Side effect information for Bupropion

Side effects

Options: Hide MedDRA Preferred Terms , display all 77 labels

MedDRA Preferred Term	Side effect	Data for drug	Placebo	Labels
				1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Nervous system disorder	Nervous system disorder	33.9%	27%																		x	x	x
Headache	Headache	postmarketing — 1.1% - 34%	22.2% - 26%		x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal disorder	Gastrointestinal disorder	25.5%																			x	x	x
Gastrointestinal disorder	Digestion impaired	2.1%				x
Dry mouth	Dry mouth	4% - 27.6%	4% - 18.4%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Weight decreased	Weight decreased	23.2%	23.2%													x
Hyperhidrosis	Sweating increased	22.3%	14.6%
	Sweating	postmarketing — 1.6% - 6%	2%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Hyperhidrosis
Insomnia	Insomnia	1% - 45%	6% - 21%		x	x	x	x		x	x			x	x	x	x	x		x			x
Insomnia	Difficulty sleeping
Application site reaction	Application site reaction	11% - 17%	7%															x		x
Weight increased	Weight increased	postmarketing — 13.6%	22.7%													x	x			x
Nasopharyngitis	Nasopharyngitis	13%	12%																		x	x	x
Nasopharyngitis	Rhinorrhoea
Nausea	Nausea	0.8% - 22.9%	0.3% - 18.9%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rhinitis	Rhinitis	6.7% - 12%	8%						x						x		x	x	x	x
Constipation	Constipation	4% - 26%	2% - 17.3%		x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x	x
Upper respiratory tract infection	Upper respiratory tract infection	9%	8%																		x	x	x
Confusional state	Confusional state	postmarketing — 8.4%	4.9%			x				x							x	x	x	x	x	x	x
Feeling abnormal	Confusional state	postmarketing — 8.4%	4.9%			x				x							x	x	x	x	x	x	x
	Malaise	postmarketing, rare		x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
	Feeling abnormal
Infection	Infection	rare, 4.7% - 9%	6%				x			x	x	x	x	x	x	x			x		x	x	x
Dizziness	Dizziness	0.5% - 22.3%	5% - 16.2%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dizziness	Syncope	postmarketing — 1.2%	0.5%	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bradykinesia	Bradykinesia	8%	8.6%
Diarrhoea	Diarrhoea	3% - 7%	1% - 8.6%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Diarrhoea	Loose stools
Anxiety	Anxiety	0.8% - 9%	1.1% - 6%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Flatulence	Flatulence	postmarketing — 1.8% - 6%	3%						x						x		x		x	x	x	x	x
Tinnitus	Tinnitus	postmarketing, 0% - 6%	0% - 2%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Arrhythmia	Arrhythmia	5.3%	4.3%							x									x		x	x	x
Hearing impaired	Auditory disorder NOS	5.3%	3.2%							x									x		x	x	x
Decreased appetite	Anorexia	1% - 18.3%	1% - 18.4%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Decreased appetite	4%	1%																		x	x	x
	Appetite absent
Asthenia	Fatigue	5%	8.6%
Asthenia	Asthenia	postmarketing — 1.6% - 4%	2%			x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Fatigue	Fatigue	5%	8.6%
Myoclonus	Myoclonus	frequent
Nocturia	Nocturia	frequent					x
Convulsion	Convulsion	postmarketing — frequent				x				x					x	x		x	x	x	x	x	x
Mania	Mania	frequent								x						x		x
Mania	Manic psychosis	postmarketing						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Influenza like illness	Influenza-like symptoms	rare, frequent					x
Influenza like illness	Influenza like illness
Sexual dysfunction	Sexual dysfunction	frequent
Cough	Cough	4%	3%																		x	x	x
Cough	Cough increased	1% - 5%	1%							x	x	x	x	x		x	x	x	x	x	x	x	x
Mediastinal disorder	Mediastinal disorder	4%	3%																		x	x	x
Vomiting	Vomiting	postmarketing — 1.6% - 22.9%	2% - 18.9%		x	x	x			x	x	x	x	x	x	x	x	x	x	x	x	x	x
Sensory disturbance	Sensory disturbance	4%	3.2%							x									x		x	x	x
Malnutrition	Malnutrition	4%	1%																		x	x	x
Palpitations	Palpitations	0% - 6%	0% - 2.2%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Increased appetite	Increased appetite	2% - 3.7%	1% - 2.2%						x	x							x	x	x	x	x	x	x
Dyspepsia	Dyspepsia	postmarketing — 3.1% - 4.7%	2.2%						x	x					x		x	x	x	x	x	x	x
Dyspepsia	Digestion impaired	2.1%				x
Influenza	Influenza	2.4% - 6.2%							x						x				x
Disturbance in attention	Cerebration impaired	3% - 9%	3.8% - 4%														x	x		x
	Impairment of attention	rare
	Disturbance in attention
Mental disability	Cerebration impaired	3% - 9%	3.8% - 4%														x	x		x
Mental disability	Thinking abnormal
Abdominal pain	Abdominal pain	1% - 9%	1% - 2%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal pain	Abdominal pain	1% - 9%	1% - 2%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal pain	Gastrointestinal pain
Chest pain	Chest pain	infrequent, 1% - 4%	1%			x	x			x	x	x	x	x	x	x	x	x	x	x	x	x	x
Chest pain	Chest discomfort
Dermatitis	Rash	postmarketing — 0.8% - 8%	0% - 6.5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rash	Rash	postmarketing — 0.8% - 8%	0% - 6.5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nervousness	Nervousness	1% - 5%	2% - 3%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Nervousness	Feeling jittery	3%	2%																		x	x	x
Tension	Nervousness	1% - 5%	2% - 3%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Tension	Tension
Pain in extremity	Pain in extremity	2% - 3%	2%																		x	x	x
Pharyngitis	Pharyngitis	1.3% - 11%	0% - 2%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Sinusitis	Sinusitis	1% - 5%	1% - 4%							x	x	x	x		x	x	x	x	x	x	x	x	x
Tremor	Tremor	1% - 21.1%	0% - 7.6%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Tremor	Shakiness
Skin disorder	Unspecified disorder of skin and subcutaneous tissue	3%	2%																		x	x	x
Skin disorder	Skin disorder	1.9% - 2.4%													x		x	x		x
Abnormal dreams	Abnormal dreams	3%	2%			x			x										x		x	x	x
Vision blurred	Vision blurred	postmarketing — 2% - 14.6%	2% - 10.3%						x	x		x		x		x		x			x	x	x
Feeling jittery	Feeling jittery	3%	2%																		x	x	x
Pollakiuria	Pollakiuria	postmarketing — 1.3% - 5%	2% - 2.2%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pollakiuria	Micturition urgency	postmarketing — 2%	0%							x	x	x	x	x		x	x	x	x	x	x	x	x
Amblyopia	Amblyopia	postmarketing — 1.8% - 3%	2%								x		x		x		x		x	x
Pruritus	Pruritus	1% - 5%	0% - 2%			x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Arthritis	Arthritis	postmarketing, 0% - 3.1%	0% - 2.7%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Breast disorder	Breast disorder	2%	1%																		x	x	x
Diplopia	Diplopia	postmarketing — 2% - 3%	2%				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysgeusia	Dysgeusia	0.3% - 4%	1% - 2%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysmenorrhoea	Dysmenorrhoea	2%	1%						x										x		x	x	x
Irritability	Irritability	postmarketing — 0.5% - 3.9%	2%			x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pain	Pain	postmarketing — 1.3% - 3%	2%				x			x	x	x	x	x	x	x	x		x	x	x	x	x
Angiopathy	Angiopathy	1.86% - 2%	0%																		x	x	x
Micturition urgency	Micturition urgency	postmarketing — 2%	0%							x	x	x	x	x		x	x	x	x	x	x	x	x
Agitation	Agitation	postmarketing — 0.3% - 31.9%	0.3% - 22.2%			x		x		x	x		x	x	x	x	x	x		x			x
Agitation	Hyperkinesia	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Injury	Accidental injury	1% - 2%	1%						x						x		x	x	x	x
Myalgia	Myalgia	postmarketing, 1.6% - 6%	1% - 3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Musculoskeletal discomfort	Myalgia	postmarketing, 1.6% - 6%	1% - 3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Musculoskeletal discomfort	Arthralgia	postmarketing, 0.5% - 5%	1% - 3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Somnolence	Somnolence	2% - 3%	1% - 2%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Muscle spasms	Muscle spasms	1.9%	3.2%
	Cramps of lower extremities	postmarketing — 0.2% - 1%						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
	Cramp muscle
Migraine	Migraine	postmarketing — 0% - 25.7%	0.3% - 22.2%		x		x			x	x	x	x	x	x	x	x	x	x	x	x	x	x
Akathisia	Akathisia	1.5%	1.1%							x									x		x	x	x
Parkinsonism	Pseudoparkinsonism	1.5%	1.6%
Parkinsonism	Parkinsonism					x
Neck pain	Neck pain	1% - 2%	0% - 1%						x						x		x	x	x	x
Arthralgia	Arthralgia	postmarketing, 0.5% - 5%	1% - 3%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Flushing	Flushing	postmarketing — 1% - 4%				x	x			x	x	x	x	x		x	x	x	x	x	x	x	x
Hypersensitivity	Hypersensitivity	postmarketing, 1%	0%			x				x					x	x	x	x		x
Paraesthesia	Paraesthesia	postmarketing — 1% - 2%	1%		x	x	x			x	x	x	x	x		x	x	x	x	x	x	x	x
Urticaria	Urticaria	postmarketing, 0% - 2%	0%		x	x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Muscle twitching	Muscle twitching	postmarketing — 0.3% - 2%				x				x	x	x	x	x	x	x	x	x	x	x	x	x	x
Menopausal symptoms	Hot flush	0.8% - 3%	0% - 1%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hot flush	Hot flush	0.8% - 3%	0% - 1%							x	x	x	x	x	x	x	x	x	x	x	x	x	x
Vaginal haemorrhage	Vaginal haemorrhage	0% - 2%								x	x	x	x	x		x			x		x	x	x
Hypertension	Hypertension	postmarketing, 1% - 4.3%	0% - 1.6%		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Back pain	Back pain	postmarketing — 1.8% - 4.5%							x						x		x		x	x
Bronchitis	Bronchitis	rare — 2%	0%				x		x								x	x	x	x
Bruxism	Bruxism	postmarketing, infrequent					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Libido decreased	Libido decreased	postmarketing — 0.5% - 3.1%	1.6%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Disturbance in sexual arousal	Libido decreased	postmarketing — 0.5% - 3.1%	1.6%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Libido increased	postmarketing, frequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
	Disturbance in sexual arousal
Dysphagia	Dysphagia	postmarketing — 0% - 2%	0%				x			x	x	x	x	x		x	x	x	x	x	x	x	x
Depersonalisation	Depersonalisation	postmarketing, infrequent				x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dyspnoea	Dyspnoea	rare — 0% - 2%	1%			x	x								x		x	x		x
Oedema	Oedema	postmarketing — frequent					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Female sexual arousal disorder	Frigidity	infrequent
Gastrooesophageal reflux disease	Gastrooesophageal reflux disease	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gingivitis	Gingivitis	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Inguinal hernia	Inguinal hernia	postmarketing, infrequent															x	x		x
Hostility	Hostility	postmarketing — 5.6%	3.8%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Jaundice	Jaundice	postmarketing, infrequent				x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Polyuria	Polyuria	postmarketing, infrequent						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Urine output increased	Polyuria	postmarketing, infrequent						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Psychotic disorder	Psychotic disorder	infrequent								x						x		x
Psychotic disorder	Paranoia	infrequent
Stomatitis	Stomatitis	postmarketing — frequent					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Stomatitis	Mouth ulceration	postmarketing — 1% - 2%	1%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Tachycardia	Tachycardia	postmarketing — 0.5% - 10.8%	8.6%			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Thirst	Thirst	postmarketing — 1% - 2%	0%				x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Toothache	Toothache	infrequent					x
Urinary tract infection	Urinary tract infection	infrequent, 0% - 1.8%					x			x	x	x	x	x	x	x			x		x	x	x
Vertigo	Vertigo	postmarketing, infrequent						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Chills	Chills	postmarketing — 1.2%	0.5%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Chills	Rigors
Mood swings	Mood swings	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Affect lability	Mood swings	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Affect lability	Affect lability
Hepatic function abnormal	Hepatic function abnormal	postmarketing, infrequent						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Mouth ulceration	Mouth ulceration	postmarketing — 1% - 2%	1%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dry skin	Dry skin	postmarketing — 2%	0%				x										x	x		x
Dysphoria	Dysphoria	postmarketing — 1% - 2%	1%					x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Memory impairment	Memory impairment	infrequent				x
Erectile dysfunction	Erectile dysfunction	postmarketing — 3.4%	3.1%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dry eye	Dry eye	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dry eye	Keratoconjunctivitis sicca
Photosensitivity reaction	Photosensitivity	postmarketing, infrequent						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
	Sunburn
	Photosensitivity reaction
Coordination abnormal	Coordination abnormal	postmarketing — frequent				x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Visual impairment	Visual disturbance	rare, infrequent				x	x
Vulvovaginal discomfort	Vaginal irritation	infrequent					x
Gingival pain	Irritation gum	infrequent					x
Gingival pain	Gingival pain
Paranoia	Paranoia	infrequent
Paranoia	Paranoid reaction	postmarketing													x		x			x
Testicular swelling	Testicular swelling	infrequent					x
Face oedema	Face oedema	postmarketing — 0% - 1%	0%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Aggression	Aggression	postmarketing			x	x	x	x	x	x	x	x	x	x		x		x	x		x	x	x
Alopecia	Alopecia	postmarketing, infrequent					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Amnesia	Amnesia	postmarketing, rare		x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Anaemia	Anaemia	postmarketing, rare			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Angioedema	Angioedema	postmarketing			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Aphasia	Aphasia	postmarketing, rare						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ataxia	Ataxia	postmarketing — frequent		x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Bronchospasm	Bronchospasm	postmarketing, rare				x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cardiovascular disorder	Cardiovascular disorder	postmarketing															x	x		x
Colitis	Colitis	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Coma	Coma	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cystitis	Cystitis	postmarketing, rare					x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Bladder pain	Cystitis	postmarketing, rare					x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Cystitis noninfective	Cystitis	postmarketing, rare					x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x
Deafness	Deafness	postmarketing						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Delirium	Delirium	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Delusion	Delusion	postmarketing, 1.2%	1.1%			x		x	x		x	x	x	x		x	x	x	x	x	x	x	x
Dermatitis exfoliative	Dermatitis exfoliative	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysarthria	Dysarthria	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Osteoarthritis	Dysarthria	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dyskinesia	Dyskinesia	postmarketing, frequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Dysuria	Dysuria	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ecchymosis	Ecchymosis	postmarketing, infrequent			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Enuresis	Enuresis	rare					x
Epistaxis	Epistaxis	rare, 1% - 2%	0%				x								x		x	x		x
Erythema multiforme	Erythema multiforme	postmarketing				x									x					x
Erythema multiforme	Stevens-Johnson syndrome	postmarketing			x	x	x								x	x		x		x
Oesophagitis	Oesophagitis	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Extrapyramidal disorder	Extrapyramidal disorder	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Body temperature increased	Body temperature increased	postmarketing — 1% - 2%	0.5%		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gastrointestinal haemorrhage	Gastrointestinal haemorrhage	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gingival bleeding	Gingival bleeding	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Angle closure glaucoma	Angle closure glaucoma	postmarketing								x
Glossitis	Glossitis	postmarketing — infrequent					x	x	x	x	x	x	x	x	x		x		x	x	x	x	x
Glycosuria	Glycosuria	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Gynaecomastia	Gynaecomastia	postmarketing, infrequent					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hallucination	Hallucination	postmarketing, frequent				x		x	x		x	x	x	x	x	x		x	x	x	x	x	x
Hepatitis	Hepatitis	postmarketing			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Hirsutism	Hirsutism	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hyperglycaemia	Hyperglycaemia	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Type IV hypersensitivity reaction	Type IV hypersensitivity reaction	postmarketing			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Hypoaesthesia	Hypoaesthesia	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypoglycaemia	Hypoglycaemia	postmarketing			x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hypotension	Hypotension	postmarketing, 2.5%	2.2%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Orthostatic hypotension	Orthostatic hypotension	postmarketing, infrequent			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Inappropriate antidiuretic hormone secretion	Inappropriate antidiuretic hormone secretion	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Libido increased	Libido increased	postmarketing, frequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Intestinal perforation	Intestinal perforation	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Leukocytosis	Leukocytosis	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Leukopenia	Leukopenia	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Menopause	Menopause	postmarketing, rare					x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Hypertonia	Hypertonia	postmarketing — 0.5% - 1.2%						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Muscle rigidity	Muscle rigidity	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Mydriasis	Mydriasis	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Myocardial infarction	Myocardial infarction	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Acute coronary syndrome	Myocardial infarction	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Neuralgia	Neuralgia	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ovarian disorder	Ovarian disorder	rare					x
Pallor	Pallor	rare					x
Pancreatitis	Pancreatitis	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pancytopenia	Pancytopenia	postmarketing, rare			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pelvic infection	Pelvic infection	rare					x
Phlebitis	Phlebitis	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pneumonia	Pneumonia	postmarketing, rare					x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Prostatic disorder	Prostatic disorder	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Pulmonary embolism	Pulmonary embolism	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rhabdomyolysis	Rhabdomyolysis	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Salpingitis	Salpingitis	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Sciatica	Sciatica	rare
Serum sickness	Serum sickness	postmarketing			x	x	x	x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Salivary hypersecretion	Salivary hypersecretion	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Stevens-Johnson syndrome	Stevens-Johnson syndrome	postmarketing			x	x	x								x	x		x		x
Gastric ulcer	Gastric ulcer	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Cerebrovascular accident	Cerebrovascular accident	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Suicide attempt	Suicide attempt	postmarketing			x		x	x					x	x		x		x					x
Shock	Syncope	postmarketing — 1.2%	0.5%	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Syncope	Syncope	postmarketing — 1.2%	0.5%	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Loss of consciousness	Syncope	postmarketing — 1.2%	0.5%	x		x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Thrombocytopenia	Thrombocytopenia	postmarketing			x		x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary incontinence	Urinary incontinence	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Urethral disorder	Urinary tract disorder	postmarketing															x	x		x
Urinary tract disorder	Urinary tract disorder	postmarketing															x	x		x
Vaginal inflammation	Vaginal inflammation	postmarketing						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Vaginal infection	Vaginal inflammation	postmarketing						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Vaginal infection	Vaginitis bacterial
Vasodilation procedure	Vasodilation	postmarketing, infrequent				x		x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Urinary retention	Urinary retention	postmarketing, 1.9%	2.2%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Skin odour abnormal	Body odor	rare					x
Akinesia	Akinesia	postmarketing, 8%	8.6%					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Oedema peripheral	Oedema peripheral	postmarketing, infrequent						x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Hypokinesia	Hypokinesia	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Atrioventricular block complete	Atrioventricular block complete	postmarketing			x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Tongue disorder	Tongue oedema	postmarketing, rare		x				x	x	x	x	x	x	x	x	x	x		x	x	x	x	x
Tongue oedema	Tongue oedema	postmarketing, rare		x				x	x	x	x	x	x	x	x	x	x		x	x	x	x	x
Electroencephalogram abnormal	Electroencephalogram abnormal	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hepatocellular injury	Hepatocellular injury	postmarketing, infrequent			x		x	x	x		x	x	x	x	x		x	x	x	x	x	x	x
Liver injury	Hepatocellular injury	postmarketing, infrequent			x		x	x	x		x	x	x	x	x		x	x	x	x	x	x	x
Muscular weakness	Muscular weakness	postmarketing			x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Malaise	Malaise	postmarketing, rare		x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Discomfort	Malaise	postmarketing, rare		x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Ill-defined disorder	Malaise	postmarketing, rare		x				x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Derealisation	Derealisation	postmarketing, rare		x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Painful erection	Painful erection	postmarketing, infrequent					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Intraocular pressure increased	Intraocular pressure increased	postmarketing			x		x	x	x			x	x	x		x		x	x		x	x	x
Euphoric mood	Euphoric mood	postmarketing, 1.2%	0.5%					x	x		x	x	x	x	x	x	x	x	x	x	x	x	x
Swollen tongue	Swollen tongue	postmarketing, rare		x				x	x	x	x	x	x	x	x	x	x		x	x	x	x	x
Hypomania	Hypomania	postmarketing — frequent		x				x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Painful ejaculation	Painful ejaculation	rare					x
Extrasystoles	Extrasystoles	postmarketing, infrequent					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Rash maculo-papular	Rash maculo-papular	postmarketing, rare						x	x		x	x	x	x	x		x		x	x	x	x	x
Suicidal ideation	Suicidal ideation	postmarketing — infrequent						x				x	x	x	x	x	x	x		x		x	x
Hyperkinesia	Hyperkinesia	postmarketing, infrequent						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Neuropathy peripheral	Neuropathy	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Hair colour changes	Hair colour changes	rare					x
Musculoskeletal chest pain	Musculoskeletal chest pain	postmarketing — infrequent			x		x	x	x		x	x	x	x	x		x		x	x	x	x	x
Musculoskeletal chest pain	Chest wall pain
Lymphadenopathy	Lymphadenopathy	postmarketing, rare			x		x	x	x	x	x	x	x	x		x	x	x	x	x	x	x	x
Tardive dyskinesia	Tardive dyskinesia	postmarketing			x			x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Completed suicide	Completed suicide	postmarketing			x		x	x	x			x	x	x		x		x			x	x	x
Completed suicide	Suicide									x						x		x
Neurological examination abnormal	Neurological examination abnormal	rare
Dyspareunia	Dyspareunia	postmarketing, rare					x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Ejaculation disorder	Abnormal ejaculation	postmarketing						x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Abdominal distension	Abdominal distension
Amenorrhoea	Amenorrhoea
Anaphylactic shock	Anaphylactic shock					x
Anger	Anger
Asthma	Asthma
Back injury	Back injury
Mental disorder	Mental disorder
Bipolar disorder	Bipolar disorder
Bipolar I disorder	Bipolar disorder
Concussion	Concussion
Breast cancer	Breast cancer
Bursitis	Bursitis
Basal cell carcinoma	Basal cell carcinoma
Carpal tunnel syndrome	Carpal tunnel syndrome
Pleuritic pain	Pleuritic pain
Conjunctivitis	Conjunctivitis
Connective tissue disorder	Connective tissue disorder																				x	x	x
Contusion	Contusion
Cyst	Cyst
Dehydration	Dehydration
Dental caries	Dental caries
Dermatitis atopic	Dermatitis atopic
Drug abuse	Drug abuse
Drug hypersensitivity	Drug hypersensitivity
Ear pain	Ear pain
Eczema	Eczema
Epicondylitis	Epicondylitis
Eructation	Eructation
Excoriation	Excoriation
Eye disorder	Eye disorder
Flank pain	Flank pain
Vitreous floaters	Vitreous floaters
Cardiac flutter	Cardiac flutter
Localised infection	Localised infection
Folliculitis	Folliculitis
Food allergy	Food allergy
Food poisoning	Food poisoning
Gastritis	Gastritis
Gastroenteritis	Gastroenteritis
Breath odour	Breath odour
Seasonal allergy	Seasonal allergy
Rhinitis seasonal	Seasonal allergy
Cardiac disorder	Cardiac disorder
Haemorrhage	Haemorrhage
Haemoglobin	Haemorrhage
Hepatitis C	Hepatitis C
Herpes zoster	Herpes zoster
Herpes virus infection	Herpes virus infection
Hordeolum	Hordeolum
Hunger	Hunger
Hypercholesterolaemia	Hypercholesterolaemia
Breast enlargement	Hypertrophy of breast
Hyperventilation	Hyperventilation
Hypotrichosis	Hypotrichosis
Immune system disorder	Immune system disorder
Laryngitis	Laryngitis
Lethargy	Lethargy
Menstrual disorder	Menstrual disorder
Metrorrhagia	Metrorrhagia
Motion sickness	Motion sickness
Hypotonia	Hypotonia
Muscle relaxant therapy	Hypotonia
Musculoskeletal disorder	Musculoskeletal disorder
Musculoskeletal pain	Musculoskeletal pain
Fungal infection	Fungal infection
Nasal congestion	Nasal congestion
Neoplasm	Neoplasm
Night sweats	Night sweats
Nightmare	Nightmare
Orgasm abnormal	Orgasm abnormal
Osteoporosis	Osteoporosis
Ovarian cyst	Ovarian cyst
Panic reaction	Panic reaction
Sinus disorder	Sinus disorder
Polyp	Polyp
Pregnancy	Pregnancy
Premenstrual syndrome	Premenstrual syndrome
Prurigo	Prurigo
Tension headache	Tension headache
Hyperacusis	Hyperacusis
Respiratory tract infection	Respiratory tract infection
Sebaceous gland disorder	Sebaceous gland disorder
Pharyngitis streptococcal	Pharyngitis streptococcal
Sinus headache	Sinus headache
Sinus headache	Sinus pain
Sleep disorder	Sleep disturbance									x									x		x	x	x
Sleep disorder	Sleep disorder
Sneezing	Sneezing
Snoring	Snoring
Soft tissue injury	Soft tissue injury
Somnambulism	Somnambulism
Sunburn	Sunburn
Supraventricular tachycardia	Supraventricular tachycardia
Tendonitis	Tendonitis
Testicular pain	Testicular pain
Tinea pedis	Tinea pedis
Tonsillitis	Tonsillitis
Tooth disorder	Tooth disorder								x										x
Trichotillomania	Trichotillomania
Micturition disorder	Micturition disorder
Wheezing	Wheezing
Wound infection	Wound infection
Laceration	Laceration
Laceration	Skin laceration
Yawning	Yawning
Muscle strain	Muscle strain
Vaginitis bacterial	Vaginitis bacterial
Apathy	Apathy
Flat affect	Apathy
Photophobia	Photophobia
Depressive symptom	Depressive symptom
Panic attack	Panic attack
Drug withdrawal syndrome	Withdrawal symptom					x
Swelling face	Swelling face
Impaired healing	Impaired healing
Hyperchlorhydria	Hyperchlorhydria
Gastric pH decreased	Hyperchlorhydria
Eye pain	Eye pain
Eye pain	Sore eye
Urethral pain	Urethral pain
Tendon disorder	Tendon disorder
Duodenal ulcer haemorrhage	Duodenal ulcer haemorrhage
Sinus congestion	Sinus congestion
Skin irritation	Skin irritation
Joint swelling	Joint swelling
Lacrimation increased	Lacrimation increased
Viral diarrhoea	Viral diarrhoea
Menstruation irregular	Menstruation irregular
Facial bones fracture	Facial bones fracture
Joint stiffness	Joint stiffness
Oral pain	Oral pain
Oral pain	Sore mouth
Nasal dryness	Nasal dryness
Cold sweat	Cold sweat
Abdominal pain upper	Abdominal pain upper
Abdominal pain lower	Abdominal pain lower
Disorientation	Disorientation
Feeling of despair	Feeling of despair
Thinking abnormal	Thinking abnormal
Perseveration	Perseveration
Hallucination, auditory	Hallucination, auditory
Rash erythematous	Rash erythematous
Muscle contractions involuntary	Muscle contractions involuntary
Poor quality sleep	Difficulty sleeping
Abdominal discomfort	Upset stomach
Abdominal discomfort	Gastrointestinal discomfort
Hepatotoxicity	Hepatotoxicity
Chest discomfort	Chest discomfort
Lacrimation decreased	Lacrimation decreased
Hepatic enzyme increased	Hepatic enzyme increased					x
Pain in jaw	Pain in jaw
Heart rate irregular	Heart rate irregular
Circumoral oedema	Circumoral oedema
Genital rash	Genital rash
Frequent bowel movements	Frequent bowel movements
Hyperaesthesia	Nipple pain
Nipple pain	Nipple pain
Prostate infection	Prostate infection
Dermal cyst	Dermal cyst
Pulmonary congestion	Pulmonary congestion
Respiratory tract congestion	Pulmonary congestion
Respiratory tract congestion	Respiratory tract congestion
Breast tenderness	Breast tenderness
Vocal cord disorder	Vocal cord disorder
Mouth injury	Mouth injury
Nerve injury	Nerve compression
Nerve compression	Nerve compression
Peripheral coldness	Peripheral coldness
Viral upper respiratory tract infection	Viral upper respiratory tract infection
Depressed mood	Depressed mood
Epigastric discomfort	Gastric irritation
Initial insomnia	Initial insomnia
Middle insomnia	Middle insomnia
Joint injury	Joint injury
Increased tendency to bruise	Increased tendency to bruise
Respiration abnormal	Respiratory sighs
Defaecation urgency	Defaecation urgency
Ligament sprain	Joint sprain
Wrist fracture	Wrist fracture
Energy increased	Energy increased
Pruritus generalised	Pruritus generalised
Dyslexia	Dyslexia
Conjunctivitis infective	Conjunctivitis infective
Blood pressure increased	Blood pressure increased					x
Tooth abscess	Tooth abscess
Breast calcifications	Breast microcalcification
Paraesthesia oral	Paraesthesia oral
Hypoaesthesia oral	Hypoaesthesia oral
Stress	Stress symptoms
Self-injurious ideation	Self-injurious ideation
Terminal insomnia	Terminal insomnia
Altered state of consciousness	Depressed level of consciousness
Depressed level of consciousness	Depressed level of consciousness
Vulvovaginal mycotic infection	Vaginal mycosis
Lip dry	Lip dry
Renal pain	Renal pain
Gastritis viral	Gastritis viral
Rubber sensitivity	Latex allergy
Sensation of heaviness	Sensation of heaviness
Ear infection	Ear infection
Throat irritation	Throat irritation
Acne	Acne
Limb injury	Limb injury
Infestation	Infestation NOS																				x	x	x
Animal scratch	Animal scratch
Arthropod bite	Arthropod bite
Feelings of worthlessness	Feelings of worthlessness
Social avoidant behaviour	Social avoidant behaviour
Laryngeal pain	Pharyngolaryngeal pain
Tooth infection	Tooth infection
Injection site joint pain	Injection site joint pain
Procedural pain	Post procedural pain
Muscle tightness	Muscle tightness
Hypertonic bladder	Hypertonic bladder
Hypersomnia	Hypersomnia
Musculoskeletal stiffness	Musculoskeletal stiffness
Infrequent bowel movements	Infrequent bowel movements
Rhinorrhoea	Rhinorrhoea
Increased upper airway secretion	Increased upper airway secretion
Parosmia	Parosmia
Lower limb fracture	Lower limb fracture
Feeling hot	Feeling hot

Side effects:	47
Source:	FDA Structured Product Label

Side effects:	61
Source:	Medsafe

Side effects:	92
Source:	FDA Structured Product Label

Side effects:	136
Source:	FDA Structured Product Label

Side effects:	145
Source:	FDA Structured Product Label

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ZYBAN Tablets / Zyban, Modified release tablet

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Color scheme:

Indication	Labels
Agitation	x	x		x	x	x	x	x	x	x					x	x	x	x
Bradypsychic response	x	x		x	x	x	x	x	x	x					x	x	x	x
Cerebration impaired	x	x		x	x	x	x	x	x	x					x	x	x	x
Chronic obstructive pulmonary disease													x	x
Convulsion		x		x
Convulsions generalised		x		x
Decreased interest	x	x		x	x	x	x	x	x	x					x	x	x	x
Depressed mood	x				x	x	x	x	x	x					x	x	x	x
Depressive disorder		x		x							x
Dysphoria		x		x
Fatigability		x		x
Fatigue	x				x	x	x	x	x	x					x	x	x	x
Feeling guilty	x	x		x	x	x	x	x	x	x					x	x	x	x
Hypersomnia	x				x	x	x	x	x	x					x	x	x	x
Insomnia	x				x	x	x	x	x	x					x	x	x	x
Major depression	x	x		x	x	x	x	x	x	x		x			x	x	x	x
Major depressive disorder, single episode	x				x	x	x	x	x	x		x			x	x	x	x
Mental disorder	x															x	x	x
Nicotine dependence			x
Seasonal affective disorder	x															x	x	x
Sexual dysfunction		x		x
Suicidal ideation	x	x		x	x	x	x	x	x	x					x	x	x	x
Suicide attempt	x				x	x	x	x	x	x					x	x	x	x

		100%
		75%
		50%
		10%
		frequent (1% to 100%)
		infrequent (0.1% to 1%)
		rare (<0.1%)
		postmarketing
		0%
		no frequency information
		not found on label

Side effects:	166
Source:	Health Canada

Side effects:	180
Source:	Health Canada