Duloxetine
Side effects
Options: Show MedDRA Preferred Terms, display all 47 labels
| Side effect | Data for drug | Placebo | Labels | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | |||
| Nausea | 9% - 30% | 7% - 11% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Headache | very common, 9% - 20% | 8% - 15% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Dry mouth | 3% - 18% | 3% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Constipation | 2% - 15% | 3% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Dizziness | 6% - 17% | 5% - 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Fatigue | 2% - 16% | 5% - 8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Insomnia | 5% - 16% | 5% - 10% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Somnolence | 5% - 21% | 3% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Diarrhoea | 7% - 13% | 5% - 8% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Decreased appetite | 1% - 14% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Hyperhidrosis | 2% - 10% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Abdominal pain | common — 2% - 6% | 4% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Neck pain | common | x | x | x | x | x | x | |||||||||||||||
| Hypoglycaemia | infrequent, frequent | x | x | |||||||||||||||||||
| Nasopharyngitis | 4% - 9% | 4% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Nervousness | common, frequent | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Nightmare | uncommon, frequent | x | x | x | x | x | x | x | x | |||||||||||||
| Skin ulcer | infrequent, frequent | x | x | |||||||||||||||||||
| Myalgia | common, 1% - 4% | 1% | x | x | x | x | x | x | x | x | ||||||||||||
| Increased appetite | infrequent, frequent | x | x | |||||||||||||||||||
| Tension | infrequent, common | x | x | x | ||||||||||||||||||
| Upset stomach | common | x | x | x | x | x | ||||||||||||||||
| Initial insomnia | frequent | x | x | x | x | x | x | x | x | x | ||||||||||||
| Middle insomnia | frequent | x | x | x | x | x | x | x | x | x | ||||||||||||
| Feeling jittery | infrequent, common | x | x | x | x | x | x | x | x | |||||||||||||
| Asthenia | frequent, 2% - 8% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Libido decreased | frequent, 1% - 6% | 0% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Cramp muscle | 4% - 5% | 3% | x | x | x | x | ||||||||||||||||
| Upper respiratory tract infection | 3% - 7% | 3% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Vomiting | 3% - 6% | 2% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Agitation | infrequent — 1% - 6% | 1% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Erectile dysfunction | 0% - 5% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Anorexia | 3% - 5% | 1% | x | x | x | x | x | x | x | x | x | |||||||||||
| Anxiety | common — 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Back pain | 2% - 5% | 3% | x | x | x | x | x | x | x | |||||||||||||
| Cough | 2% - 6% | 2% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Seasonal allergy | 3% | 2% | x | |||||||||||||||||||
| Influenza | 2% - 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Musculoskeletal pain | postmarketing — 3% - 5% | 3% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Tremor | 0% - 5% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Urinary tract infection | 3% | 3% | x | |||||||||||||||||||
| Migraine | 3% | 3% | x | |||||||||||||||||||
| Ejaculation delayed | frequent, 2% - 3% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Vision blurred | postmarketing — 2% - 3% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Pharyngolaryngeal pain | 1% - 6% | 1% - 3% | x | x | x | x | x | |||||||||||||||
| Pain | postmarketing, 4% | 4% | x | x | x | x | ||||||||||||||||
| Dyspepsia | common — 2% - 5% | 1% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Body temperature increased | 1% - 3% | 1% | x | x | x | x | ||||||||||||||||
| Orgasm abnormal | postmarketing — 2% - 4% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Palpitations | postmarketing — 2% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Paraesthesia | postmarketing — 1% - 4% | 2% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Penis disorder | 2% | 0% | x | |||||||||||||||||||
| Muscle spasms | postmarketing — 2% - 4% | 2% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Weight decreased | postmarketing — 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Yawning | postmarketing — 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Viral diarrhoea | 2% | 2% | x | |||||||||||||||||||
| Ejaculation disorder | uncommon — 2% - 4% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Blood pressure increased | uncommon, 2% | 1% | x | x | x | x | x | |||||||||||||||
| Loose stools | 2% - 3% | 1% | x | x | x | x | ||||||||||||||||
| Oropharyngeal pain | postmarketing — 2% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Pollakiuria | postmarketing — 1% - 5% | 2% | x | x | x | x | x | x | ||||||||||||||
| Alopecia | infrequent | x | x | x | ||||||||||||||||||
| Anaemia | infrequent | x | x | x | ||||||||||||||||||
| Ataxia | infrequent | x | ||||||||||||||||||||
| Atrial fibrillation | infrequent | x | x | x | ||||||||||||||||||
| Colitis | rare, infrequent | x | x | x | ||||||||||||||||||
| Conjunctivitis | infrequent | x | ||||||||||||||||||||
| Dermatitis exfoliative | rare, infrequent | x | x | |||||||||||||||||||
| Diverticulitis | rare, infrequent | x | x | |||||||||||||||||||
| Eczema | infrequent | x | x | x | ||||||||||||||||||
| Oedema | infrequent | x | x | |||||||||||||||||||
| Flushing | postmarketing — 2% - 3% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Gingivitis | rare, infrequent | x | x | x | ||||||||||||||||||
| Cardiac failure | rare, infrequent | x | x | |||||||||||||||||||
| Cardiac failure congestive | rare, infrequent | x | x | |||||||||||||||||||
| Hypercholesterolaemia | infrequent | x | x | |||||||||||||||||||
| Irritable bowel syndrome | infrequent | x | x | x | ||||||||||||||||||
| Nephropathy | rare, infrequent | x | x | |||||||||||||||||||
| Leukopenia | infrequent | x | x | x | ||||||||||||||||||
| Macular degeneration | rare, infrequent | x | x | |||||||||||||||||||
| Mydriasis | uncommon | x | x | |||||||||||||||||||
| Oliguria | rare, infrequent | x | x | |||||||||||||||||||
| Phlebitis | rare, infrequent | x | x | x | ||||||||||||||||||
| Prurigo | infrequent | x | ||||||||||||||||||||
| Retinal detachment | rare, infrequent | x | x | |||||||||||||||||||
| Thrombocytopenia | postmarketing, infrequent | x | x | x | x | |||||||||||||||||
| Urinary incontinence | infrequent | x | x | x | ||||||||||||||||||
| Urinary retention | postmarketing — uncommon | x | x | x | x | x | x | |||||||||||||||
| Bundle branch block right | rare, infrequent | x | x | |||||||||||||||||||
| Photopsia | rare, infrequent | x | x | |||||||||||||||||||
| Oedema peripheral | infrequent | x | x | x | x | |||||||||||||||||
| Syndrome sicca | infrequent | x | ||||||||||||||||||||
| Gamma-glutamyltransferase increased | uncommon | x | ||||||||||||||||||||
| Liver function test abnormal | uncommon | x | ||||||||||||||||||||
| Muscular weakness | rare, infrequent | x | x | |||||||||||||||||||
| Aspartate aminotransferase increased | postmarketing, uncommon | x | x | |||||||||||||||||||
| Alanine aminotransferase increased | postmarketing, uncommon | x | x | |||||||||||||||||||
| Urinary hesitation | infrequent — frequent | x | x | x | x | x | x | |||||||||||||||
| Abdominal pain lower | infrequent | x | x | x | x | x | x | x | x | x | ||||||||||||
| Pressure of speech | rare, infrequent | x | x | x | ||||||||||||||||||
| Abnormal dreams | postmarketing — 2% - 3% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Rash erythematous | infrequent | x | ||||||||||||||||||||
| Blood creatinine increased | rare, infrequent | x | x | |||||||||||||||||||
| Hepatic enzyme increased | uncommon | x | x | |||||||||||||||||||
| Blood pressure systolic increased | uncommon | x | x | |||||||||||||||||||
| Blood pressure diastolic increased | uncommon | x | x | |||||||||||||||||||
| Ejaculation failure | uncommon | x | x | x | x | x | x | x | x | x | ||||||||||||
| Gastric irritation | infrequent | x | ||||||||||||||||||||
| Lymphadenopathy | infrequent | x | x | x | ||||||||||||||||||
| Coordination abnormal | infrequent | x | ||||||||||||||||||||
| Influenza like illness | infrequent | x | x | |||||||||||||||||||
| Impaired gastric emptying | rare, infrequent | x | x | |||||||||||||||||||
| Face oedema | rare, infrequent | x | x | x | ||||||||||||||||||
| Urine flow decreased | rare, infrequent | x | x | x | x | x | ||||||||||||||||
| Maculopathy | rare, infrequent | x | x | |||||||||||||||||||
| White blood cell count increased | rare, infrequent | x | x | x | ||||||||||||||||||
| Oropharyngeal swelling | infrequent | x | ||||||||||||||||||||
| Oesophageal stenosis acquired | infrequent | x | x | |||||||||||||||||||
| Hyperkeratosis | rare, infrequent | x | x | |||||||||||||||||||
| Hypersomnia | infrequent, frequent | x | x | x | x | |||||||||||||||||
| Sluggishness | rare, infrequent | x | x | x | ||||||||||||||||||
| Musculoskeletal stiffness | uncommon | x | ||||||||||||||||||||
| Blood in stool | infrequent | x | x | |||||||||||||||||||
| Coronary artery disease | infrequent | x | x | |||||||||||||||||||
| Hepatic steatosis | rare, infrequent | x | x | |||||||||||||||||||
| Loss of libido | infrequent | x | x | x | x | x | x | |||||||||||||||
| Dysphagia | postmarketing, infrequent | x | x | x | x | x | ||||||||||||||||
| Hypertriglyceridaemia | rare, infrequent | x | x | |||||||||||||||||||
| Aggression | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Anaphylactic shock | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Anger | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Angioedema | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Mental disorder | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Breast disorder | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Bruxism | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Infection | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Confusional state | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Connective tissue disorder | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Dehydration | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Dermatitis contact | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Diplopia | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Dysarthria | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Dysgeusia | postmarketing — 3% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Dyskinesia | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Dysuria | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Ear pain | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Ecchymosis | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Endocrine disorder | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Eructation | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Erythema multiforme | postmarketing | x | x | x | x | |||||||||||||||||
| Oesophageal stenosis | rare | x | ||||||||||||||||||||
| Rash | postmarketing — 4% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Extrapyramidal disorder | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Eye disorder | postmarketing, 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Flatulence | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Gastritis | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Gastroenteritis | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Gastrointestinal disorder | postmarketing, 14% - 30% | 9% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Gastrointestinal haemorrhage | postmarketing — uncommon | x | x | x | x | x | x | |||||||||||||||
| Glaucoma | very rare — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Angle closure glaucoma | postmarketing | x | x | |||||||||||||||||||
| Breath odour | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Hallucination | postmarketing, rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Cardiac disorder | postmarketing, 2% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Haematochezia | postmarketing, rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Blood disorder | postmarketing | x | x | |||||||||||||||||||
| Haemorrhage | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Hyperglycaemia | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hyperlipidaemia | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hyperprolactinaemia | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Hypersensitivity | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hypertensive crisis | very rare — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Hypoaesthesia | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Orthostatic hypotension | very rare — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Hypothyroidism | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Immune system disorder | postmarketing | x | x | x | x | |||||||||||||||||
| Irritability | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Laryngitis | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Lethargy | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Mediastinal disorder | postmarketing, 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Melaena | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Menstrual disorder | postmarketing, rare | x | x | x | x | |||||||||||||||||
| Myocardial infarction | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Myoclonus | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Nervous system disorder | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Night sweats | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Nocturia | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Polyuria | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Pruritus | postmarketing — 3% | 2% | x | x | x | x | x | x | x | x | x | |||||||||||
| Restless legs syndrome | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Convulsion | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Stevens-Johnson syndrome | very rare, postmarketing | x | x | x | x | x | x | |||||||||||||||
| Gastric ulcer | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Stomatitis | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Aphthous stomatitis | rare | x | ||||||||||||||||||||
| Suicide attempt | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Tachycardia | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Testicular pain | postmarketing, infrequent | x | x | |||||||||||||||||||
| Thirst | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Tinnitus | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Trismus | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Erythema | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Urinary tract disorder | postmarketing | x | x | x | x | x | x | x | x | x | x | |||||||||||
| Urticaria | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Angiopathy | postmarketing, 2% - 3% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Vertigo | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Weight increased | postmarketing — 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Chills | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Micturition urgency | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Apathy | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Mood swings | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Malnutrition | postmarketing, 7% - 9% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Photosensitivity reaction | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Unspecified disorder of skin and subcutaneous tissue | postmarketing, 6% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x |
| Malaise | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Muscle twitching | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Cold sweat | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Disorientation | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Disturbance in attention | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Anorgasmia | postmarketing, frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Galactorrhoea | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | |||||||||
| Pharyngeal oedema | rare | x | ||||||||||||||||||||
| Throat tightness | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Menopausal symptoms | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Dyslipidaemia | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Hepatobiliary disease | postmarketing | x | x | x | x | x | ||||||||||||||||
| Peripheral coldness | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Urine odour abnormal | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Blood bilirubin increased | very rare — uncommon | x | x | |||||||||||||||||||
| Dry eye | postmarketing — uncommon | x | x | x | x | |||||||||||||||||
| Mania | very rare — infrequent | x | x | x | x | x | x | |||||||||||||||
| Increased tendency to bruise | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Rigors | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Arrhythmia supraventricular | very rare, postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Visual disturbance | postmarketing, infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||||
| Sexual dysfunction | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||
| Gait disturbance | postmarketing, rare | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Blood cholesterol increased | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Hot flush | postmarketing — 2% - 3% | 1% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Infestation NOS | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||
| Ear and labyrinth disorders | postmarketing | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Sleep disorder | postmarketing — 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |
| Completed suicide | postmarketing — infrequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Muscle tightness | postmarketing — frequent | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||
| Poor quality sleep | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||||
| Feeling abnormal | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Feeling hot | postmarketing — uncommon | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | ||||
| Visual impairment | postmarketing — uncommon | x | x | x | x | |||||||||||||||||
| Hepatitis | very rare, postmarketing | x | x | x | ||||||||||||||||||
| Hyponatraemia | very rare, postmarketing | x | x | x | ||||||||||||||||||
| Inappropriate antidiuretic hormone secretion | very rare, postmarketing | x | x | x | ||||||||||||||||||
| Jaundice | very rare, postmarketing | x | x | x | ||||||||||||||||||
| Syncope | very rare, postmarketing | x | x | x | ||||||||||||||||||
| Phosphatase alkaline increased | very rare, postmarketing | x | x | |||||||||||||||||||
| Diabetic | very rare | |||||||||||||||||||||
| Serotonin syndrome | very rare, postmarketing | x | x | x | ||||||||||||||||||
| Arrhythmia | x | |||||||||||||||||||||
| Arthralgia | x | x | x | x | ||||||||||||||||||
| Chest pain | x | |||||||||||||||||||||
| Contusion | x | |||||||||||||||||||||
| Diabetes mellitus | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | |||||||
| Electric shock | ||||||||||||||||||||||
| Epistaxis | x | |||||||||||||||||||||
| Hypertension | x | x | ||||||||||||||||||||
| Low back pain | x | x | x | x | x | |||||||||||||||||
| Osteoarthritis | x | x | x | x | x | |||||||||||||||||
| Pain in extremity | x | x | ||||||||||||||||||||
| Pancreatitis | x | |||||||||||||||||||||
| Pharyngitis | x | x | x | x | ||||||||||||||||||
| Rhabdomyolysis | x | |||||||||||||||||||||
| Sleep disturbance | x | |||||||||||||||||||||
| Supraventricular tachycardia | x | |||||||||||||||||||||
| Essential hypertension | x | |||||||||||||||||||||
| Hepatic failure | x | x | x | |||||||||||||||||||
| Ventricular arrhythmia | x | |||||||||||||||||||||
| Withdrawal symptom | x | |||||||||||||||||||||
| Creatine phosphokinase increased | x | |||||||||||||||||||||
| Secondary hypertension | x | |||||||||||||||||||||
| Liver injury | x | |||||||||||||||||||||
| Systolic hypertension | x | |||||||||||||||||||||
| Cardiac fibrillation | ||||||||||||||||||||||
| Abdominal discomfort | x | x | x | x | x | x | x | |||||||||||||||
| Abdominal pain upper | x | x | x | x | x | x | x | x | x | |||||||||||||
| Abdominal tenderness | x | x | x | x | x | x | x | |||||||||||||||
| Extrapyramidal symptoms | ||||||||||||||||||||||
| Diastolic hypertension | x | |||||||||||||||||||||
| Hepatotoxicity | x | |||||||||||||||||||||
| Glycosylated haemoglobin increased | x | |||||||||||||||||||||
| Blood pressure diastolic decreased | x | |||||||||||||||||||||
| Akathisia | x | |||||||||||||||||||||
| Suicidal ideation | x | |||||||||||||||||||||
| Paraesthesia oral | x | x | x | |||||||||||||||||||
| Terminal insomnia | x | x | x | x | x | x | x | |||||||||||||||
| Orthostatic hypertension | x | |||||||||||||||||||||
| Gastrointestinal pain | x | x | x | x | x | x | x | |||||||||||||||
| Sweating increased | x | x | x | x | x | |||||||||||||||||
| Hemorrhage abnormal | x | |||||||||||||||||||||
| Blood and lymphatic system disorders | x | x | x | |||||||||||||||||||
| Blood creatine phosphokinase increased | ||||||||||||||||||||||
| Blood potassium increased | ||||||||||||||||||||||
| Fasting blood glucose increased | x | |||||||||||||||||||||
| Renal impairment | x | |||||||||||||||||||||
| Hypoaesthesia facial | x | x | x | x | ||||||||||||||||||
| Suicidal behaviour | ||||||||||||||||||||||
| Acute liver injury | x | |||||||||||||||||||||
| Genital hypoaesthesia | x | |||||||||||||||||||||
| Labile hypertension | x | |||||||||||||||||||||
Indications
Information about indications was extracted from the indications and usage sections of the labels.
Color scheme:
standard – alternative
| 100% | ||
| 75% | ||
| 50% | ||
| 10% | ||
| frequent (1% to 100%) | ||
| infrequent (0.1% to 1%) | ||
| rare (<0.1%) | ||
| postmarketing | ||
| 0% | ||
| no frequency information | ||
| not found on label |
