x x x x x x x
Sweating increased x x x x
Abdominal pain Abdominal pain common — 2% - 6% 4% - 5% x x x x x x x x x x x x x x x x
Gastrointestinal pain Abdominal pain common — 2% - 6% 4% - 5% x x x x x x x x x x x x x x x x
Gastrointestinal pain x x x x x x
Neck pain Neck pain common x x x x x
Hypoglycaemia Hypoglycaemia infrequent, frequent x
Nasopharyngitis Nasopharyngitis 4% - 9% 4% - 5% x x x x x x x x x x x x x x x x x
Nervousness Nervousness common, frequent x x x x x x x x x
Feeling jittery infrequent, common x x x x x x x
Tension Nervousness common, frequent x x x x x x x x x
Tension infrequent, common x x
Nightmare Nightmare uncommon, frequent x x x x x x x
Skin ulcer Skin ulcer infrequent, frequent x
Myalgia Myalgia common, 1% - 4% 1% x x x x x x
Musculoskeletal discomfort Myalgia common, 1% - 4% 1% x x x x x x
Arthralgia x x x
Increased appetite Increased appetite infrequent, frequent x
Abdominal discomfort Upset stomach common x x x x
Abdominal discomfort x x x x x x
Initial insomnia Initial insomnia frequent x x x x x x x x
Middle insomnia Middle insomnia frequent x x x x x x x x
Feeling jittery Feeling jittery infrequent, common x x x x x x x
Libido decreased Libido decreased frequent, 1% - 6% 0% - 2% x x x x x x x x x x x x x x x x x x
Disturbance in sexual arousal Libido decreased frequent, 1% - 6% 0% - 2% x x x x x x x x x x x x x x x x x x
Muscle spasms Cramp muscle 4% - 5% 3% x x
Muscle spasms postmarketing — 2% - 4% 2% - 3% x x x x x x x x x x x x x x x x x
Upper respiratory tract infection Upper respiratory tract infection 3% - 7% 3% - 6% x x x x x x x x x x x x x x x x
Vomiting Vomiting 3% - 6% 2% - 4% x x x x x x x x x x x x x x x x x x x x
Agitation Agitation infrequent — 1% - 6% 1% - 3% x x x x x x x x x x x x x x x x
Erectile dysfunction Erectile dysfunction 0% - 5% 0% - 1% x x x x x x x x x x x x x x x x x x x
Anxiety Anxiety common — 3% 2% x x x x x x x x x x x x x x x x x
Back pain Back pain 2% - 5% 3% x x x x x x
Low back pain x x x x x x x x
Cough Cough 2% - 6% 2% - 4% x x x x x x x x x x x x x x x x x
Seasonal allergy Seasonal allergy 3% 2%
Rhinitis seasonal Seasonal allergy 3% 2%
Influenza Influenza 2% - 3% 2% x x x x x x x x x x x x x x x
Musculoskeletal pain Musculoskeletal pain postmarketing — 3% - 5% 3% - 4% x x x x x x x x x x x x x x
Tremor Tremor 0% - 5% 0% - 1% x x x x x x x x x x x x x x x x x x x
Urinary tract infection Urinary tract infection 3% 3%
Migraine Migraine 3% 3%
Ejaculation delayed Ejaculation delayed frequent, 2% - 3% 1% x x x x x x x x x x x x x x x x x x
Vision blurred Vision blurred postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x x x x x x x x x x x
Laryngeal pain Pharyngolaryngeal pain 1% - 6% 1% - 3% x x x
Pain Pain postmarketing, 4% 4% x x x
Dyspepsia Dyspepsia common — 2% - 5% 1% - 3% x x x x x x x x x x x x x x x x x x
Body temperature increased Body temperature increased 1% - 3% 1% x x
Orgasm abnormal Orgasm abnormal postmarketing — 2% - 4% 0% - 1% x x x x x x x x x x x x x x x x x x x
Palpitations Palpitations postmarketing — 2% 1% - 2% x x x x x x x x x x x x x x x x x x x x
Paraesthesia Paraesthesia postmarketing — 1% - 4% 2% - 4% x x x x x x x x x x x x x x x x x x
Penis disorder Penis disorder 2% 0%
Weight decreased Weight decreased postmarketing — 2% 1% x x x x x x x x x x x x x x
Yawning Yawning postmarketing — 2% 1% x x x x x x x x x x x x x x x x x
Viral diarrhoea Viral diarrhoea 2% 2%
Ejaculation disorder Ejaculation disorder uncommon — 2% - 4% 0% - 1% x x x x x x x x x x x x x x x x x x x
Blood pressure increased Blood pressure increased uncommon, 2% 1% x x x x x
Oropharyngeal pain Oropharyngeal pain postmarketing — 2% 2% x x x x x x x x x x x x x x
Pollakiuria Pollakiuria postmarketing — 1% - 5% 2% x x x x
Micturition urgency postmarketing, infrequent x x x x x x x x x x x x x x x x x
Alopecia Alopecia infrequent x x
Anaemia Anaemia infrequent x x
Ataxia Ataxia infrequent x
Atrial fibrillation Atrial fibrillation infrequent x x
Colitis Colitis rare, infrequent x x
Conjunctivitis Conjunctivitis infrequent
Dermatitis exfoliative Dermatitis exfoliative rare, infrequent x
Diverticulitis Diverticulitis rare, infrequent x
Eczema Eczema infrequent x x
Oedema Oedema infrequent x
Flushing Flushing postmarketing — 2% - 3% 1% x x x x x x x x x x x x x x x x x
Gingivitis Gingivitis rare, infrequent x x
Cardiac failure Cardiac failure rare, infrequent x
Cardiac failure congestive Cardiac failure congestive rare, infrequent x
Hypercholesterolaemia Hypercholesterolaemia infrequent x
Irritable bowel syndrome Irritable bowel syndrome infrequent x x
Functional gastrointestinal disorder Irritable bowel syndrome infrequent x x
Nephropathy Nephropathy rare, infrequent x
Leukopenia Leukopenia infrequent x x
Macular degeneration Macular degeneration rare, infrequent x
Mydriasis Mydriasis uncommon x x
Oliguria Oliguria rare, infrequent x
Phlebitis Phlebitis rare, infrequent x x
Prurigo Prurigo infrequent x
Retinal detachment Retinal detachment rare, infrequent x
Thrombocytopenia Thrombocytopenia postmarketing, infrequent x x x
Urinary incontinence Urinary incontinence infrequent x x
Urinary retention Urinary retention postmarketing — uncommon x x x x x
Bundle branch block right Bundle branch block right rare, infrequent x
Photopsia Photopsia rare, infrequent x
Oedema peripheral Oedema peripheral infrequent x x x
Sjogren's syndrome Syndrome sicca infrequent x
Gamma-glutamyltransferase increased Gamma-glutamyltransferase increased uncommon x
Liver function test abnormal Liver function test abnormal uncommon x
Muscular weakness Muscular weakness rare, infrequent x
Aspartate aminotransferase increased Aspartate aminotransferase increased postmarketing, uncommon x x
Alanine aminotransferase increased Alanine aminotransferase increased postmarketing, uncommon x x
Urinary hesitation Urinary hesitation infrequent — frequent x x x x x
Abdominal pain lower Abdominal pain lower infrequent x x x x x x x x
Pressure of speech Pressure of speech rare, infrequent x x
Abnormal dreams Abnormal dreams postmarketing — 2% - 3% 1% x x x x x x x x x x x x x x x x
Rash erythematous Rash erythematous infrequent x
Blood creatinine increased Blood creatinine increased rare, infrequent x
Hepatic enzyme increased Hepatic enzyme increased uncommon x x
Blood pressure systolic increased Blood pressure systolic increased uncommon x x
Blood pressure diastolic increased Blood pressure diastolic increased uncommon x x
Ejaculation failure Ejaculation failure uncommon x x x x x x x x
Epigastric discomfort Gastric irritation infrequent x
Lymphadenopathy Lymphadenopathy infrequent x x
Coordination abnormal Coordination abnormal infrequent
Influenza like illness Influenza like illness infrequent x
Impaired gastric emptying Impaired gastric emptying rare, infrequent x
Face oedema Face oedema rare, infrequent x x
Urine flow decreased Urine flow decreased rare, infrequent x x x x
Maculopathy Maculopathy rare, infrequent x
White blood cell count increased White blood cell count increased rare, infrequent x x
Oropharyngeal swelling Oropharyngeal swelling infrequent x
Oesophageal stenosis Oesophageal stenosis acquired infrequent x x
Oesophageal stenosis rare
Hyperkeratosis Hyperkeratosis rare, infrequent x
Hypersomnia Hypersomnia infrequent, frequent x x x
Sluggishness Sluggishness rare, infrequent x x
Musculoskeletal stiffness Musculoskeletal stiffness uncommon x
Haematochezia Blood in stool infrequent x x
Haematochezia postmarketing, rare x x x x x x x x x x x x x x
Coronary artery disease Coronary artery disease infrequent x
Hepatic steatosis Hepatic steatosis rare, infrequent x
Loss of libido Loss of libido infrequent x x x x x
Dysphagia Dysphagia postmarketing, infrequent x x x x
Hypertriglyceridaemia Hypertriglyceridaemia rare, infrequent x
Blood triglycerides increased Hypertriglyceridaemia rare, infrequent x
Aggression Aggression very rare, postmarketing x x x x x x x x x x x x x x x x x
Anaphylactic shock Anaphylactic shock very rare, postmarketing x x x x x x x x x x x x x x x x x
Anger Anger very rare, postmarketing x x x x x x x x x x x x x x x x x
Angioedema Angioedema very rare, postmarketing x x x x x x x x x x x x x x x x x
Mental disorder Mental disorder postmarketing x x x x x x x x x x x x x x x x x x x x
Breast disorder Breast disorder postmarketing x x x x x x x x x x x x x x x x x x x
Bruxism Bruxism postmarketing — uncommon x x x x x x x x x x x x x x x x x
Infection Infection postmarketing x x x x x x x x x x x x x x x x x x
Confusional state Confusional state postmarketing — uncommon x x x x x x x x x x x x x x x x
Feeling abnormal Confusional state postmarketing — uncommon x x x x x x x x x x x x x x x x
Malaise postmarketing — uncommon x x x x x x x x x x x x x x x x x
Feeling abnormal postmarketing — uncommon x x x x x x x x x x x x x x x x x
Connective tissue disorder Connective tissue disorder postmarketing x x x x x x x x x x x x x x x x x x
Dehydration Dehydration postmarketing — uncommon x x x x x x x x x x x x x x x x x x
Dermatitis contact Dermatitis contact postmarketing — uncommon x x x x x x x x x x x x x x x x
Diplopia Diplopia postmarketing, infrequent x x x x x x x x x x x x x x x x
Dysarthria Dysarthria postmarketing — infrequent x x x x x x x x x x x x x x x x
Osteoarthritis Dysarthria postmarketing — infrequent x x x x x x x x x x x x x x x x
Osteoarthritis x x x x x x x x
Dysgeusia Dysgeusia postmarketing — 3% 1% x x x x x x x x x x x x x x x x x
Dyskinesia Dyskinesia postmarketing — uncommon x x x x x x x x x x x x x x x x x
Dysuria Dysuria postmarketing — frequent x x x x x x x x x x x x x x x x x x x
Ear pain Ear pain postmarketing — uncommon x x x x x x x x x x x x x x x x x
Ecchymosis Ecchymosis postmarketing — infrequent x x x x x x x x x x x x x x x x x x
Endocrine disorder Endocrine disorder postmarketing x x x x x x x x x x x x x x x x x
Eructation Eructation postmarketing — uncommon x x x x x x x x x x x x x x x x x
Erythema multiforme Erythema multiforme postmarketing x x x
Stevens-Johnson syndrome very rare, postmarketing x x x x x
Dermatitis Rash postmarketing — 4% 2% x x x x x x x x x x x x x x x x x x x
Rash Rash postmarketing — 4% 2% x x x x x x x x x x x x x x x x x x x
Extrapyramidal disorder Extrapyramidal disorder very rare, postmarketing x x x x x x x x x x x x x x x x
Extrapyramidal symptoms
Eye disorder Eye disorder postmarketing, 3% 2% x x x x x x x x x x x x x x x x x x x x
Flatulence Flatulence postmarketing — frequent x x x x x x x x x x x x x x x x x
Gastritis Gastritis postmarketing — frequent x x x x x x x x x x x x x x x x x x x
Gastroenteritis Gastroenteritis postmarketing — uncommon x x x x x x x x x x x x x x x x x
Gastrointestinal disorder Gastrointestinal disorder postmarketing, 14% - 30% 9% x x x x x x x x x x x x x x x x x x x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage postmarketing — uncommon x x x x x x
Glaucoma Glaucoma very rare — infrequent x x x x x x x x x x x x x x x x
Angle closure glaucoma Angle closure glaucoma postmarketing x x
Breath odour Breath odour postmarketing — uncommon x x x x x x x x x x x x x x x x x
Hallucination Hallucination postmarketing, rare x x x x x x x x x x x x x x x x x
Cardiac disorder Cardiac disorder postmarketing, 2% 2% x x x x x x x x x x x x x x x x x x x
Blood disorder Blood disorder postmarketing x x
Haemorrhage Haemorrhage very rare, postmarketing x x x x x x x x x x x x x x x x
Haemoglobin Haemorrhage very rare, postmarketing x x x x x x x x x x x x x x x x
Hyperglycaemia Hyperglycaemia very rare, postmarketing x x x x x x x x x x x x x x x x x
Hyperlipidaemia Hyperlipidaemia postmarketing, infrequent x x x x x x x x x x x x x x x x
Hyperprolactinaemia Hyperprolactinaemia very rare, postmarketing x x x x x x x x x x x x x
Hypersensitivity Hypersensitivity very rare, postmarketing x x x x x x x x x x x x x x x x x
Hypertensive crisis Hypertensive crisis very rare — infrequent x x x x x x x x x x x x x x x x x x
Hypoaesthesia Hypoaesthesia postmarketing — frequent x x x x x x x x x x x x x x x x x
Hypoaesthesia facial x x x x
Orthostatic hypotension Orthostatic hypotension very rare — uncommon x x x x x x x x x x x x x x x x x x
Hypothyroidism Hypothyroidism postmarketing — infrequent x x x x x x x x x x x x x x x x x
Immune system disorder Immune system disorder postmarketing x x x
Irritability Irritability postmarketing — frequent x x x x x x x x x x x x x x x x x x x x
Laryngitis Laryngitis postmarketing — uncommon x x x x x x x x x x x x x x x x x
Lethargy Lethargy postmarketing — frequent x x x x x x x x x x x x x x x x x x x
Mediastinal disorder Mediastinal disorder postmarketing, 2% 1% x x x x x x x x x x x x x x x x x x x
Melaena Melaena postmarketing — infrequent x x x x x x x x x x x x x
Menstrual disorder Menstrual disorder postmarketing, rare x x x x
Myocardial infarction Myocardial infarction postmarketing, infrequent x x x x x x x x x x x x x x x x x
Acute coronary syndrome Myocardial infarction postmarketing, infrequent x x x x x x x x x x x x x x x x x
Myoclonus Myoclonus postmarketing — infrequent x x x x x x x x x x x x x x x x x
Nervous system disorder Nervous system disorder postmarketing x x x x x x x x x x x x x x x x x x x x
Night sweats Night sweats postmarketing — frequent x x x x x x x x x x x x x x x x x x x
Nocturia Nocturia postmarketing — uncommon x x x x x x x x x x x x x x x x x
Polyuria Polyuria postmarketing — uncommon x x x x x x x x x x x x x x x x x
Urine output increased Polyuria postmarketing — uncommon x x x x x x x x x x x x x x x x x
Pruritus Pruritus postmarketing — 3% 2% x x x x x x x
Restless legs syndrome Restless legs syndrome very rare, postmarketing x x x x x x x x x x x x x x x x
Convulsion Convulsion very rare, postmarketing x x x x x x x x x x x x x x x x x
Stevens-Johnson syndrome Stevens-Johnson syndrome very rare, postmarketing x x x x x
Gastric ulcer Gastric ulcer postmarketing — infrequent x x x x x x x x x x x x x x x x x
Stomatitis Stomatitis postmarketing — uncommon x x x x x x x x x x x x x x x x x x
Aphthous stomatitis Aphthous stomatitis rare
Suicide attempt Suicide attempt postmarketing, infrequent x x x x x x x x x x x x x x x x x
Tachycardia Tachycardia postmarketing — uncommon x x x x x x x x x x x x x x x x
Testicular pain Testicular pain postmarketing, infrequent x x
Thirst Thirst postmarketing — uncommon x x x x x x x x x x x x x x x x x x
Tinnitus Tinnitus postmarketing — uncommon x x x x x x x x x x x x x x x x x
Trismus Trismus very rare, postmarketing x x x x x x x x x x x x x x x x x
Erythema Erythema postmarketing, infrequent x x x x x x x x x x x x x x x x x
Urethral disorder Urinary tract disorder postmarketing x x x x x x x x x x x x
Urinary tract disorder Urinary tract disorder postmarketing x x x x x x x x x x x x
Urticaria Urticaria very rare, postmarketing x x x x x x x x x x x x x x x x x
Angiopathy Angiopathy postmarketing, 2% - 3% 1% x x x x x x x x x x x x x x x x x x x x
Vertigo Vertigo postmarketing — frequent x x x x x x x x x x x x x x x x x x
Weight increased Weight increased postmarketing — 2% 1% x x x x x x x x x x x x x x x x x x x x
Chills Chills postmarketing — frequent x x x x x x x x x x x x x x x x x
Rigors postmarketing — frequent x x x x x x x x x x x x x x x x x
Micturition urgency Micturition urgency postmarketing, infrequent x x x x x x x x x x x x x x x x x
Apathy Apathy postmarketing — uncommon x x x x x x x x x x x x x x x x x
Flat affect Apathy postmarketing — uncommon x x x x x x x x x x x x x x x x x
Mood swings Mood swings postmarketing, infrequent x x x x x x x x x x x x x x x x x
Affect lability Mood swings postmarketing, infrequent x x x x x x x x x x x x x x x x x
Malnutrition Malnutrition postmarketing, 7% - 9% 1% - 2% x x x x x x x x x x x x x x x x x x x x
Photosensitivity reaction Photosensitivity reaction postmarketing — uncommon x x x x x x x x x x x x x x x x x x x
Skin disorder Unspecified disorder of skin and subcutaneous tissue postmarketing, 6% 1% - 2% x x x x x x x x x x x x x x x x x x x x
Malaise Malaise postmarketing — uncommon x x x x x x x x x x x x x x x x x
Discomfort Malaise postmarketing — uncommon x x x x x x x x x x x x x x x x x
Ill-defined disorder Malaise postmarketing — uncommon x x x x x x x x x x x x x x x x x
Muscle twitching Muscle twitching postmarketing — frequent x x x x x x x x x x x x x x x x x
Cold sweat Cold sweat postmarketing — uncommon x x x x x x x x x x x x x x x x x x x
Disorientation Disorientation postmarketing — uncommon x x x x x x x x x x x x x x x x x
Disturbance in attention Disturbance in attention postmarketing — uncommon x x x x x x x x x x x x x x x x
Anorgasmia Anorgasmia postmarketing, frequent x x x x x x x x x x x x x x x x x x x
Galactorrhoea Galactorrhoea very rare, postmarketing x x x x x x x x x x x x x
Pharyngeal oedema Pharyngeal oedema rare
Throat tightness Throat tightness postmarketing — uncommon x x x x x x x x x x x x x x x x x
Menopausal symptoms Menopausal symptoms postmarketing — uncommon x x x x x x x x x x x x x x x x x
Hot flush postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x x x x x x x x x x
Dyslipidaemia Dyslipidaemia postmarketing — infrequent x x x x x x x x x x x x x x x x
Hepatobiliary disease Hepatobiliary disease postmarketing x x x x
Peripheral coldness Peripheral coldness postmarketing — uncommon x x x x x x x x x x x x x x x x x
Urine odour abnormal Urine odour abnormal postmarketing — infrequent x x x x x x x x x x x x x x x x x
Blood bilirubin increased Blood bilirubin increased very rare — uncommon x x
Dry eye Dry eye postmarketing — uncommon x x x x
Mania Mania very rare — infrequent x x x x x
Increased tendency to bruise Increased tendency to bruise postmarketing, infrequent x x x x x x x x x x x x x x x x x x
Arrhythmia supraventricular Arrhythmia supraventricular very rare, postmarketing x x x x x x x x x x x x x x x x
Visual impairment Visual disturbance postmarketing, infrequent x x x x x x x x x x x x x
Visual impairment postmarketing — uncommon x x x x
Sexual dysfunction Sexual dysfunction postmarketing — uncommon x x x x x x x x x x x x x