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Rivastigmine

More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia

ATC Code: N06DA03

Side effects

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MedDRA Preferred Term Side effect Data for drug Placebo Labels
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Decreased appetite Appetite absent very common x x x x
Decreased appetite frequent, 1% - 9% 1% - 5% x x x x
Anorexia 1% - 17% 0% - 3% x x x x x x x x x x x x x x x x x x x
Nausea Nausea very rare — 1% - 47% 0% - 12% x x x x x x x x x x x x x x x x x x
Diarrhoea Diarrhoea common — 1% - 19% 1% - 11% x x x x x x x x x x x x
Tremor Tremor common — 1% - 23% 1% - 4% x x x x x x x x x x x x x x x x x x x x
Trembling common x x
Application site erythema Application site erythema common, 1% - 13% x x x x
Anaemia Anaemia frequent x x x x x x x x
Angina pectoris Angina pectoris frequent x x x x x x x x x x x x x x x x x x x x
Arthralgia Arthralgia infrequent, frequent x x x x x x x x x
Musculoskeletal discomfort Arthralgia infrequent, frequent x x x x x x x x x
Myalgia infrequent, frequent x x x x x x x x
Arthritis Arthritis frequent x x x x x x
Rheumatoid arthritis infrequent x
Ataxia Ataxia frequent x x x x x x x x
Atrial fibrillation Atrial fibrillation postmarketing — frequent x x x x x x x x x x x x x x x x x x x x
Back pain Back pain frequent x x x x x x x x x
Bronchitis Bronchitis frequent x x x x x x x
Basal cell carcinoma Basal cell carcinoma frequent x
Transient ischaemic attack Transient ischaemic attack frequent x x x x x x x
Cerebrovascular disorder Cerebrovascular disorder frequent x
Chest pain Chest pain rare — frequent x x x x x x x x x x x x
Retrosternal pain infrequent x
Infection Infection frequent x x x x x x x x x x x x x x x x x
Confusional state Confusional state uncommon — 8% 7% x x x x x x x x x x x x x x x x x x x x
Feeling abnormal Confusional state uncommon — 8% 7% x x x x x x x x x x x x x x x x x x x x
Malaise uncommon — 4% - 5% 2% x x x x x x x x x x x x x x x x x
Constipation Constipation frequent, 5% 4% x x x x x x x x x x x x
Dehydration Dehydration postmarketing — 1% - 2% 1% x x x x x x x x x x x x x x x x x x x x
Depression Depression common, 2% - 6% 1% - 4% x x x x x x x x x x x x x x x x x
Anxiety depression x
Dyskinesia Dyskinesia common — 3% 1% x x x x x x x x x x x x
Movement disorder 0% x x x x x
Dyspepsia Dyspepsia common — 8% - 9% 4% x x x x x x x x x x x x x x x x x x
Dyspnoea Dyspnoea infrequent — 2% 1% x x x x x x x x x x
Eczema Eczema infrequent, frequent x x x x x x x x x x x
Oedema Oedema infrequent — frequent x x x x x x x x x x
Epistaxis Epistaxis frequent x x x x x x
Dermatitis Rash postmarketing — frequent x x x x x x x x x x x x x x x x x x x
Dermatitis infrequent x x x x
Rash Rash postmarketing — frequent x x x x x x x x x x x x x x x x x x x
Extrapyramidal disorder Extrapyramidal disorder frequent 0% x
Extrapyramidal symptoms x x x x x x x
Faecal incontinence Faecal incontinence frequent x x x x x x
Body temperature increased Body temperature increased frequent x x x x x x x x x x
Multiple fractures Fracture frequent x x x x x x x
Fracture Fracture frequent x x x x x x x
Gastritis Gastritis infrequent, frequent x x x x x x x x x x x
Cardiac failure Cardiac failure frequent x x x x x x x x x
Haematuria Haematuria infrequent, frequent x x x x x x x x x x
Hypersensitivity Hypersensitivity infrequent, frequent x x x x x x x x
Hypokalaemia Hypokalaemia infrequent, frequent x x x x x x x x x x x
Hypotension Hypotension infrequent — frequent x x x x x x x x x x x x x x
Orthostatic hypotension Orthostatic hypotension frequent x x x x x x x x
Muscle spasms Cramps of lower extremities frequent x x x x x x
Cramp muscle infrequent x x x x x x
Muscle spasms infrequent x x
Pain in extremity Leg pain frequent x
Myocardial infarction Myocardial infarction frequent x x x x x x x x x x x x x x x
Acute coronary syndrome Myocardial infarction frequent x x x x x x x x x x x x x x x
Nasopharyngitis Nasopharyngitis frequent x x
Nightmare Nightmare frequent x
Palpitations Palpitations frequent x x x x x x x x
Paraesthesia Paraesthesia frequent x x x x x x x x
Pharyngitis Pharyngitis frequent x x x x x x x
Pneumonia Pneumonia frequent x x x
Prostatic disorder Prostatic disorder frequent x
Convulsion Convulsion postmarketing — frequent x x x x x x x x x x x x x x x x x x x
Sinusitis Sinusitis frequent x
Skin disorder Skin disorder frequent x
Unspecified disorder of skin and subcutaneous tissue postmarketing x x x x x x x x x x x x x x
Tinnitus Tinnitus infrequent, frequent x x x x x x x x x x x
Tooth disorder Tooth disorder frequent x
Upper respiratory tract infection Upper respiratory tract infection frequent x x x x x x x
Urinary tract infection Urinary tract infection very rare — 1% - 10% 1% - 6% x x x x x x x x x x x x x x x x x x x x
Vertigo Vertigo frequent, 0% - 2% 1% x x x x x x x x x x
Viral infection Viral infection frequent x
Vomiting Vomiting very rare — 0.4% - 31% 0% - 6% x x x x x x x x x x x x x x x x x x
Injury Trauma frequent, 10% 9% x x x x x x x
Agitation Agitation postmarketing — 1% - 14% 2% x x x x x x x x x x x x x x x x x x x x
Hyperkinesia infrequent x x x x x x
Oedema peripheral Oedema peripheral frequent x x x x x x x x x
Cataract Cataract frequent x x x x x x x x x x
Paranoia Paranoid reaction frequent x x x x x x x
Malaise Malaise uncommon — 4% - 5% 2% x x x x x x x x x x x x x x x x x
Unwell uncommon x
Discomfort Malaise uncommon — 4% - 5% 2% x x x x x x x x x x x x x x x x x
Ill-defined disorder Malaise uncommon — 4% - 5% 2% x x x x x x x x x x x x x x x x x
Myalgia Myalgia infrequent, frequent x x x x x x x x
Hallucination, visual Hallucination, visual frequent x
Chills Rigors frequent 0% x x x x x x x x x x
Bradycardia Bradycardia infrequent — frequent x x x x x x x x x x x x x x x x x x x x
Gait disturbance Gait disturbance frequent, 4% 0% x x x x x x x x x x x x x
Menopausal symptoms Hot flush frequent x x x x x x x x
Hot flush Hot flush frequent x x x x x x x x
Somnolence Somnolence uncommon — 1% - 6% 1% - 3% x x x x x x x x x x x x x x x x x x
Drowsiness uncommon x
Abdominal pain Abdominal pain common, 1% - 13% 1% - 6% x x x x x x x x x x x x x x x x x x x x
Stomach ache very rare x
Gastrointestinal pain Abdominal pain common, 1% - 13% 1% - 6% x x x x x x x x x x x x x x x x x x x x
Anxiety Anxiety common, 1% - 5% 1% - 3% x x x x x x x x x x x x x x x x x x x x
Asthenia Fatigue common, 0% - 9% 0% - 5% x x x x x x x x x x x x x x x x x x x x
Asthenia common, 0% - 6% 0% - 2% x x x x x x x x x x x x x x x x x x x x
Fatigue Fatigue common, 0% - 9% 0% - 5% x x x x x x x x x x x x x x x x x x x x
Flatulence Flatulence frequent, 4% 2% x x x x x x x x x
Hallucination Hallucination very rare — 2% - 5% 3% x x x x x x x x x x x x x x x x x x x
Headache Headache common, 1% - 17% 2% - 12% x x x x x x x x x x x x x x x x x x x x
Nervousness Nervousness 4% 3% x x x x x x x
Tension Nervousness 4% 3% x x x x x x x
Rhinitis Rhinitis 4% 3% x x x x x x x
Abdominal pain upper Abdominal pain upper 1% - 4% 1% - 2% x x x x x x x x x x
Stomach ache very rare x
Hyperhidrosis Sweating increased common — 2% - 4% 1% x x x x x x x x x x x x
Hyperhidrosis uncommon — 2% 1% x x x x x x x x x
Sweating uncommon x
Cardiovascular disorder Cardiovascular disorder 3% 2% x x x x x x x x x
Unspecified circulatory system disorder infrequent x
Dizziness Dizziness common, 0% - 21% 0% - 11% x x x x x x x x x x x x x x x x x x x x
Syncope uncommon — 3% 2% x x x x x x x x x x x x x x x x x x x x
Hypertension Hypertension very rare — 1% - 3% 2% x x x x x x x x x x x x x x x x x x x x
Parkinson's disease Parkinson's disease postmarketing — 3% 1% x x x x x
Parkinsonism Parkinson's disease postmarketing — 3% 1% x x x x x
Parkinsonism 2% 1% x x x x x x x x x x x x x
Shock Syncope uncommon — 3% 2% x x x x x x x x x x x x x x x x x x x x
Syncope Syncope uncommon — 3% 2% x x x x x x x x x x x x x x x x x x x x
Syncope vasovagal infrequent x x x x x
Loss of consciousness Syncope uncommon — 3% 2% x x x x x x x x x x x x x x x x x x x x
Weight decreased Weight decreased common — 1% - 8% 0% - 1% x x x x x x x x x x x x x x x x x x x x
Cogwheel rigidity Cogwheel rigidity common, 3% 0% x x x x x x
Bradykinesia Bradykinesia common — 2% - 4% 2% x x x x x x x x x x x x
Influenza like illness Influenza-like symptoms frequent, 3% 2% x x x x x x x
Insomnia Insomnia infrequent — 1% - 9% 2% - 7% x x x x x x x x x x x x x x x x x x x x
Aggression Aggressive reaction 3% 2% x x x x x x x x x
Aggression postmarketing — 0.4% - 3% x x x x x x x x x x x x
Conjunctivitis Conjunctivitis infrequent, frequent x x x x x
Pain Pain infrequent, frequent x x x x x x x x x x
Stinging x x x
Application site pruritus Application site pruritus common, 1% - 4% x x x x x
Eructation Eructation 2% 1% x x x x x x x
Pruritus Pruritus postmarketing — 1.7% - 2% 1% x x x x x x x x x x x x x
Pollakiuria Pollakiuria infrequent, 2% 1% x x x
Micturition urgency infrequent x x x x x x
Visual impairment Abnormal vision 2% 1% x
Disorder sight x x x x x x x x
Urinary incontinence Urinary incontinence infrequent — 1% - 3% 2% x x x x x x x x x x x x x x x x
Abscess Abscess infrequent x
Adams-Stokes syndrome Adams-Stokes syndrome infrequent x x x x x
Adenocarcinoma Adenocarcinoma infrequent x
Albuminuria Albuminuria infrequent x x x x x x
Alopecia Alopecia infrequent x x x x x x
Amnesia Amnesia infrequent x x x x x x
Hypochromic anaemia Hypochromic anaemia infrequent x x x x x x
Aneurysm Aneurysm infrequent x x x x x x
Aphasia Aphasia infrequent x x x x x x
Apnoea Apnoea infrequent x x x x x x
Apraxia Apraxia infrequent x x x x x x
Arrhythmia Arrhythmia very rare — uncommon x x x x x x x x x x x x
Rheumatoid arthritis Rheumatoid arthritis infrequent x
Atrioventricular block Atrioventricular block postmarketing — uncommon x x x x x x x x x x x x x x x x x x x x
Bacterial infection Bacterial infection infrequent x
Bladder disorder Bladder disorder infrequent x
Neurogenic bladder Neurogenic bladder infrequent x x x x x
Blepharitis Blepharitis infrequent x x x x x x
Blepharospasm Blepharospasm infrequent x x x x x
Bone disorder Bone disorder infrequent x
Nervous system disorder Brain disorder NOS uncommon x
Nervous system disorder x x x x x x x x x x x x x x x x x x
Breast cancer Breast cancer infrequent x
Bronchospasm Bronchospasm infrequent x x x x x x x x x x x
Bundle branch block Bundle branch block infrequent x x x x x x
Bursitis Bursitis infrequent x
Cachexia Cachexia infrequent x x x x x x
Candida infection Candida infection infrequent x
Neoplasm malignant Carcinoma infrequent x
Skin cancer Skin cancer infrequent x
Cellulitis Cellulitis infrequent x x x x x x
Cholecystitis Cholecystitis infrequent x x x x x x x x
Cholelithiasis Cholelithiasis infrequent x
Colitis Colitis infrequent x x x x x x
Coma Coma infrequent x
Conjunctival haemorrhage Conjunctival haemorrhage infrequent x x x x x x
Cough Cough infrequent, frequent x x x x x x x x x
Cystitis Cystitis infrequent x x x x x x
Bladder pain Cystitis infrequent x x x x x x
Cystitis noninfective Cystitis infrequent x x x x x x
Deafness Deafness infrequent x
Libido decreased Libido decreased infrequent x x x x x x
Disturbance in sexual arousal Libido decreased infrequent x x x x x x
Libido increased infrequent x x x x x x x x
Dysphagia Dysphagia infrequent x x x x x x x x
Delirium Delirium infrequent, uncommon x x x x x x x x x x x x x x x x
Delusion Delusion infrequent, frequent x x x x x x x x x
Dental caries Dental caries infrequent x
Depersonalisation Depersonalisation infrequent x x x x x x
Dermatitis contact Dermatitis contact infrequent, uncommon x x x x x x x x x x
Diabetes mellitus Diabetes mellitus infrequent x x x x x x
Diplopia Diplopia infrequent x x x x x x x x
Diverticulitis Diverticulitis infrequent x x x x x x x
Duodenal ulcer Duodenal ulcer rare, infrequent x x x x x x x x x x x x x x x x x x x
Dysgeusia Dysgeusia infrequent x x x x x x
Dysuria Dysuria infrequent x x x x x x x x
Ear disorder Ear disorder infrequent x
Ear pain Ear pain infrequent x
Epilepsy Epilepsy infrequent x x x x x x x
Oesophagitis Oesophagitis infrequent x x x x x x
Congenital eye disorder Congenital eye disorder infrequent x
Eye disorder Congenital eye disorder infrequent x
Eye disorder x x x
Eyelid disorder Eyelid disorder infrequent x
Flushing Flushing infrequent x x x x x x
Furuncle Furunculosis infrequent x
Gastroenteritis Gastroenteritis infrequent x x x x x x
Gastrooesophageal reflux disease Gastrooesophageal reflux disease infrequent x x x x x x x x x x x
Gastrointestinal haemorrhage Gastrointestinal haemorrhage very rare — uncommon x x x x x x x x x x x x x x x x x x
Gingivitis Gingivitis infrequent x x x x x x
Glaucoma Glaucoma infrequent x x x x x x x x x x
Glossitis Glossitis infrequent x x x x x x
Goitre Goitre infrequent x x x x x x
Gout Gout infrequent x x x x x x
Breath odour Breath odour infrequent x x x x x x
Cardiac arrest Cardiac arrest infrequent x x x x x x
Haematemesis Haematemesis infrequent x x x x x x x x x x x
Haematochezia Haematochezia infrequent x x x
Haematoma Haematoma infrequent, frequent x x x x x x
Subdural haematoma Subdural haematoma infrequent x x
Hemiparesis Hemiparesis infrequent x x x x x
Haemorrhage Haemorrhage infrequent x x x x x x
Haemoglobin Haemorrhage infrequent x x x x x x
Haemorrhoids Haemorrhoids infrequent x x x x x x
Hernia Hernia infrequent x x x x x x x x
Herpes simplex Herpes simplex infrequent x x x x x x x x
Herpes zoster Herpes zoster infrequent x
Hiccups Hiccups infrequent x
Hip fracture Hip fracture infrequent x x x
Hypercholesterolaemia Hypercholesterolaemia infrequent x x x x x x
Hyperglycaemia Hyperglycaemia infrequent x x x x x x
Hyperlipidaemia Hyperlipidaemia infrequent x x x x x x x
Hyperventilation Hyperventilation infrequent x
Hypoaesthesia Hypoaesthesia infrequent x x x x x x x x
Hypoglycaemia Hypoglycaemia infrequent x x x x x x
Hyponatraemia Hyponatraemia infrequent x x x x x x x x x x x
Body temperature decreased Body temperature decreased infrequent x x x x x x
Hypothermia Body temperature decreased infrequent x x x x x x
Hypothyroidism Hypothyroidism infrequent x x x x x x
Libido increased Libido increased infrequent x x x x x x x x
Inflammation Inflammation infrequent x
Intestinal obstruction Intestinal obstruction infrequent x x x x x x
Arthropathy Arthropathy infrequent x
Osteoarthritis Arthropathy infrequent x
Dysarthria x
Nephrolithiasis Calculus of kidney infrequent x x x x x x
Renal failure acute Renal failure acute infrequent x x x x x x x x
Laryngitis Laryngitis infrequent x x x x x x
Leukocytosis Leukocytosis infrequent x x x x x x
Lung disorder Lung disorder infrequent x
Mastitis Mastitis infrequent x x x x x
Breast pain Breast pain infrequent x x x x x x x x
Melaena Melaena infrequent x x x x x x x x
Meniere's disease Meniere's disease infrequent x x x x x
Metrorrhagia Metrorrhagia infrequent x
Hypertonia Hypertonia infrequent x x x x x x
Fungal infection Fungal infection infrequent x
Myoclonus Myoclonus infrequent x x x x x
Nail disorder Nail disorder infrequent x
Neoplasm Neoplasm infrequent x
Neuralgia Neuralgia infrequent x x x x x x
Neurosis Neurosis infrequent x x x x x x
Nocturia Nocturia infrequent x x x x x x x x
Nystagmus Nystagmus infrequent x x x x x x x x
Oliguria Oliguria infrequent x x x x x
Osteoporosis Osteoporosis infrequent x
Otitis externa Otitis externa infrequent x
Otitis media Otitis media infrequent x x x x x x x x
Pallor Pallor infrequent x
Pancreatitis Pancreatitis very rare — infrequent x x x x x x x x x x x x x x x x x x x x
Paresis Paresis infrequent x x x x x x
Peptic ulcer Peptic ulcer infrequent x x x
Neuropathy peripheral Neuropathy peripheral infrequent x x x x x x
Neuropathy infrequent x
Peritonitis Peritonitis infrequent x x x x x
Personality disorder Personality disorder infrequent x x x x x
Phlebitis Phlebitis infrequent x
Pleural effusion Pleural effusion infrequent x
Polyuria Polyuria infrequent x x x x x x
Urine output increased Polyuria infrequent x x x x x x
Supraventricular extrasystoles Supraventricular extrasystoles infrequent x x x x x
Pruritus genital Pruritus genital infrequent x
Psychotic disorder Psychotic disorder infrequent x x x x x x
Pulmonary oedema Pulmonary oedema infrequent x
Pulmonary embolism Pulmonary embolism infrequent x x x x x x
Emphysema Emphysema infrequent x
Purpura Purpura infrequent, frequent x x x x x x
Vascular purpura Purpura infrequent, frequent x x x x x x
Pyuria Pyuria infrequent x
Anorectal disorder Rectal disorder infrequent x
Renal failure Renal failure infrequent x x
Respiratory failure Respiratory insufficiency infrequent x
Restless legs syndrome Restless legs syndrome infrequent x x x x x
Retinal disorder Retinal disorder infrequent x x x x x
Seborrhoeic dermatitis Seborrhoeic dermatitis infrequent x
Salivary hypersecretion Salivary hypersecretion infrequent — 2% 0% x x x x x x x x x x x x x x x
Sick sinus syndrome Sick sinus syndrome postmarketing, infrequent x x x x x x x x x x x x x x x x x
Skin ulcer Skin ulcer infrequent, frequent x x x x x x x x x
Speech disorder Speech disorder infrequent x
Gastric ulcer Gastric ulcer infrequent, uncommon x x x x x x x x x x x x
Mouth ulceration Ulcerative stomatitis infrequent x x x x x x
Cerebrovascular accident Cerebrovascular accident infrequent, uncommon x x x x x x x
Suicide attempt Suicide attempt infrequent x x x x x x x
Sunburn Sunburn infrequent