Muscle rigidity

Definition: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)

Synonyms (terms occurring on more labels are shown first): rigidity, muscle rigidity, muscular rigidity, rigid

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Proteins predicted to cause Muscle rigidity: DRD3, HTR2A, HTR1A (inhibition) (62 predictions in total) Show drugs for which this side effect directly occurs

Drugs with this side effect as MedDRA Preferred Term Tacrine Hydrochloride Capsules Muscle rigidity: infrequent alfentanil Muscle rigidity almotriptan Muscle rigidity: infrequent alprazolam Muscle rigidity: 4.2% amitriptyline Muscle rigidity: postmarketing aripiprazole Muscle rigidity: rare, infrequent, frequent asenapine Muscle rigidity: 7% - 12% atorvastatin calcium Muscle rigidity bicalutamide Muscle rigidity bupivacaine Muscle rigidity bupropion Muscle rigidity: postmarketing buserelin (buserelin acetate) Muscle rigidity buspirone Muscle rigidity: postmarketing, rare, infrequent chlorpromazine Muscle rigidity citalopram Muscle rigidity clozapine Muscle rigidity: 3% cytarabine Muscle rigidity delavirdine mesylate Muscle rigidity diclofenac Muscle rigidity: postmarketing dihydroergotamine Muscle rigidity: rare diltiazem Muscle rigidity: postmarketing estradiol Muscle rigidity estrogens, conjugated Muscle rigidity eszopiclone Muscle rigidity: infrequent fentanyl Muscle rigidity fluoxetine Muscle rigidity: infrequent fluphenazine Muscle rigidity fluticasone propionate Muscle rigidity fluvoxamine maleate Muscle rigidity: rare, infrequent formoterol fumarate Muscle rigidity gadoteridol Muscle rigidity gadoversetamide Muscle rigidity geodon Muscle rigidity: frequent, 0% - 1% glatiramer acetate Muscle rigidity: postmarketing hydromorphone Muscle rigidity insulin recombinant human Muscle rigidity isoflurane Muscle rigidity lansoprazole Muscle rigidity: postmarketing levitra Muscle rigidity lithium cation Muscle rigidity lotronex Muscle rigidity loxapine Muscle rigidity lubiprostone Muscle rigidity methotrexate Muscle rigidity metoclopramide Muscle rigidity: postmarketing mirtazapine Muscle rigidity: infrequent modafinil Muscle rigidity molindone hydrochloride Muscle rigidity morphine Muscle rigidity naltrexone Muscle rigidity: postmarketing naproxen Muscle rigidity naratriptan Muscle rigidity nardil Muscle rigidity nefazodone Muscle rigidity olanzapine Muscle rigidity: infrequent, 2% - 20% paliperidone Muscle rigidity pantoprazole Muscle rigidity paroxetine Muscle rigidity: postmarketing, rare pilocarpine Muscle rigidity pimozide Muscle rigidity: postmarketing pipotiazine palmitate Muscle rigidity pramipexole dihydrochloride monohydrate Muscle rigidity pregabalin Muscle rigidity: rare, infrequent prialt Muscle rigidity prochlorperazine Muscle rigidity propofol Muscle rigidity: postmarketing quetiapine (quetiapine fumarate) Muscle rigidity: 0% - 8% rabeprazole sodium Muscle rigidity riluzole Muscle rigidity risedronate sodium Muscle rigidity risperidone Muscle rigidity: 3% - 28% ritonavir Muscle rigidity rivastigmine Muscle rigidity salmeterol xinafoate Muscle rigidity selegiline Muscle rigidity: infrequent sevoflurane Muscle rigidity: postmarketing sodium oxybate Muscle rigidity: infrequent succinylcholine Muscle rigidity sufentanil Muscle rigidity sumatriptan (sumatriptan succinate) Muscle rigidity thalidomide Muscle rigidity: 0% thioridazine Muscle rigidity tiagabine hydrochloride Muscle rigidity: infrequent tramadol Muscle rigidity trifluoperazine Muscle rigidity tropicamide Muscle rigidity ultiva Muscle rigidity: 0.881% - 17% valproic acid Muscle rigidity: postmarketing venlafaxine Muscle rigidity: infrequent zaleplon Muscle rigidity: infrequent zonisamide Muscle rigidity

Drugs with this indication baclofen dantrolene hyoscyamine