Duloxetine

Side effects and indications

Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.) Information about indications was extracted from the indications and usage sections of the labels.

Show MedDRA Preferred Terms

Side effect Data for drug Placebo Labels (show all 14)
1 2 3 4 5 6 7 8 9 10
Nausea def 14% - 30% 7% - 11% x x x x x x x x x x
Somnolence def 7% - 21% 3% - 5% x x x x x x x x x x
Headache def 13% - 20% 9% - 13% x x x x x x x x x
Dry mouth def 5% - 18% 3% - 6% x x x x x x x x x x
Dizziness def 6% - 17% 5% - 7% x x x x x x x x x x
Constipation def 5% - 15% 3% - 4% x x x x x x x x x x
Diarrhoea def 2% - 13% 1% - 8% x x x x x x x x x
Decreased appetite 3% - 11% 1% - 2% x x x x x x x x x x
Nasopharyngitis def 4% - 9% 4% - 5% x x x x x x x x x
Asthenia def frequent, 2% - 8% 1% x x x x x x x x x
Hyperhidrosis def 6% - 8% 1% - 2% x x x x x x x x x
Infection def postmarketing, 3% - 7% 3% - 6% x x x x x x x x x x
Respiratory tract infection def 4% - 7% 4% - 6% x x x x x x x x x
Upper respiratory tract infection def 4% - 7% 4% - 6% x x x x x x x x x
Abdominal pain def infrequent — 4% - 6% 4% - 5% x x x x x x x x x
Cough def 3% - 6% 2% - 4% x x x x x x x x x
Vomiting def 3% - 6% 2% - 4% x x x x x x x x x x
Pharyngolaryngeal pain def 1% - 6% 1% - 3% x x x x x x
Anorexia def 3% - 5% 1% x x x x x x x x x
Libido decreased def frequent, 2% - 4% 1% x x x x x x x x x
Dysgeusia def postmarketing — 3% 1% x x x x x x
Dyspepsia def frequent, 2% - 5% 1% - 3% x x x x x x x x x
Dysuria def postmarketing — frequent x x x x x x x x x
Rash def postmarketing — 4% 2% x x x x x x x x x
Flatulence def postmarketing, frequent x x x x x
Flushing def postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x
Gastritis def postmarketing — frequent x x x x x x x x x
Hypoaesthesia def postmarketing, frequent x x x x x x x x x
Hypoglycaemia def infrequent, frequent x x x x
Lethargy def postmarketing, frequent x x x x x x x x x
Cramp muscle def 4% - 5% 3% x x x x x
Nervousness def frequent x x x x x x x x x
Night sweats def postmarketing — frequent x x x x x x x x x
Nightmare def frequent x x x x x x x x x
Orgasm abnormal def postmarketing — 2% - 3% 1% x x x x x x x x x
Palpitations def postmarketing — 2% 2% x x x x x x x x x x
Paraesthesia def postmarketing — 2% - 4% 2% - 4% x x x x x x
Pruritus def postmarketing — 3% 2% x x x x x x x x
Skin ulcer def infrequent, frequent x x
Sweating def postmarketing — frequent x x x x x x x x x x
Tremor def 0% - 5% 0% - 1% x x x x x x x x x
Ulcer def rare — frequent x x x x x x x x x
Pollakiuria def 1% - 5% 2% x x x x x x
Vertigo def postmarketing, frequent x x x x x x x
Weight increased def postmarketing — 2% 1% x x x x x x x x x
Weight decreased def postmarketing — 2% 1% x x x x x x x x x
Yawning def postmarketing — 2% 1% x x x x x x
Chills def postmarketing, frequent x x x x x
Urinary hesitation infrequent, frequent x x x x x x
Muscle twitching def postmarketing — frequent x x x x x x
Increased appetite infrequent, frequent x x x x
Anorgasmia def postmarketing, frequent x x x x x x x x x x
Ejaculation delayed frequent, 3% 1% x x x x x x x x x
Abnormal dreams postmarketing — 2% - 3% 1% x x x x x
Ejaculation disorder def frequent, 2% - 4% 0% - 1% x x x x x x x x x
Erectile dysfunction def 0% - 5% 0% - 1% x x x x x x x x x
Vision blurred def postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x
Initial insomnia frequent x x x x x x x x x
Middle insomnia frequent x x x x x x x x x
Rigors postmarketing — frequent x x x x x x x x
Hot flush def postmarketing — 2% - 3% 1% - 2% x x x x x x x x x x
Sleep disorder def postmarketing — 3% 2% x x x x x x x x x
Muscle tightness postmarketing — frequent x x x x x x
Muscle spasms def postmarketing, 3% - 4% 2% - 3% x x x x x
Myalgia def 1% - 4% 1% x x x x x x x x
Body temperature increased def 1% - 3% 1% x x x x x
Seasonal allergy def 3% 2% x
Hypersensitivity def postmarketing, 3% 2% x x x x x
Influenza def infrequent, 2% - 3% 2% x x x x x x x x
Urinary tract infection def 3% 3% x
Migraine def 3% 3% x
Gastroenteritis def postmarketing — 2% 2% x x x x x x
Penis disorder def 2% 0% x
Viral diarrhoea 2% 2% x
Alopecia def infrequent x x x x x
Anaemia def infrequent x x x x x
Ataxia def infrequent x x x
Atrial fibrillation def infrequent x x x x
Mental disorder def postmarketing, infrequent x x x x x x x x x x
Bruxism def postmarketing, infrequent x x x x x x
Bundle branch block def rare, infrequent x x x x
Colitis def rare, infrequent x x x x x
Confusional state def postmarketing, infrequent x x x x x
Conjunctivitis def infrequent x
Connective tissue disorder def rare — infrequent x x x x x x x x
Dysphagia def infrequent x x x x x
Dehydration def postmarketing, infrequent x x x x x x x x
Dermatitis def rare — infrequent x x x x x x x x
Dermatitis exfoliative def rare, infrequent x x x x
Diplopia def postmarketing, infrequent x x x x x x x x
Diverticulitis def rare, infrequent x x x x
Dysarthria def rare — infrequent x x x x x x x x
Dyskinesia def postmarketing, infrequent x x x x x
Ear pain def postmarketing, infrequent x x x x x
Ecchymosis def rare — infrequent x x x x x x x x x
Eczema def infrequent x x x x x
Oedema def postmarketing — infrequent x x x x x x x x x x
Eructation def postmarketing, infrequent x x x x x x
Oesophageal disorder def rare, infrequent x x x x x
Oesophageal stenosis def rare, infrequent x x x x x
Gingivitis def rare, infrequent x x x x x
Glaucoma def postmarketing — infrequent x x x x x x x x
Breath odour def postmarketing, infrequent x x x x x
Cardiac failure def rare, infrequent x x x x
Cardiac failure congestive def rare, infrequent x x x x
Hypercholesterolaemia def infrequent x x x x
Hyperlipidaemia def postmarketing, infrequent x x x x x x x x
Hypertensive crisis postmarketing — infrequent x x x x x x x x
Hypertriglyceridaemia def rare, infrequent x x
Hypotension def postmarketing, infrequent x x x x x x
Orthostatic hypotension def postmarketing, infrequent x x x x x x
Incontinence def infrequent x x x x x
Infarction def postmarketing, infrequent x x x x x x x x
Irritable bowel syndrome def infrequent x x x x x
Nephropathy def rare, infrequent x x x x
Laryngitis def postmarketing, infrequent x x x x x
Leukopenia def rare, infrequent x x x x x
Macular degeneration def rare, infrequent x x x
Mediastinal disorder def postmarketing, infrequent x x x x x x x x x
Melaena def rare — infrequent x x x x x x
Menopause def postmarketing, infrequent x x x x x
Myocardial infarction def postmarketing, infrequent x x x x x x x x
Myoclonus def postmarketing, infrequent x x x x x
Nocturia def postmarketing, infrequent x x x x x x
Oliguria def rare, infrequent x x x x
Phlebitis def rare, infrequent x x x x x
Prurigo def infrequent x x
Retinal detachment def rare, infrequent x x x
Gastric ulcer def rare — infrequent x x x x x x x x
Stomatitis def rare — infrequent x x x x x x x x
Swelling def infrequent x x x
Tachycardia def postmarketing, infrequent x x x x x x x x
Thirst def postmarketing, infrequent x x x x x x x x
Thrombocytopenia def rare, infrequent x x x x x
Erythema def postmarketing, infrequent x x x x x x x x x
Urinary incontinence def infrequent x x x x x
Angiopathy def rare — infrequent x x x x x x x x x x
Urinary retention def postmarketing, infrequent x x x x x
Micturition urgency def postmarketing, infrequent x x x x x x x x x
Bundle branch block right def rare, infrequent x x x x
Apathy def postmarketing, infrequent x x x x x
Mood swings postmarketing, infrequent x x x x x x x x x
Photopsia rare, infrequent x x x x
Oedema peripheral def infrequent x x x x x x
Sicca syndrome def infrequent x x x
Creatinine increased def rare, infrequent x x x x
Muscular weakness def rare, infrequent x x x x
Photosensitivity reaction def postmarketing, infrequent x x x x x x x x
Sickness infrequent x x x x
Malaise def postmarketing, infrequent x x x x x x
Cardiac fibrillation infrequent x x x x
Cold sweat postmarketing, infrequent x x x x x x x x x
Abdominal pain lower infrequent x x x x x x x x
Disorientation postmarketing, infrequent x x x x x x
Disturbance in attention postmarketing, infrequent x x x
Pressure of speech rare, infrequent x x x x
Rash erythematous infrequent x x x
Throat tightness postmarketing, infrequent x x x x
Menopausal symptoms def postmarketing, infrequent x x x x x
Dyslipidaemia def rare — infrequent x x x x x x x x
Peripheral coldness postmarketing, infrequent x x x x x x
Urine odour abnormal postmarketing, infrequent x x x x
Mania def rare, infrequent x x x x x
Photosensitivity def postmarketing, infrequent x x x x x x x x x
Gastric irritation infrequent x x x
Increased tendency to bruise postmarketing, infrequent x x x x x x x x
Lymphadenopathy def infrequent x x x x x
Coordination abnormal infrequent x
Impaired gastric emptying rare, infrequent x x x x
Detachment psychological rare, infrequent x x x
Face oedema def rare, infrequent x x x x x
Visual disturbance postmarketing, infrequent x x x x
Feeling jittery infrequent x x x x x x x x
Urine flow decreased infrequent x x x x
Blood cholesterol increased postmarketing, infrequent x x x x x x x
Acne def infrequent x x x x x
Dissecting aortic aneurysm, thoracic postmarketing, infrequent x x x x x x x x x
Maculopathy rare, infrequent x x x x
White blood cell count increased def rare, infrequent
Coldness postmarketing, infrequent x x x x x x
Completed suicide rare — infrequent x x x x x x x x x
Arterial disorder def infrequent x x x
Hypertensive postmarketing — infrequent x x x x x x x x
Hyperkeratosis def rare, infrequent x x x
Sluggishness rare, infrequent x x x x x
Urine output rare, infrequent x x x x
Blood in stool infrequent x x x
Feeling abnormal postmarketing, infrequent x x x x x x
Weakness def rare, infrequent x x x x
Coronary artery disease def infrequent x x x
Hepatic steatosis def rare, infrequent x x x x
Feeling hot postmarketing, infrequent x x x x x x
Loss of libido infrequent x x x x x
Aggression def postmarketing x x x x
Anaphylactic shock def postmarketing x x x x x x
Anger def postmarketing x x x x
Angioedema def postmarketing x x x x x
Arrhythmia def postmarketing x x x x x
Breast disorder def postmarketing x x x x x x x x
Dermatitis contact def postmarketing x x x x
Endocrine disorder def postmarketing x x x x
Erythema multiforme def postmarketing x x x x
Extrapyramidal disorder def postmarketing x x x x x x
Eye disorder def postmarketing x x x x x x x x x x
Gastrointestinal disorder def rare, postmarketing x x x x x x x x x x
Gastrointestinal haemorrhage def postmarketing x
Hallucination def postmarketing x x x x x x
Cardiac disorder def postmarketing x x x x x x x x
Haematochezia def rare, postmarketing x x x x
Haemorrhage def postmarketing x x x x
Hepatitis def postmarketing x
Hyperglycaemia def postmarketing x x x x x
Hyperprolactinaemia def postmarketing x
Hyponatraemia def postmarketing x
Hypothyroidism def postmarketing x x x x
Inappropriate antidiuretic hormone secretion def postmarketing x
Jaundice def postmarketing x
Menstrual disorder def postmarketing x
Nervous system disorder def postmarketing x x x x x x x x x x
Polyuria def postmarketing x x x x
Restless legs syndrome def postmarketing x x x x
Seizures def postmarketing x x x x
Aphthous stomatitis def rare x
Syncope def postmarketing x
Tinnitus def postmarketing x x x x
Trismus def postmarketing x x x x x
Urinary tract disorder def postmarketing x x x x x x x x x x
Urticaria def postmarketing x x x x x x
Visual impairment def postmarketing x
Phosphatase alkaline increased postmarketing x
Aspartate aminotransferase increased def postmarketing x
Alanine aminotransferase increased def postmarketing x
Galactorrhoea postmarketing x
Pharyngeal oedema rare x
Blood bilirubin increased def postmarketing x
Dry eye postmarketing x
Arrhythmia supraventricular def postmarketing x x x x
Sexual dysfunction postmarketing x x x x x x x x x
Gait disturbance def postmarketing x x x x
Infestation NOS postmarketing x x x x x x x x x
Arthralgia def x x x x x x
Neck pain def x x x x
Diabetes mellitus def x x x x
Immune system disorder def x
Pain in extremity def x x
Pharyngitis def x x x x x x
Gastric disorder def x x x x
Abdominal discomfort x x x x x
Abdominal pain upper x x x x x x x x x
Abdominal tenderness x x x x x
Discomfort def x x x x x
Tenderness def x x x x x
Upset stomach x x x x
Blood pressure diastolic decreased x
Ejaculation failure x x x x x x x x x
Hyperkinesia def x x
Blood pressure increased x x x x
Paraesthesia oral x x
Terminal insomnia x x x x x
Sedation x x x x x
Gastrointestinal pain def x x x x x
Sweating increased x x x x x x
Female sexual dysfunction x x x x
Indication Labels
Agitation def x x x x x x x x x
Anxiety def x x x x x
Anxiety disorder def x x x x x
Back pain def x x x
Bradypsychic response x x x x x x x x
Cerebration impaired def x x x x x x x x
Chronic pain def x x x
Decreased interest x x x x x x x
Depressed mood def x x x x x x x x x
Depressive disorder def x x x x x x x x x x
Depressive episode x x x x x x x x x
Diabetic peripheral neuropathic pain x x x x x x x x
Diabetic peripheral neuropathy x x x x x
Dysphoria x x x x x x x x x
Fatigue def x x x x x x x x x
Feeling guilty def x x x x x x x x x
Fibromyalgia def x x x x
Generalised anxiety disorder def x x x x x
Hypersomnia def x x x x x x x x x
Insomnia def x x x x x x x x x
Irritability def x x x x x
Low back pain def x x x
Major depression def x x x x x x x x x x
Major depressive disorder, single episode x x x x x x x x x
Muscle tension x x x x x
Musculoskeletal pain def x x x
Neuralgia def x x x x x x x x x
Neuropathy def x x x x x x x x x
Neuropathy peripheral def x x x x x x x x
Osteoarthritis def x x x
Pain def x x x x x x x x x
Sleep disturbance x x x x
Suicidal ideation def x x x x x x x
Suicide def x x x x x x x x x
Suicide attempt def x x x x x x x x x
Tension def x x x x x
Worry def x x x x x

Information

More information: STITCH, PubChem and possibly Wikipedia or Medpedia

ATC Code: N06AX21

Legend

Color scheme: standard – alternative

100%    
75%    
50%    
10%    
frequent (1% to 100%)    
infrequent (0.1% to 1%)    
rare (<0.1%)    
postmarketing    
0%    
no frequency information    
not found on label    

Labels

Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.

  1. DULOXETINE (DULOXETINE HYDROCHLORIDE) / CYMBALTA : 76 side effects (Health Canada)
  2. DULOXETINE HYDROCHLORIDE / CYMBALTA : 91 side effects (Drugs@FDA)
  3. DULOXETINE : 125 side effects (FDA XML label)
  4. duloxetine hydrochloride / Cymbalta : 153 side effects (FDA MedWatch)
  5. duloxetine hydrochloride / Cymbalta : 159 side effects (FDA MedWatch)
  6. Duloxetine : 164 side effects (FDA XML label)
  7. Duloxetine : 168 side effects (FDA XML label)
  8. DULOXETINE : 170 side effects (FDA XML label)
  9. DULOXETINE HYDROCHLORIDE / CYMBALTA : 196 side effects (Drugs@FDA)
  10. DULOXETINE HYDROCHLORIDE / CYMBALTA : 205 side effects (Drugs@FDA)