| MedDRA Preferred Term | Side effect | Data for drug | Placebo | Labels | 
|  | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 
| Decreased appetite | Appetite absent | very common |  | x |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |  |  | x | 
| Decreased appetite | frequent, 1% - 9% | 1% - 5% |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x |  |  |  |  |  | 
| Anorexia | 1% - 17% | 0% - 3% |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Nausea | Nausea | very rare — 1% - 47% | 0% - 12% | x | x | x | x | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | 
| Diarrhoea | Diarrhoea | common — 1% - 19% | 1% - 11% | x |  |  | x |  |  |  |  |  | x | x | x |  | x | x | x |  | x | x | x | 
| Tremor | Tremor | common — 1% - 23% | 1% - 4% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Trembling | common |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Application site erythema | Application site erythema | common, 1% - 13% |  |  |  |  | x |  | x |  |  | x |  | x |  |  |  |  |  |  |  |  |  | 
| Anaemia | Anaemia | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Angina pectoris | Angina pectoris | frequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Arthralgia | Arthralgia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Musculoskeletal discomfort | Arthralgia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Myalgia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Arthritis | Arthritis | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Rheumatoid arthritis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ataxia | Ataxia | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Atrial fibrillation | Atrial fibrillation | postmarketing — frequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Back pain | Back pain | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Bronchitis | Bronchitis | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Basal cell carcinoma | Basal cell carcinoma | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Transient ischaemic attack | Transient ischaemic attack | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x | x | x | 
| Cerebrovascular disorder | Cerebrovascular disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Chest pain | Chest pain | rare — frequent |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Retrosternal pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Infection | Infection | frequent |  | x | x | x | x | x | x | x | x | x | x |  | x | x |  |  | x | x | x | x | x | 
| Confusional state | Confusional state | uncommon — 8% | 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Feeling abnormal | Confusional state | uncommon — 8% | 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Malaise | uncommon — 4% - 5% | 2% | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x | x | x | x | x | x | 
| Constipation | Constipation | frequent, 5% | 4% |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | 
| Dehydration | Dehydration | postmarketing — 1% - 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Depression | Depression | common, 2% - 6% | 1% - 4% |  | x | x | x | x |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | 
| Anxiety depression |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  | 
| Dyskinesia | Dyskinesia | common — 3% | 1% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x |  | x | x | x | x | 
| Movement disorder |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dyspepsia | Dyspepsia | common — 8% - 9% | 4% | x | x | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | 
| Dyspnoea | Dyspnoea | infrequent — 2% | 1% |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | x | x | x | x | 
| Eczema | Eczema | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Oedema | Oedema | infrequent — frequent |  |  |  |  | x |  | x |  |  | x |  |  | x |  |  |  | x | x | x | x | x | 
| Epistaxis | Epistaxis | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Dermatitis | Rash | postmarketing — frequent |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Dermatitis | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  | x | 
| Rash | Rash | postmarketing — frequent |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Extrapyramidal disorder | Extrapyramidal disorder | frequent | 0% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Extrapyramidal symptoms |  |  |  | x | x |  | x | x | x | x | x |  |  |  |  |  |  |  |  |  |  | x | 
| Faecal incontinence | Faecal incontinence | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Body temperature increased | Body temperature increased | frequent |  |  |  |  |  | x | x | x | x | x |  |  |  |  |  |  | x | x | x | x | x | 
| Multiple fractures | Fracture | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Fracture | Fracture | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Gastritis | Gastritis | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Cardiac failure | Cardiac failure | frequent |  |  |  |  |  |  | x |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Haematuria | Haematuria | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Hypersensitivity | Hypersensitivity | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Hypokalaemia | Hypokalaemia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Hypotension | Hypotension | infrequent — frequent |  |  |  | x |  | x |  | x | x |  |  | x | x | x | x | x | x | x | x | x | x | 
| Orthostatic hypotension | Orthostatic hypotension | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Muscle spasms | Cramps of lower extremities | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cramp muscle | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Muscle spasms | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Pain in extremity | Leg pain | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Myocardial infarction | Myocardial infarction | frequent |  | x |  |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Acute coronary syndrome | Myocardial infarction | frequent |  | x |  |  | x |  |  |  |  | x | x | x | x | x | x | x | x | x | x | x | x | 
| Nasopharyngitis | Nasopharyngitis | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Nightmare | Nightmare | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Palpitations | Palpitations | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Paraesthesia | Paraesthesia | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Pharyngitis | Pharyngitis | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Pneumonia | Pneumonia | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x | 
| Prostatic disorder | Prostatic disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Convulsion | Convulsion | postmarketing — frequent |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Sinusitis | Sinusitis | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin disorder | Skin disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Unspecified disorder of skin and subcutaneous tissue | postmarketing |  | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x |  |  |  |  | x | 
| Tinnitus | Tinnitus | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Tooth disorder | Tooth disorder | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Upper respiratory tract infection | Upper respiratory tract infection | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Urinary tract infection | Urinary tract infection | very rare — 1% - 10% | 1% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Vertigo | Vertigo | frequent, 0% - 2% | 1% |  |  |  |  |  |  |  |  |  | x | x | x | x |  |  | x | x | x | x | x | 
| Viral infection | Viral infection | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vomiting | Vomiting | very rare — 0.4% - 31% | 0% - 6% | x | x | x | x | x |  | x | x |  | x | x | x | x | x | x | x | x | x | x | x | 
| Injury | Trauma | frequent, 10% | 9% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Agitation | Agitation | postmarketing — 1% - 14% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hyperkinesia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Oedema peripheral | Oedema peripheral | frequent |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Cataract | Cataract | frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Paranoia | Paranoid reaction | frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Malaise | Malaise | uncommon — 4% - 5% | 2% | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x | x | x | x | x | x | 
| Unwell | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Discomfort | Malaise | uncommon — 4% - 5% | 2% | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x | x | x | x | x | x | 
| Ill-defined disorder | Malaise | uncommon — 4% - 5% | 2% | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x | x | x | x | x | x | 
| Myalgia | Myalgia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Hallucination, visual | Hallucination, visual | frequent |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  | 
| Chills | Rigors | frequent | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  | x | x | x | x | x | 
| Bradycardia | Bradycardia | infrequent — frequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Gait disturbance | Gait disturbance | frequent, 4% | 0% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x | x | x | x | x | x | 
| Menopausal symptoms | Hot flush | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Hot flush | Hot flush | frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Somnolence | Somnolence | uncommon — 1% - 6% | 1% - 3% | x | x | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | 
| Drowsiness | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Abdominal pain | Abdominal pain | common, 1% - 13% | 1% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Stomach ache | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Gastrointestinal pain | Abdominal pain | common, 1% - 13% | 1% - 6% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Anxiety | Anxiety | common, 1% - 5% | 1% - 3% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Asthenia | Fatigue | common, 0% - 9% | 0% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Asthenia | common, 0% - 6% | 0% - 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Fatigue | Fatigue | common, 0% - 9% | 0% - 5% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Flatulence | Flatulence | frequent, 4% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Hallucination | Hallucination | very rare — 2% - 5% | 3% | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Headache | Headache | common, 1% - 17% | 2% - 12% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Nervousness | Nervousness | 4% | 3% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Tension | Nervousness | 4% | 3% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Rhinitis | Rhinitis | 4% | 3% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Abdominal pain upper | Abdominal pain upper | 1% - 4% | 1% - 2% |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | x | x | x | x | 
| Stomach ache | very rare |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Hyperhidrosis | Sweating increased | common — 2% - 4% | 1% |  |  |  |  |  | x |  |  | x | x | x |  |  | x | x | x | x | x | x | x | 
| Hyperhidrosis | uncommon — 2% | 1% | x | x | x | x | x |  | x | x | x | x |  |  |  |  |  |  |  |  |  | x | 
| Sweating | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Cardiovascular disorder | Cardiovascular disorder | 3% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Unspecified circulatory system disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dizziness | Dizziness | common, 0% - 21% | 0% - 11% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Syncope | uncommon — 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hypertension | Hypertension | very rare — 1% - 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Parkinson's disease | Parkinson's disease | postmarketing — 3% | 1% |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  |  | x | x | x | 
| Parkinsonism | Parkinson's disease | postmarketing — 3% | 1% |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  |  | x | x | x | 
| Parkinsonism | 2% | 1% |  | x | x |  | x |  | x | x |  |  |  | x | x | x | x |  | x | x | x | x | 
| Shock | Syncope | uncommon — 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Syncope | Syncope | uncommon — 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Syncope vasovagal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Loss of consciousness | Syncope | uncommon — 3% | 2% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Weight decreased | Weight decreased | common — 1% - 8% | 0% - 1% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Cogwheel rigidity | Cogwheel rigidity | common, 3% | 0% |  |  | x |  | x |  | x | x |  |  | x |  |  | x | x |  |  |  |  |  | 
| Bradykinesia | Bradykinesia | common — 2% - 4% | 2% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x |  | x | x | x | x | 
| Influenza like illness | Influenza-like symptoms | frequent, 3% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Insomnia | Insomnia | infrequent — 1% - 9% | 2% - 7% | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Aggression | Aggressive reaction | 3% | 2% |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Aggression | postmarketing — 0.4% - 3% |  | x | x | x | x | x | x | x | x | x | x | x |  |  | x | x |  |  |  |  |  | 
| Conjunctivitis | Conjunctivitis | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Pain | Pain | infrequent, frequent |  |  |  |  |  |  | x |  |  | x | x |  | x |  |  |  | x | x | x | x | x | 
| Stinging |  |  |  |  |  |  |  | x |  |  | x |  |  | x |  |  |  |  |  |  |  |  | 
| Application site pruritus | Application site pruritus | common, 1% - 4% |  |  |  |  | x |  | x |  |  | x |  | x | x |  |  |  |  |  |  |  |  | 
| Eructation | Eructation | 2% | 1% |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  | x | x | x | x | x | 
| Pruritus | Pruritus | postmarketing — 1.7% - 2% | 1% | x | x | x | x | x | x | x | x | x | x | x | x | x |  |  |  |  |  |  | x | 
| Pollakiuria | Pollakiuria | infrequent, 2% | 1% |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x | 
| Micturition urgency | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Visual impairment | Abnormal vision | 2% | 1% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Disorder sight |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Urinary incontinence | Urinary incontinence | infrequent — 1% - 3% | 2% |  |  |  | x |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Abscess | Abscess | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Adams-Stokes syndrome | Adams-Stokes syndrome | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Adenocarcinoma | Adenocarcinoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Albuminuria | Albuminuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Alopecia | Alopecia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Amnesia | Amnesia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypochromic anaemia | Hypochromic anaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Aneurysm | Aneurysm | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Aphasia | Aphasia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Apnoea | Apnoea | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Apraxia | Apraxia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Arrhythmia | Arrhythmia | very rare — uncommon |  | x | x | x | x | x |  | x | x | x | x | x | x | x |  |  |  |  |  |  | x | 
| Rheumatoid arthritis | Rheumatoid arthritis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Atrioventricular block | Atrioventricular block | postmarketing — uncommon |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Bacterial infection | Bacterial infection | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Bladder disorder | Bladder disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neurogenic bladder | Neurogenic bladder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Blepharitis | Blepharitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Blepharospasm | Blepharospasm | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Bone disorder | Bone disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Nervous system disorder | Brain disorder NOS | uncommon |  |  |  |  |  |  |  |  |  |  |  |  |  | x |  |  |  |  |  |  |  | 
| Nervous system disorder |  |  | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x |  | x | x | x | x | 
| Breast cancer | Breast cancer | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Bronchospasm | Bronchospasm | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Bundle branch block | Bundle branch block | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Bursitis | Bursitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cachexia | Cachexia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Candida infection | Candida infection | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neoplasm malignant | Carcinoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin cancer | Skin cancer | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Cellulitis | Cellulitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cholecystitis | Cholecystitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Cholelithiasis | Cholelithiasis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Colitis | Colitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Coma | Coma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Conjunctival haemorrhage | Conjunctival haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cough | Cough | infrequent, frequent |  |  |  |  |  |  |  |  |  |  | x |  |  |  | x | x | x | x | x | x | x | 
| Cystitis | Cystitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Bladder pain | Cystitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cystitis noninfective | Cystitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Deafness | Deafness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Libido decreased | Libido decreased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Disturbance in sexual arousal | Libido decreased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Libido increased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Dysphagia | Dysphagia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Delirium | Delirium | infrequent, uncommon |  | x |  |  | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | 
| Delusion | Delusion | infrequent, frequent |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  |  | x | x | x | x | x | 
| Dental caries | Dental caries | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Depersonalisation | Depersonalisation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Dermatitis contact | Dermatitis contact | infrequent, uncommon |  |  |  |  | x |  |  |  |  | x |  |  |  |  | x | x | x | x | x | x | x | 
| Diabetes mellitus | Diabetes mellitus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Diplopia | Diplopia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Diverticulitis | Diverticulitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Duodenal ulcer | Duodenal ulcer | rare, infrequent |  | x | x | x | x | x | x | x | x | x | x | x |  | x | x | x | x | x | x | x | x | 
| Dysgeusia | Dysgeusia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Dysuria | Dysuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Ear disorder | Ear disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ear pain | Ear pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Epilepsy | Epilepsy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Oesophagitis | Oesophagitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Congenital eye disorder | Congenital eye disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Eye disorder | Congenital eye disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Eye disorder |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Eyelid disorder | Eyelid disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Flushing | Flushing | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Furuncle | Furunculosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gastroenteritis | Gastroenteritis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Gastrooesophageal reflux disease | Gastrooesophageal reflux disease | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Gastrointestinal haemorrhage | Gastrointestinal haemorrhage | very rare — uncommon |  | x | x | x | x | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | x | 
| Gingivitis | Gingivitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Glaucoma | Glaucoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | 
| Glossitis | Glossitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Goitre | Goitre | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Gout | Gout | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Breath odour | Breath odour | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cardiac arrest | Cardiac arrest | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Haematemesis | Haematemesis | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Haematochezia | Haematochezia | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Haematoma | Haematoma | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Subdural haematoma | Subdural haematoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Hemiparesis | Hemiparesis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Haemorrhage | Haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Haemoglobin | Haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Haemorrhoids | Haemorrhoids | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hernia | Hernia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Herpes simplex | Herpes simplex | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Herpes zoster | Herpes zoster | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hiccups | Hiccups | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hip fracture | Hip fracture | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Hypercholesterolaemia | Hypercholesterolaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hyperglycaemia | Hyperglycaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hyperlipidaemia | Hyperlipidaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  | x | x | x | x | 
| Hyperventilation | Hyperventilation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hypoaesthesia | Hypoaesthesia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Hypoglycaemia | Hypoglycaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hyponatraemia | Hyponatraemia | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Body temperature decreased | Body temperature decreased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypothermia | Body temperature decreased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypothyroidism | Hypothyroidism | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Libido increased | Libido increased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Inflammation | Inflammation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Intestinal obstruction | Intestinal obstruction | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Arthropathy | Arthropathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Osteoarthritis | Arthropathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dysarthria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Nephrolithiasis | Calculus of kidney | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Renal failure acute | Renal failure acute | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Laryngitis | Laryngitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Leukocytosis | Leukocytosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Lung disorder | Lung disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Mastitis | Mastitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Breast pain | Breast pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Melaena | Melaena | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Meniere's disease | Meniere's disease | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Metrorrhagia | Metrorrhagia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hypertonia | Hypertonia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Fungal infection | Fungal infection | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Myoclonus | Myoclonus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Nail disorder | Nail disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neoplasm | Neoplasm | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Neuralgia | Neuralgia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Neurosis | Neurosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Nocturia | Nocturia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  | x | x | x | x | x | 
| Nystagmus | Nystagmus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Oliguria | Oliguria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x |  | 
| Osteoporosis | Osteoporosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Otitis externa | Otitis externa | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Otitis media | Otitis media | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Pallor | Pallor | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pancreatitis | Pancreatitis | very rare — infrequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Paresis | Paresis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Peptic ulcer | Peptic ulcer | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  | x | 
| Neuropathy peripheral | Neuropathy peripheral | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Neuropathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Peritonitis | Peritonitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Personality disorder | Personality disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x |  | 
| Phlebitis | Phlebitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pleural effusion | Pleural effusion | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Polyuria | Polyuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Urine output increased | Polyuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Supraventricular extrasystoles | Supraventricular extrasystoles | infrequent |  |  |  |  | x |  |  |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Pruritus genital | Pruritus genital | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Psychotic disorder | Psychotic disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Pulmonary oedema | Pulmonary oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Pulmonary embolism | Pulmonary embolism | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Emphysema | Emphysema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Purpura | Purpura | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Vascular purpura | Purpura | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Pyuria | Pyuria | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Anorectal disorder | Rectal disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Renal failure | Renal failure | infrequent |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Respiratory failure | Respiratory insufficiency | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Restless legs syndrome | Restless legs syndrome | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Retinal disorder | Retinal disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Seborrhoeic dermatitis | Seborrhoeic dermatitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Salivary hypersecretion | Salivary hypersecretion | infrequent — 2% | 0% |  | x | x |  | x |  | x | x |  |  | x | x | x | x | x | x | x | x | x | x | 
| Sick sinus syndrome | Sick sinus syndrome | postmarketing, infrequent |  | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x | x | x | x | x | x | 
| Skin ulcer | Skin ulcer | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  | x | x | x | x | x | 
| Speech disorder | Speech disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gastric ulcer | Gastric ulcer | infrequent, uncommon |  |  |  |  | x |  | x |  |  | x |  |  |  | x | x | x | x | x | x | x | x | 
| Mouth ulceration | Ulcerative stomatitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Cerebrovascular accident | Cerebrovascular accident | infrequent, uncommon |  | x |  |  | x |  |  |  |  | x | x | x | x |  |  | x |  |  |  |  |  | 
| Suicide attempt | Suicide attempt | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x |  | 
| Sunburn | Sunburn | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Photosensitivity reaction | Sunburn | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Tachycardia | Tachycardia | postmarketing, infrequent |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Supraventricular tachycardia | Supraventricular tachycardia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Tendonitis | Tendonitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Thirst | Thirst | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Thrombocytopenia | Thrombocytopenia | infrequent, frequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Thrombophlebitis | Thrombophlebitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Thrombosis | Thrombosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Onychomycosis | Onychomycosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Erythema | Erythema | postmarketing — 1.1% |  | x |  |  | x |  | x | x | x | x | x | x | x | x |  | x |  |  |  |  |  | 
| Urethral disorder | Urethral disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Urinary tract disorder |  |  |  |  |  | x |  | x |  |  | x |  |  | x | x | x | x | x | x | x | x | x | 
| Micturition disorder | Micturition disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Urticaria | Urticaria | postmarketing, infrequent |  | x |  |  | x |  | x | x | x | x | x | x |  |  | x | x | x | x | x | x | x | 
| Uterine disorder | Uterine disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vaginal inflammation | Vaginal inflammation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Vaginal infection | Vaginal inflammation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Varicose vein | Varicose vein | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Angiopathy | Angiopathy | infrequent |  | x | x | x |  | x | x | x | x |  |  | x | x | x |  |  |  |  |  |  | x | 
| Vasculitis | Vasculitis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Presyncope | Syncope vasovagal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Vestibular disorder | Vestibular disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin papilloma | Common wart | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Weight increased | Weight increased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dry mouth | Dry mouth | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Urinary retention | Urinary retention | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Sudden cardiac death | Sudden cardiac death | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Micturition urgency | Micturition urgency | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Apathy | Apathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Flat affect | Apathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Mood swings | Mood swings | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Affect lability | Mood swings | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Hypokinesia | Hypokinesia | infrequent — 2% - 4% | 0% |  | x | x |  | x |  | x | x |  |  | x |  |  | x | x | x | x | x | x | x | 
| Migraine | Migraine | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | x | x | x | 
| Periorbital oedema | Periorbital oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Generalised oedema | Generalised oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Fluid retention | Generalised oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Haemorrhage intracranial | Haemorrhage intracranial | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  | x | x | x | 
| Skin hypertrophy | Skin hypertrophy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Myocardial ischaemia | Myocardial ischaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Renal impairment | Kidney function abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscular weakness | Muscular weakness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Bone pain | Bone pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Eye pain | Eye pain | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Blood alkaline phosphatase increased | Phosphatase alkaline increased | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Electrocardiogram QT prolonged | Electrocardiogram QT prolonged | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Hyporeflexia | Hyporeflexia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Hyperreflexia | Hyperreflexia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Skin discolouration | Skin discolouration | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dry skin | Dry skin | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Tendon disorder | Tendon disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Spine malformation | Spine malformation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Breath sounds abnormal | Abnormal chest sounds NOS | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Musculoskeletal stiffness | Muscle stiffness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x | x | x | 
| Stiffness | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Musculoskeletal stiffness |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Atrophic vulvovaginitis | Vaginitis atrophic | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Increased appetite | Increased appetite | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Proctalgia | Rectal tenesmus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Rectal tenesmus | Rectal tenesmus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Anorectal discomfort | Rectal tenesmus | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Rash erythematous | Rash erythematous | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  | x | 
| Muscle contractions involuntary | Muscle contractions involuntary | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Disturbance in attention | Cerebration impaired | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Mental disability | Cerebration impaired | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Peripheral ischaemia | Peripheral ischaemia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Dermatitis bullous | Bullous eruption | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Blister | postmarketing |  | x |  |  | x |  |  |  |  | x | x | x |  |  |  | x |  |  |  |  |  | 
| Cold sweat | Skin cold clammy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Lacrimal disorder | Lacrimation abnormal NOS | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Skin exfoliation | Skin exfoliation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dermal cyst | Dermal cyst | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Erectile dysfunction | Erectile dysfunction | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Sepsis | Sepsis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Rectal haemorrhage | Rectal haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Extrasystoles | Extrasystoles | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Vision blurred | Vision blurred | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x |  | x | x | x | x | 
| Rash maculo-papular | Rash maculo-papular | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Suicidal ideation | Suicidal ideation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Hyperkinesia | Hyperkinesia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Lymphadenopathy | Lymphadenopathy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Dementia | Dementia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  | x | x | 
| Prostatic adenoma | Prostatic adenoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Coordination abnormal | Coordination abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Congenital joint malformation | Congenital joint malformation | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Electrocardiogram abnormal | Electrocardiogram abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Face oedema | Face oedema | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Lipase increased | Lipase increased | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Heart sounds abnormal | Heart sounds abnormal | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Colon cancer | Carcinoma colon | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Bladder cancer | Bladder carcinoma | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Infection parasitic | Infection parasitic | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Blood prolactin increased | Increased prolactin level | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Sleep disorder | Sleep disorder | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Amylase increased | Blood amylase increased | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Blood creatine phosphokinase increased | Blood creatine phosphokinase increased | infrequent |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Endometrial hypertrophy | Endometrial hypertrophy | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Hyperkeratosis | Hyperkeratosis | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Large intestine polyp | Large intestine polyp | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Freezing phenomenon | Freezing phenomenon | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | 
| Dysphonia | Dysphonia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Coronary artery disease | Coronary artery disease | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Anaemia vitamin B12 deficiency | Anaemia vitamin B12 deficiency | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Renal cyst | Renal cyst | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Ageusia | Ageusia | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Vaginal haemorrhage | Vaginal haemorrhage | infrequent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Mental disorder | Mental disorder | postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Blister | Blister | postmarketing |  | x |  |  | x |  |  |  |  | x | x | x |  |  |  | x |  |  |  |  |  | 
| Dermatitis atopic | Dermatitis atopic | postmarketing |  | x |  |  | x |  | x | x | x | x | x | x |  |  |  | x |  |  |  |  |  | 
| Cutaneous hypersensitivity | postmarketing, rare |  | x |  | x |  |  | x | x | x | x | x | x |  |  | x | x |  |  |  |  |  | 
| Cardiac disorder | Cardiac disorder | postmarketing |  | x | x | x | x | x | x | x | x | x |  | x | x | x |  |  |  |  |  |  |  | 
| Hepatitis | Hepatitis | postmarketing |  | x | x | x | x | x | x | x | x | x | x |  |  |  | x | x |  |  |  |  |  | 
| Erythema multiforme | Stevens-Johnson syndrome | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  | x | x | x | x | 
| Stevens-Johnson syndrome | Stevens-Johnson syndrome | postmarketing |  |  |  |  |  |  |  |  |  |  |  |  | x |  | x | x |  | x | x | x | x | 
| Liver function test abnormal | Liver function test abnormal | postmarketing |  |  |  |  | x |  |  |  |  | x |  | x |  |  |  |  |  |  |  |  |  | 
| Raised liver function tests |  |  |  | x | x |  | x | x | x | x |  |  |  |  |  |  |  |  |  |  |  |  | 
| Malnutrition | Malnutrition | postmarketing |  | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | x | 
| Hepatobiliary disease | Hepatobiliary disease | postmarketing |  | x | x | x |  | x | x | x | x |  | x |  | x | x | x | x |  |  |  |  |  | 
| Application site hypersensitivity | Application site hypersensitivity | postmarketing |  |  |  |  | x |  |  |  |  | x |  | x |  |  |  |  |  |  |  |  |  | 
| Oesophageal rupture | Oesophageal rupture | very rare |  | x | x | x | x | x | x | x | x | x | x |  | x |  |  |  |  |  |  |  | x | 
| Coagulopathy | Coagulopathy |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | 
| Breast disorder | Breast disorder |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Collagen disorder | Collagen disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Connective tissue disorder | Connective tissue disorder |  |  |  | x |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Drooling | Drooling |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Dysarthria | Dysarthria |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | 
| Gastrointestinal disorder | Gastrointestinal disorder |  |  | x | x | x | x | x | x | x | x | x |  | x |  |  | x | x |  | x | x | x | x | 
| Chronic obstructive pulmonary disease | Chronic obstructive pulmonary disease |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Bronchial hyperreactivity | Chronic obstructive pulmonary disease |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Mediastinal disorder | Mediastinal disorder |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x |  |  |  |  |  |  |  | 
| Movement disorder | Movement disorder |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Muscle rigidity | Muscle rigidity |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Musculoskeletal disorder | Musculoskeletal disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x | x | x | x | x | x | 
| Urinary tract disorder | Urinary tract disorder |  |  |  |  |  | x |  | x |  |  | x |  |  | x | x | x | x | x | x | x | x | x | 
| Skin irritation | Skin irritation |  |  |  |  |  | x |  | x |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Cardiac fibrillation | Cardiac fibrillation |  |  |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| Motor dysfunction | Motor dysfunction |  | 0% |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Application site oedema | Application site oedema |  |  |  |  |  |  |  | x |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Duodenitis haemorrhagic | Duodenitis haemorrhagic |  |  |  |  |  | x |  |  |  |  | x |  |  |  |  |  |  |  |  |  |  |  | 
| Hyperpyrexia | Hyperpyrexia |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Application site irritation | Application site irritation |  |  |  |  |  |  |  | x |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Application site rash | Application site rash |  |  |  |  |  |  |  | x |  |  | x |  | x | x | x |  |  |  |  |  |  |  | 
| Balance disorder | Balance disorder |  |  |  | x | x |  | x |  | x | x |  |  |  |  |  |  |  |  |  |  |  | x | 
| Infestation | Infestation NOS |  |  | x | x | x | x | x | x | x | x |  |  |  | x | x |  |  |  |  |  |  |  | 
| Application site pain | Application site burn |  |  |  |  |  |  |  | x |  |  | x |  |  | x |  |  |  |  |  |  |  |  | 
| Application site burn | Application site burn |  |  |  |  |  |  |  | x |  |  | x |  |  | x |  |  |  |  |  |  |  |  | 
| Application site eczema | Application site eczema |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  | 
| Benign prostatic hyperplasia | Benign prostatic hyperplasia |  |  |  |  |  |  |  |  |  |  |  |  |  | x | x |  |  |  |  |  |  |  |