Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.)
Information about indications was extracted from the indications and usage sections of the labels.
|
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
|
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
|
Anaemia def
|
Anaemia def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Angina pectoris def
|
Angina pectoris def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthralgia def
|
Arthralgia def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal discomfort
|
Arthralgia def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myalgia def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthritis def
|
Arthritis def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rheumatoid arthritis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Ataxia def
|
Ataxia def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation def
|
Atrial fibrillation def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Back pain def
|
Back pain def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bronchitis def
|
Bronchitis def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neoplasm malignant def
|
Carcinoma def
|
infrequent, frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Basal cell carcinoma def
|
Basal cell carcinoma def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Transient ischaemic attack def
|
Transient ischaemic attack def
|
frequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebrovascular disorder def
|
Cerebrovascular disorder def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Chest pain def
|
Chest pain def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Retrosternal pain
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Confusional state def
|
Confusional state def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Feeling abnormal
|
Confusional state def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctivitis def
|
Conjunctivitis def
|
infrequent, frequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Constipation def
|
Constipation def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Convulsion def
|
Convulsion def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough def
|
Cough def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dehydration def
|
Dehydration def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Delusion def
|
Delusion def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyskinesia def
|
Dyskinesia def
|
frequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Movement disorder def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Dyspepsia def
|
Dyspepsia def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspnoea def
|
Dyspnoea def
|
frequent
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eczema def
|
Eczema def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema def
|
Oedema def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epistaxis def
|
Epistaxis def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis def
|
Rash def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash def
|
Rash def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eruption
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Extrapyramidal disorder def
|
Extrapyramidal disorder def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Extrapyramidal symptoms
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Faecal incontinence def
|
Faecal incontinence def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Body temperature increased def
|
Body temperature increased def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flushing def
|
Flushing def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastritis def
|
Gastritis def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac failure def
|
Cardiac failure def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematoma def
|
Haematoma def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematuria def
|
Haematuria def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypersensitivity def
|
Hypersensitivity def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokalaemia def
|
Hypokalaemia def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotension def
|
Hypotension def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orthostatic hypotension def
|
Orthostatic hypotension def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Incontinence def
|
Incontinence def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infarction def
|
Infarction def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infection def
|
Infection def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Influenza def
|
Influenza def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle spasms def
|
Cramps of lower extremities
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cramp muscle def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle spasms def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Pain in extremity def
|
Leg pain
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Myocardial infarction def
|
Myocardial infarction def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acute coronary syndrome def
|
Myocardial infarction def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nasopharyngitis def
|
Nasopharyngitis def
|
frequent
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Nightmare def
|
Nightmare def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Pain def
|
Pain def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stinging
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Palpitations def
|
Palpitations def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paraesthesia def
|
Paraesthesia def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pharyngitis def
|
Pharyngitis def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pneumonia def
|
Pneumonia def
|
frequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Prostatic disorder def
|
Prostatic disorder def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Pruritus def
|
Pruritus def
|
infrequent, frequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Purpura def
|
Purpura def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vascular purpura
|
Purpura def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Respiratory tract infection def
|
Respiratory tract infection def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinusitis def
|
Sinusitis def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Skin disorder def
|
Skin disorder def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Skin ulcer def
|
Skin ulcer def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dizziness def
|
Syncope def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dizziness def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Shock def
|
Syncope def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope def
|
Syncope def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope vasovagal def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Loss of consciousness def
|
Syncope def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombocytopenia def
|
Thrombocytopenia def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tinnitus def
|
Tinnitus def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tooth disorder def
|
Tooth disorder def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Ulcer def
|
Ulcer def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Upper respiratory tract infection def
|
Upper respiratory tract infection def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary tract infection def
|
Urinary tract infection def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo def
|
Vertigo def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Viral infection def
|
Viral infection def
|
frequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Agitation def
|
Agitation def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkinesia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema peripheral def
|
Oedema peripheral def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cataract def
|
Cataract def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paranoia def
|
Paranoid reaction
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myalgia def
|
Myalgia def
|
infrequent, frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac fibrillation
|
Cardiac fibrillation
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bradykinesia
|
Bradykinesia
|
frequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chills def
|
Rigors
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bradycardia def
|
Bradycardia def
|
frequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gait disturbance def
|
Gait disturbance def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Menopausal symptoms def
|
Hot flush def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hot flush def
|
Hot flush def
|
frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Congenital anomaly def
|
Congenital anomaly def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Developmental delay
|
Congenital anomaly def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Abscess def
|
Abscess def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Adenocarcinoma def
|
Adenocarcinoma def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Adenoma benign def
|
Adenoma benign def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ageusia def
|
Ageusia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Albuminuria def
|
Albuminuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Alopecia def
|
Alopecia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amnesia def
|
Amnesia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypochromic anaemia def
|
Hypochromic anaemia def
|
infrequent
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Aneurysm def
|
Aneurysm def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aphasia def
|
Aphasia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apnoea def
|
Apnoea def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apraxia def
|
Apraxia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arrhythmia def
|
Arrhythmia def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Rheumatoid arthritis def
|
Rheumatoid arthritis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Atrioventricular block def
|
Atrioventricular block def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bacterial infection def
|
Bacterial infection def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Bladder disorder def
|
Bladder disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Neurogenic bladder def
|
Neurogenic bladder def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blepharitis def
|
Blepharitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blepharospasm def
|
Blepharospasm def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bone disorder def
|
Bone disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Breast cancer def
|
Breast cancer def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Bronchospasm def
|
Bronchospasm def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bundle branch block def
|
Bundle branch block def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bursitis def
|
Bursitis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Cachexia def
|
Cachexia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Candidiasis def
|
Candidiasis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Skin cancer def
|
Skin cancer def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Cellulitis def
|
Cellulitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholecystitis def
|
Cholecystitis def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cholelithiasis def
|
Cholelithiasis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Colitis def
|
Colitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coma def
|
Coma def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Conjunctival haemorrhage
|
Conjunctival haemorrhage
|
infrequent
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Cystitis def
|
Cystitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bladder pain def
|
Cystitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cystitis noninfective def
|
Cystitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cyst def
|
Cyst def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Deafness def
|
Deafness def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Libido decreased def
|
Libido decreased def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disturbance in sexual arousal
|
Libido decreased def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido increased def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphagia def
|
Dysphagia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Delirium def
|
Delirium def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dental caries def
|
Dental caries def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Depersonalisation def
|
Depersonalisation def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis contact def
|
Dermatitis contact def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetes mellitus def
|
Diabetes mellitus def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diplopia def
|
Diplopia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diverticulitis def
|
Diverticulitis def
|
infrequent
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Duodenal ulcer def
|
Duodenal ulcer def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysuria def
|
Dysuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ear disorder def
|
Ear disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Ear pain def
|
Ear pain def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Effusion def
|
Effusion def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Embolism def
|
Embolism def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epilepsy def
|
Epilepsy def
|
infrequent
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophagitis def
|
Oesophagitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Congenital eye disorder def
|
Congenital eye disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Eye disorder def
|
Congenital eye disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Eye disorder def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Eyelid disorder def
|
Eyelid disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Furuncle def
|
Furunculosis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Gastroenteritis def
|
Gastroenteritis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrooesophageal reflux disease def
|
Gastrooesophageal reflux disease def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal haemorrhage def
|
Gastrointestinal haemorrhage def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gingivitis def
|
Gingivitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glaucoma def
|
Glaucoma def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Glossitis def
|
Glossitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Goitre def
|
Goitre def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gout def
|
Gout def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breath odour def
|
Breath odour def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac arrest def
|
Cardiac arrest def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematemesis def
|
Haematemesis def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haematochezia def
|
Haematochezia def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Hemiparesis
|
Hemiparesis
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhage def
|
Haemorrhage def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemoglobin def
|
Haemorrhage def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Haemorrhoids def
|
Haemorrhoids def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hernia def
|
Hernia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes virus infection def
|
Herpes NOS def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes simplex def
|
Herpes simplex def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Herpes zoster def
|
Herpes zoster def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Hiccups def
|
Hiccups def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Hypercholesterolaemia def
|
Hypercholesterolaemia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperglycaemia def
|
Hyperglycaemia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperlipidaemia def
|
Hyperlipidaemia def
|
infrequent
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertrophy def
|
Hypertrophy def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperventilation def
|
Hyperventilation def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Hypoaesthesia def
|
Hypoaesthesia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoglycaemia def
|
Hypoglycaemia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyponatraemia def
|
Hyponatraemia def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Body temperature decreased def
|
Body temperature decreased def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypothermia
|
Body temperature decreased def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypothyroidism def
|
Hypothyroidism def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido increased def
|
Libido increased def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Inflammation def
|
Inflammation def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Intestinal obstruction def
|
Intestinal obstruction def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ischaemia def
|
Ischaemia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthropathy def
|
Arthropathy def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Osteoarthritis def
|
Arthropathy def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Dysarthria def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Nephrolithiasis def
|
Calculus of kidney def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal failure acute def
|
Renal failure acute def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Renal cyst def
|
Renal cyst def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Laryngitis def
|
Laryngitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Leukocytosis def
|
Leukocytosis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lung disorder def
|
Lung disorder def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Mastitis def
|
Mastitis def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast pain def
|
Breast pain def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Melaena def
|
Melaena def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Metrorrhagia def
|
Metrorrhagia def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Hypertonia def
|
Hypertonia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fungal infection def
|
Fungal infection def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Myoclonus def
|
Myoclonus def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nail disorder def
|
Nail disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Neoplasm def
|
Neoplasm def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Neuralgia def
|
Neuralgia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neurosis def
|
Neurosis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nocturia def
|
Nocturia def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nystagmus def
|
Nystagmus def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Obstruction def
|
Obstruction def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oliguria def
|
Oliguria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Osteoporosis def
|
Osteoporosis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Ear infection def
|
Otitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Otitis externa def
|
Otitis externa def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Otitis media def
|
Otitis media def
|
infrequent
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Pallor def
|
Pallor def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Pancreatitis def
|
Pancreatitis def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paresis def
|
Paresis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peptic ulcer def
|
Peptic ulcer def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Neuropathy peripheral def
|
Neuropathy peripheral def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuropathy def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peritonitis def
|
Peritonitis def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Personality disorder def
|
Personality disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Phlebitis def
|
Phlebitis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Pleural disorder def
|
Pleural disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Pleural effusion def
|
Pleural effusion def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Polyp def
|
Polyp def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Polyuria def
|
Polyuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urine output increased
|
Polyuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus genital
|
Pruritus genital
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Psychotic disorder def
|
Psychotic disorder def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary oedema def
|
Pulmonary oedema def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Pulmonary embolism def
|
Pulmonary embolism def
|
infrequent
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Emphysema def
|
Emphysema def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Pyuria def
|
Pyuria def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Anorectal disorder def
|
Rectal disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Renal failure def
|
Renal failure def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Respiratory disorder def
|
Respiratory disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Respiratory failure def
|
Respiratory insufficiency def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Restless legs syndrome def
|
Restless legs syndrome def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Retinal disorder def
|
Retinal disorder def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Seborrhoeic dermatitis def
|
Seborrhoeic dermatitis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Salivary hypersecretion def
|
Salivary hypersecretion def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sick sinus syndrome def
|
Sick sinus syndrome def
|
infrequent
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Neoplasm skin def
|
Neoplasm skin def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Speech disorder def
|
Speech disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Gastric ulcer def
|
Gastric ulcer def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stomatitis def
|
Stomatitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mouth ulceration def
|
Ulcerative stomatitis
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Completed suicide
|
Suicide def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Suicide attempt def
|
Suicide attempt def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
Tachycardia def
|
Tachycardia def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Supraventricular tachycardia def
|
Supraventricular tachycardia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tendonitis def
|
Tendonitis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Thirst def
|
Thirst def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombophlebitis def
|
Thrombophlebitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Thrombosis def
|
Thrombosis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Onychomycosis def
|
Onychomycosis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Erythema def
|
Erythema def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Urethral disorder def
|
Urethral disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Urinary tract disorder def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pollakiuria def
|
Pollakiuria def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Micturition urgency def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary incontinence def
|
Urinary incontinence def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Micturition disorder def
|
Micturition disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Urinary tract disorder def
|
Urinary tract disorder def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria def
|
Urticaria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Uterine disorder def
|
Uterine disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Vaginal inflammation def
|
Vaginal inflammation def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal infection def
|
Vaginal inflammation def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Varicose vein def
|
Varicose vein def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Angiopathy def
|
Angiopathy def
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Vasculitis def
|
Vasculitis def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Presyncope def
|
Syncope vasovagal def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vestibular disorder def
|
Vestibular disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Skin papilloma def
|
Common wart def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Weight increased def
|
Weight increased def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Dry mouth def
|
Dry mouth def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary retention def
|
Urinary retention def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sudden cardiac death def
|
Sudden cardiac death def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Micturition urgency def
|
Micturition urgency def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Apathy def
|
Apathy def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flat affect
|
Apathy def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mood swings
|
Mood swings
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Affect lability
|
Mood swings
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokinesia def
|
Hypokinesia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic function abnormal
|
Hepatic function abnormal
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Migraine def
|
Migraine def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Periorbital oedema def
|
Periorbital oedema def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Generalised oedema
|
Generalised oedema
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Fluid retention
|
Generalised oedema
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Haemorrhage intracranial def
|
Haemorrhage intracranial def
|
infrequent
|
|
|
|
x
|
|
x
|
|
x
|
x
|
x
|
|
Skin hypertrophy
|
Skin hypertrophy
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Myocardial ischaemia def
|
Myocardial ischaemia def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Renal impairment def
|
Kidney function abnormal
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Muscular weakness def
|
Muscular weakness def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Bone pain def
|
Bone pain def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Eye pain def
|
Eye pain def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood alkaline phosphatase increased def
|
Phosphatase alkaline increased
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyporeflexia
|
Hyporeflexia
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Hyperreflexia
|
Hyperreflexia
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Skin discolouration def
|
Skin discolouration def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Dry skin def
|
Dry skin def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Tendon disorder
|
Tendon disorder
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Deep vein thrombosis def
|
Deep thrombophlebitis
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Spine malformation
|
Spine malformation
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Breath sounds abnormal
|
Abnormal chest sounds NOS
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Musculoskeletal stiffness
|
Muscle stiffness
|
infrequent
|
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Stiffness
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash papular
|
Rash papular
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Atrophic vulvovaginitis
|
Vaginitis atrophic def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Increased appetite
|
Increased appetite
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Proctalgia def
|
Rectal tenesmus def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rectal tenesmus def
|
Rectal tenesmus def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anorectal discomfort
|
Rectal tenesmus def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash erythematous
|
Rash erythematous
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
x
|
|
Muscle contractions involuntary
|
Muscle contractions involuntary
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Feeling cold
|
Feeling cool
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disturbance in attention
|
Cerebration impaired def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mental disability
|
Cerebration impaired def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Peripheral ischaemia def
|
Peripheral ischaemia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis bullous def
|
Bullous eruption
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Cold sweat
|
Skin cold clammy
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sticky skin
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hepatic enzyme increased
|
Hepatic enzyme increased
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Skin exfoliation
|
Skin exfoliation
|
infrequent
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Crocodile tears syndrome
|
Crocodile tears syndrome
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Dermal cyst
|
Dermal cyst
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Erectile dysfunction def
|
Erectile dysfunction def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sepsis def
|
Sepsis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Rectal haemorrhage def
|
Rectal haemorrhage def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Extrasystoles def
|
Extrasystoles def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vision blurred def
|
Vision blurred def
|
infrequent
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac death def
|
Cardiac death def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sticky skin
|
Sticky skin
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperpyrexia
|
Hyperpyrexia
|
infrequent
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Dystonia def
|
Dystonia def
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lacrimation increased def
|
Lacrimation def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Suicidal ideation def
|
Suicidal ideation def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkinesia def
|
Hyperkinesia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lymphadenopathy def
|
Lymphadenopathy def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Prostatic adenoma
|
Prostatic adenoma
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coordination abnormal
|
Coordination abnormal
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Congenital joint malformation
|
Congenital joint malformation
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Electrocardiogram abnormal
|
Electrocardiogram abnormal
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Face oedema def
|
Face oedema def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Blood prolactin increased
|
PRL increased
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Increased prolactin level
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Heart sounds abnormal
|
Heart sounds abnormal
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Colon cancer def
|
Carcinoma colon def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Bladder cancer def
|
Bladder carcinoma def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Acne def
|
Acne def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Cardiovascular disorder def
|
Unspecified circulatory system disorder
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Cardiovascular disorder def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Infection parasitic def
|
Infection parasitic def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Sleep disorder def
|
Sleep disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Arterial disorder def
|
Arterial disorder def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Endometrial hypertrophy
|
Endometrial hypertrophy
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkeratosis def
|
Hyperkeratosis def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Insomnia def
|
Insomnia def
|
infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Colonic polyp def
|
Polyp colorectal def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Polyp colorectal def
|
Polyp colorectal def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Death
|
Death
|
infrequent
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Breast neoplasm def
|
Breast neoplasm def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Dysphonia def
|
Dysphonia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia def
|
Weakness def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fatigue def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coronary artery disease def
|
Coronary artery disease def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Vaginal haemorrhage def
|
Vaginal haemorrhage def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
|
Abdominal pain def
|
Abdominal pain def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal pain def
|
Abdominal pain def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aggression def
|
Aggression def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aggressive reaction
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Decreased appetite
|
Anorexia def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Decreased appetite
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Appetite absent
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Anxiety def
|
Anxiety def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mental disorder def
|
Mental disorder def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Coagulopathy def
|
Coagulopathy def
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Breast disorder def
|
Breast disorder def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Collagen disorder def
|
Collagen disorder def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Connective tissue disorder def
|
Connective tissue disorder def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Diarrhoea def
|
Diarrhoea def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Drooling
|
Drooling
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Dysarthria def
|
Dysarthria def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Endocrine disorder def
|
Endocrine disorder def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hormone level abnormal
|
Endocrine disorder def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eructation def
|
Eructation def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oesophageal disorder def
|
Oesophageal disorder def
|
|
|
|
x
|
|
|
|
|
|
|
x
|
|
Fatigue def
|
Fatigue def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flatulence def
|
Flatulence def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal disorder def
|
Gastrointestinal disorder def
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hallucination def
|
Hallucination def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Headache def
|
Headache def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cardiac disorder def
|
Cardiac disorder def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Subdural haematoma def
|
Subdural haematoma def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Hyperhidrosis def
|
Hyperhidrosis def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Sweating def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sweating increased
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperplasia def
|
Hyperplasia def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Hypertension def
|
Hypertension def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chronic obstructive pulmonary disease def
|
Chronic obstructive pulmonary disease def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Mediastinal disorder def
|
Mediastinal disorder def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Movement disorder def
|
Movement disorder def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Muscle rigidity def
|
Muscle rigidity def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Musculoskeletal disorder def
|
Musculoskeletal disorder def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nausea def
|
Nausea def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nervous system disorder def
|
Nervous system disorder def
|
|
|
x
|
x
|
|
|
|
x
|
x
|
x
|
x
|
|
Nervousness def
|
Nervousness def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tension def
|
Nervousness def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Supraventricular extrasystoles def
|
Supraventricular extrasystoles def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Rhinitis def
|
Rhinitis def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cerebrovascular accident def
|
Cerebrovascular accident def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Tremor def
|
Tremor def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Visual impairment def
|
Visual impairment def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Visual acuity reduced
|
Visual impairment def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Blindness def
|
Visual impairment def
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Vomiting def
|
Vomiting def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Weight decreased def
|
Weight decreased def
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood amylase increased
|
Amylase increased
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Blood creatine phosphokinase increased
|
Creatine phosphokinase increased def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Electrocardiogram QT prolonged def
|
Electrocardiogram QT prolonged def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Skin irritation def
|
Skin irritation def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Malaise def
|
Malaise def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Discomfort def
|
Malaise def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ill-defined disorder
|
Malaise def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal pain upper
|
Abdominal pain upper
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Motor dysfunction
|
Motor dysfunction
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Hepatobiliary disease def
|
Hepatobiliary disease def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Depression def
|
Anxiety depression
|
|
|
|
|
|
|
|
|
|
x
|
|
|
Lipase increased def
|
Lipase increased def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Balance disorder
|
Balance disorder
|
|
|
|
|
|
|
|
|
|
|
x
|
|
Obstructive airways disorder def
|
Obstructive airways disorder def
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Aortic dissection def
|
Dissecting aortic aneurysm, thoracic
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Infestation
|
Infestation NOS
|
|
|
x
|
x
|
|
|
|
|
|
|
|
|
Benign prostatic hyperplasia def
|
Benign prostatic hyperplasia def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Prostatic hyperplasia def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
Somnolence def
|
Somnolence def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Indication
|
Labels
|
|
Dementia def
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|