Duloxetine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

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MedDRA Preferred Term Side effect Data for drug Placebo Labels (show all 14)
1 2 3 4 5 6 7 8 9 10
Nausea def Nausea def 14% - 30% 7% - 11% x x x x x x x x x x
Somnolence def Somnolence def 7% - 21% 3% - 5% x x x x x x x x x x
Headache def Headache def 13% - 20% 9% - 13% x x x x x x x x x
Dry mouth def Dry mouth def 5% - 18% 3% - 6% x x x x x x x x x x
Dizziness def Dizziness def 6% - 17% 5% - 7% x x x x x x x x x x
Syncope def postmarketing x
Constipation def Constipation def 5% - 15% 3% - 4% x x x x x x x x x x
Diarrhoea def Diarrhoea def 2% - 13% 1% - 8% x x x x x x x x x
Decreased appetite Decreased appetite 3% - 11% 1% - 2% x x x x x x x x x x
Anorexia def 3% - 5% 1% x x x x x x x x x
Nasopharyngitis def Nasopharyngitis def 4% - 9% 4% - 5% x x x x x x x x x
Asthenia def Asthenia def frequent, 2% - 8% 1% x x x x x x x x x
Weakness def rare, infrequent x x x
Hyperhidrosis def Hyperhidrosis def 6% - 8% 1% - 2% x x x x x x x x x
Sweating def postmarketing — frequent x x x x x x x x x x
Sweating increased x x x x x
Infection def Infection def postmarketing, 3% - 7% 3% - 6% x x x x x x x x x x
Respiratory tract infection def Respiratory tract infection def 4% - 7% 4% - 6% x x x x x x x x x
Upper respiratory tract infection def Upper respiratory tract infection def 4% - 7% 4% - 6% x x x x x x x x x
Abdominal pain def Abdominal pain def infrequent — 4% - 6% 4% - 5% x x x x x x x x x
Gastrointestinal pain def Abdominal pain def infrequent — 4% - 6% 4% - 5% x x x x x x x x x
Gastrointestinal pain def x x x x x x
Cough def Cough def 3% - 6% 2% - 4% x x x x x x x x x
Vomiting def Vomiting def 3% - 6% 2% - 4% x x x x x x x x x x
Oropharyngeal pain Pharyngolaryngeal pain def 1% - 6% 1% - 3% x x x x x x
Libido decreased def Libido decreased def frequent, 2% - 4% 1% x x x x x x x x x
Disturbance in sexual arousal Libido decreased def frequent, 2% - 4% 1% x x x x x x x x x
Dysgeusia def Dysgeusia def postmarketing — 3% 1% x x x x x x x
Dyspepsia def Dyspepsia def frequent, 2% - 5% 1% - 3% x x x x x x x x x
Dysuria def Dysuria def postmarketing — frequent x x x x x x x x x
Dermatitis def Rash def postmarketing — 4% 2% x x x x x x x x x
Dermatitis def rare — infrequent x x x x x x x x
Rash def Rash def postmarketing — 4% 2% x x x x x x x x x
Flatulence def Flatulence def postmarketing, frequent x x x x x x
Flushing def Flushing def postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x
Gastritis def Gastritis def postmarketing — frequent x x x x x x x x x
Hypoaesthesia def Hypoaesthesia def postmarketing, frequent x x x x x x x x x
Hypoglycaemia def Hypoglycaemia def infrequent, frequent x x x
Lethargy def Lethargy def postmarketing, frequent x x x x x x x x x
Muscle spasms def Cramp muscle def 4% - 5% 3% x x x x x
Muscle spasms def postmarketing, 3% - 4% 2% - 3% x x x x x x
Nervousness def Nervousness def frequent x x x x x x x x x
Feeling jittery infrequent x x x x x x x x
Tension def Nervousness def frequent x x x x x x x x x
Night sweats def Night sweats def postmarketing — frequent x x x x x x x x x
Nightmare def Nightmare def frequent x x x x x x x x x
Orgasm abnormal def Orgasm abnormal def postmarketing — 2% - 3% 1% x x x x x x x x x
Palpitations def Palpitations def postmarketing — 2% 2% x x x x x x x x x x
Paraesthesia def Paraesthesia def postmarketing — 2% - 4% 2% - 4% x x x x x x x
Pruritus def Pruritus def postmarketing — 3% 2% x x x x x x x x
Skin ulcer def Skin ulcer def infrequent, frequent x x
Tremor def Tremor def 0% - 5% 0% - 1% x x x x x x x x x
Ulcer def Ulcer def rare — frequent x x x x x x x x x
Pollakiuria def Pollakiuria def 1% - 5% 2% x x x x x x
Micturition urgency def postmarketing, infrequent x x x x x x x x x
Vertigo def Vertigo def postmarketing, frequent x x x x x x x x
Weight increased def Weight increased def postmarketing — 2% 1% x x x x x x x x x
Weight decreased def Weight decreased def postmarketing — 2% 1% x x x x x x x x x
Yawning def Yawning def postmarketing — 2% 1% x x x x x x x
Chills def Chills def postmarketing, frequent x x x x x x
Rigors postmarketing — frequent x x x x x x x x
Urinary hesitation Urinary hesitation infrequent, frequent x x x x x
Muscle twitching def Muscle twitching def postmarketing — frequent x x x x x x x
Increased appetite Increased appetite infrequent, frequent x x x
Anorgasmia def Anorgasmia def postmarketing, frequent x x x x x x x x x x
Ejaculation delayed Ejaculation delayed frequent, 3% 1% x x x x x x x x x
Abnormal dreams Abnormal dreams postmarketing — 2% - 3% 1% x x x x x x
Ejaculation disorder def Ejaculation disorder def frequent, 2% - 4% 0% - 1% x x x x x x x x x
Erectile dysfunction def Erectile dysfunction def 0% - 5% 0% - 1% x x x x x x x x x
Vision blurred def Vision blurred def postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x
Initial insomnia Initial insomnia frequent x x x x x x x x x
Middle insomnia Middle insomnia frequent x x x x x x x x x
Menopausal symptoms def Hot flush def postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x
Menopausal symptoms def postmarketing, infrequent x x x x x x
Hot flush def Hot flush def postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x
Sleep disorder def Sleep disorder def postmarketing — 3% 2% x x x x x x x x x
Muscle tightness Muscle tightness postmarketing — frequent x x x x x x x
Myalgia def Myalgia def 1% - 4% 1% x x x x x x x x
Musculoskeletal discomfort Myalgia def 1% - 4% 1% x x x x x x x x
Arthralgia def x x x x x
Body temperature increased def Body temperature increased def 1% - 3% 1% x x x x x
Seasonal allergy def Seasonal allergy def 3% 2% x x
Rhinitis seasonal Seasonal allergy def 3% 2% x x
Hypersensitivity def Hypersensitivity def postmarketing, 3% 2% x x x x x x
Influenza def Influenza def infrequent, 2% - 3% 2% x x x x x x x x
Urinary tract infection def Urinary tract infection def 3% 3% x x
Migraine def Migraine def 3% 3% x x
Gastroenteritis def Gastroenteritis def postmarketing — 2% 2% x x x x x x x
Penis disorder def Penis disorder def 2% 0% x x
Viral diarrhoea Viral diarrhoea 2% 2% x x
Alopecia def Alopecia def infrequent x x x x
Anaemia def Anaemia def infrequent x x x x
Ataxia def Ataxia def infrequent x x
Atrial fibrillation def Atrial fibrillation def infrequent x x x
Mental disorder def Mental disorder def postmarketing, infrequent x x x x x x x x x x
Bruxism def Bruxism def postmarketing, infrequent x x x x x x x
Bundle branch block def Bundle branch block def rare, infrequent x x x
Colitis def Colitis def rare, infrequent x x x x
Confusional state def Confusional state def postmarketing, infrequent x x x x x x
Feeling abnormal Confusional state def postmarketing, infrequent x x x x x x
Malaise def postmarketing, infrequent x x x x x x x
Feeling abnormal postmarketing, infrequent x x x x x x x
Conjunctivitis def Conjunctivitis def infrequent x
Connective tissue disorder def Connective tissue disorder def rare — infrequent x x x x x x x x
Dysphagia def Dysphagia def infrequent x x x x
Dehydration def Dehydration def postmarketing, infrequent x x x x x x x x
Dermatitis exfoliative def Dermatitis exfoliative def rare, infrequent x x x
Diplopia def Diplopia def postmarketing, infrequent x x x x x x x x
Diverticulitis def Diverticulitis def rare, infrequent x x x
Dysarthria def Dysarthria def rare — infrequent x x x x x x x x
Osteoarthritis def Dysarthria def rare — infrequent x x x x x x x x
Dyskinesia def Dyskinesia def postmarketing, infrequent x x x x x x
Ear pain def Ear pain def postmarketing, infrequent x x x x x x
Ecchymosis def Ecchymosis def rare — infrequent x x x x x x x x x
Eczema def Eczema def infrequent x x x x
Oedema def Oedema def postmarketing — infrequent x x x x x x x x x x
Eructation def Eructation def postmarketing, infrequent x x x x x x x
Oesophageal disorder def Oesophageal disorder def rare, infrequent x x x x
Oesophageal stenosis def Oesophageal stenosis def rare, infrequent x x x x
Gingivitis def Gingivitis def rare, infrequent x x x x
Glaucoma def Glaucoma def postmarketing — infrequent x x x x x x x x
Breath odour def Breath odour def postmarketing, infrequent x x x x x x
Cardiac failure def Cardiac failure def rare, infrequent x x x
Cardiac failure congestive def Cardiac failure congestive def rare, infrequent x x x
Hypercholesterolaemia def Hypercholesterolaemia def infrequent x x x
Hyperlipidaemia def Hyperlipidaemia def postmarketing, infrequent x x x x x x x x
Hypertensive crisis Hypertensive crisis postmarketing — infrequent x x x x x x x x
Hypertriglyceridaemia def Hypertriglyceridaemia def rare, infrequent x
Blood triglycerides increased Hypertriglyceridaemia def rare, infrequent x
Hypotension def Hypotension def postmarketing, infrequent x x x x x x x
Orthostatic hypotension def Orthostatic hypotension def postmarketing, infrequent x x x x x x x
Incontinence def Incontinence def infrequent x x x x
Infarction def Infarction def postmarketing, infrequent x x x x x x x x
Intestinal functional disorder Irritable bowel syndrome def infrequent x x x x
Irritable bowel syndrome def Irritable bowel syndrome def infrequent x x x x
Nephropathy def Nephropathy def rare, infrequent x x x
Laryngitis def Laryngitis def postmarketing, infrequent x x x x x x
Leukopenia def Leukopenia def rare, infrequent x x x x
Macular degeneration def Macular degeneration def rare, infrequent x x
Mediastinal disorder def Mediastinal disorder def postmarketing, infrequent x x x x x x x x x
Melaena def Melaena def rare — infrequent x x x x x x
Menopause def Menopause def postmarketing, infrequent x x x x x x
Myocardial infarction def Myocardial infarction def postmarketing, infrequent x x x x x x x x
Acute coronary syndrome def Myocardial infarction def postmarketing, infrequent x x x x x x x x
Myoclonus def Myoclonus def postmarketing, infrequent x x x x x x
Nocturia def Nocturia def postmarketing, infrequent x x x x x x x
Oliguria def Oliguria def rare, infrequent x x x
Phlebitis def Phlebitis def rare, infrequent x x x x
Prurigo def Prurigo def infrequent x x
Retinal detachment def Retinal detachment def rare, infrequent x x
Gastric ulcer def Gastric ulcer def rare — infrequent x x x x x x x x
Stomatitis def Stomatitis def rare — infrequent x x x x x x x x
Swelling def Swelling def infrequent x x
Tachycardia def Tachycardia def postmarketing, infrequent x x x x x x x x
Thirst def Thirst def postmarketing, infrequent x x x x x x x x
Thrombocytopenia def Thrombocytopenia def rare, infrequent x x x x
Erythema def Erythema def postmarketing, infrequent x x x x x x x x x
Urinary incontinence def Urinary incontinence def infrequent x x x x
Angiopathy def Angiopathy def rare — infrequent x x x x x x x x x x
Urinary retention def Urinary retention def postmarketing, infrequent x x x x
Micturition urgency def Micturition urgency def postmarketing, infrequent x x x x x x x x x
Bundle branch block right def Bundle branch block right def rare, infrequent x x x
Apathy def Apathy def postmarketing, infrequent x x x x x x
Flat affect Apathy def postmarketing, infrequent x x x x x x
Mood swings Mood swings postmarketing, infrequent x x x x x x x x x
Affect lability Mood swings postmarketing, infrequent x x x x x x x x x
Photopsia Photopsia rare, infrequent x x x
Oedema peripheral def Oedema peripheral def infrequent x x x x x
Sicca syndrome def Sicca syndrome def infrequent x x
Blood creatinine increased Creatinine increased def rare, infrequent x x x
Muscular weakness def Muscular weakness def rare, infrequent x x x
Photosensitivity reaction def Photosensitivity reaction def postmarketing, infrequent x x x x x x x x
Photosensitivity def postmarketing, infrequent x x x x x x x x x
Malaise def Sickness infrequent x x x
Malaise def postmarketing, infrequent x x x x x x x
Discomfort def Malaise def postmarketing, infrequent x x x x x x x
Discomfort def x x x x x x
Ill-defined disorder Malaise def postmarketing, infrequent x x x x x x x
Cardiac fibrillation Cardiac fibrillation infrequent x x x
Cold sweat Cold sweat postmarketing, infrequent x x x x x x x x x
Abdominal pain lower Abdominal pain lower infrequent x x x x x x x x
Disorientation Disorientation postmarketing, infrequent x x x x x x x
Disturbance in attention Disturbance in attention postmarketing, infrequent x x x x
Pressure of speech Pressure of speech rare, infrequent x x x x
Rash erythematous Rash erythematous infrequent x x
Throat tightness Throat tightness postmarketing, infrequent x x x x x
Dyslipidaemia def Dyslipidaemia def rare — infrequent x x x x x x x x
Peripheral coldness Peripheral coldness postmarketing, infrequent x x x x x x x
Urine odour abnormal Urine odour abnormal postmarketing, infrequent x x x x x
Mania def Mania def rare, infrequent x x x x
Abdominal discomfort Gastric irritation infrequent x x
Abdominal discomfort x x x x x x
Upset stomach x x x x
Increased tendency to bruise Increased tendency to bruise postmarketing, infrequent x x x x x x x x
Lymphadenopathy def Lymphadenopathy def infrequent x x x x
Coordination abnormal Coordination abnormal infrequent x
Impaired gastric emptying Impaired gastric emptying rare, infrequent x x x
Dissociation Detachment psychological rare, infrequent x x
Face oedema def Face oedema def rare, infrequent x x x x
Visual impairment def Visual disturbance postmarketing, infrequent x x x x x
Visual impairment def postmarketing x
Feeling jittery Feeling jittery infrequent x x x x x x x x
Urine flow decreased Urine flow decreased infrequent x x x
Blood cholesterol increased Blood cholesterol increased postmarketing, infrequent x x x x x x x
Acne def Acne def infrequent x x x x
Aortic dissection def Dissecting aortic aneurysm, thoracic postmarketing, infrequent x x x x x x x x x
Maculopathy Maculopathy rare, infrequent x x x
White blood cell count increased def White blood cell count increased def rare, infrequent
Feeling cold Coldness postmarketing, infrequent x x x x x x x
Completed suicide Completed suicide rare — infrequent x x x x x x x x x
Arterial disorder def Arterial disorder def infrequent x x
Hypertension def Hypertensive postmarketing — infrequent x x x x x x x x
Hyperkeratosis def Hyperkeratosis def rare, infrequent x x
Sluggishness Sluggishness rare, infrequent x x x x
Urine output Urine output rare, infrequent x x x
Haematochezia def Blood in stool infrequent x x
Haematochezia def rare, postmarketing x x x x x
Coronary artery disease def Coronary artery disease def infrequent x x
Hepatic steatosis def Hepatic steatosis def rare, infrequent x x x
Feeling hot Feeling hot postmarketing, infrequent x x x x x x x
Loss of libido Loss of libido infrequent x x x x x x
Aggression def Aggression def postmarketing x x x x x
Anaphylactic shock def Anaphylactic shock def postmarketing x x x x x x x
Anger def Anger def postmarketing x x x x x
Angioedema def Angioedema def postmarketing x x x x x x
Arrhythmia def Arrhythmia def postmarketing x x x x x x
Breast disorder def Breast disorder def postmarketing x x x x x x x x
Dermatitis contact def Dermatitis contact def postmarketing x x x x x
Endocrine disorder def Endocrine disorder def postmarketing x x x x x
Hormone level abnormal Endocrine disorder def postmarketing x x x x x
Erythema multiforme def Erythema multiforme def postmarketing x x x x x
Extrapyramidal disorder def Extrapyramidal disorder def postmarketing x x x x x x x
Eye disorder def Eye disorder def postmarketing x x x x x x x x x x
Gastrointestinal disorder def Gastrointestinal disorder def rare, postmarketing x x x x x x x x x x
Gastrointestinal haemorrhage def Gastrointestinal haemorrhage def postmarketing x
Hallucination def Hallucination def postmarketing x x x x x x x
Cardiac disorder def Cardiac disorder def postmarketing x x x x x x x x
Haemorrhage def Haemorrhage def postmarketing x x x x x
Haemoglobin def Haemorrhage def postmarketing x x x x x
Hepatitis def Hepatitis def postmarketing x
Hyperglycaemia def Hyperglycaemia def postmarketing x x x x x x
Hyperprolactinaemia def Hyperprolactinaemia def postmarketing x
Hyponatraemia def Hyponatraemia def postmarketing x
Hypothyroidism def Hypothyroidism def postmarketing x x x x x
Inappropriate antidiuretic hormone secretion def Inappropriate antidiuretic hormone secretion def postmarketing x
Jaundice def Jaundice def postmarketing x
Menstrual disorder def Menstrual disorder def postmarketing x
Nervous system disorder def Nervous system disorder def postmarketing x x x x x x x x x x
Polyuria def Polyuria def postmarketing x x x x x
Urine output increased Polyuria def postmarketing x x x x x
Restless legs syndrome def Restless legs syndrome def postmarketing x x x x x
Convulsion def Seizures def postmarketing x x x x x
Aphthous stomatitis def Aphthous stomatitis def rare x
Shock def Syncope def postmarketing x
Syncope def Syncope def postmarketing x
Loss of consciousness def Syncope def postmarketing x
Tinnitus def Tinnitus def postmarketing x x x x x
Trismus def Trismus def postmarketing x x x x x x
Urethral disorder def Urinary tract disorder def postmarketing x x x x x x x x x x
Urinary tract disorder def Urinary tract disorder def postmarketing x x x x x x x x x x
Urticaria def Urticaria def postmarketing x x x x x x x
Visual acuity reduced Visual impairment def postmarketing x
Blindness def Visual impairment def postmarketing x
Blood alkaline phosphatase increased def Phosphatase alkaline increased postmarketing x
Aspartate aminotransferase increased def Aspartate aminotransferase increased def postmarketing x
Alanine aminotransferase increased def Alanine aminotransferase increased def postmarketing x
Galactorrhoea Galactorrhoea postmarketing x
Pharyngeal oedema Pharyngeal oedema rare x
Blood bilirubin increased def Blood bilirubin increased def postmarketing x
Dry eye Dry eye postmarketing x
Arrhythmia supraventricular def Arrhythmia supraventricular def postmarketing x x x x x
Sexual dysfunction Sexual dysfunction postmarketing x x x x x x x x x
Gait disturbance def Gait disturbance def postmarketing x x x x x
Infestation Infestation NOS postmarketing x x x x x x x x x
Arthralgia def Arthralgia def x x x x x
Neck pain def Neck pain def x x x x
Diabetes mellitus def Diabetes mellitus def x x x x x
Immune system disorder def Immune system disorder def x x
Pain in extremity def Pain in extremity def x x
Pharyngitis def Pharyngitis def x x x x x
Gastric disorder def Gastric disorder def x x x x
Abdominal pain upper Abdominal pain upper x x x x x x x x x
Abdominal tenderness Abdominal tenderness x x x x x x
Tenderness def Tenderness def x x x x x x
Blood pressure diastolic decreased Blood pressure diastolic decreased x
Ejaculation failure Ejaculation failure x x x x x x x x x
Agitation def Hyperkinesia def x x
Hyperkinesia def Hyperkinesia def x x
Blood pressure increased Blood pressure increased x x x x x
Paraesthesia oral Paraesthesia oral x x
Terminal insomnia Terminal insomnia x x x x x x
Sedation Sedation x x x x x x
Female sexual dysfunction Female sexual dysfunction x x x
Indication Labels
Agitation def x x x x x x x x x
Anxiety def x x x x x x
Anxiety disorder def x x x x x x
Back pain def x x x
Bradypsychic response x x x x x x x x
Cerebration impaired def x x x x x x x x x
Chronic pain def x x x
Decreased interest x x x x x x x
Depressed mood def x x x x x x x x x
Depressive disorder def x x x x x x x x x x
Depressive episode x x x x x x x x x
Diabetic peripheral neuropathic pain x x x x x x x x
Diabetic peripheral neuropathy x x x x x x
Dysphoria x x x x x x x x x
Fatigue def x x x x x x x x x
Feeling guilty def x x x x x x x x x
Fibromyalgia def x x x x x
Generalised anxiety disorder def x x x x x x
Hypersomnia def x x x x x x x x x
Insomnia def x x x x x x x x x
Irritability def x x x x x x
Low back pain def x x x
Major depression def x x x x x x x x x x
Major depressive disorder, single episode x x x x x x x x x
Muscle tension x x x x x x
Musculoskeletal pain def x x x
Neuralgia def x x x x x x x x x
Neuropathy def x x x x x x x x x
Neuropathy peripheral def x x x x x x x x x
Osteoarthritis def x x x
Pain def x x x x x x x x x
Sleep disturbance x x x x x
Suicidal ideation def x x x x x x x
Suicide def x x x x x x x x x
Suicide attempt def x x x x x x x x x
Tension def x x x x x x
Worry def x x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N06AX21

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. DULOXETINE (DULOXETINE HYDROCHLORIDE) / CYMBALTA : 76 side effects (Health Canada)
  2. DULOXETINE HYDROCHLORIDE / CYMBALTA : 91 side effects (Drugs@FDA)
  3. DULOXETINE : 125 side effects (FDA XML label)
  4. duloxetine hydrochloride / Cymbalta : 153 side effects (FDA MedWatch)
  5. Duloxetine : 164 side effects (FDA XML label)
  6. Duloxetine : 168 side effects (FDA XML label)
  7. DULOXETINE : 170 side effects (FDA XML label)
  8. Duloxetine : 171 side effects (FDA XML label)
  9. DULOXETINE HYDROCHLORIDE / CYMBALTA : 196 side effects (Drugs@FDA)
  10. DULOXETINE HYDROCHLORIDE / CYMBALTA : 205 side effects (Drugs@FDA)