Side effects and indications
Whenever possible, frequency information about the side effects was extracted from the labels. Aggregated frequency information for the drug and, if available, placebo is shown. To the right, you can click on shaded boxes to be taken to mentions of the side effect on the label. (In some cases, the side effect cannot be highlighted due to conversion problems.)
Information about indications was extracted from the indications and usage sections of the labels.
Hide MedDRA Preferred Terms
|
MedDRA Preferred Term
|
Side effect
|
Data for drug
|
Placebo
|
Labels
(show all 16)
|
|
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
|
Sedation
|
Sedation
|
8% - 48%
|
7% - 9%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Somnolence def
|
Somnolence def
|
6% - 39%
|
3% - 35%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Increased appetite
|
Increased appetite
|
1% - 29%
|
0% - 9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Akathisia def
|
Akathisia def
|
infrequent, 0% - 27%
|
0% - 23%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dry mouth def
|
Dry mouth def
|
2% - 22%
|
0% - 22%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Asthenia def
|
Asthenia def
|
2% - 20%
|
1% - 15%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fatigue def
|
2% - 14%
|
2% - 6%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Extrapyramidal disorder def
|
Extrapyramidal disorder def
|
8% - 20%
|
10%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Extrapyramidal symptoms
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Hypertonia def
|
Hypertonia def
|
3% - 20%
|
2% - 10%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Muscle rigidity def
|
Muscle rigidity def
|
infrequent, 2% - 20%
|
1% - 10%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tremor def
|
Tremor def
|
0% - 20%
|
0% - 10%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Akinesia
|
Akinesia
|
rare — 8% - 20%
|
10%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypokinesia def
|
Hypokinesia def
|
infrequent, 8% - 20%
|
10%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cogwheel rigidity
|
Cogwheel rigidity
|
infrequent, 8% - 20%
|
10%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Masked facies
|
Masked facies
|
8% - 20%
|
10%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Dizziness def
|
Dizziness def
|
1% - 18%
|
2% - 18%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Syncope def
|
infrequent
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Headache def
|
Headache def
|
13% - 18%
|
6% - 17%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fatigue def
|
Fatigue def
|
2% - 14%
|
2% - 6%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Insomnia def
|
Insomnia def
|
12%
|
11% - 12%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Constipation def
|
Constipation def
|
4% - 11%
|
0% - 11%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyspepsia def
|
Dyspepsia def
|
3% - 11%
|
1% - 11%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Agitation def
|
Hyperkinesia def
|
5% - 11%
|
1%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperkinesia def
|
Hyperkinesia def
|
5% - 11%
|
1%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough def
|
Cough def
|
3% - 9%
|
3% - 6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cough increased
|
6%
|
3% - 6%
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nausea def
|
Nausea def
|
postmarketing — 0% - 9%
|
2% - 9%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aggression def
|
Aggression def
|
8%
|
4%
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
Personality disorder def
|
Personality disorder def
|
8%
|
4%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diarrhoea def
|
Diarrhoea def
|
infrequent, 2% - 7%
|
0% - 4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nasal congestion def
|
Nasal congestion def
|
1% - 7%
|
3%
|
|
|
|
x
|
|
|
|
|
|
|
|
Rhinitis def
|
Rhinitis def
|
7%
|
6% - 7%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abdominal pain def
|
Abdominal pain def
|
infrequent, 3% - 6%
|
2% - 7%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gastrointestinal pain def
|
Abdominal pain def
|
infrequent, 3% - 6%
|
2% - 7%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Body temperature increased def
|
Body temperature increased def
|
rare — 0% - 6%
|
0% - 6%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Fever chills
|
rare, infrequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Nasopharyngitis def
|
Nasopharyngitis def
|
1% - 6%
|
2%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Pain def
|
Pain def
|
rare — 0% - 6%
|
0% - 7%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pain in extremity def
|
Pain in extremity def
|
5% - 6%
|
0% - 5%
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vomiting def
|
Vomiting def
|
postmarketing — 1% - 6%
|
2% - 4%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Gait disturbance def
|
Gait disturbance def
|
infrequent, 6%
|
1% - 6%
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amenorrhoea def
|
Amenorrhoea def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Amnesia def
|
Amnesia def
|
infrequent, frequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthralgia def
|
Arthralgia def
|
2% - 5%
|
0% - 5%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal discomfort
|
Arthralgia def
|
2% - 5%
|
0% - 5%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Myalgia def
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Back pain def
|
Back pain def
|
3% - 5%
|
2% - 5%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Conjunctivitis def
|
Conjunctivitis def
|
frequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Libido decreased def
|
Libido decreased def
|
infrequent, frequent
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Disturbance in sexual arousal
|
Libido decreased def
|
infrequent, frequent
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Libido increased def
|
infrequent
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Delusion def
|
Delusion def
|
frequent
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
Dyspnoea def
|
Dyspnoea def
|
frequent
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ecchymosis def
|
Ecchymosis def
|
5%
|
3% - 5%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flatulence def
|
Flatulence def
|
infrequent — 1% - 2%
|
0%
|
x
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Haematuria def
|
Haematuria def
|
infrequent, frequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypotension def
|
Hypotension def
|
frequent, 1% - 5%
|
0% - 3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Orthostatic hypotension def
|
Orthostatic hypotension def
|
1% - 5%
|
0% - 3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Influenza def
|
Influenza def
|
frequent
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Leukopenia def
|
Leukopenia def
|
infrequent, frequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Metrorrhagia def
|
Metrorrhagia def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dyskinesia def
|
Movement disorder def
|
1% - 5%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Dyskinesia def
|
infrequent, 0% - 2%
|
4%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Buccoglossal syndrome
|
0% - 2%
|
4%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Movement disorder def
|
Movement disorder def
|
1% - 5%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Myoclonus def
|
Myoclonus def
|
1% - 5%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Paraesthesia def
|
Paraesthesia def
|
rare, frequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Salivary hypersecretion def
|
Salivation def
|
frequent
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Salivary hypersecretion def
|
frequent
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Completed suicide
|
Suicide def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Suicide attempt def
|
Suicide attempt def
|
infrequent, frequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperhidrosis def
|
Sweating def
|
infrequent, frequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sweating increased
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Thirst def
|
Thirst def
|
frequent
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Toothache def
|
Toothache def
|
frequent, 3% - 4%
|
0%
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Vaginal inflammation def
|
Vaginal inflammation def
|
frequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vaginal infection def
|
Vaginal inflammation def
|
frequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Mood swings
|
Mood swings
|
infrequent, frequent
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Affect lability
|
Mood swings
|
infrequent, frequent
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Mania def
|
Manic psychosis
|
frequent
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
Injection site pain
|
Injection site pain
|
frequent, 2% - 3%
|
0%
|
|
|
|
x
|
x
|
|
|
|
x
|
x
|
|
Schizophreniform disorder def
|
Schizophrenic reaction
|
frequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Joint stiffness def
|
Joint stiffness def
|
frequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Muscle twitching def
|
Muscle twitching def
|
infrequent — 1% - 5%
|
1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Abnormal dreams
|
Abnormal dreams
|
frequent, 0% - 2%
|
0%
|
x
|
x
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Euphoric mood def
|
Euphoric mood def
|
frequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Musculoskeletal stiffness
|
Stiffness
|
frequent, 1% - 4%
|
0% - 1%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neck stiffness
|
infrequent, 2% - 3%
|
1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ear pain def
|
Ear pain def
|
infrequent, 1% - 4%
|
2%
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Infection def
|
Infection def
|
0% - 4%
|
0% - 2%
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pharyngitis def
|
Pharyngitis def
|
4%
|
3% - 4%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Respiratory tract infection def
|
Respiratory tract infection def
|
1% - 4%
|
2%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Upper respiratory tract infection def
|
Upper respiratory tract infection def
|
1% - 4%
|
2%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Vaginal discharge def
|
Vaginal discharge def
|
0% - 4%
|
0%
|
|
|
|
x
|
|
|
|
|
|
|
|
Hepatic enzyme increased
|
Hepatic enzyme increased
|
1% - 4%
|
1%
|
|
|
|
x
|
|
|
|
|
|
|
|
Tooth infection def
|
Tooth infection def
|
0% - 4%
|
0%
|
|
|
|
x
|
|
|
|
|
|
|
|
Amblyopia def
|
Amblyopia def
|
3%
|
2% - 3%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chest pain def
|
Chest pain def
|
3%
|
1% - 3%
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oedema def
|
Oedema def
|
rare — 3%
|
1% - 3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Epistaxis def
|
Epistaxis def
|
infrequent, 3%
|
0%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hallucination def
|
Hallucination def
|
0% - 3%
|
2%
|
x
|
x
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Hypertension def
|
Hypertension def
|
0% - 3%
|
0% - 2%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sinusitis def
|
Sinusitis def
|
3%
|
0%
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Muscle spasms def
|
Muscle spasms def
|
1% - 3%
|
0% - 1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Spasm generalised
|
2% - 3%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Cramps of lower extremities
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cramp muscle def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Tachycardia def
|
Tachycardia def
|
3%
|
1% - 3%
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Torticollis def
|
Torticollis def
|
2% - 3%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Oculogyric crisis
|
Oculogyric crisis
|
2% - 3%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Oedema peripheral def
|
Oedema peripheral def
|
infrequent, 3%
|
1% - 3%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Edema of lower extremities
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Upper limb oedema
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Nuchal rigidity
|
Neck stiffness
|
infrequent, 2% - 3%
|
1%
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Opisthotonus
|
Opisthotonus
|
2% - 3%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Thinking abnormal
|
Thinking abnormal
|
0% - 3%
|
1%
|
x
|
x
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Mental disability
|
Thinking abnormal
|
0% - 3%
|
1%
|
x
|
x
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Dystonia def
|
Dystonia def
|
2% - 3%
|
1%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Oropharyngeal pain
|
Pharyngolaryngeal pain def
|
2% - 3%
|
2%
|
|
|
|
x
|
|
|
|
|
|
|
|
Phonological disorder def
|
Phonological disorder def
|
infrequent, 2%
|
1% - 2%
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysarthria def
|
Dysarthria def
|
infrequent, 0% - 2%
|
0%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Osteoarthritis def
|
Dysarthria def
|
infrequent, 0% - 2%
|
0%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arthropathy def
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Incontinence def
|
Incontinence def
|
infrequent, 2%
|
1% - 2%
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Sneezing def
|
Sneezing def
|
0% - 2%
|
0%
|
|
|
|
x
|
|
|
|
|
|
|
|
Urinary incontinence def
|
Urinary incontinence def
|
2%
|
1% - 2%
|
x
|
x
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urinary tract infection def
|
Urinary tract infection def
|
2%
|
1% - 2%
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Viral infection def
|
Viral infection def
|
0% - 2%
|
0%
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Choreoathetosis
|
Choreoathetosis
|
0% - 2%
|
4%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Buccoglossal syndrome
|
Buccoglossal syndrome
|
0% - 2%
|
4%
|
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Tardive dyskinesia def
|
Tardive dyskinesia def
|
infrequent, 0% - 2%
|
4%
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Acne def
|
Acne def
|
0% - 2%
|
0%
|
x
|
|
x
|
x
|
x
|
x
|
|
x
|
x
|
x
|
|
Sleep disorder def
|
Sleep disorder def
|
0% - 2%
|
1%
|
x
|
|
|
x
|
|
|
|
x
|
x
|
x
|
|
Abscess def
|
Abscess def
|
infrequent
|
|
|
|
|
x
|
|
|
x
|
x
|
x
|
x
|
|
Acidosis def
|
Acidosis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Alopecia def
|
Alopecia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaemia def
|
Anaemia def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Apnoea def
|
Apnoea def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Arthritis def
|
Arthritis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Rheumatoid arthritis def
|
rare
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Asthma def
|
Asthma def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Ataxia def
|
Ataxia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Atelectasis def
|
Atelectasis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Atrial fibrillation def
|
Atrial fibrillation def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Atrioventricular block def
|
Atrioventricular block def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Block heart def
|
infrequent
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Blepharitis def
|
Blepharitis def
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Breast feeding def
|
Breast feeding def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Bursitis def
|
Bursitis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Candidiasis def
|
Candidiasis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Oral candidiasis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Oral candidiasis def
|
Oral candidiasis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Neck pain def
|
Neck pain def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Coma def
|
Coma def
|
rare — infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Confusional state def
|
Confusional state def
|
infrequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Feeling abnormal
|
Confusional state def
|
infrequent
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cyanosis def
|
Cyanosis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cystitis def
|
Cystitis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Bladder pain def
|
Cystitis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cystitis noninfective def
|
Cystitis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Deafness def
|
Deafness def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dysphagia def
|
Dysphagia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dehydration def
|
Dehydration def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Delirium def
|
Delirium def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dental caries def
|
Dental caries def
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Depersonalisation def
|
Depersonalisation def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dermatitis def
|
Dermatitis def
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Rash def
|
rare — infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dermatitis contact def
|
Dermatitis contact def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Diabetes mellitus def
|
Diabetes mellitus def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Diplopia def
|
Diplopia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dysgeusia def
|
Dysgeusia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dysuria def
|
Dysuria def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Urination impaired
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eczema def
|
Eczema def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Eructation def
|
Eructation def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Oesophagitis def
|
Oesophagitis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Rash def
|
Rash def
|
rare — infrequent
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye haemorrhage def
|
Eye haemorrhage def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
VIIth nerve paralysis
|
Facial paralysis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Faecal incontinence def
|
Faecal incontinence def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Faecalith def
|
Faecalith def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Faecaloma
|
Faecalith def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Gastritis def
|
Gastritis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Gastroenteritis def
|
Gastroenteritis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Gingivitis def
|
Gingivitis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Glycosuria def
|
Glycosuria def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Gynaecomastia def
|
Gynaecomastia def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cardiac arrest def
|
Cardiac arrest def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cardiac failure def
|
Cardiac failure def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cardiac failure congestive def
|
Cardiac failure congestive def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Haemoptysis def
|
Haemoptysis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Haemorrhage def
|
Haemorrhage def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Haemoglobin def
|
Haemorrhage def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hepatitis def
|
Hepatitis def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyperbilirubinaemia def
|
Hyperbilirubinaemia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypercholesterolaemia def
|
Hypercholesterolaemia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hyperglycaemia def
|
Hyperglycaemia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hyperkalaemia def
|
Hyperkalaemia def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hyperventilation def
|
Hyperventilation def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypoaesthesia def
|
Hypoaesthesia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypoglycaemia def
|
Hypoglycaemia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypokalaemia def
|
Hypokalaemia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypomenorrhoea
|
Hypomenorrhoea
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hyponatraemia def
|
Hyponatraemia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Libido increased def
|
Libido increased def
|
infrequent
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Inflammation def
|
Inflammation def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Arthropathy def
|
Arthropathy def
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Laryngitis def
|
Laryngitis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Leiomyoma def
|
Leiomyoma def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Uterine leiomyoma def
|
Leiomyoma def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Uterine leiomyoma def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Uterine fibroids enlarged
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Leukocytosis def
|
Leukocytosis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Breast pain def
|
Breast pain def
|
infrequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Melaena def
|
Melaena def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Menorrhagia def
|
Menorrhagia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypotonia def
|
Hypotonia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Muscle relaxant therapy
|
Hypotonia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Pallor def
|
Pallor def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Palpitations def
|
Palpitations def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Pelvic pain def
|
Pelvic pain def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Tooth abscess
|
Abscess periodontal def
|
infrequent
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Tooth abscess
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Pneumonia def
|
Pneumonia def
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
|
|
|
|
Pneumonia aspiration def
|
Pneumonia aspiration def
|
infrequent
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Polyuria def
|
Polyuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urine output increased
|
Polyuria def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pruritus def
|
Pruritus def
|
postmarketing, infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pyuria def
|
Pyuria def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Seborrhoeic dermatitis def
|
Seborrhoeic dermatitis def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Skin ulcer def
|
Skin ulcer def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Stomatitis def
|
Stomatitis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Mouth ulceration def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cerebrovascular accident def
|
Cerebrovascular accident def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Dysphemia
|
Stuttering def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Withdrawal syndrome def
|
Withdrawal syndrome def
|
infrequent
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Shock def
|
Syncope def
|
infrequent
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Syncope def
|
Syncope def
|
infrequent
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Loss of consciousness def
|
Syncope def
|
infrequent
|
|
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Thrombocytopenia def
|
Thrombocytopenia def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tinnitus def
|
Tinnitus def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Tooth impacted def
|
Tooth impacted def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Ulcer def
|
Ulcer def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Pollakiuria def
|
Pollakiuria def
|
infrequent
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
|
Micturition urgency def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Urticaria def
|
Urticaria def
|
rare — infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vasodilation procedure
|
Vasodilation def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Vertigo def
|
Vertigo def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Water intoxication def
|
Water intoxication def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Urinary retention def
|
Urinary retention def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Chills def
|
Chills def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Micturition urgency def
|
Micturition urgency def
|
rare, infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Stupor def
|
Stupor def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Depressed level of consciousness def
|
Stupor def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Cataract def
|
Cataract def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Mouth ulceration def
|
Mouth ulceration def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Migraine def
|
Migraine def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Corneal lesion
|
Corneal lesion
|
rare, infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Blood creatine phosphokinase increased
|
Creatine phosphokinase increased def
|
infrequent
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue disorder
|
Tongue oedema
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tongue oedema
|
Tongue oedema
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Ventricular extrasystoles def
|
Ventricular extrasystoles def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Eye pain def
|
Eye pain def
|
infrequent
|
|
|
|
|
|
|
|
x
|
|
x
|
x
|
|
Blood alkaline phosphatase increased def
|
Phosphatase alkaline increased
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rash pustular def
|
Vesiculobullous rash
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Rash pustular def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dermatitis bullous def
|
Vesiculobullous rash
|
infrequent
|
|
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Skin discolouration def
|
Skin discolouration def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dry skin def
|
Dry skin def
|
infrequent
|
|
x
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Accommodation disorder
|
Accommodation disorder
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photosensitivity reaction def
|
Photosensitivity reaction def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Photosensitivity def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Malaise def
|
Malaise def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Discomfort def
|
Malaise def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Ill-defined disorder
|
Malaise def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Cardiac fibrillation
|
Cardiac fibrillation
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Antisocial personality disorder def
|
Antisocial behaviour def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Antisocial behaviour def
|
Antisocial behaviour def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Asocial behaviour
|
Antisocial behaviour def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Eye inflammation
|
Eye inflammation
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypoxia def
|
Hypoxia def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypoventilation def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Erectile dysfunction def
|
Erectile dysfunction def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Rectal haemorrhage def
|
Rectal haemorrhage def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dry eye
|
Dry eye
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Extrasystoles def
|
Extrasystoles def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Anxiety def
|
Phobia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Anxiety def
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Phobia def
|
Phobia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Abdominal distension def
|
Enlargement abdomen def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Rash maculo-papular def
|
Rash maculo-papular def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Bradycardia def
|
Bradycardia def
|
infrequent
|
|
|
|
|
|
x
|
|
x
|
x
|
x
|
x
|
|
Lymphadenopathy def
|
Lymphadenopathy def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Coordination abnormal
|
Coordination abnormal
|
infrequent
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Paralysis def
|
Paralysis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Face oedema def
|
Face oedema def
|
infrequent
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Aspiration
|
Aspiration
|
infrequent
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Poisoning def
|
Intoxication
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Blood uric acid increased
|
Hyperuricaemia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hyperuricaemia def
|
Hyperuricaemia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Thrombocytosis def
|
Thrombocytosis def
|
rare, infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Muscular weakness def
|
Myasthenia def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Dysphonia def
|
Voice disturbance
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Ejaculation disorder def
|
Abnormal ejaculation
|
infrequent
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Vaginal haemorrhage def
|
Vaginal haemorrhage def
|
infrequent
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Albuminuria def
|
Albuminuria def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Angioedema def
|
Angioedema def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Arteritis def
|
Arteritis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Rheumatoid arthritis def
|
Rheumatoid arthritis def
|
rare
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Sudden death def
|
Sudden death def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
Diabetic ketoacidosis def
|
Diabetic ketoacidosis def
|
rare, postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Embolism def
|
Embolism def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
|
Thromboembolic event
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
|
Embolus def
|
rare
|
|
|
|
|
|
|
|
x
|
|
|
|
|
Enteritis def
|
Enteritis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Oesophageal disorder def
|
Oesophageal disorder def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hepatic steatosis def
|
Liver fatty def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Liver fatty deposition
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
|
|
Glaucoma def
|
Glaucoma def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Glossitis def
|
Glossitis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Goitre def
|
Goitre def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Gout def
|
Gout def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hiccups def
|
Hiccups def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hirsutism def
|
Hirsutism def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypernatraemia def
|
Hypernatraemia def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hypersensitivity def
|
Hypersensitivity def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypertrophy def
|
Hypertrophy def
|
rare
|
|
|
|
|
|
|
|
|
x
|
x
|
x
|
|
Hypoproteinaemia def
|
Hypoproteinaemia def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Intestinal obstruction def
|
Intestinal obstruction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Jaundice def
|
Jaundice def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Keratitis def
|
Keratoconjunctivitis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Ketosis def
|
Ketosis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Lens disorder def
|
Lens disorder def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Mastitis def
|
Mastitis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Miosis def
|
Miosis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Myopathy def
|
Myopathy def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Mydriasis def
|
Mydriasis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Neuralgia def
|
Neuralgia def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Neutropenia def
|
Neutropenia def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Nystagmus def
|
Nystagmus def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Obstruction def
|
Obstruction def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Oliguria def
|
Oliguria def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Osteoporosis def
|
Osteoporosis def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pancreatitis def
|
Pancreatitis def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Priapism def
|
Priapism def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Pulmonary oedema def
|
Pulmonary oedema def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Pulmonary embolism def
|
Pulmonary embolism def
|
rare, postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
x
|
x
|
|
Rhabdomyolysis def
|
Rhabdomyolysis def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
|
Aphthous stomatitis def
|
Aphthous stomatitis def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Stridor def
|
Stridor def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Subarachnoid haemorrhage def
|
Subarachnoid haemorrhage def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Thrombosis def
|
Thrombosis def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
|
Venous thrombosis def
|
Venous thrombosis def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
|
Normochromic normocytic anaemia
|
Normocytic anemia
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Encephalopathy def
|
Encephalopathy def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Deep vein thrombosis def
|
Deep vein thrombosis def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
x
|
x
|
|
Tongue discolouration
|
Tongue discolouration
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Lenticular pigmentation
|
Lenticular pigmentation
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Bone pain def
|
Bone pain def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Paraesthesia oral
|
Circumoral paresthesia
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Oesophageal ulcer def
|
Oesophageal ulcer def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Leukoderma def
|
Leukoderma def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Ketoacidosis
|
Ketoacidosis
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Hangover
|
Hangover
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lenticular opacities
|
Lenticular deposits
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
|
|
|
Anaphylactic shock def
|
Anaphylactoid reaction
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Anaphylactoid reaction
|
Anaphylactoid reaction
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Hypoventilation def
|
Hypoventilation def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Respiratory failure def
|
Hypoventilation def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Neuropathy peripheral def
|
Neuropathy def
|
rare
|
|
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Ileus def
|
Ileus def
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetic hyperglycaemic coma
|
Diabetic coma def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Diabetic coma def
|
Diabetic coma def
|
postmarketing
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Death
|
Death
|
rare
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
Breast enlargement
|
Breast enlargement
|
rare
|
|
|
|
|
|
|
|
|
|
x
|
x
|
|
Decreased appetite
|
Anorexia def
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Breast disorder def
|
Breast disorder def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Connective tissue disorder def
|
Connective tissue disorder def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Convulsion def
|
Convulsion def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Fungal skin infection def
|
Fungal skin infection def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Dysmenorrhoea def
|
Dysmenorrhoea def
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Eye disorder def
|
Eye disorder def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Fasting def
|
Fasting def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Gastrointestinal disorder def
|
Gastrointestinal disorder def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Hostility def
|
Hostility def
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Lethargy def
|
Lethargy def
|
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Mediastinal disorder def
|
Mediastinal disorder def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Menstrual disorder def
|
Menstrual disorder def
|
|
|
x
|
x
|
|
|
|
|
|
x
|
x
|
x
|
|
Nervous system disorder def
|
Nervous system disorder def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Nervousness def
|
Nervousness def
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Tension def
|
Nervousness def
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Neurosis def
|
Neurosis def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Tension headache def
|
Tension headache def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Schizoaffective disorder def
|
Schizoaffective disorder def
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Speech disorder def
|
Speech disorder def
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Unintended pregnancy def
|
Unintended pregnancy def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Angiopathy def
|
Angiopathy def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Visual impairment def
|
Visual impairment def
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Visual acuity reduced
|
Visual impairment def
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Blindness def
|
Visual impairment def
|
|
|
x
|
|
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Weight decreased def
|
Weight decreased def
|
|
|
x
|
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Hepatic failure def
|
Hepatic failure def
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Apathy def
|
Apathy def
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Flat affect
|
Apathy def
|
|
|
x
|
x
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Lower respiratory tract infection
|
Lower respiratory tract infection
|
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Gamma-glutamyltransferase increased def
|
Gamma-glutamyltransferase increased def
|
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Injection site reaction def
|
Injection site reaction def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Injection site mass
|
Injection site mass
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Paranoia def
|
Paranoid reaction
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Aspartate aminotransferase increased def
|
Aspartate aminotransferase increased def
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Alanine aminotransferase increased def
|
Alanine aminotransferase increased def
|
|
|
|
x
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Sinus congestion
|
Sinus congestion
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Myalgia def
|
Myalgia def
|
|
|
x
|
x
|
|
|
|
|
x
|
x
|
x
|
x
|
|
Musculoskeletal pain def
|
Buttock pain def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Abdominal pain upper
|
Abdominal pain upper
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Abdominal pain lower
|
Abdominal pain lower
|
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Psychiatric symptom
|
Psychiatric symptom
|
|
|
x
|
|
x
|
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Throat tightness
|
Throat tightness
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Protrusion tongue
|
Protrusion tongue
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Blood pressure systolic decreased
|
Blood pressure systolic decreased
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Induration def
|
Induration def
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Platelet count decreased
|
Platelet count decreased
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Blood prolactin increased
|
PRL increased
|
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Aortic dissection def
|
Dissecting aortic aneurysm, thoracic
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Infestation
|
Infestation NOS
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Electrocardiogram change def
|
Electrocardiogram change def
|
|
|
|
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Blood triglycerides normal
|
Triglycerides normal
|
|
|
|
|
|
x
|
|
|
|
|
|
|
|
Respiratory tract infection viral
|
Respiratory tract infection viral
|
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Hypersomnia def
|
Hypersomnia def
|
|
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Liver disorder def
|
Hepatic impairment
|
|
|
|
|
x
|
x
|
x
|
x
|
|
|
|
|
|
Drug dependence def
|
Drug dependence def
|
|
|
|
x
|
|
|
|
|
|
|
|
|
|
Indication
|
Labels
|
|
Agitation def
|
x
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Bipolar disorder def
|
x
|
x
|
|
|
|
|
|
x
|
x
|
x
|
|
Bipolar I disorder
|
x
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Dementia def
|
|
x
|
|
|
|
|
|
|
|
|
|
Depressive disorder def
|
|
|
|
|
x
|
|
|
|
|
|
|
Elderly def
|
|
x
|
|
|
|
|
|
|
|
|
|
Hyperlipidaemia def
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Major depression def
|
|
|
|
|
x
|
|
|
|
|
|
|
Mania def
|
x
|
x
|
x
|
|
x
|
x
|
|
x
|
x
|
x
|
|
Psychotic disorder def
|
|
x
|
|
|
|
|
|
|
|
|
|
Schizophrenia def
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
x
|
|
Tension def
|
x
|
|
|
|
x
|
|
|
|
x
|
x
|
|
Weight increased def
|
|
|
x
|
|
x
|
x
|
|
|
|
|
|
Information
More information: STITCH, PubChem and possibly Wikipedia or Medpedia
ATC Code:
N05AH03
Legend
Color scheme:
standard – alternative
|
100%
|
|
|
|
75%
|
|
|
|
50%
|
|
|
|
10%
|
|
|
|
frequent (1% to 100%)
|
|
|
|
infrequent (0.1% to 1%)
|
|
|
|
rare (<0.1%)
|
|
|
|
postmarketing
|
|
|
|
0%
|
|
|
|
no frequency information
|
|
|
|
not found on label
|
|
|
Labels
Labels were obtained from different sources and potentially contain different sets of side effects. If you click on the label name, a HTML version of the label will be shown with proteins, chemicals and side efffects highlighted using Reflect.
- olanzapine tablets / Zyprexa :
81 side effects
(FDA MedWatch)
- OLANZAPINE / NOVO-OLANZAPINE :
83 side effects
(Health Canada)
- OLANZAPINE :
167 side effects
(FDA XML label)
- Olanzapine :
168 side effects
(FDA XML label)
- OLANZAPINE :
175 side effects
(FDA XML label)
- OLANZAPINE :
176 side effects
(FDA XML label)
- olanzapine / Zyprexa :
298 side effects
(FDA MedWatch)
- olanzapine / Zyprexa :
306 side effects
(FDA CDER)
- OLANZAPINE / ZYPREXA :
315 side effects
(Drugs@FDA)
- OLANZAPINE / ZYPREXA ZYDIS :
315 side effects
(Drugs@FDA)
|